10-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-K

[X]  ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the fiscal year ended December 31, 2013

[  ] TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

Commission file number 0-29630

SHIRE PLC

(Exact name of registrant as specified in its charter)

Jersey (Channel Islands) (State or other jurisdiction of incorporation or organization)	98-0601486 (I.R.S. Employer Identification No.)
5 Riverwalk, Citywest Business Campus, Dublin 24, Republic of Ireland (Address of principal executive offices and zip code)	+353 1 429 7700 (Registrant’s telephone number, including area code)
Securities registered pursuant to Section 12(b) of the Act:
Title of each class	Name of exchange on which registered
American Depositary Shares, each representing three Ordinary Shares 5 pence par value per share	NASDAQ Global Select Market
Securities registered pursuant to Section 12(g) of the Act:
None
(Title of class)

Indicate by check mark whether the Registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act

Yes  [X]    No   [  ]

Indicate by check mark if the Registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Act

Yes  [  ]    No   [X]

Indicate by check mark whether the Registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the Registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.

Yes  [X]    No   [  ]

Indicate by check mark if disclosure of delinquent filers pursuant to Item 405 of Regulation S-K is not contained herein, and will not be contained, to the best of the Registrant’s knowledge, in definitive proxy or information statements incorporated by reference to Part III of this Form 10-K or any amendment to this Form 10-K.

[X]

Indicate by check mark whether the Registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer.  See definition of “accelerated filer and large accelerated filer” in Rule 12b-2 of the Exchange Act.

Large accelerated filer  [X] Accelerated filer Non-accelerated filer Smaller reporting company

Indicate by check mark whether the Registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).

Yes  [ ]    No    [X]

Indicate by check mark whether the Registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (232,405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).

Yes  [X]    No   [  ]

As at June 30, 2013, the last business day of the Registrant’s most recently completed second quarter, the aggregate market value of the ordinary shares, £0.05 par value per share of the Registrant held by non-affiliates was approximately $17.4 billion. This was computed using the average bid and asked price at the above date.

As at February 14, 2014, the number of outstanding ordinary shares of the Registrant was 597,689,635.

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THE “SAFE HARBOR” STATEMENT UNDER THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995

Statements included herein that are not historical facts are forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, Shire’s results could be materially adversely affected. The risks and uncertainties include, but are not limited to, that:

· Shire’s products may not be a commercial success;

· revenues from ADDERALL XR are subject to generic erosion and revenues from INTUNIV will become subject to generic competition starting in December 2014;

· the failure to obtain and maintain reimbursement, or an adequate level of reimbursement, by third-party payors in a timely manner for Shire's products may impact future revenues, financial condition and results of operations;

· Shire conducts its own manufacturing operations for certain of its Rare Diseases products and is reliant on third party contract manufacturers to manufacture other products and to provide goods and services. Some of Shire’s products or ingredients are only available from a single approved source for manufacture. Any disruption to the supply chain for any of Shire’s products may result in Shire being unable to continue marketing or developing a product or may result in Shire being unable to do so on a commercially viable basis for some period of time;

· the development, approval and manufacturing of Shire’s products is subject to extensive oversight by various regulatory agencies and regulatory approvals or interventions associated with changes to manufacturing sites, ingredients or manufacturing processes could lead to significant delays, increase in operating costs, lost product sales, an interruption of research activities or the delay of new product launches;

· the actions of certain customers could affect Shire's ability to sell or market products profitably. Fluctuations in buying or distribution patterns by such customers can adversely impact Shire’s revenues, financial condition or results of operations;

· investigations or enforcement action by regulatory authorities or law enforcement agencies relating to Shire’s activities in the highly regulated markets in which it operates may result in significant legal costs and the payment of substantial compensation or fines;

· adverse outcomes in legal matters and other disputes, including Shire’s ability to enforce and defend patents and other intellectual property rights required for its business, could have a material adverse effect on Shire’s revenues, financial condition or results of operations;

· Shire faces intense competition for highly qualified personnel from other companies, academic institutions, government entities and other organizations. Shire is undergoing a corporate reorganization and the consequent uncertainty could adversely impact Shire’s ability to attract and/or retain the highly skilled personnel needed for Shire to meet its strategic objectives;

· failure to achieve Shire’s strategic objectives with respect to the acquisition of ViroPharma Incorporated may adversely affect Shire’s financial condition and results of operations;

and other risks and uncertainties detailed from time to time in Shire’s filings with the Securities and Exchange Commission, including those risks outlined in “Item 1A: Risk Factors” in Shire’s Annual Report on Form 10-K for the years ended December 31, 2013 and 2012.

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The following are trademarks either owned or licensed by Shire plc or its subsidiaries, which are the subject of trademark registrations in certain territories, or which are owned by third parties as indicated and referred to in this Form 10-K:

ADDERALL XR® (mixed salts of a single entity amphetamine)

AGRYLIN® (anagrelide hydrochloride)

APLIGRAF® (trademark of Organogenesis, Inc. (“Organogenesis”))

APRISO® (trademark of Salix Pharmaceuticals, Ltd. (“Salix”))

ASACOL® (trademark of Medeva Pharma Suisse AG (used under license by Warner Chilcott Company, LLC (“Warner Chilcott”)))

ATRIPLA® (trademark of Bristol Myers Squibb Company and Gilead Sciences, Inc. (“Gilead”))

BERINERT® (trademark of CSL Behring GmbH)

BERINERT P® (trademark of Aventis Behring GmbH)

CARBATROL® (carbamazepine extended-release capsules)

CEREZYME® (trademark of Genzyme Corporation (“Genzyme”))

CINRYZE® (C1 esterase inhibitor [human])

CLAVERSAL® (trademark of Merckle Recordati)

COLAZAL® (trademark of Salix Pharmaceuticals, Inc)

COMBIVIR® (trademark of GlaxoSmithKline (“GSK”))

CONCERTA® (trademark of Alza Corporation (“Alza”))

CONSTELLATM (trademark of Ironwood Pharmaceuticals)

DAYTRANA® (trademark of Noven Pharmaceutical Inc. (“Noven”))

DELZICOL® (trademark of Warner Chilcott)

DERMAGRAFT® (trademark of Organogenesis)

ELAPRASE® (idursulfase)

ELELYSO®(trademark of Pfizer Inc.)

ELVANSE® (lisdexamfetamine dimesylate)

EPIFIX®(trademark of Surgical Biologics, LLC)

EPIVIR® (trademark of GSK)

EPZICOM®/KIVEXA (EPZICOM)® (trademark of GSK)

EQUASYM® (methylphenidate hydrochloride)

EQUASYM XL® (methylphenidate hydrochloride)

FIRAZYR® (icatibant)

FOCALIN®(trademark of Novartis AG)

FOCALIN XR® (trademark of Novartis AG)

FOSRENOL® (lanthanum carbonate)

FABRAZYME® (trademark of Genzyme)

HUNTERASETM (trademark of Green Cross Corp.)

INTUNIV® (guanfacine extended release)

KALBITOR® (trademark of Dyax Corporation)

KAPVAY® (trademark of Shionogi Pharma, Inc. (“Shionogi”))

KIVEXA® (trademark of Viiv Healthcare UK Ltd)

LIALDA® (trademark of Nogra International Limited)

MATRISTEM® (trademark of ACell, Inc.)

MEDIKINET® (trademark of Medice Arzneimittel Pütter GmbH & Co. KG (“Medice”))

METADATE CD® (trademark of UCB Pharma, S.A.)

MEZAVANT® (trademark of Giuliani International Limited)

MICROTROL® (trademark of Supernus Pharmaceuticals, Inc. (“Supernus”))

MOVICOL® (trademark of Edra AG, S.A.)

OASIS® (trademark of Healthpoint, Ltd. (“Healthpoint”))

PENTASA® (trademark of Ferring B.V. Corp (“Ferring”))

PREMIPLEX®(IGF-I/IGFBP-3)

PROMOGRAN PRISMA® (trademark of Johnson & Johnson (“J&J”))

QUILLIVANT®(trademark of Next Wave Pharmaceuticals, Inc.)

REGRANEX® (trademark of Healthpoint)

REMINYL® (galantamine hydrobromide) (United Kingdom ("UK”) and Republic of Ireland) (trademark of J&J), excluding UK and Republic of Ireland)

RENASYS® (trademark of Smith & Nephew Plc (“Smith & Nephew”))

REPLAGAL® (agalsidase alfa)

RESOLOR® (prucalopride)

RITALIN LA® (trademark of Novartis AG)

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RUCONEST® (trademark of Pharming Intellectual Property B.V.)

SALOFALK® (trademark of Dr Falk Pharma)

STRATTERA® (trademark of Eli Lilly and Company)

THERASKIN® (trademark of Soluble Systems, LLC)

TRIZIVIR® (trademark of GSK)

TRUVADA® (trademark of Gilead)

TYVENSE® (lisdexamfetamine dimesylate)

UCERIS® (trademark of Santarus, Inc.)

VASCUGEL® (allogeneic aortic endothelial cells cultured in a porcine gelatin matrix [Gelfoam®] with cytokines, implanted)

VENVANSE® (lisdexamfetamine dimesylate)

VPRIV® (velaglucerase alfa)

VYVANSE® (lisdexamfetamine dimesylate)

XAGRID® (anagrelide hydrochloride)

ZAVESCA® (trademark of Actelion Pharmaceuticals, Ltd.)

ZEFFIX® (trademark of GSK)

3TC® (trademark of GSK)

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SHIRE PLC

2013 Form 10-K Annual Report

Table of contents

PART I
ITEM 1. BUSINESS
	General	7
	Strategy	7
	Business model	7
	2013 highlights	8
	Financial information about operating segments	8
	Sales and marketing	8
	Manufacturing and distribution	20
	Intellectual property	21
	Competition	24
	Government regulation	26
	Third party reimbursement and pricing	27
	Responsibility	29
	Employees	29
	Available information	29
ITEM 1A. RISK FACTORS		30
ITEM 1B. UNRESOLVED STAFF COMMENTS		37
ITEM 2.   PROPERTIES		38
ITEM 3.   LEGAL PROCEEDINGS		39
ITEM 4.   MINE SAFETY DISCLOSURES		39
PART II
ITEM 5.    MARKET FOR THE REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER  MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES		40
ITEM 6.    SELECTED FINANCIAL DATA		44
ITEM 7.    MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS		46
ITEM 7A.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK		75
ITEM 8.    FINANCIAL STATEMENTS AND SUPPLEMENTARY DATA		78
ITEM 9.    CHANGES IN AND DISAGREEMENTS WITH ACCOUNTANTS ON ACCOUNTING  AND FINANCIAL DISCLOSURE		78
ITEM 9A.  CONTROLS AND PROCEDURES		78
ITEM 9B.  OTHER INFORMATION		78
PART III
ITEM 10.   DIRECTORS, EXECUTIVE OFFICERS AND CORPORATE GOVERNANCE		79
ITEM 11.   EXECUTIVE COMPENSATION		83
ITEM 12.   SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT AND RELATED STOCKHOLDER MATTERS		106
ITEM 13.   CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS AND DIRECTOR INDEPENDENCE		107
ITEM 14.   PRINCIPAL ACCOUNTANT FEES AND SERVICES		107
PART IV
ITEM 15.   EXHIBITS AND FINANCIAL STATEMENT SCHEDULES		109

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PART I

ITEM 1: Business

General

Shire plc and its subsidiaries (collectively referred to as either “Shire”, or the “Company”) is a leading specialty biopharmaceutical company that focuses on developing and marketing innovative specialty medicines that address significant unmet patient needs.

The Company has grown through acquisition, completing a series of major transactions that have brought therapeutic, geographic and pipeline growth and diversification. The Company will continue to evaluate companies, products and pipeline opportunities that offer a good strategic fit and have the potential to deliver demonstrable value to all of the Company’s stakeholders: patients, physicians, policy makers, payors, investors and employees.

Strategy

Shire’s vision is to transform the lives of people around the world whose health is impacted by rare and other specialized conditions, through providing innovative treatments. The Company’s strategy for achieving its vision is to grow its business and deliver value to its stakeholders by focusing on significant unmet patient needs in specialist areas and providing more innovative treatments to more patients. Through deep understanding of patients’ needs, the Company:

· serves patients with high unmet needs in select, commercially attractive specialty therapeutic areas;

· drives optimum performance of its marketed products (known as “In-Line”) – to serve patients today;

· builds its pipeline of innovative specialist treatments through both R&D and business development activities (known as “Pipeline”) – to enable the Company to serve patients in the future.

Business model

The Company unified its business during 2013 by integrating the operations of the Specialty Pharmaceuticals (“SP”), Human Genetic Therapies (“HGT”) and Regenerative Medicine (“RM”) business units into a simplified “One Shire” organization. The One Shire model has created a simple structure and a focused, efficient organization that is scalable for growth.

Shire has four commercial units that focus exclusively on the commercial execution of its In-Line products in the following specialist therapeutic areas: Rare Diseases, Neuroscience, Gastrointestinal (GI) and Internal Medicine, each supported by Shire’s commercial organization. This ensures that the Company provides innovative treatments, and services the needs of its customers and patients, as efficiently as possible.

The Company has moved to a single R&D organization that focuses on developing a pipeline of innovative treatments to address unmet patient needs. The Company prioritizes the treatments that have the highest chance of clinical success and are aligned with its current priority therapeutic areas as listed above, as well as potential new therapeutic areas such as ophthalmology and hematology/oncology. Shire’s early stage research is primarily focused on rare diseases.

Growth is also fuelled by the acquisition or licensing of new development programs and marketed products. Shire’s global business development team searches for value-added therapeutics that fit Shire’s strategic focus and address patients’ unmet needs. 

Shire’s support functions, including Technical Operations, are unified across the business to run as efficiently and effectively as possible to support the In-Line and Pipeline activities.

Shire leads its business through the Executive Committee, with support from its In-Line Committee and Pipeline Committee which comprise senior management from across functions and commercial units to support the In-Line products and Pipeline activities. The Executive Committee is responsible for ensuring the appropriate allocation of resources and focused decision making across the enterprise in the best interests of Shire, patients, shareholders and other stakeholders.

This unified way of working means that Shire can quickly adapt to focus its resources where the greatest opportunities exist.

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2013 Highlights

See “Currently marketed products” and “Products under development” below for a full discussion of 2013 Product, pipeline and business highlights, including:

Pipeline development:

· the approval by the US Food and Drug Administration (“FDA”) of VYVANSE as a maintenance treatment in children and adolescents with ADHD. VYVANSE is currently the only stimulant approved for maintenance treatment in children and adolescents aged 6 to 17 years with Attention Deficit Hyperactivity Disorder (“ADHD”), as well as in adults with ADHD;

· positive top-line results from two randomized placebo-controlled Phase 3 studies evaluating the efficacy and safety of VYVANSE in adults with binge eating disorder (“BED”);

· the announcement of the top-line results from OPUS-2, a Phase 3 efficacy and safety study, comparing Lifitegrast to placebo administered twice daily for 84 days (12 weeks) in dry eye patients. Lifitegrast met the prespecified co-primary endpoint for the patient-reported symptom of eye dryness. Lifitegrast did not meet the prespecified co-primary endpoint for the sign of inferior corneal staining score using fluorescein staining compared with placebo;

Geographical expansion:

· approval from Health Canada for INTUNIV XR as monotherapy for the treatment of ADHD in children aged 6 to 12 years and as adjunctive therapy to psychostimulants for the treatment of ADHD in children, aged 6 to 12 years;

· the launch of ELVANSE in Germany, UK, Denmark and Ireland for ADHD in children aged 6 years of age and over when response to previous methylphenidate treatment is considered clinically inadequate;

Business development:

· the acquisition of SARcode Bioscience Inc. (“SARcode”) which added global rights to a Phase 3 compound, Lifitegrast, for the treatment of Dry Eye disease;

· the acquisition of Premacure AB (“Premacure”) which added global rights to a protein replacement therapy (“PREMIPLEX”) in Phase 2 development, for the prevention of Retinopathy of Prematurity (“ROP”);

· the acquisition of Lotus Tissue Repair, Inc. (“Lotus Tissue Repair”) which added global rights to a protein replacement therapy in pre-clinical development for the treatment of Dystrophic Epidermolysis Bullosa (“DEB”);

· the acquisition of ViroPharma Inc. (“ViroPharma”) (completed in January 2014) which added a marketed product for the prophylactic treatment of Hereditary Angioedema (“HAE”), CINRYZE, as well as a number of other marketed products and a pipeline of product candidates in the rare disease area.

Financial information about operating segments

Historically the Company had three business units and three reportable segments: SP, HGT and RM. The Company unified its business during 2013 and now comprises a single operating and reportable segment. This segment is engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs. Additional segment information is presented in Note 24 to the Company’s consolidated financial statements contained in ITEM 15: Exhibits and Financial Statement Schedules of this Annual Report on Form 10-K.

Sales and marketing

At December 31, 2013 the Company employed 2,185 (2012: 2,207) sales and marketing staff to service its operations throughout the world, including its major markets in North America, Europe, Latin America, and Asia Pacific.

Currently marketed products

The table below lists the Company’s main marketed products by geography at December 31, 2013 indicating the owner/licensor, disease area and the key territories in which Shire markets the product.

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Products	Disease area	Owner/licensor	Key territories
Treatments for Neuroscience
VYVANSE/VENVANSE/ ELVANSE/TYVENSE (lisdexamfetamine dimesylate)	ADHD	Shire	US, Europe, Canada and Brazil (1)
ADDERALL XR (mixed salts of a single-entity amphetamine)	ADHD	Shire	US and Canada
INTUNIV (extended release guanfacine)	ADHD	Shire	US and Canada
EQUASYM (methylphenidate hydrochloride) modified release (XL)	ADHD	Shire	Europe
Treatments for gastrointestinal (“GI”) diseases
LIALDA (mesalamine)/ MEZAVANT(mesalazine)	Ulcerative Colitis	Nogra SpA	US, Canada and Europe (2,3)
PENTASA (mesalamine)	Ulcerative Colitis	Shire	US
RESOLOR (prucalopride)	Chronic constipation in women	Shire	Europe
Treatments for Rare Diseases
REPLAGAL (agalsidase alfa)	Fabry disease	Shire	Europe, Latin America and Asia Pacific(5)
ELAPRASE (idursulfase)	Hunter syndrome (Mucopolysaccharidosis Type II, MPS II)	Shire	Global(6)
VPRIV (velaglucerase alfa)	Gaucher disease, Type 1	Shire	US, Europe and Latin America
FIRAZYR (icatibant)	Hereditary Angioedema (“HAE”)	Shire	US, Europe and Latin America
Treatments for diseases in Other therapeutic areas
FOSRENOL (lanthanum carbonate)	Hyperphosphatemia in end stage renal disease	Shire	US, Europe and Japan(2, 4)
XAGRID (anagrelide hydrochloride)	Elevated platelet counts in at risk essential thrombocythemia patients	Shire	Europe (2)

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DERMAGRAFT (human fibroblast-derived dermal substitute)	Diabetic Foot Ulcers (“DFU”)	Shire	US (7)
Recently acquired product
Following the acquisition of ViroPharma on January 24, 2014, Shire acquired the following marketed product.
Products	Disease area	Owner/licensor	Key territories
CINRYZE	HAE	Shire	US and Europe

(1) The product is marketed in Brazil as VENVANSE and in the EU as ELVANSE or TYVENSE.

(2) Marketed by distributors in certain other markets.

(3) Marketed in US as LIALDA and in Europe as MEZAVANT XL or MEZAVANT.

(4) Marketed in Japan under license by Bayer Yakuhin Limited (“Bayer”).

(5) Marketed in Japan under license by Dainippon Sumitomo Pharma Co., Ltd. (“DSP”).

(6) Marketed in Asia Pacific under license by Genzyme.

(7) Shire divested its DERMAGRAFT business in January 2014.

Treatments for Neuroscience

ADHD is a chronic neurobehavioral disorder that manifests as a persistent pattern of inattention and/or hyperactivity-impulsivity that is more frequent and severe than is typically observed in individuals at a comparable level of development. Although there is no cure for ADHD, there are accepted treatments that have been demonstrated to improve symptoms. Standard treatments include educational approaches, psychological therapies that may include behavior modification, and/or medication.

The worldwide prevalence of ADHD is estimated at 5.3% (Am J Psych. 2007). In the US, approximately 9.5% of all school-aged children (4-17 years old) have been diagnosed with ADHD at some point in their lives. However, only two-thirds (66.3%) of those with a current ADHD diagnosis were taking medication (CDC, 2010). Over 50% of children may have symptoms that persist into adulthood. According to the results from the National Comorbidity Survey Replication (Am J Psychiatry, 2006), the disorder is estimated to affect 4.4% of US adults aged 18 to 44. The international ADHD market was approximately $884 million in 2012 (moving annual total (“MAT”) Q3 2012) and grew 10.9% to reach approximately $981million in the same period in 2013.   

According to IMS Health National Prescription Audit (“IMS NPA”), a leading global provider of business intelligence for the pharmaceutical and healthcare industries, the US ADHD market was valued at approximately $8.29 billion for the twelve months ending December 2013; this represents a decline of approximately 0.6% from the twelve months ending December 2012.

VYVANSE/ VENVANSE/ ELVANSE/ TYVENSE

VYVANSE is the first pro-drug stimulant for the treatment of ADHD, where the amino acid l-lysine is linked to d-amphetamine. VYVANSE is therapeutically inactive until metabolized in the body.

The FDA approved VYVANSE as a once-daily treatment for children aged 6 to 12 with ADHD in February 2007, for adults in April 2008 and for adolescents aged 13 to 17 in November 2010. In addition VYVANSE became the first drug in its class to be approved by the FDA for maintenance treatment, having been approved both as a maintenance treatment in adults with ADHD in January 2012, and as a maintenance treatment in pediatrics and adolescents aged 6 to 17 in April 2013. VYVANSE is available in the US in six dosage strengths: 20mg, 30mg, 40mg, 50mg, 60mg and 70mg.

VYVANSE was approved by Health Canada for the treatment of ADHD in paediatric patients aged 6 to 12 in February 2009, for adolescents and adults in November 2010, and was launched in Canada in February 2011.

VENVANSE was granted marketing authorization by ANVISA, the Brazilian health authority, for the treatment of ADHD in children aged 6-12, and launched in April 2011.

ELVANSE/TYVENSE received a positive outcome from the European Decentralised Procedure in December 2012. ELVANSE is indicated as part of a comprehensive treatment program for ADHD in children 6 years of age and over when response to previous methylphenidate treatment is considered clinically inadequate.Product labelling has been agreed by

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and Marketing Authorization approvals granted in eight countries (UK, Germany, Sweden, Spain, Norway, Finland, Denmark, and Ireland). The product has launched in five of the eight countries with remaining launches expected in 2014.

Litigation proceedings relating to the Company’s VYVANSE patents are in progress. For further information see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

ADDERALL XR

ADDERALL XR is an extended release treatment for ADHD, which uses MICROTROL drug delivery technology and is designed to provide once-daily dosing. It is available in 5mg, 10mg, 15mg, 20mg, 25mg and 30mg capsules.

The FDA approved ADDERALL XR as a once-daily treatment for children aged 6 to 12 with ADHD in October 2001, for adults in August 2004 and for adolescents aged 13 to 17 in July 2005.

Teva Pharmaceutical Industries, Ltd. (“Teva”) and Impax Laboratories, Inc. (“Impax”) commenced commercial shipment of their authorized generic versions of ADDERALL XR in April and October 2009, respectively. Shire currently receives royalties from Impax’s sales of authorized generic ADDERALL XR.  Shire has extended its supply agreement with Teva until September 30, 2016.  From the third quarter of 2012 Shire also started receiving royalties from Actavis’ sales of its generic version of ADDERALL XR. In December 2013, Shire entered an agreement with Sandoz Inc. (“Sandoz”) whereby Shire will supply Sandoz with an authorized generic version of Adderall XR beginning July 1, 2016.  From the December 1, 2013 effective date of the agreement through the end of the agreement’s five-year term, Sandoz has agreed to exclusively sell the authorized generic version of Adderall XR supplied by Shire. Shire will receive a royalty on Sandoz's sales of the product.

In June 2012 the FDA stated that it will require that all abbreviated new drug applications (“ANDAs”) for ADDERALL XR will have to establish bioequivalence using partial area under the curve measurements at multiple time points post-dosing and for both d- and l-amphetamine. The FDA response is consistent with recent decisions on other long-acting ADHD products.

Litigation proceedings relating to the Company’s ADDERALL XR patents are in progress. For further information see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

INTUNIV

INTUNIV is a selective alpha-2A receptor agonist indicated for the treatment of ADHD. Alpha-2A-adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signalling in the prefrontal cortex (Cell. 2007;129:397-410). INTUNIV is non-scheduled and has no known potential for abuse or dependence.

The FDA approved INTUNIV as a once-daily monotherapy treatment of ADHD in children and adolescents aged 6 to 17 and as adjunctive therapy to stimulants in February 2011. It is available in 1mg, 2mg, 3mg and 4mg tablets.

INTUNIV XR was approved by Health Canada as monotherapy for the treatment of ADHD in children aged 6 to 12 years and as adjunctive therapy to psychostimulants for the treatment of ADHD in children, aged 6 to 12 years, with a sub-optimal response to psychostimulants in July 2013 and was launched in Canada in November 2013.

In April 2013, Shire settled outstanding litigation with Actavis Inc. and certain of its respective affiliates (“Actavis”) and six other ANDA filers regarding their respective ANDAs for INTUNIV. The settlement provides Actavis with a license to make and market Actavis’ generic versions of INTUNIV in the United States for 180 days starting on December 1, 2014.   Such sales will require the payment of a royalty of 25% of gross profits to Shire during the 180 day period of Actavis’ exclusivity.  The settlement also provides the other six ANDA filers with a license to make and market their respective generic versions of INTUNIV in the United States 181 days after Actavis’ launch of generic INTUNIV.

For further information on the litigation proceedings relating to the Company’s INTUNIV patents, see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

EQUASYM

In March 2009, Shire acquired from UCB the worldwide rights (excluding US, Canada and Barbados) to EQUASYM immediate release and modified release (XL) preparations for the treatment of ADHD in children and adolescents aged 6 to 17.  Shire is focusing exclusively on the XL form. At December 31, 2013 EQUASYM XL was commercially available in 10 countries in 10mg, 20mg and 30mg strengths. EQUASYM XL is marketed in Mexico and South Korea under the trade name METADATE CD.

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Treatments for Ulcerative Colitis (“UC”)

Ulcerative Colitis was estimated to affect approximately 1.2 million patients in major markets (US and EU5) in 2010 according to Ulcerative Colitis: Decision Resources’ Market Forecast and Opportunity Analysis (May, 2012). UC is a serious chronic inflammatory disease of the colon in which part or all of the large intestine becomes inflamed and often ulcerated. Typically, patients go through periods of relapse and remission and can suffer from diarrhea, bleeding and abdominal pain. Once diagnosis is confirmed, patients are usually treated for life. The first line treatment for inflammatory bowel disease is mesalamine (5-aminosalicylic acid (“5-ASA”)) based products.

LIALDA/MEZAVANT

LIALDA is indicated in the US and Canada for the induction of remission in patients with mild to moderately active UC and for the maintenance of remission of UC. The addition of the indication for maintenance of remission of UC was approved by Health Canada in February 2011 and by the FDA in July 2011.  LIALDAis the first and only FDA-approved once-daily oral formulation of mesalamine indicated for the induction and maintenance of remission.  LIALDA contains the highest commercially available mesalamine dose per tablet (1.2g), so patients can take as few as two tablets once daily.In 2012, the FDA issued draft bioequivalence guidelines for orally-delivered delayed or extended-release mesalamine-based drugs (including LIALDA and PENTASA; see PENTASA section below).

LIALDA was approved by the FDA in January 2007 and was launched in the US in March 2007. Following approvals in other countries, at December 31, 2013 LIALDA/MEZAVANT was commercially available in 19 countries either directly or through distributor arrangements.

Litigation proceedings relating to the Company’s LIALDA patents are in progress. For further information see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

PENTASA

PENTASA controlled release capsules are marketed by Shire in the US and are indicated for the induction of remission and for the treatment of patients with mild to moderately active UC.

PENTASA is an ethylcellulose-coated, controlled release capsule formulation designed to release therapeutic quantities of mesalamine throughout the gastrointestinal tract. PENTASA is available in the US in 250mg and 500mg capsules.

In September 2012, the FDA issued draft bioequivalence guidelines for generic approvals of orally-delivered delayed or extended-release mesalamine-based drugs (including LIALDA and PENTASA).

Treatments for chronic constipation

Chronic idiopathic constipation is a widespread and often debilitating disorder. The constipated patient population can be split into three distinct groups: (1) patients with primary constipation (without other underlying diseases or not caused by use of medication); (2) patients constipated as a result of regular use of medication such as opioids and (3) patients with severe constipation resulting from neurodegenerative disorders such as multiple sclerosis and Parkinson’s disease. Chronic constipation is characterized by infrequent and difficult passage of stool over a prolonged period. Other symptoms include infrequent bowel movements, bloating, straining, abdominal discomfort and pain, incomplete evacuation and unsuccessful attempts at evacuation. The disease has been clearly defined by the widely accepted Rome III criteria based on the type and duration of the symptoms. Chronic constipation is seen as a persistent disease with approximately 70% of patients having more than three symptom episodes per week.

RESOLOR

RESOLOR is the first of a new generation of selective, high-affinity 5-HT4 receptor agonists that stimulates gastrointestinal motility and acts primarily on different parts of the lower gastrointestinal tract (prokinetic).

In October 2009 RESOLOR was approved by the EMA throughout the EU as a once daily oral treatment for symptomatic treatment of chronic constipation in women in whom laxatives fail to provide adequate relief. In July 2010, Swissmedic granted RESOLOR marketing authorization in Switzerland for the treatment of idiopathic chronic constipation in adults for whom the currently available treatment options involving dietary measures and laxatives do not provide sufficient effect. RESOLOR is available in 1mg and 2mg dose strengths, both for once-daily dosing. As of December 31, 2013 RESOLOR was available in 18 EU countries.

On January 10, 2012 Shire announced that it had acquired the rights to develop and market prucalopride in the US pursuant to an agreement with Janssen Pharmaceutica N.V., part of the J&J Group.

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Treatments for Rare Diseases

REPLAGAL

REPLAGAL is marketed for the treatment of Fabry disease outside of the US. Fabry disease is a rare, inherited genetic disorder resulting from a deficiency in the activity of the lysosomal enzyme alpha-galactosidase A, which is involved in the breakdown of fats. Although the signs and symptoms of Fabry disease vary widely from patient to patient, the most common include severe pain of the extremities, impaired kidney function which often progresses to kidney failure, early heart disease, stroke and disabling gastrointestinal symptoms. The disease is estimated to affect 1 in 27,000 people (Spada et al, 2006).

REPLAGAL is a fully human alpha-galactosidase A protein made in human cells that replaces the deficient alpha-galactosidase A with an active enzyme to ameliorate certain clinical manifestations of Fabry disease.

In August 2001, REPLAGAL was granted marketing authorization in the EU. At December 31, 2013 REPLAGAL was approved in 46 countries excluding the US.

ELAPRASE

ELAPRASE is a treatment for Hunter syndrome (also known as Mucopolysaccharidosis Type II or MPS II). Hunter syndrome is a rare, inherited genetic disorder mainly affecting males that interferes with the body's ability to break down and recycle waste substances called mucopolysaccharides, also known as glycosaminoglycans or GAGs. In patients with Hunter syndrome, cumulative build-up of GAGs in cells throughout the body interferes with the way certain tissues and organs function, leading to severe clinical complications and early mortality. The disease is estimated to affect approximately 1 in 162,000 males (Meikle et al, 1999).

ELAPRASE was approved by the FDA in July 2006 and granted marketing authorization by the EMA in January 2007 for the long term treatment of patients with Hunter syndrome. ELAPRASE has been granted orphan drug exclusivity by both the FDA and the EMA. ELAPRASE also benefits from the 12 years of data exclusivity from the date of grant of registration given to innovator biologics in the US under the Affordable Care Act.

ELAPRASE received approval from the Ministry of Health, Labour and Welfare in Japan in October 2007. As part of an agreement with Genzyme, Genzyme manages the sales and distribution of ELAPRASE in Japan as well as certain other countries in the Asia Pacific region.

At December 31, 2013 ELAPRASE was approved in 51 countries.

VPRIV

VPRIV is a treatment for Type 1 Gaucher disease. Gaucher disease is a rare, inherited genetic disorder which results in a deficiency of the lysosomal enzyme beta-glucocerebrosidase. This enzymatic deficiency causes an accumulation of glucocerebroside, primarily in macrophages called Gaucher cells in the liver, spleen, bone marrow, and other organs. The accumulation of glucocerebrosidase in Gaucher cells in the liver and spleen leads to organomegaly. Presence of Gaucher cells in the bone marrow and spleen leads to clinically significant anemia and thrombocytopenia. The disease is estimated to affect 1 in 40,000 individuals, with a higher incidence in the Ashkenazi Jewish population (Sidransky et al, 2010, and National Gaucher Foundation).

VPRIV was approved by the FDA in February 2010 for the long term treatment of patients with Type 1 Gaucher disease. The EMA approved the marketing authorization for the use of VPRIV in August 2010. VPRIV has been granted orphan drug status in the EU with up to ten year’s market exclusivity from August 2010. VPRIV also benefits from the 12 years of data exclusivity in the US from the date of grant of registration given to innovator biologics under the Affordable Care Act.

At December 31, 2013 VPRIV was approved in 40 countries.

FIRAZYR

FIRAZYR is a first-in-class peptide-based therapeutic developed for the symptomatic treatment of acute attacks of HAE. HAE is a debilitating and potentially life-threatening genetic disease characterized by unpredictable recurring swelling attacks in the hands, feet, face, larynx, or abdomen. The disease is estimated to affect approximately 1 in 50,000 individuals (Bowen et al, 2008).

In July 2008 the EMA granted marketing authorization throughout the EU for the use of FIRAZYR for the symptomatic treatment of acute attacks of HAE, and in May 2011 approved FIRAZYR for self-administration after training in subcutaneous injection technique by a healthcare professional. In August 2011 the FDA granted marketing approval for FIRAZYR in the US for treatment of acute attacks of HAE in adults aged 18 and older and, after injection training, patients may self-administer FIRAZYR. FIRAZYR has been granted orphan drug exclusivity by both the FDA and the EMA,

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providing it with up to 7 and 10 years market exclusivity in the US and EU, respectively, from the date of the grant of the relevant marketing authorization.

At December 31, 2013 FIRAZYR was approved in 38 countries.

CINRYZE

Following the acquisition of ViroPharma on January 24, 2014, Shire has added CINRYZE to its portfolio of currently marketed products. CINRYZE is a C1 esterase inhibitor therapy for routine prophylaxis against HAE, also known as C1 inhibitor (C1-INH) deficiency. CINRYZE is marketed and sold in the US for routine prophylaxis against HAE attacks in adolescent and adult patients with HAE. ViroPharma acquired rights to CINRYZE for the US in October 2008 and in January 2010 acquired expanded rights to commercialize CINRYZE and future C1-INH derived products in certain European countries and other territories throughout the world as well as rights to develop future C1-INH derived products for additional indications and new formulations. In June 2011, marketing authorization in the EU was granted for CINRYZE in adults and adolescents with HAE for routine prevention, pre-procedure prevention and acute treatment of angioedema attacks. The approval also includes a self administration option for appropriately trained patients. ViroPharma had begun to commercialize CINRYZE in Europe and Shire will continue to evaluate the commercialization opportunities in countries where ViroPharma has distribution rights.

CINRYZE has been granted orphan drug exclusivity by the FDA, providing it with up to 7 years market exclusivity in the US from October 2008. CINRYZE also benefits from the 12 years of data exclusivity from the date of grant of registration given to innovator biologics in the US under the Affordable Care Act from October 2008.

Treatments for Other therapeutic areas

FOSRENOL

FOSRENOL is a phosphate binder that is indicated for use in end-stage renal disease (stage 5) receiving dialysis and, from October 2009, is also indicated in the EU for the treatment of adult patients with CKD who are not on dialysis with serum phosphate > 1.78 mmol/L (5.5 mg/dL) in which a low phosphate diet alone is insufficient to control serum phosphate levels. It is estimated that there are approximately 2 million patients worldwide with end-stage renal disease on dialysis (Nephrol Dial Transplant, 2005). In this condition the kidneys are unable to regulate the balance of phosphate in the body. If untreated, the blood phosphate levels can become elevated (hyperphosphatemia). The Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend that serum phosphate levels in CKD patients should be managed towards normal (Kidney International, 2009). FOSRENOL binds dietary phosphate in the gastrointestinal tract to prevent it from passing through the gut lining and, based upon this mechanism of action, phosphate absorption from the diet is decreased.

Formulated as a chewable tablet, FOSRENOL is available in 500mg, 750mg and 1,000mg dosage strengths. The FDA approved the 500mg dosage strength in 2004 and the 750mg and 1,000 mg dosage strengths were approved in 2005. In March 2009 FOSRENOL was launched in Japan. An oral powder formulation wasapproved and made available in certain European countries in 2012.

For further information on the litigation proceedings relating to the Company’s FOSRENOL patents see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

XAGRID

Myeloproliferative disorders (“MPD”), including essential thrombocythemia (“ET”), are a group of diseases in which one or more blood cell types are overproduced. In the case of ET, excess numbers of platelets, which are involved in the blood clotting process, can result in abnormal blood clot formation giving rise to events such as heart attack and stroke. Excessive platelet production can also lead to the formation of abnormal platelets, which may not be as effective in the clotting process. This can lead to events such as gastrointestinal bleeding.

XAGRID is marketed in Europe for the reduction of elevated platelet counts in at-risk ET patients. It was granted a marketing authorization in the EU in November 2004. XAGRID has been granted orphan drug status in the EU, providing it with orphan drug exclusivity until November 2014.

In the US, anagrelide hydrochloride is sold by the Company under the trade name AGRYLIN for the treatment of thrombocythemia secondary to a MPD. Generic versions of AGRYLIN have been available in the US market since 2005.

DERMAGRAFT

DERMAGRAFT is approved by the FDA as a Class III medical device for the treatment of full-thickness DFUs greater than six weeks in duration, which extend through the dermis, but without tendon, muscle, joint capsule, or bone exposure. 

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On January 16, 2014, the Company sold and transferred substantially all of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc. For further information, see ITEM 15: Exhibits and Financial Statement Schedules and Note 8, “Results of discontinued operations and assets held for sale” to the consolidated financial statements set forth in this Annual Report on Form 10-K).

Royalties received from other products

Antiviral products

The Company receives royalties on antiviral products based on certain of the Company’s patents licensed to GSK.  These antiviral products are for Human Immunodeficiency Virus (“HIV”) and Hepatitis B virus. Royalty terms expired in most territories outside of the US during 2012. In the US, royalty terms expire between 2014 and 2018.

ADHD

ADDERALL XR

Shire receives royalties from Impax’s sales of its authorized generic version of ADDERALL XR. From the third quarter of 2012, Shire also started receiving royalties from Actavis’ sales of their generic version of ADDERALL XR.

Hyperphosphatemia

FOSRENOL

The Company licensed the rights to FOSRENOL in Japan to Bayer in December 2003. Bayer launched FOSRENOL in Japan in March 2009.  Shire receives royalties from Bayer’s sales of FOSRENOL in Japan. The Company has also received milestone payments from Bayer based on the achievement of certain sales thresholds and may receive further milestone payments in the future if certain sales thresholds are achieved.

Other royalties

The Company has licensed the rights to certain other products to third parties and receives royalties on third party sales.

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Products under development

The Company focuses its development resources on projects in a number of therapeutic areas, including Neuroscience, Rare Diseases, Ophthalmology, Hematology and GI, and focuses its early development projects on rare diseases. Total R&D expenditures of $933.4 million, $953.0 million and $764.5 million were incurred in the years ended December 31, 2013, 2012 and 2011 respectively.

The table below lists the Company’s products in clinical development and registration as of December 31, 2013 by stage of development indicating the most advanced development status reached in major markets and the Company’s territorial rights in respect of each product candidate. If these product candidates are ultimately approved and marketed, they may benefit from patent and/or other forms of exclusivity, as described in more detail in the sections headed “Intellectual property” and “Government Regulation” in this ITEM 1. Some of the patents (or their analogous foreign patent applications or foreign granted patents) listed in the table on pages 21-23 of this ITEM 1 are potentially relevant to the corresponding development projects listed below. However as these product candidates remain in development and are subject to change as development progresses, the patents listed may not necessarily be representative of the scope of patent protection that may ultimately be available if each product candidate is approved and marketed.

Product	Disease area	Development status at December 31, 2013	The Company’s territorial rights
FIRAZYR	ACE inhibitor-induced Angioedema	Registration in EU (regulatory submission in Q4 2012)	Global
XAGRID	Essential thrombocythaemia	Registration in Japan (regulatory submission in Q4 2013)	Global
INTUNIV	ADHD in children and adolescents	Phase 3 completed in EU in Q3 2013	Global
LDX (lisdexamfetamine dimesylate)	Adjunctive therapy in MDD	Phase 3  in US (entered Phase 3 in Q4 2011)	Global
LDX (lisdexamfetamine dimesylate)	BED in adults	Phase 3 in US (entered Phase 3 in Q4 2012)	Global
INTUNIV	ADHD in children and adolescents	Phase 3 in Japan (entered Phase 3 in Q2 2013)	Global(1)
SHP 606 (4)	Treatment of DED	Phase 3 in US (entered Phase 3 in Q4 2012)	Global
SHP 555 (prucalopride)	Chronic constipation in Males Chronic constipation	Phase 3 in EU (entered Phase 3 in Q4 2010) Phase 3-ready  in US	US (2)
SHP 609 (4)	Hunter syndrome with CNS symptoms	Phase 2/ 3-ready	Global (3)
FIRAZYR	ACE inhibitor-induced Angioedema	Phase 3 in US (entered Phase 3 in Q4 2013)	Global
LDX (lisdexamfetamine dimesylate)	ADHD in children and adolescents	Phase 2 in Japan	Global(1)
SHP 602 (FBS 0701) (4)	Chronic Iron-overload	Phase 2	Global
SHP 610 (4)	Sanfilippo A Syndrome (MPS IIIA)	Phase 2b-ready	Global(3)
SHP 613 (4)	Arteriovenous (“AV”) access in hemodialysis patients	Phase 2	Global

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SHP 607 (4)	Retinopathy of Prematurity	Phase 2	Global
SHP 611 (4)	Metachromatic Leukodystrophy (“MLD”)	Phase 1/ 2	Global

(1)   Under co-development with Shionogi as a result of a license and collaboration agreement.

(2)   US rights were acquired from J&J in January 2012.

(3)   Genzyme has rights to manage marketing and distribution in Japan and certain other Asia Pacific countries under a license with Shire.

(4)   Following the announcement of the Company’s reorganization into a simplified One Shire organization the Company assigned new code to its existing development programs.

Products in registration as at December 31, 2013

FIRAZYR for the treatment of Acute Angiotensin Converting Enzyme Inhibitor-Induced Angioedema (“ACE-I AE”) in Europe

In the fourth quarter of 2012, following the completion of a small investigator sponsored trial (“IST”), Shire submitted a supplemental Marketing Authorization Application (“MAA”), to the European Medicines Agency (“EMA”) seeking approval for FIRAZYR for the treatment of ACE-I AE in Europe. In February 2014, following the review and discussion of the data from this IST with the EU agencies, Shire withdrew its supplemental MAA and expects to resubmit it with the data from the ongoing Company sponsored Phase 3 trial.

XAGRID for the treatment of essential thrombocythaemia in Japan

In the fourth quarter of 2013, Shire submitted a Marketing Authorisation to the Ministry of Health, Labour and Welfare (“MHLW”) in Japan, seeking approval for XAGRID in adult essential thrombocythaemia patients treated with cytoreductive therapy who have become intolerant to their current therapy or whose platelet counts have not been reduced to an acceptable level.

VPRIV for the treatment of Gaucher disease in Japan

In the fourth quarter of 2013, Shire submitted a Marketing Authorisation to the Ministry of Health, Labour and Welfare (“MHLW”) in Japan, seeking approval for VPRIV for the treatment of adult and paediatric patients with Gaucher disease.

Products in clinical development as at December 31, 2013

Phase 3

Lisdexamfetamine dimesylate (“LDX”)1 for the treatment of inadequate response in major depressive disorder (“MDD”)

On February 6, 2014 Shire announced top-line results from two pivotal Phase 3 investigational studies evaluating the efficacy and safety of LDX versus placebo as an adjunctive treatment for MDD in adults who inadequately responded to antidepressant monotherapy with a selective serotonin reuptake inhibitors or serotonin and norepinephrine reuptake inhibitors. LDX did not meet the primary efficacy endpoint versus placebo for either study. The safety profile for LDX in these two studies appears to be generally consistent with the known profile established in studies in adults with ADHD. Based on these clinical trial results, Shire will no longer pursue this clinical development program.

LDX for the treatment of Binge Eating Disorder

In November 2013, the Company reported positive top-line results from two identically designed randomized placebo-controlled Phase 3 studies evaluating the efficacy and safety of LDX versus placebo in adults with BED. In both studies LDX was found to be statistically superior to placebo on the primary efficacy analysis (p-value <0.001) of the change from baseline at weeks 11 to 12 in terms of number of binge days per week. The safety for LDX in these two studies appears to be generally consistent with the known profile established in studies in adults with ADHD. Shire plans to file for FDA regulatory approval of VYVANSE for the treatment of BED in adults (ages 18 to 55) by the third quarter of 2014.

INTUNIV for the treatment of ADHD in the EU

INTUNIV for the treatment of ADHD in children aged 6 to 17 in the EU was initiated in the fourth quarter of 2011 and has been completed.  Submission for Marketing Authorization is targeted for the first quarter of 2014.

INTUNIV for the treatment of ADHD in Japan

Under a collaboration agreement, Shionogi and Shire will co-develop and sell ADHD products in Japan, including INTUNIV. A Phase 3 clinical program to evaluate the efficacy and safety of INTUNIV in Japanese patients aged 6 to 17 was initiated in the second quarter of 2013.

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SHP606 (formerly SPD-606) Lifitegrast for the treatment of Dry Eye disease

A Phase 3 clinical program to further assess the efficacy of SHP606 for the treatment of Dry Eye disease was initiated in the US in the fourth quarter of 2012 and top-line results from OPUS-2, a Phase 3 efficacy and safety study of 5.0% Lifitegrast ophthalmic solution, were announced on December 6, 2013. OPUS-2 compared Lifitegrast to placebo administered twice daily for 84 days (12 weeks) in dry eye patients with history of active artificial tear use within 30 days prior to screening. Lifitegrast met the prespecified co-primary endpoint for the patient-reported symptom of eye dryness (change in Eye Dryness Score from baseline to week 12) (p-value<0.0001). Lifitegrast did not meet the prespecified co-primary endpoint for the sign of inferior corneal staining score (change from baseline to Week 12) using fluorescein staining compared with placebo (p-value=0.6186). Shire intends to investigate the full data from OPUS-2 and is planning further interactions with the FDA in the first half of 2014 in order to advance this program.

SHP555 (formerly SPD-555) (prucalopride; marketed as RESOLOR in the EU) for the treatment of chronic constipation in the US

On January 10, 2012, Shire announced that it had acquired the rights to develop and market prucalopride in the US in an agreement with Janssen Pharmaceutica N.V. Discussions are planned with the FDA to determine potential clinical development pathways.

FIRAZYR for the treatment of ACE-I AE

A Phase 3 clinical trial to assess the efficacy of FIRAZYR for the treatment of ACE-I AE was initiated in the fourth quarter of 2013 and is ongoing.

SHP609 (formerly HGT-2310) for the treatment of Hunter syndrome with CNS symptoms

SHP609 is in development as an enzyme replacement therapy (“ERT”) delivered intrathecally for Hunter syndrome patients with CNS symptoms. The Company initiated a pivotal Phase 2/3 clinical trial in the fourth quarter of 2013 which is ongoing. This product has been granted orphan designation in the US.

Phase 2

LDX for the treatment of ADHD in Japan

Under a collaboration agreement, Shionogi and Shire will co-develop and sell ADHD products in Japan, including LDX. A Phase 2 clinical program to evaluate the efficacy and safety of LDX in Japanese patients aged 6 to 17 was initiated in the second quarter of 2013 and is ongoing.

SHP602 (formerly SPD-602) iron chelating agent for the treatment of iron overload secondary to chronic transfusion

A Phase 2 trial in pediatric and adult patients with transfusional iron overload is ongoing. This product has received orphan drug designation by the EMA and the FDA for the treatment of chronic iron overload requiring chelation therapy.

SHP610 (formerly HGT-1410) for Sanfilippo A Syndrome (Mucopolysaccharidosis IIIA)

SHP610 is in development as an ERT delivered intrathecally for the treatment of Sanfilippo A Syndrome, a Lysosomal Storage Disorder (“LSD”). The Company initiated a Phase 1/2 clinical trial in August 2010 which has now completed. Shire is currently planning the next clinical trial for SHP610, designed to measure a clinical response, which is expected to initiate in the first quarter of 2014. The product has been granted orphan drug designation in the US and in the EU.

SHP613 (formerly SRM-003 or VASCUGEL) for the treatment of improvement in patency of arteriovenous (“AV”) access in hemodialysis patients

SHP613 is a novel endothelial cell based therapy in development for enhancing blood vessel repair and improving hemodialysis access for patients with end-stage renal disease (“ESRD”).  This product has been granted orphan drug designation in the US and the EU. In March 2013, Shire enrolled the first patients in its two Phase 2 studies designed to evaluate the efficacy and safety of SHP613 in improving AV Fistula (“AVF”) maturation and AV Graft (“AVG”) patency to facilitate hemodialysis in patients with ESRD.

SHP607 (formerly HGT-ROP-001 or PREMIPLEX) for the treatment of Retinopathy of Prematurity (“ROP”)

SHP607 is in development as a protein replacement therapy for the preventative treatment of ROP, a rare eye disorder associated with premature birth. This product has been granted orphan drug designation both in the US and EU. A Phase 2 clinical trial is ongoing.

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Phase 1

SHP611 (formerly HGT-1110) for the treatment of Metachromatic Leukodystrophy (“MLD”)

SHP611 is in development as an ERT delivered intrathecally for the treatment of the late infantile form of MLD. This product has been granted orphan drug designation in the US and the EU. The Company initiated a Phase 1/2 clinical trial in August 2012. This trial is ongoing.

Other pre-clinical development projects

A number of additional early development projects, primarily focused on rare diseases, are underway in various stages of pre-clinical development.

Following the acquisition of ViroPharma on January 24, 2014, Shire acquired ViroPharma’s pipeline portfolio comprising a number of programs at various stages of development. Shire is currently assessing ViroPharma’s pipeline portfolio.

1Currently marketed as VYVANSE in the US and ELVANSE in certain countries in the EU for the treatment of ADHD.

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Manufacturing and distribution

Active pharmaceutical ingredient (“API”) sourcing

The Company sources API from third party suppliers for its products: VYVANSE, INTUNIV, ADDERALL XR, LIALDA, FOSRENOL, PENTASA, XAGRID and FIRAZYR. Shire has manufacturing capability for agalsidase alfa, idursulfase and velaglucerase alfa at its protein manufacturing plants in Cambridge, and Lexington, Massachusetts, US for its products: REPLAGAL, ELAPRASE and VPRIV, respectively.

The Company currently has dual sources of API for VPRIV, VYVANSE, ADDERALL XR, LIALDA and PENTASA and is developing a second source for INTUNIV. The Company manages the risks associated with reliance on single sources of API by carrying additional inventories or developing second sources of supply.

In order to support the growth of VPRIV and REPLAGAL, as well as to support clinical development, additional manufacturing capacity has been added in Lexington, Massachusetts, US. In February 2014, Shire received approval from the FDA for production of VPRIV drug substance. The facility has now been approved by both the FDA and by the EMA for the purification of REPLAGAL and the manufacture and purification of VPRIV.

Finished Product Manufacturing

The Company sources its products: VYVANSE, INTUNIV, ADDERALL XR, LIALDA, PENTASA, FOSRENOL, EQUASYM and XAGRID from third party contract manufacturers. Finished products: REPLAGAL, ELAPRASE, VPRIV and FIRAZYR are manufactured by contract manufacturers specializing in aseptic fill-finish operations.

The Company currently has dual sources for finished product manufacturing for ELAPRASE, REPLAGAL, VPRIV and VYVANSE and is developing a second source for the finished product manufacturing of LIALDA. The Company sources finished product for ADDERALL XR, FIRAZYR, FOSRENOL, INTUNIV, PENTASA, RESOLOR and VPRIV (in some markets) from a single contract manufacturer for each product. The Company manages the risks associated with reliance on single sources of production by carrying additional inventories.

Distribution

The Company’s US distribution center, which includes a large vault to house US Drug Enforcement Administration (“DEA”) regulated Schedule II products, is located in Kentucky. From there, the Company primarily distributes its products: VYVANSE, INTUNIV, ADDERALL XR, LIALDA, PENTASA, FOSRENOL, EQUASYM and XAGRID to the US market through the three major wholesalers who have hub or distribution centers that stock Schedule II drugs in the US, providing access to nearly all pharmacies in the US.

The distribution and warehousing of products: REPLAGAL, ELAPRASE, VPRIV and FIRAZYR for the US market is contracted out to specialist third party contractors. 

Outside of the US, physical distribution of Company’s products is either contracted out to third parties (where the Company has local operations) or facilitated via distribution agreements (where the Company does not have local operations).

ViroPharma

As of the closing of Shire’s merger with ViroPharma on January 24, 2014, Viropharma utilizes a virtual supply manufacturing and distribution chain for all of its products by contracting with third parties for the manufacture, warehousing, order management, billing and collection and distribution of its products. Each product is manufactured at separate contract manufacturing organizations (“CMO’s”), and then distributed via third party logistics/distribution suppliers in either Europe or the US.

CINRYZE is derived from human plasma sourced from commercial plasma suppliers. The sourcing of plasma, and the production of products derived from plasma, is regulated extensively by the FDA, the EMA and other medical product and health care regulatory agencies. ViroPharma relies on a combination of sources for plasma including long term supply agreements and periodic “spot purchases” of plasma from third party plasma suppliers. ViroPharma uses a single CMO for the manufacture of CINRYZE, with manufacturing facilities in Belgium and the Netherlands.

Material customers

Shire’s three largest trade customers are McKesson Corp, Cardinal Health, Inc., and AmerisourceBergen which are based in the US. In 2013, these wholesale customers accounted for approximately 19%, 18% and 15% of product sales, respectively.

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Intellectual Property

An important part of the Company’s business strategy is to protect its products and technologies through the use of patents and trademarks, to the extent available. The Company also relies on trade secrets, unpatented know-how, technological innovations and contractual arrangements with third parties to maintain and enhance its competitive position where it is unable to obtain patent protection or where marketed products are not covered by specific patents. The Company’s commercial success will depend, in part, upon its ability to obtain and enforce strong patents, to maintain trade secret protection, to operate without infringing the proprietary rights of others and to comply with the terms of licenses granted to it. The Company’s policy is to seek patent protection for proprietary technology whenever possible in the US, Canada, major European countries and Japan. Where practicable, the Company seeks patent protection in other countries on a selective basis. In all cases the Company endeavors to either obtain patent protection itself or support patent applications by its licensors. The markets for some of the Company’s currently marketed and potential future products, such as those for rare genetic diseases, are small and where possible the Company has sought and will seek orphan drug designation for products directed to these markets which, if granted, provides regulatory exclusivity for 7 years in the US and 6 years in the EU from the date of product approval (see “Government Regulation” below).

In the regular course of business, the Company’s patents may be challenged by third parties. The Company is a party to litigation or other proceedings relating to intellectual property rights. Details of ongoing litigation are provided in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements.

The degree of patent protection afforded to pharmaceutical inventions around the world is uncertain. If patents are granted to other parties that contain claims having a scope that is interpreted by the relevant authorities to cover any of the Company’s products or technologies, there can be no guarantee that the Company will be able to obtain licenses to such patents or make other arrangements at reasonable cost, if at all.

The existence, scope and duration of patent protection varies among the Company’s products and among the different countries where the Company’s products may be sold. They may also change over the course of time as patents are granted or expire, or become extended, modified or revoked. The following non-exhaustive list sets forth details of granted US and European Patent (“EP”) patents pertaining to the Company’s more significant revenue-generating products and certain products from which the Company receives a royalty, which are owned by or licensed to the Company and that are relevant to an understanding of the Company’s business taken as a whole.The listed EP patents do not necessarily have a corresponding national patent registered in each EU member state and the rights granted pursuant to an EP patent are enforceable only in the EU member state where the EP patent has been registered as a national patent.  The expiration dates set forth below do not necessarily reflect changes to the patent term afforded by Patent Term Extensions in the United States, nor supplementary protection certificates (“SPCs”) which are available in many EU member states.  The Company also holds patents in other jurisdictions, such as Canada and Japan and has patent applications pending in such jurisdictions, as well as in the US and the EU.

	Granted US and EP Patents	Expiration Date
ADDERALL XR	US 6,322,819 US RE 41148 US 6,605,300 US RE 42096 US 6,913,768 EP 1123087 EP 1542660	October 21, 2018 October 18, 2018 October 18, 2018 October 21, 2018 May 24, 2023 October 21, 2019 September 24, 2023
ELAPRASE	US 5,728,381 US 5,798,239 US 5,932,211	March 17, 2015 August 25, 2015 September 3, 2019
FIRAZYR	US 5,648,333	July 15, 2014

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FOSRENOL	US 5,968,976 US 7,381,428 US 7,465,465 EP 0817639	October 26, 2018 August 26, 2024 August 26, 2024 March 19, 2016
INTUNIV	US 6,287,599 US 6,811,794	December 20, 2020 July 4, 2022
LIALDA/MEZAVANT	US 6,773,720 EP 1198226 EP 1183014 EP 1287822	June 8, 2020 June 8, 2020 June 9, 2020 June 8, 2020
REPLAGAL	US 5,733,761 US 6,083,725 US 6,395,884 US 6,458,574 EP 0935651 EP 2186902	March 31, 2015 September 12, 2017 September 12, 2017 September 12, 2017 September 12, 2017 March 9, 2020
RESOLOR	EP 807110	November 16, 2015
VPRIV	US  5,641,670 US  5,733,761 US  6,270,989 US  6,566,099 US  7,138,262 US  7,833,766 EP  0672160 EP 1986612	June 24, 2014 June 24, 2014 June 24, 2014 September 12, 2017 August 18, 2020 February 6, 2027 December 2, 2013 February 7, 2027

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VYVANSE	US 7,105,486 US 7,223,735 US 7,655,630 US 7,659,253 US 7,659,254 US 7,662,787 US 7,671,030 US 7,671,031 US 7,674,774 US 7,678,770 US 7,678,771 US 7,687,466 US 7,687,467 US 7,700,561 US 7,718,619 US 7,723,305 US 7,662,788 US 7,713,936 EP 1644019	February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 28, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 February 24, 2023 June 1, 2024
LAMIVUDINE: EPIVIR/EPIVIR-ZEFFIX/3TC	US 5,693,787 US 5,663,320 US 5,696,254 US 6,180,639	December 2, 2014 September 2, 2014 December 9, 2014 July 30, 2018

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Competition

Shire believes that competition in its markets is based on, among other things, product safety, efficacy, convenience of dosing, reliability, availability and price. Companies with more resources and larger R&D expenditures than Shire have a greater ability to acquire assets as well as fund the research and clinical trials necessary for regulatory applications, and consequently may have a better chance of obtaining approval of drugs that would then compete with Shire’s products. Other products now in use or being developed by others may be more effective or have fewer side effects than the Company’s current or future products. The market share data provided below is sourced from IMS Health.

ADHD market

Competition in the US ADHD market has increased with the launch of competing products in recent years, including authorized generic and generic versions of CONCERTA and RITALIN LA, ADDERALL XR, KAPVAY (twice daily, clonidine extended release), FOCALIN XR, and QUILLIVANT, a liquid methylphindate. Shire’s share of the US ADHD prescription market in December 2013 was 25.7% (compared to 26.0% in December 2012). Overall the US ADHD prescription market grew by 7.7% in the year ended December 31, 2013 (compared to 9.0% in the same period in 2012).

Shire’s key ADHD market is the US, with the Company having three products for the treatment of ADHD (VYVANSE, ADDERALL XR and INTUNIV). Shire also has ADHD products in Canada, Brazil, Mexico, South Korea and selected EU markets and further geographic expansion plans are underway, including a collaboration agreement with Shionogi to co-develop and sell VYVANSE and INTUNIV in Japan.

Key branded competitors in the US are stimulants CONCERTA and FOCALIN XR, and non-stimulants STRATTERA and KAPVAY. Generic immediate release stimulants which constitute 32.6% of the ADHD market (IMS NPA, December 2013) are showing strong growth in the US ADHD market, growing 12.0% in the year from December 31, 2012 to December 31, 2013.

Key competitors in the European ADHD market are CONCERTA (Janssen-Cilag), RITALIN LA (Novartis), MEDIKINET (Medice and distributors) and STRATTERA (Eli Lilly), depending upon the country.  In European countries where Shire is launching ELVANSE (known as TYVENSE in Ireland), the ADHD market size was $503.2 million (moving annual total (“MAT”) Q3 2013), with annual growth of over 5.7% compared to the same period in 2012.

The Company is also aware of several clinical development programs underway by other pharmaceutical companies. Eli Lilly and Company Limited, Targacept, Otsuka Pharmaceutical Co., Ltd., Purdue, Alcobra (in collaboration with Teva), Theravance, Euthymics, Neuroderm, Durect Pharma and Supernus are seeking to develop additional treatment options for ADHD.

GI

Ulcerative Colitis (UC) market

UC is a type of inflammatory bowel disease. The first-line treatments for patients with mild to moderate UC are formulations containing mesalamine (also known as 5-ASA). Shire defines the 5-ASA competitive set as the non-sulfasalazine, oral mesalamine and mesalamine pro-drug products.

Competitors vary across markets.  Principal competitors in major markets include DELZICOL, ASACOL and ASACOL HD/ASACOL 800 (Actavis, Tillots, various other licensees), APRISO (Salix), PENTASA (Ferring Pharmaceuticals, outside of the US only), SALOFALK (Dr. Falk) and CLAVERSAL (Faes Farma, Recordati S.p.A).

5-ASA products are generally protected by formulation patents only. In December 2007, several generic versions of Salix’s COLAZAL (balsalazide) entered the US market, but no other generic versions of products in the oral 5-ASA competitive set have been introduced to the US market since that time.  Generic mesalamine products are available in several European markets, but are not significant competitors in those markets. UCERIS (budesonide) was approved by the FDA in January 2013 and represents an alternative to 5-ASA products for acute treatment (up to 8 weeks) of mild to moderate UC.

The Company is aware of other 5-ASA and non-ASA biologic treatments in development for UC.

Chronic constipation market

In Europe, over-the-counter and prescription laxatives are the current first line therapy for chronic constipation. The highest value laxative (by revenue) is MOVICOL, a polyethylene glycol (“PEG”) 3350, sold by Norgine.  In Europe, RESOLOR is indicated for symptomatic treatment of chronic constipation in women in whom laxatives fail to provide adequate relief and currently there are no other products available in the EU with the same indication. Additional competitor products in this category include CONSTELLA (guanylate cyclase-C agonist; Almirall S.A., Ironwood Pharmaceuticals Inc) approved by the EMA for the treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) and AMITIZA (chloride channel antagonist; Sucampo Pharmaceuticals, Inc.) approved for the

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treatment of chronic idiopathic constipation. The Company is aware of other therapies for the treatment of chronic constipation and IBS-C being developed.

Markets for the treatment of rare genetic diseases

REPLAGAL competes with Genzyme’s FABRAZYME in markets outside the US. Shire is aware of the early stage development of certain compounds to treat Fabry disease by Genzyme, Protalix, JCR Pharmaceuticals Co. Ltd, and Isu-Abxis.

VPRIV competes with Genzyme’s CEREZYME, Actelion’s ZAVESCA and Protalix’s ELELYSO (which was refused registration in the EU and is marketed by Pfizer outside of Israel). Genzyme also has a small molecule therapy in Phase 3 development for the treatment of Gaucher disease. Shire is also aware of four companies that have early stage biosimilar development programs for Gaucher disease: JCR; Isu-Abxis; Harvest Moon; and Dong A Pharmaceuticals.

ELAPRASE is the only product licensed to treat Hunter syndrome in all the markets in which it is registered except South Korea. In 2012, Korean Green Cross Corporation was granted approval in South Korea for HUNTERASE, an ERT to treat Hunter syndrome. Shire is also aware that JCR is in early stage development of an ERT for the treatment of Hunter syndrome.

FIRAZYR competes in Europe with CSL Behring’s BERINERT P and Pharming Group N.V.’s RUCONEST. FIRAZYR competes in the US with BERINERT and with Dyax Corporation’s KALBITOR.

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Government regulation

The clinical development, manufacturing and marketing of Shire’s products is subject to governmental regulation in the US, the EU and other territories. The Federal Food, Drug, and Cosmetic Act, the Prescription Drug Marketing Act and the Public Health Service Act in the US, and numerous directives and guidelines in the EU, govern the development, design, non-clinical and clinical research, testing, manufacture, safety, efficacy, labeling, packaging, storage, record keeping, premarket clearance or approval, adverse event reporting, advertising and promotion of the Company’s products. Product development and approval within these regulatory frameworks takes a number of years and involves the expenditure of substantial resources. Pharmaceutical and medical device manufacturers are also inspected regularly by the FDA.

In general, pharmaceutical and biotechnology products must undergo rigorous preclinical testing. Clinical trials for new products are typically conducted in three sequential phases that may overlap. In Phase 1, the initial introduction of the product into healthy human volunteers, the emphasis is on testing for safety (adverse effects), dosage tolerance, metabolism, distribution, excretion and clinical pharmacology. Phase 2 involves studies in a limited patient population to determine the initial efficacy of the product for specific targeted indications, to determine dosage tolerance and optimal dosage and to identify possible adverse side effects and safety risks. Once a product is found to be effective and to have an acceptable safety profile in Phase 2 evaluations, Phase 3 trials are undertaken with a larger number of patients to provide enough data to statistically evaluate the efficacy and safety of the product and to evaluate more fully clinical outcomes. The failure to demonstrate adequately the quality, safety and efficacy of a product under development can delay or prevent regulatory approval of the product.

In order to gain marketing approval the Company must submit to the relevant regulatory authority for review information on the quality (chemistry, manufacturing and pharmaceutical) aspects of the product as well as the non-clinical and clinical data. The FDA undertakes this review for the US. In the EU the review may be undertaken by the following: (i) members of the EMA’s Committee for Medicinal Products for Human Use as part of a centralized procedure; (ii) an individual country's regulatory agency, followed by “mutual recognition” of this review by a number of other countries' agencies, depending on the process applicable to the product in question; or (iii) a competent member state’s regulatory agency through a decentralized procedure, an alternative authorization procedure to the “mutual recognition” procedure.

Approval can take several months to several years, or be denied. The approval process can be affected by a number of factors. For example, additional studies or clinical trials may be requested during the review and may delay marketing approval and involve unbudgeted costs. As a condition of approval, the regulatory agency will require post-marketing surveillance to monitor for adverse effects, and may require other additional studies as it deems appropriate. After approval for the initial indication, further clinical studies are usually necessary to gain approval for any additional indications. The terms of any approval, including labeling content, may be more restrictive than expected and could affect the marketability of a product.

As a condition of approval, the regulatory agency will require that the product continues to meet regulatory requirements as to quality, safety and efficacy and will require strict procedures to monitor and report any adverse effects. Where adverse effects occur or may occur, the regulatory agency may require additional studies or changes to the labeling (for example, application of a “black box” warning). Compelling new “adverse” data may result in a product approval being withdrawn at any stage following review by an agency and discussion with the Company.

Some jurisdictions, including the EU and the US, may designate products for disease treatment within a relatively small patient population as “orphan drugs”. Generally, if a product that has an orphan drug designation subsequently receives the first marketing approval for the indication for which it has such designation, the product is entitled to orphan drug exclusivity. Orphan drug exclusivity means that applications to market the same product for the same indication may not be approved, except in limited circumstances, for a period of up to ten years in the EU and for up to seven years in the US. These laws are particularly pertinent to Shire’s rare disease products.

In the US, the Drug Price Competition and Patent Restoration Term Act of 1984, known as the US Hatch-Waxman Act, established a period of marketing exclusivity for brand-name drugs as well as abbreviated application procedures for generic versions of those drugs. Once the applicable exclusivity period for the brand-name drug has expired (which may range from 3-5 years), generic manufacturers may file with the FDA for approval to manufacture and market generic versions of the brand-name drug. Approval is sought by filing an ANDA. As a substitute for conducting full-scale pre-clinical and clinical studies, the FDA can accept data establishing that the drug formulation, which is the subject of an abbreviated application, is bio-equivalent and has the same therapeutic effect as the previously approved drug, among other requirements. EU legislation also contains data exclusivity provisions. All medicinal products will be subject to an “8+2+1” exclusivity regime. A generic company may file a marketing authorization application for that product with the health authorities referencing the innovator’s data eight years after the innovator has received its first community authorization for a medicinal product. The generic company may not commercialize the product until after either 10 (8+2) or 11 years (8+2+1) have elapsed from the date of grant of the initial marketing authorization. The one-year extension is available if the innovator obtains an additional indication during the first eight years of the marketing authorization that is of significant advancement in clinical benefit.

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In the US, the DEA also regulates the national production and distribution of scheduled drugs (i.e. those drugs containing controlled substances) by allocating production quotas based, in part, upon the DEA’s view of national demand. As scheduled drugs, the production and distribution of Shire’s stimulant ADHD products (ADDERALL XR, VYVANSE and EQUASYM) are strictly controlled and supply of active ingredient is dependent on the DEA’s permitted annual quotas and its willingness to update those quotas to meet any shortage of drugs.

The branch of the FDA responsible for product marketing oversight routinely reviews company marketing practices and also may impose pre-clearance requirements on materials intended for use in marketing of approved drug products. Shire is also subject to various US federal and state laws pertaining to healthcare fraud and abuse, including anti-kickback and false claims laws. Similar review and regulation of advertising and marketing practices exists in the other geographic areas where the company operates.

The FDA has broad regulatory compliance and enforcement powers. If the FDA determines that a Company failed to comply with applicable regulatory requirements, it can take a variety of compliance or enforcement actions, such as issuing an FDA Form 483 notice of inspectional observations, a warning letter, an untitled letter, imposing civil money penalties, suspending or delaying issuance of approvals, requiring product recall, imposing a total or partial shutdown of production, withdrawal of approvals or clearances already granted, pursuing product seizures, consent decrees or other injunctive relief, or criminal prosecution through the Department of Justice. The FDA can also require a Company to repair, replace or refund the cost of products that the Company manufactured or distributed. Outside the US, regulatory agencies may exert a range of similar powers.

The Department of Health and Human Services (“HHS”) administers the Medicare and Medicaid programs, major government payors for the elderly and poor in the US, respectively.  Shire is subject to various mandated discounts and rebates, as well as compliance requirements, in order to participate in these programs.  HHS will be interpreting, implementing and enforcing manufacturers’ compliance with rebate payments, discounts and mandated price reporting changes under the Patient Protection and Affordable Care Act (“PPACA” or “ACA”).

Regulatory Developments

In the US various legislative proposals at the federal and state levels could bring about major changes in the affected health care systems. Some states have passed such legislation, and further federal and state proposals are possible. Such proposals and legislation include, and future proposals could include, price controls, patient access constraints to medicines, cost sharing through improved patient health outcomes and increases in required rebates or discounts. Similar issues exist in the EU. The Company cannot predict the outcome of such initiatives, but will work to maintain patient access to its products and to oppose price constraints. Additionally, legislation is being debated at the federal and state level in the US that could allow patient access to drugs approved in other countries – most notably Canada. This is generally referred to as drug re-importation. Although there is substantial opposition to this potential legislation within areas of the federal government, including the FDA, the Company cannot predict the outcome of such legislative activities.  Several local US jurisdictions, including the King County of Washington State and Alameda County in California, have imposed drug-disposal responsibilities and fees on drug manufacturers.  Depending on the outcome of court cases, these additional costs of doing business in the US may extend to other localities. The US market is a litigious one, and several agencies, including the Office of Inspector General, Department of Justice and Drug Enforcement Agency have been stepping up their enforcement activities as part of the Affordable Care Act, leading to the imposition of an increasing number of Corporate Integrity Agreements (CIA) with pharmaceutical and biotechnology companies as part of ultimate settlements.

The performance of orphan products acquired by Shire as part of its acquisition of ViroPharma will depend on the same regulatory developments already impacting Shire’s Rare Diseases products.

Similar regulatory and legislative issues are encountered in Europe and other international markets where governments regulate pharmaceutical prices and patient reimbursement levels. The differing approach to price regulation has led to some parallel trade within the EU where Shire’s products are imported into markets with higher prices from markets with lower prices. Exploitation of price differences between countries in this way can adversely impact domestic sales in those markets with higher prices.

Third party reimbursement and pricing

· General.  The Company’s revenue depends, in part, upon the price that third parties, such as health care providers and governmental organizations, reimburse on behalf of patients and physicians for the cost of the Company’s products or competitive products and treatments.  These third party payors are increasingly challenging the pricing of drugs and medical devices through tougher contracting and, seeking increased pharmaco-economic data in order to justify the pricing of products.

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In the US:

· Commercial Managed Care. Commercial payors negotiate the pricing of products to control their costs, including the use of formularies to encourage members to utilize preferred products with favorable terms.  Exclusion from a formulary, or a disfavored formulary position, can reduce product usage in the payor’s patient population. The consolidation of Pharmacy Benefits Managers (PBMs) may result in increased pricing pressure from the larger purchasing power of such consolidated entities.  Whether manufacturers can continue to issue coupons for managed care members, without being removed from the plan’s formulary, will also affect utilization of a manufacturer’s drugs.  Although the Secretary of Health and Human Services (HHS) has approved the use of coupons for health exchange (HIX) plans, several groups are fighting the implementation of the guidance. Overall drug usage could increase due to the expansion of covered lives under the PPACA albeit with greater rebate liability.

· Medicaid.  Many of the Company’s products are reimbursed by Medicaid, a joint federal and state health insurance plan for the poor in the US.  Medicaid mandates federal rebates from manufacturers for participation in the program.  Many states outsource management of Medicaid benefits to third parties (“Managed Medicaid” or “MMC”), leaving it to them to negotiate commercial rebates and formulary position with manufacturers.  Other states manage their own formulary and require manufacturers to pay additional “state supplemental” rebates for positioning on its preferred drug list.

· Medicare.  Medicare reimbursement rates to physicians for injectable drugs like Shire’s orphan drugs have been reduced from 106% of Average Sales Price (ASP) to 104% ASP, and may decrease further.  The Centers for Medicare and Medicaid Services (“CMS”) are also increasingly bundling drug reimbursement into procedure costs, which can severely decrease the reimbursement rates to physicians for some manufacturers’ drugs, biologicals and medical devices.

· ACA.  The rate of implementation of the Medicaid expansion, HIX and Accountable Care Organizations (ACO) varies tremendously on a state-by-state basis.  It is not possible to predict the overall increases in Medicaid, Managed Medicaid and HIX business, and the cost for Shire specifically.  Depending on HHS’ ability to rectify the HIX’s technology issues, and HHS’ flexibility with states asking for alternative approaches to Medicaid expansion, the ACA expansion in covered lives could be severely reduced.

·  “Dual-eligibles” are those individuals that qualify for both Medicare and Medicaid.  Although CMS has recently placed dual-eligibles under the coverage of Medicare Part D, there are several initiatives aimed at moving these individuals back under Medicaid, where their drug utilization would again be subjected to full Medicaid rebates.

The pharmaceutical industry awaits finalization of the CMS proposed interpretation of Medicaid rebate increases related to product line extensions under the ACA.  Depending on the guidelines, Shire’s Medicaid rebates could increase.  CMS’ issuance of new Average Manufacturer’s Price (“AMP”) rules could also increase Medicaid rebate costs.  CMS’ proposed expansion of the Medicaid rebate program to US Territories (including Puerto Rico, US Virgin Islands, Guam, Northern Mariana Islands and Samoa) could also impact both the Company’s contracting strategies to some of these Territories and increase Shire’s Medicaid rebate costs.  CMS’ publication of its own pricing compendium, (“NADAC”), as well as AMP-based Federal Upper Limits (FUL) could affect reimbursement to pharmacists for drugs, depending on the rate of each state’s adoption. The tax revenue aspects of the fiscal cliff in the Budget Control Act were partially resolved via the Taxpayers Relief Act of 2012; however, the spending cuts to government programs like Medicare, Medicaid and others have not been finalized, and could affect government payor utilization of Shire’s products.

In the EU, price controls and non-reimbursement for new, highly priced medicines have been experienced. Uncertainty exists about the pricing and reimbursement status of newly approved products in the EU. Germany, for example, has implemented the Act for the Restructuring of the Pharmaceutical Market in Statutory Health Insurance. This law essentially maintains free pricing for new chemical entities, but assess the patient relative benefit of new drugs within three months of commercialization, in order to inform subsequent price negotiations. Prices of drugs bringing added value will qualify for price negotiation, while those with no added value will be subject to reference pricing (where price is determined by taking the lowest and/or average price of similar medicines in other countries). Criteria required to prove a drug’s benefit include "additional patient-related outcomes".  Third party reimbursement limits may reduce the demand for the Company’s products. The slow pace of the price applications process in some countries have delayed and, occasionally, prevented product launches. In some countries regional authorities are seeking to constrain drug prices and uptake. As such the Company’s estimated product launches may be delayed.  The novelty of ADHD and behavioral drugs in the EU and other markets will require strong education and promotion efforts in order to gain acceptance and an economically viable reimbursement profile.

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Responsibility

Corporate responsibility (“Responsibility”) is embedded at Shire and is a clear expectation of all employees.  Individual performance reviews include an evaluation of how goals were achieved, not just that they were achieved. Responsibility is also reflected in how Shire operates as a “corporate citizen.” This commitment to responsibility is supported by Shire’s Board of Directors, championed by the Chief Executive and driven forward by Shire’s senior leaders.

During 2013 Shire focused on Access to Medicines and Disease Awareness. These areas have been identified by Shire, and its stakeholders, as being of primary importance from a Responsibility perspective.

At the end of 2013, Shire undertook quantitative and qualitative research with external stakeholders to obtain input and feedback for its Responsibility strategy for 2014 and beyond.

A number of senior managers at Shire sponsor focus areas such as the environment, health and safety, compliance and risk management, our people and the community. These sponsors are responsible for setting goals which support Shire’s overall strategy, and for ensuring progress is made against these goals. Responsibility objectives are reviewed quarterly, and Sponsors meet as a group at least once a year to monitor progress. Shire’s Responsibility Steering and Communications Group, chaired by the Company General Counsel, facilitate the working groups, sponsors and communications.

Shire communicates regularly to employees about Responsibility. The Company also communicates to external stakeholders with a bi-annual publication (Responsibility Matters) and has a section on its website dedicated to information and ongoing updates on Shire’s work, initiatives and achievements that illustrate Shire’s commitment to Responsibility.

Employees

The Company’s employees are vital to its success. At December 31, 2013 the Company had 5,338 employees (2012: 5,367 employees).

Available information

The Company maintains a global internet site at www.shire.com. The Company makes available on its website its Annual Report on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and amendments to those reports filed or furnished pursuant to Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as soon as reasonably practicable after such reports are electronically filed with, or furnished to, the Securities and Exchange Commission (“SEC”). Shire's reports filed with, or furnished to, the SEC are also available on the SEC's website at www.sec.gov in a document, and for Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, in an XBRL (Extensible Business Reporting Language) format. XBRL is an electronic coding language to create an interactive financial statement data over the internet. The information on the Company’s website is neither part of nor incorporated by reference in this Annual Report on Form 10-K.

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ITEM 1A:  Risk Factors

The Company has adopted a risk management strategy designed to identify, assess and manage the significant risks that it faces. While the Company aims to identify and manage such risks, no risk management strategy can provide absolute assurance against any losses.

Set out below are the key risk factors associated with the business that have been identified through the Company's approach to risk management. Some of these risk factors are specific to the Company, and others are more generally applicable to the pharmaceutical industry or specific markets in which the Company operates. The Company believes that these risk factors apply equally and therefore all should be carefully considered before any investment is made in Shire.

RISK FACTORS RELATED TO THE COMPANY’S BUSINESS

The Company’s products may not be a commercial success

The commercial success of the Company’s marketed products and other new products that the Company may launch in the future, will depend on their approval and acceptance by physicians, patients and other key decision-makers, as well as the receipt of marketing approvals in different countries, the time taken to obtain such approvals, the scope of marketing approvals as reflected in the product labels, approval of reimbursement at commercially sustainable prices in those countries where price and reimbursement is negotiated, and safety, efficacy, convenience and cost-effectiveness of the product as compared to competitive products.

The Company’s revenues, financial condition or results of operations may be adversely affected if any or all of the following occur:

· if the Company’s products, or competitive products, are genericized;

· if the prices of the Company’s products suffer forced reductions or if prices of competitor products are reduced significantly;

· if there are unanticipated adverse events experienced with the Company’s products or those of a competitor’s product not seen in clinical trials that impact  physicians’ willingness to prescribe the Company’s products;

· if issues arise from clinical trials being conducted for post-marketing purposes or for registration in another country which raise questions or concerns about a product;

· if the regulatory agencies in one country act in a way that raises concerns for regulatory agencies or for prescribers or patients in another country;

· if patients, payors or physicians favor other treatments over the Company’s products;

· if the Company’s products are subject to more stringent government regulation than competitor products;

· if patent protection or other forms of exclusivity are lost or curtailed, or if competitors are able to challenge or circumvent the Company’s patents or other forms of exclusivity (See ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K for details of current litigation);

· if launch of the Company’s products in new markets is not successful;

· if the sizes of the patient populations for the Company’s products are less than expected; or

· if there are lawsuits filed against Shire, including but not limited to, product liability claims, consumer law claims, and payor or reimbursement litigation.

If the Company is unable to commercialize its products successfully, there may be a material adverse effect on the Company’s revenues, financial condition or results of operations.

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Revenues from ADDERALL XR are subject to generic erosion and revenues from INTUNIV will become subject to generic competition starting in December 2014

During 2012 the FDA clarified the regulatory pathway required for approval of generic versions of ADDERALL XR. Consequently in June 2012 and February 2013, Actavis and Teva, respectively, received approval to launch their own generic versions of ADDERALL XR. Shire currently sells authorized generic versions of ADDERALL XR to Teva and Impax and also continues to sell the branded version of ADDERALL XR.

In 2013, Shire settled a number of patent lawsuits in the United States against certain companies that had filed for approval of their generic versions of INTUNIV. Under the terms of the settlements, Actavis was granted a license to make and market Actavis' generic versions of INTUNIV in the United States on December 1, 2014.  All other parties with whom Shire has settled will be able to enter the market with their respective ANDA-approved products after Actavis’ 180 day exclusivity period has expired.

Revenues from ADDERALL XR declined following the launch of Actavis’ generic version of ADDERALL XR.  Revenues from INTUNIV are expected to decline as a result of the launch of Actavis’ generic versions of INTUNIV and to decline further following the expected launch of generic versions of INTUNIV by other companies after Actavis’ 180 day exclusivity period expires.

Factors which could cause further or more rapid revenue decline include:

· generic or authorized generic versions of the Company’s products capture more of Shire’s branded market share than expected;

· the FDA approves additional ANDAs for generic versions of the Company’s products which, if launched,  further reduce branded market share or impact the amount of authorized generic sales and related royalties;

· the production of ADDERALL XR is disrupted by difficulties in obtaining a sufficient supply of amphetamine salts including, but not limited to, an inability to obtain sufficient quota from the DEA;

· there are changes in reimbursement policies of third-party payors; or

· there are changes to the level of sales deductions for ADDERALL XR and INTUNIV for private or public payors.

The failure to obtain and maintain reimbursement, or an adequate level of reimbursement, by third-party payors in a timely manner for the Company's products may impact future revenues, financial condition and results of operations.

The Company's revenues are partly dependent on the level of reimbursement provided to the Company by governmental reimbursement schemes for its products. Changes to governmental policy or practices could adversely affect the Company's revenues, financial condition and results of operations. In addition, the reimbursement of treatments by health care providers, private health insurers and other organizations, such as health maintenance organizations and managed care organizations is under downward pressure and this, in turn, could adversely impact the prices at which the Company can sell its products. Factors affecting the Company’s ability to obtain and maintain adequate reimbursement for its products include:

· higher levels of controls on the use of the Company’s products and/or requirements for additional price concessions by managed health care organizations or government authorities;

· legislative proposals to reform health care and government insurance programs in many of the Company's markets; and

· price controls, unsuccessful government tenders, or non-reimbursement of new medicines or new indications.

The cost of treatment for some of the Company's products is high, particularly those which are used for the treatment of rare genetic diseases. The Company may encounter difficulty in obtaining or maintaining satisfactory pricing and reimbursement for such products. The failure to obtain and maintain pricing and reimbursement at satisfactory levels for its products may adversely affect the Company’s revenues, financial condition or results of operations.

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The Company conducts its own manufacturing operations for certain of its Rare Diseases products and is reliant on third party contract manufacturers to manufacture other products and to provide goods and services.  Some of the Company’s products or ingredients are only available from a single approved source for manufacture. Any disruption to the supply chain for any of the Company’s products may result in the Company being unable to continue marketing or developing a product or may result in the Company being unable to do so on a commercially viable basis for some period of time.

The Company sources some products from third party contract manufacturers, and for certain products has its own manufacturing capability. Although the Company dual-sources certain key products and/or active ingredients, the Company currently relies on a single source for production of the final drug product for each of ADDERALL XR, CINRYZE, FIRAZYR, FOSRENOL, INTUNIV, LIALDA, PENTASA, and RESOLOR, relies on a single active ingredient source for each of ELAPRASE, FIRAZYR, FOSRENOL, INTUNIV, REPLAGAL, RESOLOR and VPRIV (in the US) and relies on limited third party sources to provide the donated human plasma necessary for the manufacture of CINRYZE.

The Company may experience supply failures or delays beyond its control if it does not, or if any of its third party manufacturers do not, supply the Company on time with the required volumes, or supply products that do not meet regulatory requirements. Any such supply failures could lead to significant delays, increase in operating costs, lost product sales, an interruption of research activities, or the delay of new product launches, all of which could have a material adverse effect on the Company’s revenues, financial condition or results of operations.

The Company has also entered into many agreements with third parties for the provision of goods and services to enable it to manufacture its products. If these third parties are unable to manufacture products, or provide these goods and services, in each case in accordance with its respective contractual obligations, the Company’s ability to manage its manufacturing processes or to operate its business, including to continue the development or commercialization of its products as planned or on a commercial basis, may be adversely impacted.

The development, approval and manufacturing of the Company’s products is subject to extensive oversight by various regulatory agencies and regulatory approvals or interventions associated with changes to manufacturing sites, ingredients or manufacturing processes could lead to significant delays, increase in operating costs, lost product sales, an interruption of research activities or the delay of new product launches

Pharmaceutical and device manufacturing sites must be inspected and approved by regulatory agencies such as the FDA, and similar agencies in other countries. Active ingredients, excipients and packaging materials used in the manufacturing process must be obtained from sources approved by regulatory agencies.

The development, approval and manufacturing of the Company's products depend on the ability to procure ingredients and packaging materials from approved sources and for the manufacturing process to be conducted at approved sites. Changes of manufacturer or changes of source of ingredients or packaging materials must generally be approved by the regulatory agencies, which will involve testing and additional inspections to ensure compliance with the applicable regulatory agency’s regulations and standards. The need to qualify a new manufacturer or source of ingredients or packaging materials can take a significant amount of time.  Should it become necessary to change a manufacturer or supplier of ingredients or packaging materials, or to qualify an additional supplier, the Company may not be able do so quickly, or at all, which could delay or disrupt the manufacturing process.

US-based manufacturers must be registered with the DEA and similar regulatory authorities in other countries if they handle controlled substances.Certain of the Company’s products, including ADDERALL XR and VYVANSE, contain ingredients which are controlled substances subject to quotas managed by the DEA.  As a result, the Company’s procurement and production quotas may not be sufficient to meet commercial demand.

CINRYZE, ELAPRASE, REPLAGAL and VPRIV are manufactured using  highly complex biological processes. The complexity of the manufacturing results in a number of risks, including the risk of viral or other contamination.  Additionally, CINRYZE is derived from human plasma, and is therefore subject to the risk of biological contamination inherent in plasma-derived products. The sole manufacturer of CINRYZE has received observations on Form 483 and a warning letter from the FDA identifying issues with respect to the manufacturing process for CINRYZE which must be addressed to the satisfaction of the FDA.   Any regulatory interventions, in relation to these, or any other issues, if they occur, may delay or disrupt the manufacture of the Company’s products.

The Company has made significant investments in a new biologics manufacturing plant at its site in Lexington, Massachusetts.  The Company’s ability to manufacture certain of its Rare Diseases products or constituents in this new facility remains subject to the approval of the facility by the FDA and other international agencies.

The failure to obtain regulatory approvals promptly or at all and/or regulatory interventions associated with changes to manufacturing sites, ingredients or manufacturing processes could lead to significant delays, an increase in operating costs, lost product sales, an interruption of research activities, the delay of new product launches or constraints on

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manufacturing output, all of which could have a material adverse effect on the Company’s revenues, financial condition and results of operations.

The actions of certain customers could affect the Company's ability to sell or market products profitably.  Fluctuations in buying or distribution patterns by such customers can adversely impact the Company’s revenues, financial conditions or results of operations

A considerable portion of the Company’s product sales are made to major pharmaceutical wholesale distributors, as well as to large pharmacies, in both the US and Europe. In 2013, for example, 52% of the Company's product sales were attributable to three customers in the US: McKesson Corp., Cardinal Health, Inc and AmerisourceBergen Corp. In the event of financial failure of any of these customers there could be a material adverse effect on the Company’s revenues, financial condition or results of operations. The Company’s revenues, financial condition or results of operations may also be affected by fluctuations in customer buying or distribution patterns. These fluctuations may result from seasonality, pricing, wholesaler inventory objectives, or other factors. A significant portion of the Company's revenues for certain products for treatment of rare genetic diseases are concentrated within a small number of customers. Changes in the buying patterns of those customers may have an adverse effect on the Company's revenues, financial condition or results of operations.

Investigations or enforcement action by regulatory authorities or law enforcement agencies relating to the Company’s activities in the highly regulated markets in which it operates may result in significant legal costs and the payment of substantial compensation or fines

The Company engages in various marketing, promotional and educational activities pertaining to, as well as the sale of, pharmaceutical products and medical devices in a number of jurisdictions around the world. The promotion, marketing and sale of pharmaceutical products and medical devices is highly regulated and the operations of market participants, such as the Company, are closely supervised by regulatory authorities and law enforcement agencies, including the US Department of HHS, the FDA, the US Department of Justice, the SEC and the DEA. These authorities and agencies and their equivalents in countries outside the US have broad authority to investigate market participants for potential violations of laws relating to the sales, marketing and promotion of pharmaceutical products and medical devices, including the False Claims Act, the Anti-Kickback Statute and the Foreign Corrupt Practices Act, among others, for alleged improper conduct, including corrupt payments to government officials, improper payments to medical professionals, off-label marketing of pharmaceutical products and medical devices, and the submission of false claims for reimbursement by the federal government. Healthcare companies may also be subject to enforcement actions or prosecution for such improper conduct.  Any inquiries or investigations into the operations of, or enforcement or other regulatory action against, the Company by such authorities could result in significant defense costs, fines, penalties and injunctive or administrative remedies, distract management to the detriment of the business, result in the exclusion of certain products, or the Company, from government reimbursement programs or subject the Company to regulatory controls or government monitoring of its activities in the future. The Company is subject to certain ongoing investigations by governmental agencies. For further information, see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K).

Adverse outcomes in legal matters and other disputes, including Shire’s ability to enforce and defend patents and other intellectual property rights required for its business, could have a material adverse effect on the Company’s revenues, financial condition or results of operations

During the ordinary course of its business the Company may be involved in claims, disputes and litigation with third parties, employees, regulatory agencies, governmental authorities and other parties.  The range of matters of a legal nature that might arise is extremely broad but could include, without limitation, employment claims and disputes, intellectual property claims and disputes, contract claims and disputes, product liability claims and disputes, regulatory litigation and tax audits and disputes.

Any unfavorable outcome in such matters could adversely impact the Company’s ability to develop or commercialize its products, adversely affect the profitability of existing products, subject the Company to significant defence costs, fines, penalties, audit findings and injunctive or administrative remedies, distract management to the detriment of the business, result in the exclusion of certain products, or the Company, from government reimbursement programs or subject the Company to regulatory controls or government monitoring of its activities in the future.  Any such outcomes could have a material adverse effect on the Company’s revenue, financial condition or results of operations.  (For further information see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K).

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The Company faces intense competition for highly qualified personnel from other companies, academic institutions, government entities and other organizations. The Company is undergoing a corporate reorganization and the consequent uncertainty could adversely impact the Company’s ability to attract and/or retain the highly skilled personnel needed for the Company to meet its strategic objectives

The Company relies on recruiting and retaining highly skilled employees to meet its strategic objectives. The Company faces intense competition for highly qualified personnel and the supply of people with the requisite skills may be limited, generally or geographically. The range of skills required and the geographies in which they are required by the Company may also change over time as Shire’s business evolves.  The Company’s ongoing One Shire reorganization, which aims to simplify the Company’s organizational structure, involves changes to, and geographic relocation of, certain skilled roles. If the Company is unable to retain key personnel or attract new personnel with the requisite skills and experience, it could adversely affect the implementation of the Company’s strategic objectives and ultimately adversely impact the Company’s revenues, financial condition or results of operations.

Failure to achieve the Company’s strategic objectives with respect to the acquisition of ViroPharma may adversely affect the Company’s financial condition and results of operations.

On January 24, 2014, Shire completed the acquisition of ViroPharma for a total cash consideration of approximately $4.2 billion. Acquisitions of this size typically entail various risks, which, if they materialize, may adversely impact the Company’s revenues, financial condition or results of operations.

These risks include but are not limited to:

· failure to achieve the targeted growth and expected benefits of the acquisition if sales of ViroPharma products, including CINRYZE, are lower than anticipated;

· difficulties in integrating ViroPharma into Shire may lead to the combined company not being able to realize the expected operating efficiencies, cost savings, revenue enhancements, synergies or other benefits in the timeframe anticipated, or at all;

· undiscovered or unanticipated risks and liabilities, including legal and compliance related liabilities, may emerge after closing the acquisition or may be higher than anticipated; and

· the Company may not be able to retain the existing customers of ViroPharma or attract new customers.

Any failure to achieve the Company’s strategic objectives with respect to the ViroPharma acquisition could result in slower growth, higher than expected costs, the recording of asset impairment charges and other actions which could adversely affect the Company’s business, financial condition and results of operations.

GENERAL RISK FACTORS RELATED TO THE COMPANY AND TO THE HEALTHCARE INDUSTRY

The actions of governments, industry regulators and the economic environments in which the Company operates may adversely affect its ability to develop and profitably market its products

The healthcare industry is heavily regulated.  Changes to laws or regulations impacting the healthcare industry, in any country in which the Company conducts its business, may adversely impact the Company's revenues, financial condition or results of operations. For example, changes to the regulations relating to the exclusivity periods available for the Company’s products may allow for the earlier entry of generic or biosimilar competitor products.

A slowdown of global economic growth, or continued instability of the Eurozone, could have negative consequences for the Company’s business and increase the risk of non-payment by the Company’s customers

Growth of the global pharmaceutical market has become increasingly tied to global economic growth. Accordingly a substantial and lasting slowdown of the global economy or major national economies could negatively affect growth in the markets in which the Company operates. Such a slowdown, or any resultant austerity measures adopted by governments in response to a slowdown, could also reduce the level of reimbursement that governments are willing and able to provide to the Company for its products and, as a result, adversely affect the Company’s revenues, financial condition or results of operations.

Any slowing economic environment may also lead to financial difficulties for some of the Company’s significant customers. In such situations, the Company could experience delays in payment or non-payment of amounts owed which may result in a rising level of contractual defaults by its contractual counterparties.

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The Company does business, both directly (with government hospitals, clinics, pharmacies and other agencies) and indirectly (through wholesalers and distributors), with a number of Eurozone governments, includingthegovernments of Greece, Ireland, Italy, Portugal and Spain.  These and other countries have experienced, and may continue to experience, declines in their creditworthiness.  These events could in turn result in these countries making significant cuts to their public spending, including national healthcare budgets, in an attempt to manage their budget deficits, or could result in a greater risk of default or non-payment of outstanding payment obligations, any of which could adversely affect the Company’s revenues, financial condition or results of operations.

In addition, concerns have been expressed for the overall stability and suitability of the Euro as a single currency, given the economic and political challenges facing individual Eurozone countries. Continuing deterioration in the creditworthiness of Eurozone countries, the withdrawal of one or more member countries from the EU, or the failure of the Euro as a common European currency could adversely affect the Company’s revenues, financial condition or results of operations. (For further information see ITEM 7A: Quantitative and qualitative disclosures about market risk, concentration of credit risk set forth in this Annual Report on Form 10-K).

The introduction of new products by competitors may impact future revenues

The pharmaceutical, biotechnology and device industries are highly competitive and are characterized by substantial investment in continuous product development and technological change. The Company's products could, therefore, be rendered obsolete or uneconomic, through the development of new products, new methods of treatment, or technological advances in manufacturing or production by its competitors which may impact future revenues.

The successful development of products is highly uncertain and requires significant expenditures and time

Products that initially appear promising in research or development may be delayed or fail to reach later stages of development as:

· preclinical or clinical tests may show the product to lack safety or efficacy;

· delays may be caused by slow enrolment in clinical studies; regulatory requirements for clinical trial drug supplies; extended length of time to achieve study endpoints; additional time requirements for data analysis or dossier preparation; time required for discussions with regulatory agencies, including regulatory agency requests for additional preclinical or clinical data; delays at regulatory agencies due to staffing or resource limitations; analysis of or changes to study design; unexpected safety, efficacy, or manufacturing issues; delays may arise from shared control with collaborative partners in the planning and execution of the product development, scaling of the manufacturing process, or getting approval for manufacturing;

· manufacturing issues, pricing or reimbursement issues, or other factors may render the product economically unviable;

· the proprietary rights of others and their competing products and technologies may prevent the product from being developed or commercialized; or

· the product may fail to receive necessary regulatory approvals.

Success in preclinical and early clinical trials does not ensure that late stage clinical trials will be successful. Clinical results are frequently susceptible to varying interpretations that may delay, limit, or prevent regulatory approvals. The length of time necessary to complete clinical trials and to submit an application for marketing approval for a final decision by a regulatory authority varies significantly and may be difficult to predict. If the Company’s large-scale or late-stage clinical trials for a product are not successful, the Company will not recover its substantial investments in that product.

In addition, even if the products receive regulatory approval, they remain subject to ongoing regulatory requirements, including, for example, obligations to conduct additional clinical trials or other non-clinical testing, changes to the product label (which could impact its marketability and prospects for commercial success), new or revised requirements for manufacturing, written notifications to physicians, or product recalls or withdrawals.

The failure of a strategic partner to develop and commercialize products could result in delays in development, approval or loss of revenue

The Company enters into strategic partnerships with other companies in areas such as product development, manufacturing, sales and marketing. In these partnerships, the Company is sometimes dependent on its partner to deliver results. While these partnerships are governed by contracts, the Company may not exercise direct control. If a partner fails to perform or experiences financial difficulties, the Company may suffer a delay in the development, a delay in the approval or a reduction in sales, or royalties of a product.

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The failure to secure new products or compounds for development either through in-licensing, acquisition or internal research and development efforts, or the failure to realize expected benefits from acquisitions of businesses or products, may have an adverse impact on the Company's future results

The Company's future results will depend, to a significant extent, upon its ability to develop, in-license or acquire new products or compounds, or to acquire other businesses. The expected benefits from acquired products, compounds or businesses may not be realized or may require significantly greater resources and expenditure than originally anticipated. The failure to realize expected benefits from acquisitions of businesses or products including those resulting from integration into the Group, or the failure to develop, in-license or acquire new products or compounds on a commercially viable basis, could have a material adverse effect on the Company's revenues, financial condition or results of operations.

The Company may fail to obtain, maintain, enforce or defend the intellectual property rights required to conduct its business

The Company's success depends upon its ability and the ability of its partners and licensors to protect their intellectual property rights. Where possible, the Company's strategy is to register intellectual property rights, such as patents and trademarks. The Company also relies on various trade secrets, unpatented know-how and technological innovations and contractual arrangements with third parties to maintain its competitive position.  The failure to obtain, maintain, enforce or defend such intellectual property rights, for any reason, could allow third parties to make competing products or impact the Company’s ability to develop, manufacture and market its own products on a commercially viable basis, or at all, which could have a material adverse effect on the Company's revenues, financial condition or results of operations.

The Company intends to enforce its patent rights vigorously and believes that its commercial partners, licensors and third party manufacturers intend to enforce vigorously those patent rights they have licensed to the Company. However, the Company’s patent rights, and patent rights that the Company has licensed, may not provide valid patent protection sufficiently broad to prevent any third party from developing, using or commercializing products that are similar or functionally equivalent to the Company's products or technologies.  These patent rights may be challenged, revoked, invalidated, infringed or circumvented by third parties. Laws relating to such rights may in future also be changed or withdrawn.

Additionally, the Company's products, or the technologies or processes used to formulate or manufacture those products may now, or in the future, infringe the patent rights of third parties. It is also possible that third parties will obtain patent or other proprietary rights that might be necessary or useful for the development, manufacture or sale of the Company's products. The Company may need to obtain licenses for intellectual property rights from others and may not be able to obtain these licenses on commercially reasonable terms, if at all.

The Company also relies on trade secrets and other un-patented proprietary information, which it generally seeks to protect by confidentiality and nondisclosure agreements with its employees, consultants, advisors and partners. These agreements may not effectively prevent disclosure of confidential information and may not provide the Company with an adequate remedy in the event of unauthorized disclosure. In addition, if the Company's employees, scientific consultants or partners develop inventions or processes that may be applicable to the Company's products under development, such inventions and processes will not necessarily become the Company's property, but may remain the property of those persons or their employers.

The Company has filed applications to register various trademarks for use in connection with its products in various countries and also, with respect to certain products, relies on the trademarks of third parties. These trademarks may not afford adequate protection or the Company or the third parties may not have the financial resources to enforce their rights under these trademarks which may enable others to use the trademarks and dilute their value.

In the regular course of business, the Company is party to litigation or other proceedings relating to intellectual property rights. (See ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K for details of current patent litigation).

If a marketed product fails to work effectively or causes adverse side effects, this could result in damage to the Company's reputation, the withdrawal of the product and legal action against the Company

Unanticipated side effects or unfavorable publicity from complaints concerning any of the Company's products, or those of its competitors, could have an adverse effect on the Company's ability to obtain or maintain regulatory approvals or successfully market its products. The testing, manufacturing, marketing and sales of pharmaceutical products and medical devices entails a risk of product liability claims, product recalls, litigation and associated adverse publicity. The cost of defending against such claims is expensive even when the claims are not merited. A successful product liability claim against the Company could require the Company to pay a substantial monetary award. If, in the absence of adequate insurance coverage, the Company does not have sufficient financial resources to satisfy a liability resulting from such a claim or to fund the legal defense of such a claim, it could become insolvent. Product liability insurance coverage is

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expensive, difficult to obtain and may not be available in the future on acceptable terms. Although the Company carries product liability insurance when available, this coverage may not be adequate. In addition, it cannot be certain that insurance coverage for present or future products will be available. Moreover, an adverse judgment in a product liability suit, even if insured or eventually overturned on appeal, could generate substantial negative publicity about the Company's products and business and inhibit or prevent commercialization of other products.

ITEM 1B: Unresolved Staff Comments

None.

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ITEM 2: Properties

The following are the principal premises of the Company, as at December 31, 2013:

Location	Use	Approximate Square Footage	Owned or Leased
Dublin, Ireland	Office accommodation	21,500	Leased
Lexington, Massachusetts, US	Office accommodation, laboratories and manufacturing, warehousing and distribution facility	806,115	Owned and  Leased
Wayne, Pennsylvania, US	Office accommodation	420,000	Leased
Basingstoke, UK	Office accommodation	127,000	Owned
Florence, Kentucky, US	Warehousing and distribution facility	96,000	Leased
North Reading, Massachusetts, US	Warehousing facility	91,676	Leased
Nyon, Switzerland	Office accommodation	81,300	Leased
Cambridge, Massachusetts, US	Manufacturing facility/Warehouse	30,072	Leased
Sao Paulo, Brazil	Office accommodation and Laboratory	26,200	Leased

At December 31, 2013 all of the above sites were utilized by the Company. The Company owns or leases smaller locations in a number of countries around the world.

The acquisition of ViroPharma was completed on January 24, 2014. The table below list the principal premises of ViroPharma, as at December 31, 2013:

Location	Use	Approximate Square Footage	Owned or Leased
Exton, Pennsylvania	Office accommodation	78,264	Leased

ViroPharma also has other smaller locations in several other countries around the world.

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ITEM 3: Legal Proceedings

The information required by this Item is incorporated herein by reference to Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements listed under ITEM 15: Exhibits and Financial Statement Schedules in this Annual Report on Form 10-K.

On January 24, 2014 Shire acquired ViroPharma. ViroPharma has been party to litigation in the ordinary course of its business. ViroPharma’s principal pending legal and other proceedings are disclosed below.

On May 17, 2012, a class action complaint was filed in the United States District Court for the Eastern District of Pennsylvania naming as defendants ViroPharma Incorporated and Vincent J. Milano, who resigned as ViroPharma Incorporated’s President and Chief Executive Officer upon completion of the ViroPharma acquisition by Shire. The complaint alleges, among other things, securities laws violations by the defendants in connection with certain statements made by the defendants related to VANCOCIN. On October 19, 2012, the complaint was amended to include individuals who were then officers of ViroPharma Incorporated as named defendants and allege additional information as the basis for the claim. ViroPharma moved to dismiss the complaint and an oral argument was held on June 10, 2013, but no decision has been issued.

On April 6, 2012, ViroPharma received a notification that the United States Federal Trade Commission (“FTC”) is conducting an investigation into whether ViroPharma had engaged in unfair methods of competition with respect to VANCOCIN. On August 3, 2012, ViroPharma received a Civil Investigative Demand from the FTC requesting additional information related to this matter. Shire intends to continue to cooperate fully with the FTC investigation. At this time, Shire is unable to predict the outcome or duration of this investigation.

ITEM 4: Mine Safety Disclosures

Not applicable.

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PART II

ITEM 5: Market for Registrant’s common equity, related stockholder matters and issuer purchases of equity securities

Ordinary shares

The Company’s ordinary shares are traded on the London Stock Exchange (“LSE”).

The following table presents the high and low closing mid-market quotation per ordinary share of Shire as quoted in the Daily Official List of the LSE for the periods indicated.

	High £ per ordinary share		Low £ per ordinary share
Year to December 31, 2013
1st Quarter		21.53		19.10
2nd Quarter		22.13		18.62
3rd Quarter		25.93		20.88
4th Quarter		28.58		23.81
Year to December 31, 2012
1st Quarter		23.00		20.20
2nd Quarter		20.48		17.43
3rd Quarter		20.18		17.95
4th Quarter		19.56		17.27

The total number of record holders of ordinary shares of Shire on February 14, 2014 was 5,407. Since certain of the ordinary shares are held by broker nominees, the number of record holders may not be representative of the number of beneficial owners.

American Depositary Shares

American Depositary Shares (“ADSs”) each represent three ordinary shares of Shire. An ADS is evidenced by an American Depositary Receipt (“ADR”) issued by Citibank, N.A. as depositary, and is listed on the NASDAQ Global Select Market. On February 14, 2014 the proportion of ordinary shares represented by ADRs was 16.26% of the outstanding ordinary shares.

The following table presents the high and low market quotations for ADSs quoted on the NASDAQ Global Select Market for the periods indicated.

	High $ per ADS		Low $ per ADS
Year to December 31, 2013
1st Quarter		101.63		89.83
2nd Quarter		99.85		86.59
3rd Quarter		123.53		94.97
4th Quarter		141.29		113.87
Year to December 31, 2012
1st Quarter		108.20		94.75
2nd Quarter		99.15		82.65
3rd Quarter		95.05		84.24
4th Quarter		94.19		82.45

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The number of record holders of ADSs on February 14, 2014 was 1,522. Since certain of the ADSs are held by broker nominees, the number of record holders may not be representative of the number of beneficial owners.

Share Buy-back Program

On October 25, 2012 the Company commenced a share buy-back program of up to $500 million through both direct purchases of ordinary shares and through the purchase of ordinary shares underlying ADRs. The purchases have been made through independent third parties who have made trading decisions independently of, and uninfluenced by, the Company. The independence of the third parties enabled the Company to purchase ordinary shares (including ordinary shares underlying ADRs) during close periods and other prohibited periods, should they arise. The amount, timing or prices of purchases, varied based on market conditions and other factors. The shares purchased to date are held as treasury shares.

During the year ended December 31, 2013, the Company made on-market repurchases totaling 6,191,965 ordinary shares at a cost of $193 million (excluding transaction costs). This represents 1.0% of the issued share capital of the Company as at the end of the quarter. At its Annual General Meeting (“AGM”) on April 24, 2012 the Company was authorized to make market purchases of up to 56,253,208 of its own ordinary shares. That authority expired at the AGM held on April 30, 2013 and was renewed. Under the new authority, which expires on the earlier of July 29, 2014 or the conclusion of the 2014 AGM, the Company was authorized to make market purchases of up to 55,741,587 of its own ordinary shares.

On November 11, 2013, contemporaneous with Shire’s announcement of its acquisition of ViroPharma, the Company’s share buyback program was terminated. Since the inception of the share buyback program the Company had purchased $300 million of ordinary shares and ordinary shares underlying ADRs.

The following table provides information about purchases by the Company in the year to December 31, 2013 of equity securities that are registered by the Company pursuant to Section 12 of the Exchange Act.

Period	Total Number of ordinary shares Purchased		Average Price Paid Per ordinary share (£)		Total Number of ordinary shares underlying ADRs Purchased		Average Price Paid Per ordinary share underlying ADRs ($)		Approximate Dollar Value of ordinary shares that May Yet Be Purchased Under the Share Buy-back Program
January 2013		715,203		19.934		336,300		32.360	$360 million
February 2013		448,896		20.748		164,100		31.954	$340 million
March 2013		466,918		20.110		244,200		30.518	$318 million
April 2013		866,594		19.731		500,400		30.263	$277 million
May 2013		1,136,618		19.383		418,698		30.081	$231 million
June 2013		320,688		20.716		181,857		32.247	$215 million
July 2013		112,365		21.833		46,782		32.727	$209 million
August 2013		59,513		24.020		26,331		37.291	$206 million
September 2013		52,350		24.679		26,016		39.411	$203 million
October 2013		48,892		24.911		14,493		39.339	$200 million
November 2013		9,800		28.332		951		44.837	$Nil1

1. Share Buy-back Program was terminated effective November 11, 2013.

Conversion of Shire’s 2.75% Convertible Bonds

On May 9, 2007 Shire issued $1,100 million 2.75% convertible bonds due 2014 (the “Bonds”). On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed dated May 9, 2007 (the “Trust Deed”) to holders of the Company’s Bonds. Consequently, as of December 31, 2013, Bonds in an aggregate principal amount of the $1,099,050,000 had been voluntarily converted into 33,806,464 fully paid ordinary shares at a conversion price of

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US$32.51 per ordinary share in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principal amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. See ITEM 7: Management’s Discussion and Analysis of Financial Condition and Results of Operations; Liquidity and Capital resources section for further details.

Dividend policy

A first interim dividend for the six months to June 30, 2013 of 3.00 US cents (1.95 pence) per ordinary share, equivalent to 9.00 US cents per ADS, was paid in October 2013. The Board has resolved to pay a second interim dividend of 16.93 US cents (10.21 pence) per ordinary share equivalent to 50.79 US cents per ADS for the six months to December 31, 2013.

A first interim dividend for the six months to June 30, 2012 of 2.73 US cents (1.74 pence) per ordinary share, equivalent to 8.19 US cents per ADS, was paid in October 2012. A second interim dividend for the six months to December 31, 2012 of 14.60 US cents (9.39 pence) per ordinary share equivalent to 43.80 US cents per ADS was paid in April 2013.

This is consistent with Shire’s stated policy of paying a dividend semi-annually, set in US cents per ordinary share.  Typically, the first interim payment each year will be higher than the previous year’s first interim USD dividend.  Dividend growth for the full year will be reviewed by the Board when the second interim dividend is determined. However there is no guarantee that dividends will be declared for any periods.

Income Access Share Arrangements

Pursuant to the Scheme of Arrangement (the “Scheme”) that became effective on May 23, 2008 Shire plc became the holding company of the former holding company of the Shire group, Shire Biopharmaceuticals Holdings (“Old Shire”). As a result of the Scheme, Shire has put in place income access arrangements which enable Shire ordinary shareholders, other than Shire ADS holders, to choose whether they receive their dividends from Shire, a company tax resident in the Republic of Ireland, or from Old Shire, a Shire group company tax resident in the UK.

Old Shire has issued one income access share to the Income Access Trust (the “IAS Trust”) which is held by the trustee of the IAS Trust (the “Trustee”). The mechanics of the arrangements are as follows:

i)   If a dividend is announced or declared by Shire plc on its ordinary shares, an amount is paid by Old Shire by way of a dividend on the income access share to the Trustee, and such amount is paid by the Trustee to ordinary shareholders who have elected (or are deemed to have elected) to receive dividends under these arrangements. The dividend which would otherwise be payable by Shire plc to its ordinary shareholders will be reduced by an amount equal to the amount paid to its ordinary shareholders by the Trustee.

ii)   If the dividend paid on the income access share and on-paid by the Trustee to ordinary shareholders is less than the total amount of the dividend announced or declared by Shire plc on its ordinary shares, Shire plc will be obliged to pay a dividend on the relevant ordinary shares equivalent to the amount of the shortfall. In such a case, any dividend paid on the ordinary shares will generally be subject to Irish withholding tax at the rate of 20% or such lower rate as may be applicable under exemptions from withholding tax contained in Irish law.

iii)   An ordinary shareholder is entitled to make an income access share election such that she/he will receive his/her dividends (which would otherwise be payable by Shire plc) under these arrangements from Old Shire.

iv)   An ordinary shareholder who holds 25,000 or fewer ordinary shares at the first record date after she/he first becomes an ordinary shareholder, and who does not make a contrary election, will be deemed to have made an election (pursuant to the Shire plc articles of association) such that she/he will receive his/her dividends under these arrangements from Old Shire.

The ADS Depositary has made an election on behalf of all holders of ADSs such that they will receive dividends from Old Shire under the income access share arrangements. Dividends paid by Old Shire under the income access share arrangements will not, under current legislation, be subject to any UK or Irish withholding taxes. If a holder of ADSs does not wish to receive dividends from Old Shire under the income access share arrangements, she/he must withdraw his/her ordinary shares from the ADS program prior to the dividend record date set by the Depositary and request delivery of the Shire plc ordinary shares. This will enable him/her to receive dividends from Shire plc (if necessary, by making an election to that effect).

It is the expectation, although there can be no certainty, that Old Shire will distribute dividends on the income access share to the Trustee for the benefit of all ordinary shareholders who make (or are deemed to make) an income access share election in an amount equal to what would have been such ordinary shareholders’ entitlement to dividends from Shire plc in the absence of the income access share election. If any dividend paid on the income access share and or paid to the ordinary shareholders is less than such ordinary shareholders’ entitlement to dividends from Shire plc in the absence of the income access share election, the dividend on the income access share will be allocated pro rata among the ordinary shareholders and Shire plc will pay the balance to these ordinary shareholders by way of dividend. In such

42

circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

Shire will be able to suspend or terminate these arrangements at any time, in which case the full Shire plc dividend will be paid directly by Shire plc to those ordinary shareholders (including the Depositary) who have made (or are deemed to have made) an income access share election. In such circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

In the year ended December 31, 2013 Old Shire paid dividends totalling $91.1 million (2012: $81.5 million; 2011: $67.6 million) on the income access share to the Trustee in an amount equal to the dividend ordinary shareholders would have received from Shire plc.

Distributable Reserves

The payment of dividends by Shire plc is governed by Jersey law. Under Jersey law, Shire plc is entitled to make payments of dividends from its accumulated profits and other distributable reserves. Prior to making any dividend payment, the Directors of Shire plc who authorize the payment of the dividend must make a solvency statement to the effect that Shire plc will be able to continue to carry on its business and discharge its debts as they fall due immediately after the payment is made and for the twelve month period following the making of the payment. Shire's future dividend policy will be dependent upon the amount of its distributable reserves, its financial condition, the terms of its then existing debt facilities and other relevant factors existing at the time.

For dividends paid by Old Shire on the income access share to the Trustee, the ability of Old Shire to pay dividends is determined under English law. As a matter of English law Old Shire can only pay dividends out of its distributable profits, which are the accumulated realized profits of Old Shire and not the consolidated group, so far as not previously utilized by distribution or capitalization, less accumulated realized losses, so far as not previously written off in a reduction or reorganization of capital.

Equity Compensation Plan Information

Equity compensation plan information is incorporated herein by reference to ITEM 12: Security Ownership of Certain Beneficial Owners and Management and Related Stock Holder Matters of this Form 10-K.

43

ITEM 6: Selected financial data

The selected consolidated financial data presented below as at December 31, 2013 and 2012 and for the years to December 31, 2013, 2012 and 2011 were derived from the audited consolidated financial statements of the Company, included herein.

The selected consolidated financial data presented below as at December 31, 2011, 2010 and 2009 and for the years to December 31, 2010 and 2009 were derived from the audited consolidated financial statements of the Company, which are not included herein.

The selected consolidated financial data should be read in conjunction with ITEM 7: Management’s Discussion and Analysis of Financial Condition and Results of Operations and with the consolidated financial statements and related notes appearing elsewhere in this report.

Year to December 31,	2013			2012			2011			2010			2009
	$	’M		$	’M		$	’M		$	’M		$	’M
Statements of Operations:
Total revenues		4,934.3			4,527.4			4,158.1			3,471.1			3,007.7
Gain/(loss) on sale of product rights		15.9			18.1			(6.0	)		16.5			6.3
Other operating expenses(1)		(3,216.7	)		(3,500.3	)		(3,016.3	)		(2,693.5	)		(2,392.2	)
Operating income		1,733.5			1,045.2			1,135.8			794.1			620.2
Total other (expense)/income, net(2)		(39.9	)		(37.4	)		(18.7	)		(24.8	)		22.8
Income from continuing operations before income taxes and equity in earnings/(losses) of equity method investees		1,693.6			1,007.8			1,117.1			769.3			643.0
Income taxes		(277.9	)		(203.1	)		(236.9	)		(182.7	)		(138.5	)
Equity in earnings/(losses) of equity method investees, net of taxes		3.9			1.0			2.5			1.4			(0.7	)
Income from continuing operations, net of tax		1,419.6			805.7			882.7			588.0			503.8
Loss from discontinued operations, net of tax		(754.5	)		(60.3	)		(17.7	)		-			(12.4	)
Net income		665.1			745.4			865.0			588.0			491.4
Add: net loss attributable to the noncontrolling interest in subsidiaries		-			-			-			-			0.2
Net income attributable to Shire plc		665.1			745.4			865.0			588.0			491.6
Earnings per share – basic
Income from continuing operations		257.2	c		145.1	c		160.1	c		107.7	c		93.2	c
Loss from discontinued operations		(136.7c	)		(10.9c	)		(3.2c	)		-			(2.3c	)
Earnings per ordinary share - basic		120.5	c		134.2	c		156.9	c		107.7	c		90.9	c
Earnings per share – diluted
Income from continuing operations		245.3	c		141.0	c		153.9	c		105.3	c		91.9	c
Loss from discontinued operations		(127.8c	)		(10.1c	)		(3.0c	)		-			(2.2c	)
Earnings per ordinary share - diluted		117.5	c		130.9	c		150.9	c		105.3	c		89.7	c

44

(1) The following significant items are included within Other operating expenses:

· Up-front and milestone payments for in-licensed development projects, expensed to R&D, of $nil, $23.0 million, $nil, $45.0 million and $43.4 million in the years ended December 31, 2013, 2012, 2011, 2010 and 2009 respectively;

· Costs of $62.9 million associated with the termination of the Women’s Health development agreement with Duramed Pharmaceuticals, Inc. (“Duramed”) in the year to December 31, 2009; and

· Impairment loss of $7.1 million related to the goodwill allocated to the former RM reporting unit and impairment loss of $19.9 million in respect of RESOLOR in-process research and development (“IPR&D”) assets in the year to December 31, 2013; Impairment loss of $197.9 million in respect of RESOLOR intangible assets (finite lived intangible assets ($126.7 million) and IPR&D assets ($71.2 million)) in the year to December 31, 2012; Impairment loss of $16.0 million in respect of RESOLOR IPR&D assets in the year to December 31, 2011; and impairment loss of $42.7 million following the decision to divest DAYTRANA to Noven in the year to December 31, 2010.

(2)   The following items are included within Total other (expense)/ income, net:

· Gains on sale of non-current investments of $15.9 million, $18.1 million, $23.5 million, $11.1 million and $55.2 million in the years ended December 31, 2013, 2012, 2011, 2010 and 2009 respectively; and

· Other than temporary impairment charges for available-for-sale investments of $nil, $nil, $2.4 million, $1.5 million, and $0.8 million in the years ended December 31, 2013, 2012, 2011, 2010 and 2009 respectively.

For further information, see ITEM 7: Management’s Discussion and Analysis of Financial Condition and Results of Operations and ITEM 15: Exhibits and Financial Statement Schedules.

Weighted average number of shares (millions):
	2013			2012			2011			2010			2009
Basic		552.0			555.4			551.1			546.2			540.7
Diluted		590.3			593.5			595.4			590.3			548.0
Cash dividends declared and paid per ordinary share		17.600	c		15.320	c		13.330	c		11.500	c		9.908	c

December 31,
	2013		2012		2011		2010		2009
		$’M		$’M		$’M		$’M		$’M
Balance sheets:
Total current assets		4,288.3		3,212.1		2,208.2		1,880.3		1,570.2
Total assets		8,323.0		7,317.2		6,380.2		5,387.6		4,617.5
Total current liabilities		1,807.9		1,645.6		2,534.3		1,293.3		1,020.0
Long term obligations		588.5		1,341.6		144.3		1,290.8		1,390.7
Total liabilities		2,957.0		3,508.0		3,195.2		2,936.2		2,705.0
Total equity		5,366.0		3,809.2		3,185.0		2,451.4		1,912.5

45

ITEM 7: Management’s discussion and analysis of financial condition and results of operations

The following discussion should be read in conjunction with the Company’s consolidated financial statements contained in Part IV in this Annual Report on Form 10-K.

Overview

Shire is a leading specialty biopharmaceutical company that focuses on developing and marketing innovative specialty medicines that address significant unmet patient needs. The Company has grown through acquisition, completing a series of major transactions that have brought therapeutic, geographic and pipeline growth and diversification. The Company will continue to evaluate companies, products and pipeline opportunities that offer a good strategic fit and have the potential to deliver demonstrable value to all of the Company’s stakeholders: patients, physicians, policy makers, payors, investors and employees.

The Company’s vision is to transform the lives of people around the world whose health is impacted by rare and other specialized conditions, through providing innovative treatments. The Company will execute on its vision through its strategy and business model. For further details of Shire’s strategy and business model, refer to Part I ITEM 1: Business of this Annual Report on Form 10-K.

Through deep understanding of patients’ needs, the Company is able to:

· serve patients with high unmet needs in select, commercially attractive specialty therapeutic areas;

· drive optimum performance of its marketed products – to serve patients today;

· build its pipeline of innovative specialist treatments through both R&D and Business Development activities – to enable the Company to serve patients in the future.

Shire’s in-licensing and acquisition efforts are focused on products in specialist markets with strong intellectual property protection or other forms of market exclusivity and global rights. Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

Substantially all of the Company’s revenues, expenditures and net assets are attributable to the R&D, manufacture, sale and distribution of pharmaceutical products within one reportable segment. The Company also earns royalties (where Shire has out-licensed products to third parties) which are recorded as revenues.

Revenues are derived primarily from two sources - sales of the Company’s own products and royalties:

· 96% (2012: 94%) of total revenues are derived from product sales; and

· 3% of total revenues are derived from royalties (2012: 5%).

The markets in which the Company conducts its business are highly competitive and highly regulated.

There is increasing legislation both in the US and the rest of the world which is placing downward pressure on the net pricing of pharmaceutical products and medical devices. For example the US government passed healthcare reform legislation in 2010 which included an increase in Medicaid rebate rates and extended Medicaid rebates to those products provided through Medicaid managed care organizations. The legislation also imposed excise fees to be paid by both pharmaceutical manufacturers (from 2011) and medical device companies (from 2013). The CMS are also increasingly bundling drug reimbursement into procedure costs, which can severely decrease the reimbursement rates to physicians for some manufacturers’ drugs, biologicals and medical devices. The impact of these recent changes to US healthcare legislation, and other healthcare reforms in the rest of the world, has not to date had a material impact on the Company’s results of operations.

The health-care industry is also experiencing:

· pressure from governments and healthcare providers to keep prices low while increasing access to drugs;

· increasing challenges from third party payors for products to have demonstrable clinical benefit, with pricing and reimbursement approval becoming increasingly linked to a product’s clinical effectiveness and impact on overall costs of patient care;

· increased R&D costs, because development programs are typically larger and take longer to get approval from regulators;

· challenges to existing patents from generic manufacturers;

· governments and healthcare systems favoring earlier entry of low cost generic drugs; and

46

· higher marketing costs, due to increased competition for market share.

Shire’s strategy has been developed to address these industry-wide competitive pressures. This strategy has resulted in a series of initiatives in the following areas:

Markets

Shire’s current portfolio of approved products focuses on the following markets: Rare Diseases, Neuroscience and Gastrointestinal (“GI”) diseases. Shire also has a number of marketed products for other therapeutic areas from which it generates product revenues or royalties from third parties. In 2013 Shire derived 41% of product sales from Neuroscience products, 33% from Rare Diseases products, 17% from GI products and 9% from products addressing other therapeutic areas. Shire’s early stage research is focused on rare diseases.

Shire has grown through acquisition which has brought therapeutic, geographic and pipeline growth and diversification. For example the recent acquisitions of FerroKin in 2012 and Lotus Tissue Repair, Premacure and SARcode in 2013 provide potential access to new markets such as ophthalmology, neonatology and hematology/oncology. The acquisition of ViroPharma, which closed in January 2014, expands Shire’s Rare Diseases portfolio including adding CINRYZE, a leading currently marketed product for the prophylactic treatment of HAE.

In 2013 Shire derived 30% of product sales from outside of the US. Shire has ongoing commercialization and late-stage development activities, which are expected to further supplement the diversification of revenues in the future, including the following:

· filing in 2013 of an application in Japan for the approval of VPRIV for the treatment of Gaucher disease;

· filing in 2013 of an application in Japan for the approval of XAGRID for the treatment of elevated platelet counts in at risk essential thrombocythemia patients; and

· INTUNIV Phase 3 clinical program to support submission of an MAA in the EU.

R&D

Shire reorganized its R&D efforts in 2013, combining the R&D organizations of its former divisions into a single One Shire R&D organization focused around a prioritized portfolio of development and research programs. Shire has focused its R&D efforts on five therapeutic areas; Rare diseases, Neuroscience, GI, Hematology and Ophthalmology. Shire concentrates its resources on obtaining regulatory approval for later-stage pipeline products within these therapeutic areas and focuses its early stage research activities primarily in rare diseases.

Evidence of the successful progression of the late stage pipeline can be seen in the granting of approval and associated launches of the Company’s products over the last five years. In this time several products have received regulatory approval including: in the US, INTUNIV in 2009, VPRIV in 2010, and FIRAZYR in 2011; in the EU, VPRIV in 2010 and ELVANSE/TYVENSE in 2012; in Canada, VYVANSE in 2010.

Prior to the One Shire R&D reorganization, the Company’s management reviewed R&D expenditure by operating segment. Following the One Shire R&D reorganization, Shire’s management reviews direct costs for R&D projects by development phase.

Shire’s R&D costs in 2013 included expenditure on programs in all stages of development. The following table provides an analysis of the Company’s direct R&D spend categorized by development stage, based upon the development stage of each program as at December 31, 2013:

Year to December 31,	2013
	$'M
Early stage programs		102
Late stage programs		327
Currently marketed products		179
Total		608

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In addition to the above, the Company recorded R&D employee costs of $282 million in 2013 and other indirect R&D costs (comprising depreciation and impairment charges) of $43 million.

For a discussion of the Company’s current development projects see ITEM 1: Business.

Patents and Market Exclusivity

The loss or expiration of patent protection or regulatory exclusivity with respect to any of the Company’s major products could have a material adverse effect on the Company’s revenues, financial condition and results of operations, as generic or biosimilar products may enter the market. Companies selling generic products often do not need to complete extensive clinical studies when they seek registration of a generic or biosimilar product and accordingly, they are generally able to sell generic version of the Company’s products at a much lower price.

As expected, in 2009 Teva and Impax commenced commercial shipments of their authorized generic versions of ADDERALL XR, which led to lower sales of branded ADDERALL XR compared to the period prior to the authorized generic launch.

In 2011 authorized generic and generic versions of the Company’s CARBATROL and REMINYL products respectively were launched, which led to lower sales of these branded products compared to the period before loss of exclusivity.

Shire is engaged in various legal proceedings with generic manufacturers with respect to its VYVANSE, LIALDA and ADDERALL XR patents. For more detail of current patent litigation, see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

Business Development

Shire seeks to focus its business development activity on the acquisition and in-licensing of products and compounds which offer a good strategic fit and have the potential to deliver demonstrable value to all of the Company’s stakeholders.

Recent mergers or acquisitions

On January 24, 2014 Shire completed the acquisition of ViroPharma which added a marketed product for the prophylactic treatment of HAE, CINRYZE, as well as a number of other marketed products and a pipeline of product candidates in the rare disease area.

In 2013, Shire acquired:

· SARcode which added SHP 606 to the Shire portfolio (SHP 606 is currently in Phase 3 development for the treatment of Dry Eye disease).

· Premacure which added SHP607 to the Shire portfolio (SHP 607 is currently in Phase 3 for the prevention of ROP).

· Lotus Tissue Repair which added global rights to a protein replacement therapy in pre-clinical development, for the treatment of DEB.

In 2012, Shire acquired:

· FerroKin Biosciences Inc. (“FerroKin”) which added SHP 602 to the Shire portfolio (SHP 602 is in Phase 2 for the treatment of iron overload following numerous blood transfusions).

· Substantially all the assets and certain liabilities of Pervasis Therapeutics Inc. (“Pervasis”), which added VASCUGEL (now SHP 613) to the Shire portfolio (SHP 613 is in Phase 2 development for acute vascular repair).

Collaboration and licensing activity

Shire has also entered into a number of collaboration and license agreements in recent years, including:

· A collaboration and license agreement with Sangamo to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo’s ZFP technology in 2012;

· A worldwide exclusive license from IGAN Biosciences, Inc. (“IGAN”) to develop and commercialize protease-based therapeutics for the treatment of IgA nephropathy, a rare kidney disease in 2012; and

· Shionogi co-development and co-commercialization agreement in 2012 for VYVANSE and INTUNIV in Japan.

Organization and Structure

On May 2, 2013 the Company announced that there would be a reorganization of the Company’s business to integrate its SP, HGT and RM business units and reportable segments into a simplified One Shire organization in order to drive future

48

growth and innovation. Consequently the SP, HGT and RM segments no longer exist. Shire now comprises a single operating and reportable segment. For further details see ITEM 15: Exhibits and Financial Statements Schedules and Note 24 “Segment reporting” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

On November 7, 2013 the Company announced that, as part of the One Shire reorganization, the Company had undertaken a review of all of Shire’s pipeline programs to identify those projects that fit with Shire’s new strategic direction and have an acceptable likelihood of success. Shire’s pre-clinical investments will now be primarily focused on rare diseases, meaning that the majority of other pre-clinical projects will not continue. Several clinical programs have also been discontinued.

The impact of the prioritization and rationalization of the Company’s development portfolio means many of the R&D programs currently run from Basingstoke, UK will cease. Taken together with the overall streamlining of the R&D organization, this has resulted in a significant number of R&D roles in Basingstoke being eliminated and some positions being re-located. A small number of functional roles that support R&D in Basingstoke have also been affected.

In addition the Company announced plans to relocate its international commercial hub from Nyon, Switzerland to Zug, Switzerland. All Nyon-based employees have been impacted by the One Shire transition and the move to Zug. Shire is planning for the new Zug office to be ready for occupancy in summer 2014, and will phase out the Nyon office over a reasonable period of time to enable employees and their families to manage their re-locations.

On October 22, 2013 Shire announced that it had decided to discontinue the construction of its new manufacturing facility in San Diego. On January 16, 2014, the Company sold and transferred certain of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc. For further information, see ITEM 15: Exhibits and Financial Statement Schedules and Note 8, “Results of discontinued operations and assets held for sale” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

On January 23, 2013 Shire announced that it had decided to proceed with a collective dismissal and business closure at its site in Turnhout, Belgium. This decision followed the conclusion of an information and consultation process. Shire continues to sell RESOLOR in Europe and the supply of RESOLOR for patients in Europe who rely on the medicine will not be affected. The closure of the Turnhout site was completed during 2013.

For further details see ITEM 15: Exhibits and Financial Statements Schedules and Note 5 “Reorganization costs” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

49

Results of operations for the years to December 31, 2013 and 2012

Financial highlights for the year to December 31, 2013 are as follows:

· Product sales from continuing operations in 2013 were up 12% to $4,757 million (2012: $4,253 million).

The strong growth in product sales from continuing operations was driven by VYVANSE (up 19% to $1,228 million), LIALDA/MEZAVANT (up 32% to $529 million), VPRIV (up 12% to $343 million), INTUNIV (up 16% to $335 million) and FIRAZYR (up 102% to $235 million).

· Total revenues from continuing operations were up 9% to $4,934 million (2012: $4,527 million) as the growth in product sales was partially offset, as expected, by lower royalties and other revenues (down 36%).

· Operating income from continuing operations in 2013 was up 66% to $1,734 million (2012: $1,045 million), primarily due to the strong growth in product sales and an overall reduction in total operating expenses in 2013 compared to 2012 as the Company focuses on delivering efficient growth. Operating expenses in 2013 include a net credit of $159 million due to change in the fair value of contingent consideration liabilities, in particular relating to the acquisition of SARcode following the release of top-line Opus-2 data. Operating expenses in 2012 include impairment charges of $197.9 million related to RESOLOR intangible assets. R&D expenditure decreased by 2%. SG&A expenditure decreased by 15%.

· Diluted earnings per ordinary share from continuing operations increased 74% to $2.45 (2012: $1.41) due to the higher operating income from continuing operations and a lower effective tax rate of 16% (2012: 20%).

Total revenues

The following table provides an analysis of the Company’s total revenues by source:

Year to December 31,	2013		2012		Change
	$'M		$'M		%
Product sales		4,757.5		4,252.9		+12	%
Royalties		153.7		241.6		-36	%
Other revenues		23.1		32.9		-30	%
Total		4,934.3		4,527.4		+9	%

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Product sales

	Year to December 31,		Year to December 31,		Product sales		Non GAAP CER		US prescription			Exit market
	2013		2012		growth		growth4		growth1			share1
	$'M		$'M		%		%		%			%
Net product sales:
VYVANSE		1,227.8		1,029.8		+19		+19		+6			16
ELAPRASE		545.6		497.6		+10		+11		n/a	2		n/a	2
LIALDA/MEZAVANT		528.9		399.9		+32		+32		+18			28
REPLAGAL		467.9		497.5		-6		-4		n/a	3		n/a	3
ADDERALL XR		375.4		429.0		-12		-12		-9			5
VPRIV		342.7		306.6		+12		+12		n/a	2		n/a	2
INTUNIV		334.9		287.8		+16		+16		+8			5
PENTASA		280.6		265.8		+6		+6		-1			14
FIRAZYR		234.8		116.3		+102		+101		n/a	2		n/a	2
FOSRENOL		183.4		172.0		+7		+6		-18			4
XAGRID		99.4		97.2		+2		+1		n/a	2		n/a	2
Other product sales		136.1		153.4		-11		-11		n/a			n/a
Total product sales		4,757.5		4,252.9		+12

(1) Data provided by IMS Health National Prescription Audit (“IMS NPA”). Exit market share represents the average US market share in the month ended December 31, 2013.

(2) IMS NPA Data not available.

(3) Not sold in the US in the year to December 31, 2013.

(4) The Company’s management analyzes product sales and revenue growth for certain products sold in markets outside of the US on a constant exchange rate (“CER”) basis, so that product sales and revenue growth can be considered excluding movements in foreign exchange rates. Product sales and revenue growth on a CER basis is a Non GAAP financial measure (“Non GAAP CER”), computed by comparing 2013 product sales and revenues restated using 2012 average foreign exchange rates to 2012 actual product sales and revenues. This Non GAAP financial measure is used by Shire’s management, and is considered to provide useful information to investors about the Company’s results of operations, because it facilitates an evaluation of the Company’s year on year performance on a comparable basis. Average exchange rates for the year to December 31, 2013 were $1.56:£1.00 and $1.33:€1.00 (2012: $1.59:£1.00 and $1.29:€1.00).

VYVANSE – ADHD

VYVANSE product sales grew strongly (+19%) in 2013 primarily as a result of price increases1 as well as higher prescription demand, primarily due to growth in the US ADHD market (+6%).

Litigation proceedings regarding VYVANSE are ongoing. Further information about this litigation can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

ELAPRASE – Hunter syndrome

Reported ELAPRASE sales growth (+10%) was driven by an increase in the number of patients on therapy.

LIALDA/MEZAVANT – Ulcerative colitis

The growth in product sales for LIALDA/MEZAVANT (+32%) in 2013 was primarily driven by higher market share in the US, the effects of which were partially offset by higher sales deductions in 2013 as compared to 2012.

Litigation proceedings regarding LIALDA are ongoing. Further information about this litigation can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

REPLAGAL – Fabry disease

REPLAGAL sales were down 6% compared to 2012  (down  4% on a Non GAAP CER basis) as sales in 2013 were impacted by foreign exchange, pricing pressure (primarily in Europe) and slightly lower volumes due to the return of competition to the Fabry market.

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ADDERALL XR – ADHD

ADDERALL XR product sales decreased 12% in 2013 as a result of higher sales deductions, partially offset by the effect of higher stocking in 2013 compared to 2012.

Litigation proceedings regarding ADDERALL XR are ongoing. Further information about this litigation and the Impax settlement, can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

VPRIV – Gaucher disease

Reported VPRIV sales growth of 12% was driven by an increase in the number of patients on therapy.

INTUNIV – ADHD

INTUNIV product sales were up 16% compared to 2012, driven by growth in US prescription demand (up 9% compared to 2012), together with price increases1. These positive factors were partially offset by higher sales deductions in 2013 compared to 2012.

Further information about litigation proceedings regarding INTUNIV can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

PENTASA – Ulcerative Colitis

PENTASA product sales were up 6% as the benefit of price increases1 was partially offset by higher sales deductions in 2013 as compared to 2012.

FIRAZYR – Hereditary Angioedema

FIRAZYR sales growth (+102% compared to 2012) was primarily driven by the US market, where we continue to see both good growth in new patients and increased levels of repeat usage by existing patients.

1 The actual net effect of price increases on current period net sales compared to the comparative period is difficult to quantify due to the various managed care rebates, Medicaid discounts, other discount programs in which the Company participates and fee for service agreements with wholesalers customers.

Royalties

	Year to		Year to
	December 31,		December 31,
	2013		2012		Change
	$'M		$'M		%
FOSRENOL		48.1		53.3		-10	%
3TC and ZEFFIX		46.7		91.6		-49	%
ADDERALL XR		27.6		70.3		-61	%
Other		31.3		26.4		19	%
Total		153.7		241.6		-36	%

Royalties from ADDERALL XR in 2013 were significantly impacted by the lower royalty rate payable on sales of authorized generic ADDERALL XR by Impax, following the launch of a new generic version of ADDERALL XR late in the second quarter of 2012 as well as by Impax’s lower market share in 2013 versus 2012.

Royalties from 3TC and ZEFFIX in 2013 were lower, as 2012 included one-time royalty income of $38 million in respect of prior periods due to resolution of a disagreement with GlaxoSmithKline and ViiV Healthcare.

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Cost of product sales from continuing operations

Cost of product sales increased to $670.8 million for the year to December 31, 2013 (14% of product sales), up from $585.8 million in the corresponding period in 2012 (2012: 14% of product sales). The costs of product sales as a percentage of product sales remained broadly constant in 2013 as compared to 2012.

For the year to December 31, 2013 cost of product sales included depreciation of $37.5 million (2012: $29.0 million).

R&D from continuing operations

R&D expenditure decreased to $933.4 million for the year to December 31, 2013 (20% of product sales), compared to $953.0 million in the corresponding period in 2012 (22% of product sales). In the year to December 31, 2012 R&D included up-front payments of $13.0 million to Sangamo and $10.0 million to acquire the US rights for prucalopride (marketed in certain countries in Europe as RESOLOR) and IPR&D impairment charges in respect of RESOLOR of $71.2 million (2013: $19.9 million). Excluding these costs R&D increased by $54.7 million or 6% in the year to December 31, 2013 due to the Company’s continuing investment in a number of targeted R&D programs, particularly new uses for LDX and other recently acquired assets including SHP606 (Lifitegrast), SHP607 (for the prevention of Retinopathy of Prematurity) and SHP608 (for the treatment of DEB).

R&D in the year to December 31, 2013 included depreciation of $23.3 million (2012: $22.5 million).

SG&A from continuing operations

SG&A expenditure decreased to $1,651.3 million (35% of product sales) for the year to December 31, 2013 from $1,948.0 million (46% of product sales) in the corresponding period in 2012. In the year to December 31, 2012 SG&A included impairment charges of $126.7 million related to RESOLOR intangible assets and higher legal and litigation costs, including a charge of $57.5 million in relation to the agreement in principle with the US Government to resolve a previously disclosed civil investigation. Excluding these costs SG&A decreased by $43.1 million or 3% due to the Company’s continuing focus on simplifying its business and delivering efficient growth.

For the year to December 31, 2013 SG&A included depreciation of $66.8 million (2012: $57.5 million) and amortization of $152.0 million (2012: $153.6 million).

Goodwill impairment charges from continuing operations

In the first quarter of 2013 Shire recorded a goodwill impairment charge of $198.9 million (2012: $nil) in relation to the former RM business unit. Following a review of future forecasts for the RM business unit, management determined in the first quarter of 2013 that future sales were expected to be lower than anticipated at the time of acquisition and consequently in accordance with US GAAP, it was determined that the goodwill attributable to the RM business unit was impaired. Following the divestment of DERMAGRAFT on January 16, 2014 the Company has reclassified $191.8 million of the impairment charge (being the portion of the RM reporting unit goodwill impairment charge that related to the DERMAGRAFT business) to discontinued operations.

Reorganization costs from continuing operations

For the year to December 31, 2013 Shire recorded reorganization costs of $88.2 million (2012: $nil) comprising costs relating to the One Shire reorganization ($64.6 million), which included involuntary termination benefits and other reorganization costs (of which approximately $42 million was paid in cash during 2013) as Shire transitions to a new operating structure, and the cost of closing Shire’s facility at Turnhout, Belgium ($23.6 million).

Integration and acquisition costs from continuing operations

For the year to December 31, 2013 Shire recorded a net credit of $134.1 million in integration and acquisition costs (2012: $13.5 million charge). This comprised a credit of $159.1 million (2012: $9.2 million charge) relating to the change in fair values of contingent consideration liabilities, in particular relating to the acquisition of SARcode, partially offset by $25.0 million of acquisition and integration costs, primarily for the acquisition of ViroPharma and integration of SARcode and Lotus Tissue Repair. In 2012 integration and acquisition costs was primarily related to the acquisition of FerroKin.

Interest expense from continuing operations

For the year to December 31, 2013 Shire incurred interest expense of $38.1 million (2012: $38.2 million). Interest expense principally related to the coupon and amortization of issue costs on the Bonds which were fully redeemed or converted in the year, and to a lesser extent costs incurred on facilities related to the purchase of ViroPharma.

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Taxation from continuing operations

The effective tax rate was 16% (2012: 20%).

The effective tax rate is lower than 2012 primarily due to the impact of changes in the fair values of contingent consideration liabilities which have no tax impact and impairment charges in 2012 which had no tax benefit and were not repeated in 2013.

Discontinued operations

The loss from discontinued operations for the year to December 31, 2013 was $754.5 million net of tax (2012: $60.3 million), which included impairment charges in respect of the assets held for sale ($636.9 million), goodwill impairment charges ($191.8 million), net losses on the discontinued DERMAGRAFT business ($252.2 million including reorganization costs) and related taxes (credit) of $326.4 million.

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Results of operations for the years to December 31, 2012 and 2011

Financial highlights for the year to December 31, 2012 are as follows:

· Product sales from continuing operations in 2012 were up 11% to $4,253 million (2011: $3,845 million). On a CER basis, which is a Non GAAP measure, product sales were up 12%.

Product sales excluding ADDERALL XR grew strongly and were up 16% particularly driven by growth from VYVANSE (up 28% to $1,030 million), VPRIV(up 20% to $307 million), INTUNIV (up 29% to $288 million) and FIRAZYR (up 252% to $116 million).

ADDERALL XR product sales were down 19% to $429 million primarily due to lower prescription volumes following the approval of a new generic version of ADDERALL XR in the second quarter of 2012. Reported product sales were also impacted by the accounting for the settlement of the Impax Laboratories, Inc. (“Impax”) litigation (see ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K for further details).

· Total revenues increased by 9% (up 11% on a Non GAAP CER basis) as the growth in product sales was partially offset by lower royalties and other revenues (down 12%), primarily ADDERALL XR royalties following the launch of a new generic competitor in the second quarter of 2012. The decline in ADDERALL XR royalties was partially offset by the recognition of one-time royalty income of $38 million following resolution of a disagreement with GSK and ViiV relating to royalty payments for 3TC and ZEFFIX.

· Operating income from continuing operations in 2012 was down 8% to $1,045 million (2011: $1,135 million) primarily resulting from charges to impair intangible assets for RESOLOR in the EU ($198 million). The impairments were due to lower actual and projected performance for the product given the increasingly challenging European reimbursement environment. Operating income in 2012 was also impacted by a charge of $58 million in relation to the agreement in principle with the US Government to resolve a previously disclosed civil investigation. Further information about litigation proceedings can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K. Excluding these charges operating income in 2012 was up by 9%.

· Diluted earnings per ordinary share decreased by 13% to $1.31 (2011: $1.51) primarily due to the lower operating income, partially offset by a lower effective tax rate of 20% (2011: 21%).

1. Average exchange rates for the year to December 31, 2012 were $1.59:£1.00 and $1.29:€1.00 (2011: $1.60:£1.00 and $1.39:€1.00).

Total revenues

The following table provides an analysis of the Company’s total revenues by source:

Year to December 31,	2012		2011		Change
	$'M		$'M		%
Product sales		4,252.9		3,844.9		+11
Royalties		241.6		283.5		-15
Other revenues		32.9		29.7		+11
Total		4,527.4		4,158.1		+9

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Product sales

	Year to		Year to
	December 31,		December 31,		Product sales		Non GAAP CER		US prescription			Exit market
	2012		2011		growth		growth		growth1			share1
	$'M		$'M		%		%		%			%
VYVANSE		1,029.8		805.0		+28		+28		+17			16
ELAPRASE		497.6		464.9		+7		+11		n/a	3		n/a	3
REPLAGAL		497.5		475.2		+5		+10		n/a	2		n/a	2
ADDERALL XR		429.0		532.8		-19		-19		-11			5
LIALDA / MEZAVANT		399.9		372.1		+7		+8		+5			22
VPRIV		306.6		256.2		+20		+23		n/a	2		n/a	2
INTUNIV		287.8		223.0		+29		+29		+34			5
PENTASA		265.8		251.4		+6		+6		-5			14
FOSRENOL		172.0		166.9		+3		+6		-19			4
FIRAZYR		116.3		33.0		+252		+258		n/a	2		n/a	2
XAGRID		97.2		90.6		+7		+14		n/a	2		n/a	2
EQUASYM		29.2		19.9		+47		+53		n/a	2		n/a	2
RESOLOR		11.8		6.1		+93		n/a		n/a	3		n/a	3
Other product sales		112.4		147.8		-24		-23		n/a			n/a
Total product sales		4,252.9		3,844.9		+11

(1) Data provided by IMS. Exit market share represents the average US market share in the month ended December 31, 2012.

(2) IMS NPA Data not available.

(3) Not sold in the US in the year to December 31, 2012.

VYVANSE – ADHD

VYVANSE product sales grew strongly (28%) in 2012 as a result of higher prescription demand, due to growth in US ADHD market (+9%) and VYVANSE’s share of that market, and as a result of a price increase1 taken in 2012. These positive factors, together with lower sales deductions in 2012, more than offset the effect of higher retailer destocking in 2012 compared to 2011 and some shipment slippage at the end of the fourth quarter.

Litigation proceedings regarding VYVANSE are ongoing. Further information about this litigation can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

ELAPRASE – Hunter syndrome

Reported ELAPRASE sales growth (7%) was driven by an increase in the number of patients on therapy. On a Non GAAP CER basis, ELAPRASE sales grew by 11% as reported sales were held back by unfavorable foreign exchange (amounting to approximately $20 million) primarily due to weaker European currencies in 2012 compared to 2011. The increase in ELAPRASE sales between the third quarter and fourth quarter of 2012 was partly driven by the timing of certain large orders from markets which order less frequently.

REPLAGAL – Fabry disease

Reported REPLAGAL sales growth (5%) was driven by an increase in the number of patients on therapy. On a Non GAAP CER basis, REPLAGAL sales grew by 10%, as reported sales were impacted by unfavorable foreign exchange (amounting to approximately $26 million), primarily due to weaker European currencies in 2012 compared to 2011. The reduction in REPLAGAL sales between the third and fourth quarter of 2012 was partly driven by the timing of certain large orders from markets which order less frequently.

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ADDERALL XR – ADHD

ADDERALL XR product sales decreased (-19%) in 2012 as a result of lower US prescription demand following the introduction of a new generic competitor and the impact of the accounting for the legal settlement with Impax, which reduced reported product sales by $42 million in 2012, in addition to the effect of product destocking in 2012 compared to stocking in 2011 and, higher sales deductions. These negative factors were partially offset by the benefit of a price increase taken during 2012.

On February 7, 2013 Shire and Impax settled all litigation relating to Shire’s contract to supply Impax with authorized generic ADDERALL XR. Under the terms of the settlement Shire will make a one-time cash payment to Impax of $48 million, which has been recorded as a liability at December 31, 2012.  In accordance with US GAAP, as this represents a payment to a customer, the amount has been recorded in the Income Statement as a reduction in reported ADDERALL XR product sales and royalties ($42 million and $6 million respectively) in 2012.

Litigation proceedings regarding ADDERALL XR are ongoing. Further information about this litigation and the Impax settlement, can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

LIALDA/MEZAVANT – Ulcerative Colitis

The growth in product sales for LIALDA/MEZAVANT (7%) in 2012 was primarily driven by higher market share in the US and a price increase1 taken since the fourth quarter of 2011, the effects of which were partially offset by product destocking in 2012 compared to a small amount of product stocking in 2011 and higher sales deductions in 2012. Growth in US net product sales was partially offset by the impact of lower priced imports into certain European markets.

Litigation proceedings regarding LIALDA are ongoing. Further information about this litigation can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

VPRIV – Gaucher disease

Reported VPRIV sales growth (20%) was driven by an increase in the number of patients on therapy. On a Non GAAP CER basis, VPRIV sales increased by 23% as reported sales were also held back by unfavorable foreign exchange (amounting to approximately $8 million).

INTUNIV – ADHD

INTUNIV product sales were up 29% compared to 2011, primarily driven by strong growth in US prescription demand (up 34% compared to 2011), together with price increases1 taken during 2012. These positive factors were partially offset by lower stocking in 2012 and higher sales deductions in 2012 compared to 2011.

Further information about litigation proceedings regarding INTUNIV can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

PENTASA – Ulcerative Colitis

PENTASA product sales were up 6% as the benefit of price increases1 was partially offset by lower prescription demand, a small amount of destocking in 2012 and higher sales deductions as compared to 2011.

FOSRENOL – Hyperphosphatemia

Product sales of FOSRENOL in the US increased (3%) due to the effect of price increases1 in 2012 and lower sales deductions compared to 2011, which more than offset the decline in prescription demand. Product sales of FOSRENOL outside the US decreased marginally primarily because of the impact of unfavorable foreign exchange.

Further information about litigation proceedings regarding FOSRENOL can be found in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

FIRAZYR – HAE

Reported FIRAZYR sales growth (252%) was driven largely by the first full year of sales in the US market, following launch of FIRAZYR in the market in fourth quarter of 2011.

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1 The actual net effect of price increases on current period net sales compared to the comparative period is difficult to quantify due to the various managed care rebates, Medicaid discounts, other discount programs in which the Company participates and fee for service agreements with wholesalers customers.

Royalties

Year to December 31,	2012		2011		Change
	$'M		$'M		%
3TC and ZEFFIX		91.6		82.7		+11
ADDERALL XR		70.3		107.1		-34
FOSRENOL		53.3		46.5		+15
Others		26.4		47.2		-44
Total		241.6		283.5		-15

Royalties from 3TC and ZEFFIX include one-time royalty income of $38 million in respect of prior periods due to resolution of the disagreement between Shire, GSK and ViiV as to how the royalty rate for these products should be applied. This one-time income more than offset the underlying decline in 3TC and ZEFFIX royalties as a result of increased competition and the expiry of patents in certain territories in 2012.

Royalties from ADDERALL XR in 2012 were significantly impacted by the lower royalty rate payable on sales of authorized generic ADDERALL XR by Impax, following the launch of a new generic version of ADDERALL XR in late second quarter of 2012.

FOSRENOL royalties increased primarily due to higher royalties received on sales in Japan.

Other royalties decreased primarily due to increased generic competition.

Cost of product sales from continuing operations

Cost of product sales increased to $585.8 million for the year to December 31, 2012 (14% of product sales), up from $551.7 million in the corresponding period in 2011 (14% of product sales). The costs of product sales as a percentage of product sales remained broadly constant in 2013 as compared to 2012.

For the year to December 31, 2012 cost of product sales included depreciation of $29.0 million (2011: $32.5 million).

R&D from continuing operations

R&D expenditure increased to $953.0 million for the year to December 31, 2012 (22% of product sales), compared to $764.5 million in the corresponding period in 2011 (20% of product sales). In the year to December 31, 2012 R&D included up-front payment of $13.0 million to Sangamo, $10.0 million to acquire the US rights for prucalopride (marketed in certain countries in Europe as RESOLOR) and IPR&D impairment charges in respect of RESOLOR of $71.2 million (2011: $16.0 million). Excluding these costs R&D increased by $110.3 million or 14% in the year to December 31, 2012 due to the Company’s continued investment in a number of targeted R&D programs, particularly new uses of LDX and recently acquired assets including SHP602 for iron overload (acquired with FerroKin).

R&D in the year to December 31, 2012 included depreciation of $22.5 million (2011: $25.2 million).

SG&A from continuing operations

SG&A expenditure increased to $1,948.0 million (46% of product sales) for the year to December 31, 2012 from $1,675.7 million (44% of product sales) in the corresponding period in 2011, primarily due to higher intangible asset amortization, the impact of impairment charges and higher legal and litigation costs, which included a charge of $57.5 million in relation to the agreement in principle with the US Government to resolve a previously disclosed civil investigation and settling the litigation related to the termination of a co-promotion agreement for VYVANSE.

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Impairment charges of $126.7 million were related to RESOLOR intangible assets as the actual and projected performance for RESOLOR was adversely affected by the challenging European reimbursement environment. Shire evaluated alternative sales and marketing strategies for RESOLOR in response to these challenges but has judged that projected profitability levels will continue to be below the level forecast at the time of the acquisition of Movetis.

For the year to December 31, 2012 SG&A included depreciation of $57.5 million (2011: $61.8 million) and amortization of $153.6 million (2011: $145.0 million).

(Gain)/loss on sale of product rights from continuing operations

For the year to December 31, 2012 Shire recorded a gain on sale of product rights of $18.1 million (2011: loss of $6.0 million) following re-measurement of the contingent consideration receivable from the divestment of DAYTRANA.

Integration and acquisition costs from continuing operations

For the year to December 31, 2012 Shire recorded integration and acquisition costs of $13.5 million (2011: $0.1 million), primarily associated with the acquisition of FerroKin.

Interest expense from continuing operations

For the year to December 31, 2012 Shire incurred interest expense of $38.2 million (2011: $39.1 million). Interest expense principally relates to the coupon and amortization of issue costs on Shire’s Bonds.

Taxation

The effective rate of tax in 2012 was 20% (2011: 21%). The effective tax rate in 2012 is lower than 2011 due to favorable changes in profit mix in 2012 and the benefit of the recognition of foreign tax credits.

Discontinued operations

The loss from discontinued operations for the year to December 31, 2012 was $60.3 million net of tax (2011: $17.7 million), representing losses from the discontinued DERMAGRAFT business, and related tax adjustments.

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Financial condition at December 31, 2013 and 2012

Cash & cash equivalents

Cash and cash equivalents increased by $757.2 million to $2,239.4 million (December 31, 2012: $1,482.2 million). Cash generated by operating activities of $1,463.0 million was offset by the cost of acquiring SARcode, Premacure and Lotus Tissue Repair, the purchase of shares (both by the employee benefit trust (“EBT”) and under the share buy-back program), other capital expenditure and dividend payments.

Accounts receivable, net

Accounts receivable, net increased by $137.0 million to $961.2 million (December 31, 2012: $824.2 million), primarily due to the increase in revenue in the year to December 31, 2013. Days sales outstanding decreased to 46 days (December 31, 2012: 50 days).

Other intangible assets, net

Other intangible assets increased by $75.5 million to $2,312.6 million (December 31, 2012: $2,388.1 million), due to the IPR&D assets acquired with SARcode, Premacure and Lotus Tissue Repair, offset by the divestment of DERMAGRAFT intangible assets, intangible asset amortization, IPR&D impairment and foreign exchange movements.

Convertible Bonds

As of December 31, 2013, Bondholders had voluntarily converted $1,099,050,000 aggregate principal amount of the Bonds into 33,806,464 fully paid ordinary shares. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013.

Non-current deferred tax liabilities

Non-current deferred tax liabilities increased by $39.8 million to $560.6 million (December 31, 2012: $520.8 million), primarily due to deferred tax liabilities arising on the IPR&D assets acquired with SARcode and Lotus Tissue Repair offset by a reduction in deferred tax liabilities arising from the impairment of DERMAGRAFT intangible assets.

Other non-current liabilities

Other non-current liabilities increased by $346.9 million to $588.5 million (December 31, 2012: $241.6 million) primarily due to the recognition of non-current contingent consideration payable related to the SARcode, Premacure and Lotus Tissue Repair business combinations.

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Liquidity and capital resources

General

The Company’s funding requirements depend on a number of factors, including the timing and extent of its development programs; corporate, business and product acquisitions; the level of resources required for the expansion of certain manufacturing and marketing capabilities as the product base expands; increases in accounts receivable and inventory which may arise with any increase in product sales; competitive and technological developments; the timing and cost of obtaining required regulatory approvals for new products; the timing and quantum of milestone payments on collaborative projects; the timing and quantum of tax and dividend payments; the timing and quantum of purchases by the EBT of Shire shares in the market to satisfy awards granted under Shire’s employee share plans; and the amount of cash generated from sales of Shire’s products and royalty receipts.

An important part of Shire’s business strategy is to protect its products and technologies through the use of patents, proprietary technologies and trademarks, to the extent available. The Company intends to defend its intellectual property and as a result may need cash for funding the cost of litigation.

The Company finances its activities through cash generated from operating activities; credit facilities; private and public offerings of equity and debt securities; and the proceeds of asset or investment disposals.

Shire’s balance sheet includes $2,239.4 million of cash and cash equivalents at December 31, 2013. Shire has a revolving credit facility of $1,200 million which matures in 2015, of which $700 million was utilized on January 24, 2014 to partially fund the ViroPharma acquisition (See section “Term Loan”, “Facilities Agreement” for further details). In addition, in connection with its acquisition of ViroPharma, Shire entered into a $2.60 billion Facilities Agreement which was subsequently reduced to $1.40 billion, and comprises of two credit facilities: (i) a $0.55 billion term loan facility, of which $0.35 billion was utilized on January 24, 2014 and (ii) a $0.85 billion term loan facility, fully utilized on January 24, 2014 (See section “Term Loan Agreement” for further details). Further on January 24, 2014 ViroPharma commenced a tender offer to repurchase, at the option of each holder, any and all of ViroPharma’s outstanding 2.00% Convertible Senior Notes Due 2017 (the “Convertible Notes”) and notified the holders of their separate right to convert the Convertible Notes. The repurchase and payment for conversion of the Convertible Notes forms part of the cash consideration payable to ViroPharma.

Shire 2.75% Convertible Bonds due 2014

On May 9, 2007 Shire issued $1,100 million in principal amount of Bonds. As of December 31, 2013 all of the Bonds had been converted or redeemed as described below.

On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed to the holders of the Bonds. The aggregate outstanding principal amount of Bonds on November 25, 2013, the last practicable date prior to the date of the optional redemption notice, was $1,075,070,000. The last day on which bondholders were able to exercise their conversion rights was December 13, 2013. Those Bonds which were not voluntarily converted were redeemed by the Company on December 27, 2013 at par together with interest accrued to that date. As of December 31, 2013, Bonds in an aggregate principal amount of the $1,099,050,000 had been voluntarily converted into 33,806,464 fully paid ordinary shares at a conversion price of US$32.51 per ordinary share, in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. Following the redemption of all the outstanding Bonds, the Company cancelled the listing of the Bonds on the Official List maintained by the UK Listing Authority and the admission to trading of the Bonds on the Professional Securities Market of the London Stock Exchange.

Revolving Credit Facilities Agreement

On November 23, 2010 the Company entered into a committed multicurrency revolving and swingline facilities agreement with a number of financial institutions, for which Abbey National Treasury Services Plc (trading as Santander Global Banking and Markets), Bank of America Securities Limited, Barclays Capital, Citigroup Global Markets Limited, Lloyds TSB Bank plc and The Royal Bank of Scotland plc acted as mandated lead arrangers and bookrunners (the “RCF”). The RCF is for an aggregate amount of $1,200 million and cancelled the Company’s then existing committed revolving credit facility. The RCF, which includes a $250 million swingline facility, may be used for general corporate purposes and matures on November 23, 2015.

The interest rate on each loan drawn under the RCF for each interest period is the percentage rate per annum which is the aggregate of the applicable margin (ranging from 0.90 to 2.25 per cent per annum) and LIBOR for the applicable currency and interest period. Shire also pays a commitment fee on undrawn amounts at 35 per cent per annum of the applicable margin.

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Under the RCF it is required that (i) Shire’s ratio of Net Debt to EBITDA (as defined within the RCF agreement) does not exceed 3.5 to 1 for either the 12 month period ending December 31 or June 30 unless Shire has exercised its option (which is subject to certain conditions) to increase it to 4.0 to 1 for two consecutive testing dates; (ii) the ratio of EBITDA to Net Interest (as defined in the RCF agreement) must not be less than 4.0 to 1, for either the 12 month period ending December 31 or June 30, and (iii) additional limitations on the creation of liens, disposal of assets, incurrence of indebtedness, making of loans, giving of guarantees and granting security over assets. These financial and operating covenants have not had, and are not expected to have, an effect on the Company’s financial position and liquidity.

On entering into the RCF in November 2010 the Company paid arrangement costs of $8.0 million, which have been recorded as deferred charges, with amortization of these costs to the Company’s income statement over the contractual term of the RCF.

The availability of loans under the new RCF is subject to customary conditions. The full terms are set out in Exhibit 10.28 to this Annual Report on Form 10-K.

Term Loan Agreement

On November 11, 2013, Shire entered into a $2.60 billion Facilities Agreement with, among others, Morgan Stanley Bank International Limited (acting as lead arranger and agent) (the “Facilities Agreement”).  The Facilities Agreement comprises two credit facilities: (i) a $1.75 billion term loan facility and (ii) a $0.85 billion term loan facility.  

On December 13, 2013 and on February 21, 2014, the Company cancelled part of the $2.60 billion term loan facility. The revised Facilities Agreement of $1.40 billion now comprises two credit facilities: (i) a $0.55 billion term loan facility and (ii) a $0.85 billion term loan facility. All other terms and conditions remain unchanged.

The $0.55 billion term loan facility, which matures on November 10, 2014, may be used only to finance the purchase price payable in respect of Shire’s proposed acquisition of ViroPharma (including certain related costs) and for the redemption of Shire’s Bonds.  Shire has the option to extend the maturity of the $0.55 billion term loan facility once by a further 364 days.

The $0.85 billion term loan facility, which matures on November 11, 2015, may be used only to finance the purchase price payable in respect of Shire’s proposed acquisition of ViroPharma (including certain related costs).

Interest on any loans made under the facilities will be payable on the last day of each interest period, which may be one week or one, two, three or six months at the election of Shire, or as otherwise agreed with the lenders.  The interest rate applicable to the $0.55 billion term loan facility is LIBOR plus 0.75% per annum and increases by 0.25% per annum on August 11, 2014 and on three-month intervals thereafter.

The interest rate applicable to the $0.85 billion term loan facility commenced at LIBOR plus 1.15% per annum until delivery of the compliance certificate for the year ending December 31, 2013 and thereafter is subject to change depending upon the prevailing ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement), in respect of the most recently completed financial year or financial half year.

Shire shall also pay a commitment fee on the available but unutilized commitments under the $0.55 billion term loan facility and the $0.85 billion term loan facility for the availability period applicable to each facility. With effect from first utilization, the commitment fee rate will be 35% of the applicable margin. Before first utilization, the commitment fee rate will increase in stages from 0% to 35% of the applicable margin over a period of 3 months.

The Facilities Agreement includes customary representations and warranties, covenants and events of default, including requirements that the ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement) must not, at any time, exceed 3.5:1 for the Relevant Period (as defined in the Facilities Agreement), except that following certain acquisitions, including the ViroPharma acquisition, Shire may elect to increase the ratio to 4.0:1 in the relevant period in which the acquisition was completed and the immediately following relevant period.  In addition, for each 12-month period ending December 31 or June 30, the ratio of EBITDA of the Group to Net Interest (each as defined in the Facilities Agreement) must not be less than 4.0:1.

The Facilities Agreement restricts (subject to certain covenants) Shire’s ability to incur additional financial indebtedness, grant security over its assets or provide or guarantee loans.  Further, any lender may require mandatory prepayment of its participation if there is a change of control of Shire. In addition, in certain circumstances, the net proceeds of certain shares, undertakings or business disposals by Shire must be applied towards the mandatory prepayment of the facilities, subject to certain exceptions.

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Events of default under the facilities include: (i) non-payment of any amounts due under the facilities, (ii) failure to satisfy any financial covenants, (iii) material misrepresentation in any of the finance documents, (iv) failure to pay, or certain other defaults, under other financial indebtedness, (v) certain insolvency events or proceedings, (vi) material adverse changes in the business, operations, assets or financial condition of Shire and its subsidiaries, (vii) if it becomes unlawful for Shire or any of its subsidiaries that are parties to the Facilities Agreement to perform their obligations or (viii) if Shire or any subsidiary of Shire which is a party to the Facilities Agreement repudiates the Facilities Agreement or any other finance document, among others. The Facilities Agreement is governed by English law.

Financing

Shire anticipates that its operating cash flow together with available cash, cash equivalents, the RCF will be sufficient to meet its anticipated future operating expenses, capital expenditures, tax and interest payments, lease obligations and milestone payments as they become due over the next twelve months.

Shire’s existing cash, the Facilities Agreement and the RCF are sufficient to finance the acquisition of ViroPharma.

If the Company decides to acquire other businesses in addition to ViroPharma, it expects to fund these acquisitions from cash resources, the RCF and possibly through new borrowings or the issuance of new equity if necessary.

Share buy-back program

Shire has a strong balance sheet and continued robust cash generation, and considers efficient use of capital on behalf of shareholders an important objective. Therefore, during the year to December 31, 2012 the Company commenced a share buy-back program, for the purpose of returning funds to shareholders, of up to $500 million through both direct purchases of ordinary shares and through the purchase of ordinary shares underlying ADRs.

During the year ended December 31, 2013 the Company made on-market repurchases totaling 6,191,965Ordinary Shares at a cost of $193 million (excluding transaction costs). The program covers purchases of Ordinary Shares for cancellation or to be held as treasury shares, in accordance with the authority renewed by shareholders at the Company’s AGM on April 30, 2013 when the Company was authorized to make market purchases of up to 55,741,587 of its own Ordinary Shares.

On November 11, 2013, contemporaneous with Shire’s announcement of its acquisition of ViroPharma, the Company’s share buyback program was terminated. Since the inception of the share buyback program the Company had purchased $300 million of ordinary shares and ordinary shares underlying ADRs.

Sources and uses of cash

The following table provides an analysis of the Company’s gross and net cash (excluding restricted cash), as at December 31, 2013 and 2012:

	2013			2012
December 31,		$’M			$’M
Cash and cash equivalents1		2,239.4			1,482.2
Shire 2.75% Convertible bonds		-			(1,100.0	)
Other debt		(8.9	)		(9.3	)
Total debt		(8.9	)		(1,109.3	)
Net cash		2,230.5			372.9

(1) Substantially all of the Company’s cash and cash equivalents are held by foreign subsidiaries (i.e, those subsidiaries incorporated outside of Jersey, Channel Islands, the jurisdiction of incorporation of Shire plc, Shire’s holding company). The amount of cash and cash equivalents held by foreign subsidiaries has not had, and is not expected to have, a material impact on the Company’s liquidity and capital resources.

(2) Net cash is a Non GAAP measure.  The Company believes that Net cash is a useful measure as it indicates the level of borrowings after taking account the cash and cash equivalents that could be utilized to pay down the outstanding borrowings.

Cash flow activity

Net cash provided by operating activities for the year to December 31, 2013 increased by $80.1 million or 6% to $1,463.0 million (2012: $1,382.9 million) as higher cash receipts from gross product sales were more than offset by

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payments made in relation to the One Shire reorganization (approximately $42 million), costs incurred on the closure of Shire’s facility at Turnhout in Belgium (approximately $24 million) and the payment to settle the litigation with Impax ($48 million) (see note 18 for details).

Net cash provided by operating activities for the year to December 31, 2012 increased by $309.3 million or 29% to $1,382.9 million (2011: $1,073.6 million) as higher cash receipts from gross product sales and improved cash collections for aged European receivables more than offset higher operating expenses and sales deduction payments in the year.

Net cash used in investing activities was $360.9 million in the year to December 31, 2013, principally relating to the cash paid (net of cash acquired) for the acquisitions of SARcode, Premacure and Lotus Tissue Repair and for purchases of PP&E.

Net cash used in investing activities was $271.0 million in the year to December 31, 2012, principally relating to the expenditure on property, plant and equipment of $149.6 million and the cash paid (net of cash acquired) of $97.0 million for the acquisition of FerroKin ($94.5 million) and Pervasis ($2.5 million). Capital expenditure on property, plant and equipment primarily includes expenditure of $65.0 million on computer software and hardware due to SAP upgrade and construction and leasehold improvements at different Company sites of $45.2 million.

Net cash used in financing activities was $344.6 million for the year to December 31, 2013, principally due to the purchase of shares under the share buy-back program, purchase of shares by the EBT and the dividend payment.

Net cash used in financing activities was $244.3 million for the year to December 31, 2012, principally due to the purchase of shares by the EBT, the purchase of shares under the share buy-back program and dividend payments, offset by the tax benefit associated with the exercise of stock options.

Outstanding Letters of credit

At December 31, 2013, the Company had irrevocable standby letters of credit and guarantees with various banks totaling $51.0 million, providing security for the Company’s performance of various obligations. These obligations are primarily in respect of the recoverability of insurance claims, lease obligations and supply commitments.

Cash Requirements

At December 31, 2013 the Company’s cash requirements for long term liabilities reflected on the Balance Sheet and other contractual obligations were as follows:

	Payments due by period
			Less than						More than
	Total		1 year		1 – 3 years		3 – 5 years		5 years
		$’M		$’M		$’M		$’M		$’M
Operating leases obligation (i)		215.9		44.9		57.5		30.1		83.4
Purchase obligations (ii)		609.8		500.1		96.2		11.9		1.6
Other long term liabilities reflected on the Balance Sheet (iii)		578.5		-		375.3		72.6		130.6
Total		1,404.2		545.0		529.0		114.6		215.6

(i)   The Company leases certain land, facilities, motor vehicles and certain equipment under operating leases expiring through 2021.

(ii)   Purchase obligations include agreements to purchase goods, investments or services (including clinical trials, contract manufacturing and capital equipment), including open purchase orders, that are enforceable and legally binding and that specify all significant terms. Shire expects to fund these commitments with cash flows from operating activities.

(iii)   Unrecognized tax benefits and associated interest and penalties of $115.7 million are included within payments due in one to three years.

The contractual obligations table above does not include certain milestones and other contractual commitments where payment is contingent upon the occurrence of events which are yet to occur (and therefore payment is not yet due). At

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December 31, 2013 the most significant of the Company’s milestone and contractual commitments which are contingent on the occurrence of future events are as follows:

(i)           Research Collaboration with Santaris Pharma A/S (“Santaris”) on Locked Nucleic Acid (“LNA”) Drug Platform

On August 24, 2009 Shire announced that it had entered into a research collaboration with Santaris, to develop its proprietary LNA technology in a range of rare diseases. LNA technology has the benefit of shortened target validation and proof of concept, potentially increasing the speed and lowering the cost of development. As part of the joint research project Santaris will design, develop and deliver pre-clinical LNA oligonucleotides for Shire-selected orphan disease targets, and Shire will have the exclusive right to further develop and commercialize these candidate compounds on a worldwide basis.

In the year to December 31, 2013 Shire paid success milestones and other support costs of $1.5 million (2012: $3.0 million; 2011: $2.5 million) and $4.5 million (2012: $8.1 million; 2011: $5.3 million) to Santaris respectively, which were expensed to R&D. Shire has remaining obligations to pay Santaris development and sales milestones up to a maximum of $71.0 million for current indication. Shire will also pay single or double digit tiered royalties on net sales of the product.

Shire and Santaris have formed a joint research committee to monitor R&D activities through preclinical lead candidate selection at which point all development and commercialization costs will be the responsibility of Shire.

(ii)           Collaboration and license agreement with Sangamo to develop therapeutics for hemophilia

On February 1, 2012 Shire and Sangamo announced that they had entered into a collaboration and license agreement to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo’s ZFP technology. Sangamo is responsible for all activities through submission of Investigational New Drug Applications and European Clinical Trial Applications for each product and Shire will reimburse Sangamo for its internal and external research program-related costs. Shire is responsible for clinical development and commercialization of products arising from the collaboration. 

In the year to December 31, 2012 Shire made an upfront payment to Sangamo of $13.0 million, for technology access and R&D funding, which was expensed to R&D.

In the year to December 31, 2013 Shire’s share of R&D costs under this collaboration agreement was $15.2 million (2012: $8.9 million; 2011: $nil) which were expensed to R&D. Shire may be required to pay research, regulatory, development and commercial milestone payments up to a maximum of $213.5 million and to pay royalties on net sales of the product.

(iii)           Acquisition of FerroKin

On April 2, 2012 Shire completed the acquisition of 100% of the outstanding share capital of FerroKin. The acquisition-date fair value of consideration totaled $159.3 million, comprising cash consideration paid on closing of $94.5 million and the fair value of contingent consideration payable of $64.8 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $225.0 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon the achievement of certain clinical development, regulatory and net sales milestones. For further details refer to Part IV ITEM 15: Exhibits and Financial StatementSchedules, Note 3 of this Annual Report on Form 10-K.

(iv)           Acquisition of certain assets & liabilities of Pervasis

On April 19, 2012 Shire acquired substantially all the assets and certain liabilities of Pervasis. The acquisition date fair value of the consideration totaled $26.1 million, comprising cash consideration paid on closing of $2.5 million and the fair value of contingent consideration payable of $23.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $169.5 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon achievement of certain clinical development, regulatory and net sales milestones. For further details refer to Part IV ITEM 15: Exhibits and Financial StatementSchedules, Note 3 of this Annual Report on Form 10-K.

(v)           Acquisition of Lotus Tissue Repair

On February 12, 2013 Shire completed the acquisition of 100% of the outstanding share capital of Lotus Tissue Repair. The acquisition date fair value of consideration totaled $174.2 million, comprising cash consideration paid on closing of $49.4 million, and the fair value of contingent consideration payable of $124.8 million.  The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $275 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon achievement of certain pre-clinical and clinical

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development milestones. For further details refer to Part IV ITEM 15: Exhibits and Financial Statement Schedules, Note 3 of this Annual Report on Form 10-K.

(vi)           Acquisition of Premacure

On March 8, 2013 Shire completed the acquisition of 100% of the outstanding share capital of Premacure. The acquisition date fair value of the consideration totaled $140.2 million, comprising cash consideration paid on closing of $30.6 million, and the fair value of contingent consideration payable of $109.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods, dependent upon the successful completion of certain development and commercial milestones, is $169 million. Shire will also pay royalties on relevant net sales. For further details refer to Part IV ITEM 15: Exhibits and Financial Statement Schedules, Note 3 of this Annual Report on Form 10-K.

(vii)           Acquisition of SARcode

On April 17, 2013 Shire completed the acquisition of 100% of the outstanding share capital of SARcode. The acquisition date fair value of the consideration totaled $368 million, comprising cash consideration paid on closing of $151 million and the fair value of contingent consideration payable of $217 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $225 million dependent upon achievement of certain clinical, regulatory and net sales milestones. For further details refer to Part IV ITEM 15: Exhibits and Financial Statement Schedules, Note 3 of this Annual Report on Form 10-K.

(vii)           Acquisition of ViroPharma

On November 11, 2013, Shire signed a definitive agreement to acquire all of the outstanding share capital of ViroPharma for $50 per share in cash or approximately $4.2 billion. The transaction was completed on January 24, 2014 at which time ViroPharma became a wholly-owned subsidiary. Shire’s consolidated financial statements will reflect the fair values of assets acquired and the liabilities assumed at, and the results of ViroPharma will be included in Shire’s consolidated statement of income from, January 24, 2014. Further on January 24, 2014 ViroPharma commenced a tender offer to repurchase, at the option of each holder, any and all of ViroPharma’s Convertible Notes and notified the holders of their separate right to convert the Convertible Notes. The repurchase and payment for conversion of the Convertible Notes forms part of the cash consideration payable to ViroPharma. For further details refer to Part IV ITEM 15: Exhibits and Financial Statement Schedules, Note 3 of this Annual Report on Form 10-K.

Off-balance sheet arrangements

There are no off-balance sheet arrangements, aside from the collaborations containing contractual commitments and milestones which are contingent on future events as outlined above, that have, or are reasonably likely to have, a current or future material effect on the Company’s financial condition, revenues or expenses, results of operations, liquidity, capital expenditures or capital resources.

Foreign currency fluctuations

A number of the Company’s subsidiaries have a functional currency other than the US Dollar. As such, the consolidated financial results are subject to fluctuations in exchange rates, particularly in the Euro, Swiss Franc and Pound Sterling against the US Dollar.

The accumulated foreign currency translation differences at December 31, 2013 of $25.3 million are reported within accumulated other comprehensive income in the consolidated balance sheet and foreign exchange losses for the year to December 31, 2013 of $8.7 million are reported in the consolidated statements of income.

At December 31, 2013, the Company had outstanding swap and forward foreign exchange contracts to manage the currency risk associated with intercompany transactions. For further information, see ITEM 7A: Quantitative and qualitative disclosures about market risk in this Annual Report on Form 10-K. At December 31, 2013 the fair value of these contracts was a net asset of $1.2 million.

Concentration of credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor’s and by Moody’s credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against

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these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company’s revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2013 there were three customers in the US that accounted for 52% of the Company’s product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these wholesalers to honor their debts to the Company could have an adverse effect on Company’s financial condition and results of operations.

A substantial portion of the Company’s accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company’s recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments.  In recent years the creditworthiness and general economic condition of a number of Eurozone countries (including Greece, Italy, Portugal and Spain (the “Relevant Countries”)) has deteriorated. As a result, in some of these countries the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers. The Company continued to receive remittances in relation to government-owned or government-supported healthcare providers in all the Relevant Countries in the year to December 31, 2013, including receipts of $116.8 million and $144.7 million in respect of Spanish and Italian receivables, respectively.

To date the Company has not incurred significant losses on accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable. The Company will continue to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company’s financial condition and results of operations. For further information, see PART II: ITEM 7A of the Company’s Annual Report on Form 10-K for the year ended December 31, 2013.

Inflation

Although at reduced levels in recent years, inflation continues to apply upward pressure on the cost of goods and services which are used in the business. However, the Company believes that the net effect of inflation on its revenues and operations has been minimal during the past three years.

Critical accounting estimates

The preparation of consolidated financial statements, in conformity with accounting principles generally accepted in the United States (“US GAAP”) and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestments,contingent consideration payable in respect of business combinations and asset purchases and noncurrent assets or disposal groups classified as held for sale. If actual results differ from the Company’s estimates, or to the extent these estimates are adjusted in future periods, the Company’s results of operations could either benefit from, or be adversely affected by, any such change in estimate.

(i)   Valuation of intangible assets

In accordance with US GAAP the Company classifies intangible assets into three categories: (1) finite lived intangible assets, which are amortized over their estimated useful lives; (2) intangible assets with indefinite lives, which are not subject to amortization; and (3) goodwill.

At December 31, 2013 the carrying value of the Company’s finite lived intangible assets was $1,361.0 million (2012: $2,157 million; 2011: $2,373 million), the carrying value of the Company’s indefinite lived intangible assets was $952 million (2012: $231 million; 2011: $120 million), and the carrying value of the Company’s goodwill was $625 million (2012: $645 million; 2011: $593 million). The Company’s indefinite lived intangible assets relate solely to IPR&D assets acquired through business combinations.

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a)   Initial valuation of intangible assets acquired through business combinations

The Company accounts for business combinations using the acquisition method of accounting, which requires that the assets acquired and liabilities assumed be recorded at the date of acquisition at their respective fair values. Any excess of the fair value of consideration given and the fair value of any noncontrolling interest over the fair values of the identifiable assets and liabilities acquired is recorded as goodwill. The determination of estimated fair values of acquired intangible assets, as well as the useful economic life ascribed to finite lived intangible assets, requires the use of significant judgement. The use of different estimates and assumptions to those used by the Company could result in a materially different valuation of acquired intangible assets, which could have a material effect on the Company’s results of operations.

Initial valuation of finite lived intangible assets

At December 31, 2013 the carrying value of the Company’s finite lived intangible assets was $1,361 million  primarily representing the following products: VYVANSE ($737 million), REPLAGAL ($220 million), FIRAZYR ($200 million) and RESOLOR ($121 million).

The fair values of all finite lived identifiable intangible assets, for commercialized products and developed product technologies, acquired through business combinations have been determined using an income approach on a project-by-project basis using the multi-period excess earnings method. The multi-period excess earnings method starts with a forecast of all expected future net cash flows which a market participant could have either generated or saved as a result of ownership of the intellectual property, customer relationships, product technologies and other intangible assets. These cash flows are then adjusted to present value by applying a market participant discount rate that reflects the risk factors that a market participant would associate with the cash flows (to the extent the underlying cash flows have not similarly been risk adjusted). Forecasting these future cash flows requires various assumptions to be made. These valuations are based on information at the time of the acquisition of the identifiable intangible assets, and the expectations and assumptions that (i) have been deemed reasonable by the Company’s management and (ii) are based on information, expectations and assumptions that would be available to and made by a market participant. No assurance can be given, however, that the underlying assumptions or events associated with such valuations will occur as projected. For these reasons, among others, actual cash flows may differ from these forecasts and, dependent on the outcome of future events or circumstances, impairment losses (as outlined below) may result. The use of different estimates and assumptions to those used by the Company could result in a materially different valuation of finite lived intangible assets. However, as the valuation process for intangible assets involves a number of inter-related assumptions, the Company does not consider it meaningful to quantify the sensitivity of the valuation of intangible assets to changes in any individual assumption.

Initial valuation of indefinite lived intangible assets (IPR&D)

IPR&D represents the fair value assigned to incomplete technologies and development projects that the Company has acquired through business combinations which completed after January 1, 2009 which, at the time the business combination closed,  had not reached technological feasibility or which had no alternative future use. At December 31, 2013 the carrying value of the Company’s indefinite lived intangible assets (IPR&D) was $952 million, primarily representing the following pipeline programs or products: Lifitegrast (SHP606) for the treatment of Dry Eye disease ($412 million); rC7, for the treatment of Dystrophic Epidermolysis Bullosa ($177 million); SHP602, an iron chelating agent for the treatment of iron overload secondary to chronic transfusion ($166 million); and SHP607 (PREMIPLEX) for the treatment of Retinopathy of Prematurity ($151 million).

The fair value of IPR&D assets is determined using the income approach on a project-by-project basis using the multi-period excess earnings method. The fair value of the acquired IPR&D assets has been based on the present value of probability adjusted incremental cash flows which a market participant would expect the IPR&D projects to generate after the deduction of contributory asset charges for other assets employed in these projects. This method incorporates an evaluation of the probability of success of each development project, and the application of an appropriate market participant discount rate commensurate with the project's stage of completion, the nature of the product, the scientific data associated with the technology, the current patent situation and market competition.

The cash flows that will ultimately be generated by IPR&D projects are subject to major risks and uncertainties including whether the IPR&D projects will be completed in a timely manner, if at all, whether the necessary regulatory approvals will be obtained and how commercially successful the project will be subsequent to commercial launch. The Company is required to use estimates and assumptions in relation to these risks and uncertainties when valuing IPR&D projects. The use of different estimates and assumptions to those used by the Company could result in a materially different valuation of the related IPR&D. However, as the valuation process for IPR&D involves a number of inter-relating assumptions, the Company does not consider it meaningful to quantify the sensitivity of the valuation of IPR&D to changes in any individual assumption.

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The initial valuation of indefinite lived IPR&D is based on information that existed at the time of the acquisition of the relevant development project, and utilizes expectations and assumptions that (i) have been deemed reasonable by the Company’s management, and (ii) are based on information, expectations and assumptions that would be available to and made by a market participant. However, no assurance can be given that the underlying assumptions or estimates associated with the valuation of IPR&D will occur as projected. If IPR&D projects fail during development, are abandoned, or do not receive the relevant regulatory approvals, the Company may not realize the future cash flows that it has estimated nor recover the value of the R&D investment made subsequent to acquisition of the project. If such circumstances occur, the Company’s future operating results could be materially adversely impacted.

b)   Subsequent measurement of intangible assets

Finite lived intangible assets – estimation of amortization charges and impairment losses

Management’s estimate of the useful life of its finite lived intangible assets considers, amongst other things, the following factors:

(i)   the expected use of the finite lived intangible asset by the Company;

(ii)   any legal, regulatory, or contractual provisions that may limit or extend the useful life;

(iii)   the effects of demand and competition, including the launch of generic products; and

(iv)   other general economic and/or industry specific factors (such as the stability of the industry, known technological advances, legislative action that results in an uncertain or changing regulatory environment, and expected changes in distribution channels).

The Company reviews the useful life of its intangible assets subject to amortization at each reporting period, and revises its estimate of the useful life if warranted by events or circumstances. Any future changes to the useful life of the Company’s finite lived intangible assets could result in higher or lower amortization charges in future periods, which could materially affect the Company’s results from operations.

The Company reviews its finite lived intangible assets for impairment using a “two-step” approach, whenever events or circumstances suggest that the carrying value of its finite lived intangible assets may not be recoverable. Under step one, if the undiscounted cash flows resulting from the use and ultimate disposition of the finite lived intangible asset (based on entity specific assumptions) are less than its carrying value, the intangible asset is considered not to be recoverable. The impairment loss is determined under step two as the amount by which the carrying value of the intangible asset exceeds its fair value (based on market participant assumptions).

Events or circumstances that could suggest that the Company’s finite lived intangible assets may not be recoverable, and which would lead to an evaluation of the recoverability of the relevant asset, include but are not limited to, the following:

(i)   changes to a product’s commercialization strategy;

(ii)   the loss of patent protection, regulatory exclusivity or challenge or circumvention by competitors of the Company’s regulatory exclusivity patents;

(iii)   the development and marketing of competitive products, including generic entrants into the marketplace;

(iv)   changes to the product labels, or other regulatory intervention;

(v)   sustained government pressure on prices and, specifically, competitive pricing;

(vi)   the occurrence of significant adverse events in respect to the Company’s products;

(vii)   a significant deterioration in a product’s operating performance compared to expectations; and

(viii)   an expectation that the intangible asset will be divested before the end of its previously estimated useful life.

The occurrence of any such events or circumstances may result in the Company reducing the estimated future net cash flows to be generated by, and the fair value of, its finite lived intangible assets and therefore give rise to an impairment loss.

As a result of divestment of DERMAGRAFT to Organogenesis, the Company has reclassified the DERMAGRAFT intangible asset (and other assets subject to disposal) as Assets held for sale and recorded an impairment charge of $611.4 million, measured at fair value less cost to sell, in the year to December 31, 2013.  In the year to December 31, 2012 the Company recognized impairment losses of $126.7 million to write-down its RESOLOR finite lived intangible assets to their fair value.

Dependent on future events or circumstances, the Company’s operating results could be materially and adversely affected by future impairment losses relating to its finite lived intangible assets.

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Indefinite lived intangible assets (IPR&D) – estimation of impairment losses

The Company reviews its indefinite lived intangible assets (which currently only relate to IPR&D assets) for impairment annually or more frequently if events or changes in circumstances indicate that the asset might be impaired. Indefinite lived assets are reviewed for impairment by comparing the fair value of the indefinite lived asset (based on market participant assumptions) with its carrying amount. An impairment loss is recognized to the extent that the carrying value exceeds the estimated fair value of the relevant indefinite lived intangible asset.

Events or circumstances that could suggest that the Company’s IPR&D assets may not be recoverable, and which would lead to an evaluation of the relevant asset for impairment, include those factors considered for finite lived intangible assets (outlined above) as well as any adverse changes to the technological or commercial viability of the IPR&D projects, which could include abandonment of the IPR&D project or a decline in its estimated commercial potential. The occurrence of any such events or circumstances could result in the Company reducing the estimated future net cash flows to be generated by, and the fair value of, its indefinite lived intangible assets and therefore give rise to an impairment loss.

After the identification of any such events or circumstances, and the resultant impairment reviews, the Company recognized impairment losses of $19.9 million in the year to December 31, 2013 (2012: $71.2 million; 2011:$16.0 million) to write-down its RESOLOR IPR&D assets to their fair value (See ITEM 15 of PART IV: EXHIBITS AND FINANCIAL STATEMENT SCHEDULES and Note 12, “Other intangible assets, net” to the consolidated financial statements set forth in this Annual Report on Form 10-K for details). Dependent on future events or circumstances, the Company’s operating results could be materially and adversely affected by future impairment losses relating to its indefinite lived intangible assets.

Goodwill – estimation of impairment losses

The Company reviews goodwill for impairment at least annually, or more frequently if events or circumstances indicate the carrying amount of goodwill may not be recoverable.

The Company reviews goodwill for impairment by firstly comparing the fair value of a reporting unit with its carrying value. If the fair value of a reporting unit exceeds its carrying value, then the goodwill is considered recoverable and no further testing is performed. If the carrying value of a reporting unit is greater than its fair value, then goodwill is considered impaired and a further test is performed to determine the amount by which the carrying value of a reporting unit’s goodwill exceeds its fair value, with an impairment loss recognized in an amount equal to that excess.

The Company determines the fair value of a reporting unit (and if required the fair value of its goodwill) through a present value technique, principally using the income approach. The determination of fair value of a reporting unit requires the use of significant judgment and assumptions, which include, amongst other things, the estimation of future forecast cash flows and an appropriate discount rate used to determine the fair value.

In the first quarter of 2013 the Company identified circumstances which indicated that the carrying value of goodwill in the RM reporting unit may not be recoverable, which triggered an impairment test in advance of the annual testing date. The results of the Company’s March 31, 2013 impairment test showed that the carrying amount of the RM reporting unit exceeded its fair value and the implied value of the goodwill was $nil. As a result the Company recorded an impairment charge of $198.9 million related to the goodwill allocated to the RM reporting unit of which $191.8 million was subsequently presented within discontinued operations (See ITEM 15 of PART IV: EXHIBITS AND FINANCIAL STATEMENT SCHEDULES and Note 11, “Goodwill” to the consolidated financial statements set forth in this Annual Report on Form 10-K for details).

The Company performed its annual goodwill impairment review at October 1, 2013, which indicated that the Company’s goodwill was recoverable and was not deemed to be at risk of failing the first step in testing for impairment.

(ii)   Sales Deductions

Sales deductions consist primarily of statutory rebates to State Medicaid and other government agencies, Medicare Part D rebates, contractual rebates with Managed Care Organizations (“MCOs”), product returns, sales discounts (including trade discounts), distribution service fees, wholesaler chargebacks, and allowances for coupon and patient assistance programs. These deductions are recorded as reductions to revenue in the same period as the related sales. Estimates of future obligations are derived from historical experience adjusted to reflect known changes in the factors that impact such reserves. On the balance sheet the Company records wholesaler chargebacks and trade discounts as a reserve against accounts receivable, whereas all other sales deductions are recorded within current liabilities.

The Company has the following significant categories of sales deductions, all of which involve estimates and judgments which the Company considers to be critical accounting estimates, and require the Company to use information from external sources:

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Medicaid and Managed Care Rebates

Statutory and any supplemental rebates to State Medicaid agencies and contractual rebates to MCOs under managed care programs are based on statutory or negotiated discounts to the selling price. Medicaid rebates generally increase as a percentage of the selling price over the life of the product (if prices increase faster than general inflation).

As it can take up to six months for information to reach the Company on actual usage of the Company’s products in managed care and Medicaid programs and on the total rebates to be reimbursed, the Company estimates the reserves required for amounts payable under these programs relating to sold products.

The amount of these reserves is based on historical experience of rebates, the timing of payments, the level of reimbursement claims, changes in prices (both normal selling prices and statutory or negotiated prices), changes in prescription demand patterns, projected product returns and the levels of inventory in the distribution channel.  Adjustments are made for known changes in these factors.

Shire’s estimates of the level of inventory in the distribution channel are derived from product-by-product inventory data provided by wholesalers and results of independently commissioned retail inventory surveys.

Revisions or clarification of guidelines from the CMS related to State Medicaid and other government program reimbursement practices with retroactive application can result in changes to management’s estimates of the rebates reported in prior periods.

The accrual estimation process for Medicaid and managed care rebates involves in each case a number of interrelating assumptions, which vary for each combination of product and Medicaid agency or MCO. Accordingly, it would not be meaningful to quantify the sensitivity to change for any individual assumption or uncertainty.  However, Shire does not believe that the effect of these uncertainties, taken as a whole, significantly impacts the Company’s financial condition or results of operations.

Aggregate accruals for Medicaid and MCO rebates at December 31, 2013, 2012 and 2011 were $807.2 million, $640.5 million and $612.6 million, or 17%, 15% and 16%, respectively of net product sales. Historically, actual rebates have not varied significantly from the reserves provided.

Product Returns

The Company typically accepts customer product returns in the following circumstances: (a) expiration of shelf life; (b) product damaged while in Shire’s possession ; (c) under sales terms that allow for unconditional return (guaranteed sales); or (d) following product recalls or product withdrawals. Generally, returns for expired product are accepted up to one year after expiration date of the relevant product and the returned product is destroyed. Depending on the product and the Company’s return policy with respect to that product, the Company may either refund the sales price paid by the customer by issuance of a credit, or exchange the returned product with replacement inventory. The Company typically does not provide cash refunds.

Shire estimates the proportion of recorded revenue that will result in a return by considering relevant factors, including:

(i)   past product returns activity;

(ii)   the duration of time taken for products to be returned;

(iii)   the estimated level of inventory in the distribution channel;

(iv)   product recalls and discontinuances;

(v)   the shelf life of products;

(vi)   the launch of new drugs or new formulations; and

(vii)   the loss of patent protection or new competition.

Shire’s estimates of the level of inventory in the distribution channel are based on product-by-product inventory data provided by wholesalers and results of independently commissioned third party retail inventory surveys.

Returns reserves for new products and for those products with generic competition generally require a higher level of estimation than those for established products without generic competition.

For shipments made to support the commercial launch of a new product (which can include guaranteed sales), the Company’s policy is to defer recognition of the sales revenue until there is evidence of end-patient acceptance of the new product (primarily through third-party prescription data). For shipments after launch under standard terms (i.e. not guaranteed sales), the Company’s initial estimates of sales return accruals are primarily based on the historical sales returns experience of similar products shortly after launch. Once sufficient historical data on actual returns of the product are available, the returns provision is based on this data and any other relevant factors as noted above.

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The Company estimates returns reserves for products with generic competition based on historical sales, the estimated level of inventory in the distribution channel, product utilization and rebate data, which are modified through the use of management judgment to take into account many factors, including, but not limited to, current market dynamics, changes in contract terms, changes in sales trends and product pricing.

The accrual estimation process for product returns involves, in each case, a number of interrelating assumptions, which vary for each combination of product and customer. Accordingly, it would not be meaningful to quantify the sensitivity to change for any individual assumption or uncertainty. However, Shire does not believe that the effect of uncertainties, as a whole, significantly impacts the Company’s financial condition or results of operations.

At December 31, 2013, 2012 and 2011, provisions for product returns were $98.8 million, $90.5 million, and $88.8 million or 2%, 2% and 2% respectively, of net product sales. Historically, actual returns have not varied significantly from the reserves provided.

(iii)   Income Taxes

In accounting for uncertainty in income taxes, management is required to develop estimates as to whether a tax benefit should be recognized in the consolidated financial statements, based on whether it is more likely than not that the technical merits of the position will be sustained based on audit by the tax authorities. The measurement of the tax benefit recognized in the consolidated financial statements is based upon the largest amount of tax benefit that, in management’s judgment, is greater than 50% likely to be realized based on a cumulative probability assessment of the possible outcomes. In accounting for income tax uncertainties, management is required to make judgments in the determination of the unit of account, the evaluation of the facts, circumstances and information in respect of the tax position taken, together with the estimates of amounts that the Company may be required to pay in ultimate settlement with the tax authority.

Shire operates in numerous countries where its income tax returns are subject to audit and adjustment by local tax authorities. As Shire operates globally, the nature of the uncertain tax positions is often very complex and subject to change and the amounts at issue can be substantial. Shire develops its cumulative probability assessment to measure uncertain tax positions using internal expertise, experience and judgment, together with assistance from professional advisors. Original estimates are refined as additional information becomes known. For example, in the year to December 31, 2013 the Company recognized additional provisions for uncertain tax positions of $91.3 million in relation to ongoing compliance management for current and prior years.

Any outcome upon settlement that differs from the recorded provision for uncertain tax positions may result in a materially higher or lower tax expense in future periods, which could significantly impact the Company’s results of operations or financial condition. However, the Company does not believe it is possible to reasonably estimate the potential impact of any such change in assumptions, estimates or judgments and the resultant change, if any, in the Company’s provision for uncertain tax positions, as any such change is dependent on factors such as future changes in tax law or administrative practice, the amount and nature of additional taxes which may be asserted by the taxation authorities, and the willingness of the relevant tax authorities to negotiate a settlement for any such position.

At December 31, 2013 the Company recognized a liability of $355.2 million for total unrecognized tax benefits (2012: $278.7 million) and had accrued $112.2 million (2012: $119.6 million) for the payment of interest and penalties. The Company is required in certain tax jurisdictions to make advance deposits to tax authorities on receipt of a tax assessment. These payments are either offset against the income tax liability or establish an income tax receivable but do not reduce the provision for unrecognized tax benefits.

The Company has significant deferred tax assets due to various tax attributes, including net operating losses (“NOLs”), tax credits (from Research and Development and Investment Tax Credits) principally in the Republic of Ireland, the US, Belgium, Germany and the UK. At December 31, 2013 the Company had gross deferred tax assets of $822 million (2012: $764 million; 2011: $667 million), against which the Company had recorded valuation allowances of $282 million (2012: $269 million; 2011: $212 million) and deferred tax liabilities of $644 million (2012: $740 million; 2011: $714 million).

The realization of these assets is not assured and is dependent on various factors. Management is required to exercise judgment in determining whether it is more likely than not that it would realize these deferred tax assets. In assessing the need for a valuation allowance, management weighs all available positive and negative evidence including cumulative losses in recent years, expectations of future taxable income, carry forward and carry back potential under relevant tax law, expiration period of tax attributes, taxable temporary differences, and prudent and feasible tax-planning strategies. A valuation allowance is established where there is an expectation that on the balance of probabilities management considers it is more likely than not that the relevant deferred tax assets will not be realized. If actual events differ from management’s estimates, or to the extent that these estimates are adjusted in the future, any changes to the valuation allowance could significantly impact the Company’s financial condition and results of operations.

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(iv)   Litigation and legal proceedings

The Company has a number of lawsuits pending. The Company’s principal pending legal and other proceedings are disclosed in ITEM 3: Legal Proceedings and Note 18, “Commitments and Contingencies, Legal proceedings” to the consolidated financial statements set forth in this Annual Report on Form 10-K. The Company recognizes loss contingency provisions for probable losses when management is able to reasonably estimate the loss. When the estimated loss lies within a range, the Company records a loss contingency provision based on its best estimate of the probable loss. If no particular amount within that range is a better estimate than any other amount, the minimum amount is recorded.  Estimates of losses may be developed substantially before the ultimate loss is known, and are therefore refined each accounting period as additional information becomes known. In instances where the Company is unable to develop a reasonable estimate of loss, no loss contingency provision is recorded at that time. As information becomes known a loss contingency provision is recorded when a reasonable estimate can be made. These estimates are reviewed quarterly and changed when expectations are revised. An outcome that deviates from the Company’s estimate may result in an additional expense (or credit) in a future accounting period. At December 31, 2013 provisions for litigation losses, insurance claims and other disputes totaled $72.7 million (December 31, 2012: $130.5 million; 2011: $36.9 million).

The outcomes of these proceedings are not always predictable and can be affected by various factors. For those legal and other proceedings for which it is considered at least reasonably possible that a loss has been incurred, the Company discloses the possible loss or range of possible loss in excess of the recorded loss contingency provision, if any, where such excess is both material and estimable. The estimation of the likelihood, amount and range of any loss arising from these proceedings requires significant judgment. Any revisions in the Company’s estimates, or outcomes upon settlement that deviate from the Company’s best estimate may result in an additional expense (or credit) in a future accounting period, which could materially impact the Company’s financial condition or results of operations.

(v)   Contingent consideration receivable from product divestments

At December 31, 2013 the Company has contingent consideration assets of $36.1 million (2012: $38.3 million; 2011: $37.8 million), all of which relate to the divestment of DAYTRANA to Noven in October 2010.

Consideration receivable by the Company on the divestment of product rights typically includes up-front receipts and/or milestones and royalties which are contingent on the outcome of future events (with such milestones and royalties being, for example, based upon the future sales performance of the divested product). Contingent consideration occasionally represents a significant proportion of the economic value receivable by the Company for a divested product. In these situations the Company initially recognizes this contingent consideration as an asset at its divestment date fair value, with re-measurement of this asset to its then current fair value at subsequent balance sheet dates.

The Company estimates the fair value of contingent consideration receivable using the income approach, based on a discounted cash flow method. This discounted cash flow approach uses significant unobservable Level 3 inputs (as defined in US GAAP) including: the probability weightings applied to different sales scenarios and related forecast future royalties receivable under scenarios developed by the Company; and the discount rate to be applied in calculating the present value of these forecast future cash flows. Significant judgment is employed by the Company in developing these estimates and assumptions. If actual events differ from management’s estimates, or to the extent that these estimates are adjusted in the future, the Company’s financial condition and results of operations could be affected in the period of any such change of estimate.

(vi)   Contingent consideration payable

The fair value of the Company’s contingent consideration payable at December 31, 2013 was $405.9 million (December 31, 2012: $136.4 million).

Contingent consideration payable represents (i) future milestones the Company may be required to pay in conjunction with various business combinations and (ii) future royalties payable as a result of certain business combinations and licenses. The amounts ultimately payable by Shire are dependent upon (i) the successful achievement of the relevant milestones and (ii) future net sales of the relevant products over the life of the royalty term respectively.

The Company re-measures its contingent consideration payable to fair value at each balance sheet date. Gains or losses arising on changes to the fair value of contingent consideration payable are recorded within Integration and acquisition costs in the Company’s consolidated income statement.

The Company estimates the fair value of contingent consideration payable using the income approach, based on a discounted cash flow method. The discounted cash flow method uses significant unobservable Level 3 inputs (as defined under US GAAP), including: the probability of, and period in which, the relevant milestone event is expected to be achieved; the amount of royalties that will be payable based on forecast net sales of the relevant products; and the discount rates to be applied in calculating the present values of the relevant milestone or royalty. Significant judgment is

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employed by the Company in developing these estimates and assumptions. If actual events differ from management’s estimates, or to the extent that these estimates are adjusted in the future, the Company’s financial condition and results of operations could be materially affected in the period of any such change of estimate.

(vii)   Assets held for sale

Assets held for sale comprise noncurrent assets or disposal groups (together with any liabilities), the carrying amounts of which will be realized principally through a sale transaction expected to conclude within the next twelve months, rather than through continued use.

At December 31, 2013 the Company has presented $31.6 million (2012: $nil; 2011: $nil) of net assets as assets held for sale in the consolidated balance sheet. The assets and liabilities within this disposal group all relate to the disposal of the DERMAGRAFT asset group, which was announced on January 16, 2014.

At the time of their classification as “held for sale,” such assets are collectively measured at the lower of their carrying amount and fair value less costs to sell, and depreciation or amortization ceases. An impairment charge of $637.0 million was recorded in the fourth quarter of 2013 reflecting the adjustment of the DERMAGRAFT disposal group’s carrying amount to its fair value less cost to sell.

Significant judgment is employed by the Company in assessing: at what point all the held for sale presentation conditions are met for the disposal group; whether it is necessary to allocate goodwill to the disposal group; and estimating both the fair value of the disposal group and the incremental costs to transact a sale of the disposal group. If actual events differ from management’s estimates, or to the extent that estimates of selling price or costs to sell are adjusted in the future, the Company’s financial condition and results of operations could be affected in the period of any such change of estimate.

Recent accounting pronouncements update

See Note 2(x) to the consolidated financial statements contained in ITEM 15: Exhibits and Financial Statement Schedules of this Annual Report on Form 10-K for a full description of recent accounting pronouncements, including the expected dates of adoption and effects on the Company’s financial condition, results of operations and cash flows.

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Financial Information Relating to the Shire IAS Trust

The results of operations and the financial position of the IAS Trust are included in the Consolidated Financial Statements of the Company. An explanation of the IAS Trust is included in ITEM 5: Market for Registrant’s common equity, related stockholder matters and issuer purchases of equity securities of this Annual Report. Separate, audited financial statements of the IAS Trust are included in ITEM 15: Exhibits and Financial Statement Schedules of this Annual Report.

For the year to December 31, 2013 the IAS Trust recorded income before tax of $91.1 million (2012: $81.5 million; 2011: $67.6 million). This income reflected dividends received on the Income Access Share.

At December 31, 2013 the IAS Trust had total equity of $nil. In future periods, to the extent that dividends are unclaimed on the expiry of dividend checks, or to the extent they are returned unpresented, the IAS Trust will record a liability for these unclaimed dividends.

The movements in cash and cash equivalents of the IAS Trust consist of dividends received on the Income Access Share, (2013: $91.1 million, 2012: $81.5 million, 2011: $67.6 million), and distributions made on behalf of Shire to shareholders (2013: $91.1 million, 2012: $81.5 million, 2011: $67.6 million).

ITEM 7A: Quantitative and qualitative disclosures about market risk

Treasury policies and organization

The Company’s principal treasury operations are coordinated by its corporate treasury function. All treasury operations are conducted within a framework of policies and procedures approved annually by the Board of Directors. As a matter of policy, the Company does not undertake speculative transactions that would increase its credit, currency or interest rate exposure.

Interest rate risk

The Company is exposed to interest rate risk on its $1,200 million RCF, its $0.55 billion term loan facility, its $0.85 billion term loan facility (the “Facilities”), to the extent the Facilities are utilized,restricted cash, cash and cash equivalents and on foreign exchange contracts on which interest is at floating rates. This exposure is primarily to US dollar, Pounds sterling, Euro and Canadian dollar interest rates. The Company has evaluated the interest rate risk on its debt facilities and considers the floating rate as appropriate. As the Company maintains all of its cash, liquid investments and foreign exchange contracts on a short term basis for liquidity purposes, this risk is not actively managed. In the year to December 31, 2013 the average interest rate received on cash and liquid investments was less than 1% per annum. The largest proportion of these cash and liquid investments was in US dollar money market and liquidity funds. At December 31, 2013 the Facilities were not utilized.

No derivative instruments were entered into during the year to December 31, 2013 to manage interest rate exposure. The Company continues to review its interest rate risk and the policies in place to manage the risk.

Foreign exchange risk

The Company trades in numerous countries and as a consequence has transactional and translational foreign exchange exposures.

Transactional exposure arises where transactions occur in currencies different to the functional currency of the relevant subsidiary. The main trading currencies of the Company are the US dollar, Pounds Sterling, Swiss Franc and the Euro. It is the Company’s policy that these exposures are minimized to the extent practicable by denominating transactions in the subsidiary’s functional currency.

Where significant exposures remain, the Company uses foreign exchange contracts (being spot, forward and swap contracts) to manage the exposure for balance sheet assets and liabilities that are denominated in currencies different to the functional currency of the relevant subsidiary. These assets and liabilities relate predominantly to intercompany financing. The foreign exchange contracts have not been designated as hedging instruments. Cash flows from derivative instruments are presented within net cash provided by operating activities in the consolidated cash flow statement, unless the derivative instruments are economically hedging specific investing or financing activities.

Translational foreign exchange exposure arises on the translation into US dollars of the financial statements of non-US dollar functional subsidiaries.

At December 31, 2013 the Company had 29 swap and forward foreign exchange contracts outstanding to manage currency risk. The swap and forward contracts mature within 90 days. The Company did not have credit risk related contingent features or collateral linked to the derivatives. The Company has master netting agreements with a number of  counterparties to these foreign exchange contracts and on the occurrence of specified events, the Company has the

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ability to terminate contracts and settle them with a net payment by one party to the other. The Company has elected to present derivative assets and derivative liabilities on a gross basis in the consolidated balance sheet. As at December 31, 2013 the potential effect of rights of set off associated with the foreign exchange contracts would be an offset to both assets and liabilities of $0.7 million, resulting in net derivative assets and derivative liabilities of $3.3 million and $2.1 million, respectively. Further details are included below.

Foreign exchange risk sensitivity

The following exchange rate sensitivity analysis summarises the sensitivity of the Company’s reported revenues and net income to hypothetical changes in the average annual exchange rates of the Euro, Pound Sterling and Swiss Franc against the US Dollar, (assuming a hypothetical 10% strengthening of the US Dollar against each of the aforementioned currencies in the year to December 31, 2013):

	Increase/ (reduction) in revenues			Increase/ (reduction) in net income
		$M			$M
Euro		(78	)		(36	)
Pound Sterling		(19	)		(7	)
Swiss Franc		-			9

A 10% weakening of the US Dollar against the aforementioned currencies would have an equal and opposite effect.

The table below provides information about the Company's swap and forward foreign exchange contracts by currency pair. The table presents the net principal amounts and weighted average exchange rates of all outstanding contracts. All contracts have a maturity date of less than three months.

December 31, 2013	Principal
	Value of		Weighted
	Amount		Average		Fair
	Receivable		Exchange Rate		Value
		$’M				$’M
Swap foreign exchange contracts
Receive USD/Pay EUR		256.0		1.36		(2.2	)
Receive GBP/Pay USD		158.0		1.62		2.8
Receive USD/Pay JPY		1.6		0.01		-
Receive SEK/Pay USD		24.3		0.15		0.6
Receive USD/Pay MXN		10.4		0.08		-

Concentration of credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor’s and by Moody’s credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company’s revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2013 there were three customers in the US that accounted for 52% of the Company’s product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these

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wholesalers to honor their debts to the Company could have an adverse effect on the Company’s financial condition and results of operations.

A substantial portion of the Company’s accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company’s recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments.  In recent years the creditworthiness and general economic condition of the Relevant Countries has deteriorated. As a result, in some of these countries the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers.

The Company’s aggregate accounts receivable, net of the allowance for doubtful accounts, in total from government-owned or government-supported healthcare providers in the Relevant Countries are as follows:

	December 31, 2013 $’M			December 31, 2012 $’M
Total accounts receivable, net in the Relevant Countries		127			136
Total accounts receivable, net in the Relevant Countries as a percentage of total outstanding accounts receivable, net		13	%		17	%
Accounts receivable, net due from government-owned or government-supported healthcare providers for the Relevant Countries		116			129

Accounts receivable due from government-owned or government-supported healthcare providers in the Relevant Countries of $116 million (2012: $130 million) are split by country as follows: Greece $4 million (2012: $6 million); Italy $59 million (2012: $62 million); Portugal $14 million (2012: $13 million) and Spain $39 million (2012: $48 million).

The Company continues to receive remittances in relation to government-owned or government-supported healthcare providers in the Relevant Countries and in the year to December 31, 2013 received $284.9 million in settlement of accounts receivable in the Relevant Countries - $9.5 million was from Greece; $145.0 million from Italy; $13.4 million from Portugal and $117.0 million from Spain.

To date the Company has not incurred significant losses on the accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable.

Other than the accounts receivable from government-owned or supported healthcare providers outlined above, the Company does not hold any other government debt from the Relevant Countries. Additionally the Company does not consider it is currently exposed to significant sovereign credit risk outside of the Relevant Countries.

The Company continues to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company’s financial condition and results of operations.

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ITEM 8: Financial statements and supplementary data

The consolidated financial statements and supplementary data called for by this item are submitted as a separate section of this report. See ITEM 15: Exhibits and financial statement schedules.

ITEM 9: Changes in and disagreements with accountants on accounting and financial disclosure

Not applicable.

ITEM 9A: Controls and procedures

Disclosure Controls and Procedures

The Company maintains disclosure controls and procedures that are designed to ensure that information required to be disclosed in reports that the Company file under the Securities Exchange Act of 1934, as amended, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

The Company, under the supervision and with the participation of the Company’s management, including the Chief Executive Officer and the Chief Financial Officer, has performed an evaluation of the effectiveness of the Company’s disclosure controls and procedures (including those applicable to the Income Access Share Trust) (as defined in Exchange Act Rule 13a-15(e)), as at December 31, 2013.

The Company’s management necessarily applied its judgment in assessing the costs and benefits of such controls and procedures, which by their nature can provide only reasonable assurance regarding management’s control objectives. Based on this evaluation, the Company’s Chief Executive Officer and Chief Financial Officer concluded that the Company’s disclosure controls and procedures (including those applicable to the Income Access Share Trust) are effective at the reasonable level of assurance to ensure that information required to be disclosed in reports that the Company file under the Securities Exchange Act of 1934, as amended, is recorded, processed, summarized and reported within the time periods specified in the rules and forms of the SEC.

Management’s Report on Internal Control Over Financial Reporting

The Company’s management is responsible for establishing and maintaining adequate internal control over financial reporting as defined in Rule 13(a)-15(f) or 15(d)-15(f) promulgated under the US Securities Exchange Act of 1934.

Because of its inherent limitations, internal control over financial reporting may not prevent or detect misstatements. Projections of any evaluation of effectiveness to future periods are subject to the risk that controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

The Company’s management assessed the effectiveness of the Company’s internal control over financial reporting (including those applicable to the Income Access Share Trust) as at December 31, 2013. In making this assessment, the Company’s management used the criteria set forth by the Committee of Sponsoring Organizations of the Treadway Commission in its Internal Control-Integrated Framework issued in 1992 (the “1992 Framework”). Based on its assessment, management believes that, as at December 31, 2013, the Company’s internal control over financial reporting is effective based on those criteria.

Deloitte LLP, an independent registered public accounting firm, has issued an audit report on the Company’s internal control over financial reporting, including those controls applicable to the Income Access Share Trust. This report appears on page F-3 of the Company’s consolidated financial statements contained in ITEM 15: Exhibits and financial statement schedules of this Annual Report on Form 10-K.

Changes in Internal Control Over Financial Reporting

The Company has an integrated information system covering financial processes, production, logistics and quality management. Various upgrades and new implementations were made to the information system during 2013 and 2012. The Company reviewed each system change as it was implemented together with any internal controls affected. Alterations were made to affected controls at the time the system changes were implemented. Management believes that the controls as modified are appropriate and functioning effectively.

ITEM 9B: Other Information

None

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PART III

ITEM 10: Directors and executive officers of the registrant

Directors of the Company

Name	Age	Position
Matthew Emmens1	62	Non-executive Chairman
Susan Kilsby2	55	Non-Executive Chairman Designate
Dr. Flemming Ornskov3	56	Chief Executive Officer (“CEO”)
Graham Hetherington4	55	Chief Financial Officer (“CFO”)
David Kappler	66	Deputy Chairman and Senior Independent Non-Executive Director
Dominic Blakemore5	44	Non-Executive Director
William Burns	66	Non-Executive Director
Dr. Steven Gillis	50	Non-Executive Director
Dr. David Ginsburg	61	Non-Executive Director
Anne Minto	60	Non-Executive Director
David Stout	59	Non-Executive Director

(1)  Mr. Emmens will be stepping down as Chairman on April 29, 2014.

(2)  Susan Kilsby was appointed Chairman Designate on January 23, 2014 and will become the Chairman with effect from April 29, 2014.

(3)  Dr. Flemming Ornskov was appointed CEO Designate on January 2, 2013 and became CEO with effect from April 30, 2013.

(4)  Mr. Hetherington will be stepping down as CFO on March 1, 2014.

(5)  Dominic Blakemore was appointed as a Non-Executive Director with effect from January 1, 2014.

Executive Officers of the Company

Name	Age	Position
Dr Flemming Ornskov	56	CEO
Graham Hetherington1	55	CFO
Tatjana May	48	General Counsel and Company Secretary

(1) Mr. Hetherington will be stepping down as CFO on March 1, 2014. James Bowling will be appointed as interim CFO from March 1, 2014.

(2) Phil Vickers, Head of R&D and Ginger Gregory, Chief Human Resources Officer will join the Executive Committee on March 1, 2014.

For the purposes of the NASDAQ corporate governance rules, the independent directors are Dominic Blakemore, William Burns, Dr. Steven Gillis, Dr. David Ginsburg, David Kappler, Susan Kilsby, Anne Minto and David Stout. There is no family relationship between or among any of the directors or executive officers.

Non-Executive Directors are appointed by the Board ordinarily for a term of two years, subject to reappointment by the Board. In addition, in accordance with the UK Corporate Governance Code issued by the UK Financial Reporting Council in September 2012 (the “UK Governance Code”),  the Company’s Directors, including Non-Executive Directors, are subject to annual re-election by shareholders.

The current terms of the Non-Executive Directors are as set out below:

Name	Date of Term Expiration
Matthew Emmens1	June 17, 2014
Susan Kilsby	August 31, 2015
David Kappler	April 4, 2014
Dominic Blakemore	December 31, 2015
William Burns	March 14, 2014
Dr. Steven Gillis	September 30, 2014
Dr. David Ginsburg	June 15, 2014
Anne Minto	June 15, 2014
David Stout	October 30, 2015

(1)  Mr. Emmens will be stepping down as Chairman on April 29, 2014.

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Executive Directors are appointed pursuant to service agreements, which are not limited in term.

Matthew Emmens

Chairman

Mr Emmens was appointed Chairman on June 18, 2008, and has been a member of the Board since 2003. He is also a member of the Nomination Committee. Mr Emmens served as Shire’s Chief Executive Officer from 2003 to 2008. With 40 years of pharmaceutical experience he contributes a wealth of strategic and operational knowledge to the Company. Mr Emmens is due to step down as Chairman on April 29, 2014.

Mr Emmens began his career in international pharmaceuticals with Merck & Co, Inc. in 1974, where he held a wide range of sales, marketing and administrative positions. In 1992 he helped to establish Astra Merck Inc., a joint venture between Merck and Astra AB of Sweden, becoming President and Chief Executive Officer. In 1999 he joined Merck KGaA and established EMD Pharmaceuticals, the company’s US prescription pharmaceuticals business. He later served as President of Merck KGaA’s global prescription pharmaceuticals business in Germany.  Mr Emmens previously held the positions of Chairman, CEO and President at Vertex Pharmaceuticals Inc., and served on the Board of Incyte Corporation. He holds a degree in Business Management.

Susan Kilsby

Chairman Designate

Ms Kilsby was appointed to the Board on September 1, 2011, and is to be appointed Chairman on April 29, 2014. Ms Kilsby is Chairman of the Audit, Compliance & Risk Committee, from which she will step down on April 29, 2014, and is a member of the Nomination Committee. Ms Kilsby brings to her role her extensive M&A and finance experience. She has had a distinguished global career in investment banking having held senior positions with The First Boston Corporation, Bankers Trust, Barclays de Zoete Wedd and most recently Credit Suisse where she was Chairman of the EMEA Mergers & Acquisitions team until 2009.  Ms Kilsby has served as a part-time senior advisor to Credit Suisse since 2009 and will step down from this role on April 29, 2014.  She is also a former Director of Hong Kong listed global skin care company, L’Occitane International S.A., and currently holds Non-Executive Directorships at Green Mountain Coffee Roasters, Inc., BBA Aviation plc and Coca-Cola HBC AG. Ms Kilsby holds a BA in Economics and a MBA.

Dr Flemming Ornskov

Chief Executive Officer

Dr Ornskov was appointed to the Board on January 2, 2013, serving as Chief Executive Officer Designate prior to his appointment as Chief Executive Officer on April 30, 2013. Dr Ornskov brings to his role his operational and medical knowledge and his extensive international, strategic and operational experience in the pharmaceutical sector. From 2010 to 2012 he was Chief Marketing Officer and Global Head, Strategic Marketing for General and Speciality Medicine at Bayer. From 2008 to 2010 Dr Ornskov served as Global President, Pharmaceuticals and OTC at Bausch & Lomb, Inc. He also served as Chairman, and later as President and Chief Executive Officer, of Life-Cycle Pharma A/S from 2006 to 2008, and as President and Chief Executive officer of Ikaria, Inc. from 2005 to 2006. Earlier in his pharmaceutical career Dr Ornskov had roles of increasing responsibility at Merck & Co., Inc. and Novartis AG, following a distinguished period spent in hospitals and academic medicine. He formerly held the position of Non-Executive Chairman of Evotec AG and was Non-Executive Director of PCI Biotech Holding ASA. Dr Ornskov received his MD from the University of Copenhagen, MBA from INSEAD and Master of Public Health from Harvard University.

Graham Hetherington

Chief Financial Officer

Mr Hetherington was appointed to the Board on July 1, 2008, and is a member of the Executive Committee. Mr Hetherington brings to his position a broad range of international finance management and planning, audit, risk management and M&A experience. He was Chief Financial Officer of Bacardi in 2007 and Chief Financial Officer of Allied Domecq plc from 1999 to 2005. Mr Hetherington is a Fellow of the Chartered Institute of Management Accountants.Mr Hetherington will be stepping down from the Board on March 1, 2014.

David Kappler

Deputy Chairman and Senior Independent Non-Executive Director

Mr Kappler was appointed to the Board on April 5, 2004, and was later appointed as Senior Independent Non-Executive Director in July 2007 and as Deputy Chairman in June 2008. He is also Chairman of the Nomination Committee and a member of the Audit, Compliance & Risk Committee. Mr Kappler brings to the Board his extensive knowledge and experience in financial reporting, risk management and internal financial controls. He retired from Cadbury Schweppes plc in 2004 after serving as Chief Financial Officer since 1995. Mr Kappler worked for the Cadbury Schweppes Group between 1965 and 1984 and rejoined the company in 1989 following its acquisition of the Trebor Group, where he was Financial Director. He was Chairman of Premier Foods plc until 2010 and held directorships at Camelot Group plc and

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HMV Group plc. Mr Kappler holds the position of Non-Executive Director at InterContinental Hotels Group plc and is a Fellow of the Chartered Institute of Management Accountants.

Dominic Blakemore

Non-Executive Director

Mr Blakemore was appointed to the Board on January 1, 2014 and is a member of the Audit, Compliance & Risk Committee, to which he is to be appointed Chairman on April 29, 2014. Mr Blakemore brings to the Board strategic and financial experience having held the positions of Chief Financial Officer at Iglo Foods Group and European Finance & Strategy Director, Corporate Finance Director, and Group Financial Controller at Cadbury plc. Earlier in his career he worked at PricewaterhouseCoopers where he advised pharmaceutical sector clients. Mr Blakemore holds the position of Group Finance Director at Compass Group PLC.

William Burns

Non-Executive Director

Mr Burns was appointed to the Board on March 15, 2010 and is a member of the Nomination Committee, Remuneration Committee and Science & Technology Committee. Mr Burns brings to the Board extensive international sales, marketing, integration and operational experience in the pharmaceutical sector. He worked for many years for Roche, holding the position of CEO of their pharmaceuticals division from 2005 to 2009 and serving as a member of the Roche Group Corporate Executive Committee. Mr Burns holds Directorships at Roche Holdings Ltd, Genentech, Inc., Chugai Pharmaceutical Co., Ltd and Vesterfaard Frandesen, is Chairman of Masters Pharmaceuticals and Vice Chairman of Biotie Therapies Corp. In addition, he holds positions at Wellcome Trust, the University of Strathclyde and the University of Cologne/Bonn Center for Integrated Oncology. He holds a BA (Hons).

Dr Steven Gillis

Non-Executive Director

Dr Gillis was appointed to the Board on October 1, 2012 and is a member of the Remuneration Committee and the Science & Technology Committee. Dr Gillis brings to the Board his extensive technical and scientific knowledge and commercial experience. He is currently a Managing Director at ARCH Venture Partners, a provider of venture capital for technology firms, where he is focused on the evaluation of new life science technologies and the development and growth of ARCH’s biotechnology portfolio companies.  Prior to this, Dr Gillis was a founder and director of Corixa Corporation, acquired by GlaxoSmithKline in 2005. Prior to starting Corixa, he was a founder and director of Immunex Corporation. Dr Gillis is a Director of Bluebird Bio, Inc.

An immunologist by training, Dr Gillis has authored more than 300 peer-reviewed publications in the areas of molecular and tumor immunology. He is credited as being a pioneer in the field of cytokines and cytokine receptors, directing the development of multiple marketed products including Leukine, (GM-CSF), Prokine (IL-2) and Enbrel (soluble TNF receptor-Fc fusion protein) as well as the regulatory approval of Bexxar (radiolabeled anti-CD20) and the novel vaccine adjuvant, MPL. Dr Gillis received his BA from Williams College and his Ph.D. from Dartmouth College.

Dr David Ginsburg

Non-Executive Director

Dr Ginsburg was appointed to the Board on June 16, 2010 and is a Chairman of the Science & Technology Committee. Dr Ginsburg brings to the Board his clinical medical background in Internal Medicine, Hematology-Oncology, and Medical Genetics, as well as his extensive basic biomedical laboratory research expertise. He obtained his BA at Yale University, MD at Duke University and completed his medical and research training at Harvard Medical School. Dr Ginsburg is the recipient of numerous honours and awards, including election to membership in the National Academy of Sciences, the Institute of Medicine and the American Academy of Arts and Sciences. He currently holds the positions of James V. Neel Distinguished University Professor of Internal Medicine, Human Genetics and Pediatrics at the University of Michigan and Howard Hughes Medical Institute Investigator.

Anne Minto OBE

Non-Executive Director

Ms Minto was appointed to the Board on June 16, 2010. She is Chairman of the Remuneration Committee and a member of the Nomination Committee. Ms Minto brings to the Board her extensive legal, commercial and remuneration experience. She held the position of Group Director, Human Resources at Centrica plc from 2002 to 2011 and was a member of the Centrica Executive Committee.  Her extensive business career includes senior management roles at Shell UK, the position of Deputy Director-General of the Engineering Employers’ Federation and the position of Group Director Human Resources at Smiths Group plc. She is also a former Director of Northumbrian Water plc and SITA UK. Ms Minto holds a Law degree and a postgraduate diploma in Human Resources, and is also a qualified lawyer. She is also a Fellow of the Chartered Institute of Personnel & Development, the Royal Society of Arts and the London City and Guilds and a Member of Law Society of Scotland. Ms Minto holds Non-Executive Directorships at Tate & Lyle PLC and ExlService

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Holdings, Inc., is a trustee for the University of Aberdeen Development Trust and is Patron for the University of Aberdeen Alumni Fund.

David Stout

Non-Executive Director

Mr Stout was appointed to the Board on October 31, 2009, and is a member of the Audit, Compliance & Risk Committee and the Remuneration Committee. He brings to the Board extensive international sales, marketing, operational and supply chain experience gained in the pharmaceutical sector. Mr Stout was President, Pharmaceutical Operations at GlaxoSmithKline, where he was responsible for the company’s global pharmaceutical operations from 2003 to 2008.  Prior to that he was President of GlaxoSmithKline’s US Pharmaceuticals Business and before that SmithKline Beecham’s North American Pharmaceuticals Business. Before joining SmithKline Beecham, Mr Stout worked for many years at Schering-Plough. He is also a former Director of Allos Therapeutics, Inc.. Mr Stout holds directorships at Jabil Circuit, Inc. and Airgas, Inc.. He holds a BA in Biology.

Angus Russell

Former Chief Executive Officer

Mr Russell was appointed to the Board in 1999, serving as Chief Financial Officer until 2008. From June 18, 2008 until April 30, 2013 Mr Russell served as Chief Executive Officer. He brought to his position his operational knowledge of Shire and his extensive finance, risk management, strategic and operational experience in the pharmaceutical sector. Mr Russell held positions at InterMune, Inc. and City of London Investment Trust plc, and positions of increasing responsibility at ICI, Zeneca and AstraZeneca PLC, including Vice President, Corporate Finance at AstraZeneca and Group Treasurer at Zeneca. Mr Russell is a Chartered Accountant and is a Fellow of the Association of Corporate Treasurers.

Executive officers

Tatjana May has been with Shire since May 2001. She is General Counsel and Company Secretary and a member of Shire’s Executive Committee. Ms May was previously Assistant General Counsel at the corporate headquarters of AstraZeneca plc. Prior to that she worked at the law firm Slaughter and May.

Audit, Compliance & Risk Committee Financial Expert

The members of the Audit, Compliance & Risk Committee as at December 31, 2013 were Ms Kilsby, Mr. Kappler and Mr. Stout.

The Board has determined that Mr. Kappler is the serving financial expert on the Audit, Compliance & Risk Committee and that he is independent as defined under applicable SEC rules. A description of Mr. Kappler’s relevant experience is provided above.

Code of Ethics

Shire’s Board of Directors has adopted a Code of Ethics that applies to all its directors, officers and employees, including its Chief Executive Officer, Chief Financial Officer and Group Financial Controller. The Code of Ethics is posted on Shire’s website at www.shire.com.

NASDAQ Corporate Governance Exemption

As a foreign private issuer incorporated in Jersey (Channel Islands) with its principal listing on the London Stock Exchange, Shire follows its “home country” corporate governance practices in lieu of the provisions of the NASDAQ Stock Market’s Marketplace Rule 5600 series that apply to the constitution of a quorum for any meeting of shareholders.

Shire also complies with the laws of Jersey and the UK Governance Code in lieu of The NASDAQ Stock Market’s rules regarding the constitution of a quorum for any meeting of shareholders. The NASDAQ Stock Market’s rules provide for a quorum of no less than 33⅓% of Shire’s outstanding shares. However, Shire’s By-laws provide that a quorum has been established when two members are present in person or by proxy and entitled to vote except where the rights attached to any existing class of shares are proposed to be varied, and then the quorum shall be two persons entitled to vote and holding or representing by proxy not less than one-third in nominal value of the issued shares of the class.

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ITEM 11: Executive compensation

In respect of the financial year to December 31, 2013, the total compensation paid to Shire plc’s directors and executive officers as a group for the periods during which they served in any capacity was $20.6 million. The total amounts set aside or accrued by the Company to provide pension, retirement or similar benefits for this group was $0.8 million. During 2013, members of the group were granted awards over ordinary shares and ADSs of the Company. All such holdings were issued pursuant to the various executive share plans described in Note 27 to the Company’s consolidated financial statements contained in ITEM 15: Exhibits and financial statements schedules of this Annual Report on Form 10-K.

The Company provides information on the individual compensation of its directors in the Directors’ Remuneration Report included within its financial statements filed with the United Kingdom Listing Authority (“UKLA”). As the Remuneration Report is made publicly available, it is reproduced in full below. As at the time of filing this Form 10-K, the Directors’ Remuneration Report is subject to approval by Shire plc’s shareholders at the Annual General Meeting (“AGM”).

Directors’ Renumeration Report

This report has been prepared in compliance with Schedule 8 of the Large and Medium Sized Companies and Groups (Accounts and Reports) Regulations 2008 (as amended during the course of 2013) (the “Schuedule 8 Regulations”), as well as the companies Act 2006 and other related regulations.

The Directors’ Remuneration Policy (Part 2 of this report) will be subject to a binding shareholder vote at the 2014 AGM to obtain approval for a period of no more than 12 months effective from January 1, 2015. A strategic remuneration review is scheduled for 2014 and it is anticipated that a new remuneration policy will be presented to shareholders at the 2015 AGM. The remaider of this report will be put to an advisory shareholder vote at the 2014 AGM.

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Part 1 - Annual Statement

Dear Shareholder

As Chairman of the Remuneration Committee, I am pleased to present our Remuneration Report for the financial year ended December 31, 2013 which has been prepared in compliance with the new UK reporting requirements.

The Committee believes that the purpose of its remuneration policy is to support the Company’s strategy to grow the business and deliver value to stakeholders by focusing on significant unmet patient need in specialist areas and providing more innovative treatments to more patients. The remuneration policy therefore has a strong focus on strategic alignment and both corporate and individual performance-based remuneration, in particular remuneration delivered in shares and vesting over the longer term. It also recognizes that we compete internationally, and in particular in the US labour market, for limited talent in the biotechnology and pharmaceutical sectors.

We have sought to ensure that the Remuneration Report sets out clearly our remuneration policy and how it was implemented in 2013. Ahead of the detail, I would like to take this opportunity to outline the Committee’s key decisions over the past year and summarize the performance and other context for these decisions.

Context to the Committee’s decisions

Following the appointment of a new CEO in 2013, we have undertaken significant changes at Shire: we refined our strategy; enhanced and reprioritized our portfolio to focus even more on rare diseases and late stage assets; created a simpler, more streamlined and effective organization, One Shire; implemented a new governance model to ensure enterprise wide decision making and resource allocation; and reset our cost base. Shareholders have responded well to these wide ranging changes and share price performance has been strong with an Ordinary Share price increase of 51% and an American Depositary Shares (ADS) price increase of 53% in 2013.

As well as implementing this major transformation which has made us even stronger, more flexible and focused, we have continued to deliver on short term performance as demonstrated by a strong set of financial results. Highlights of Shire’s financial performance during 2013 include:

·   Product sales from continuing operations in 2013 were up 12% to $4,757 million and including DERMAGRAFT product sales were up 10% to $4,847 million;

·   Non GAAP operating income from continuing operations increased by 23% to $1,860 million in 2013; and

·   Non GAAP Adjusted ROIC grew by 180 basis points in 2013 over 2012 to 15.6%.

In addition, our non-financial accomplishments include the successful completion of four acquisitions, notably our most recent acquisition, ViroPharma, which is the highest value deal in Shire’s history; further geographical expansion, particularly into Asia; and other achievements which further expanded our In-Line product portfolio and development Pipeline.

Key Committee decisions

The Committee is satisfied that there is strong alignment between Company performance and the remuneration of the Executive Directors. The key decisions made by the Committee include:

·   A salary increase of approximately 8% for the CEO reflecting both his performance in role and bringing his salary in line with the median for comparable roles, as set out in last year’s Remuneration Report and in line with our remuneration policy. This is consistent with the pattern of increases across the organization where strong performers are given above average increases to achieve appropriate market positioning.

·   Incentive awards for the CEO subject to stretching performance conditions above target levels reflecting Shire’s strong corporate performance in 2013 as well as his individual contribution to the Company’s continued success.

·   The maximum vesting of the 2011 Portfolio Share Plan (PSP) award to the CFO reflecting our excellent financial performance over the performance period (on the basis of a Compound Annual Growth Rate (CAGR) of 18.2% in Non GAAP EBITDA and a 220 basis point increase in Non GAAP Adjusted ROIC over the last three years).

·   In addition, the Committee carefully considered the remuneration decisions in relation to the CFO’s departure, including no salary increase or long term incentive award to be made in 2014 in the light of his scheduled leave date. In line with the Committee’s policy of transparency with shareholders, further detail is set out later in this report.

Given the strategic and organizational changes through 2013 as well as the strong level of support from shareholders for our remuneration policy and decisions in recent years, the Committee decided not to make any significant changes to our overall remuneration approach.

However, a large amount of time was spent considering the new UK reporting requirements and associated guidance as well meeting with our major shareholders and key shareholder advisory bodies to ensure the Remuneration Report was compliant, clear and met our shareholders’ expectations as far as possible. In the light of these shareholder discussions, the Committee made two important decisions. Firstly, pending a wider remuneration review in 2014, to seek shareholder approval for a long term incentive grant policy limited to existing target ranges rather than the higher plan rule grant maxima. And secondly, to further enhance the transparency of its annual incentive award disclosure compared to previous years.

Looking forward

2013 was an important year in Shire’s continued development as we laid foundations to grow the value of Shire for the benefit of our patients, shareholders and other stakeholders. With the revised strategy and organizational structure coming into place, a review of our remuneration policy and arrangements will take place in 2014 to ensure they remain appropriate. This review will take into account a variety of considerations including strategic alignment, linkages to performance, market practice and shareholder views. We will, of course, engage with shareholders at the appropriate time to discuss the findings.

Finally, I would like to thank my fellow Committee members for their extensive contributions as well as both the internal and external teams that have supported the Committee over the past year.

On behalf of the Board

Anne Minto

Chairman of the Remuneration Committee

February 24, 2014

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Part 2 - Directors’ Remuneration Policy

a) Executive Director remuneration policy

Purpose & link to strategy	Operation & Performance Assessment	Opportunity
Overall remuneration
To recruit and retain high-calibre executives and encourage them to enhance the Company’s performance, responsibly, in line with the Company’s strategy and shareholder interests.	The overall remuneration package for the Executive Directors is designed to provide an appropriate balance between fixed and variable, performance-related components, with a significant element of long term variable pay given the long term nature of the business. Overall remuneration is positioned in line with a Mid-Atlantic peer group which comprises a blend of US and UK companies, taking into account scale and international complexity. UK market data is based on other companies within the FTSE 100 index excluding financial services, utilities and mining companies. The greater number of comparable US companies allows further refinement of US market data to only include companies in the pharmaceutical, biotechnology and related sectors. The Committee is satisfied that the composition and structure of the remuneration package is appropriate and does not incentivize undue risk taking.	In terms of total remuneration, the Company’s policy is to target at around median of the relevant market and to allow for higher pay levels to recognize superior performance.
Fixed elements - Base salary
To recognise the market value of the role, an individual’s skills, experience and performance, as well as their contribution to leadership and Company strategy.	Base salary is paid in cash and is pensionable. Individual and corporate performance are factors considered during the annual base salary review process. Any increases typically take effect on January 1 each year. Any significant salary increases, such as in cases where Executive Directors are relatively new in role, changes in responsibilities or significant variance to the market, will be appropriately explained.	Base salary is targeted at around median of the Mid-Atlantic peer group. The exact positioning depends on a variety of factors such as individual experience and performance, total remuneration increases across the Company and shareholder views. Where appropriate, annual increases are made in line with the average of employees’ salary increases, unless the Committee determines otherwise based on the factors listed above. The annual base salaries for the Executive Directors are set out in Part 3(a) of this report.
Fixed elements - Retirement and other benefits
To ensure that benefits are competitive in the markets in which the Company operates.	Dr. Ornskov participates in the 401(k) Plan and the Supplemental Executive Retirement Plan (SERP) in the US. The SERP is an unfunded defined contribution scheme; the benefits are payable as lump sums on leaving the Company’s employment or in the event of death or disability. Mr. Hetherington’s retirement benefits are provided through a combination, at his election, of cash allowance and participation in a UK HMRC registered defined contribution plan, which the Company operates for UK employees. The Company provides a range of other benefits which may include a car allowance, long term disability and life cover, private medical insurance and financial and tax advisory support. These benefits are not pensionable. Other benefits may be offered if considered appropriate by the Committee. The Company may also meet certain mobility costs, such as relocation support, expatriate allowances, temporary living and transportation expenses, in line with the prevailing mobility policy and practice for senior executives. Executive Directors are eligible to participate in any all-employee share plans operated by the Company, such as the Sharesave scheme in the UK and the Employee Stock Purchase Plan (ESPP) in the US and other countries.	Dr. Ornskov receives a total fixed contribution of 30% of annual salary and Mr. Hetherington receives a total fixed contribution of 25% of annual salary by way of retirement benefit provision. The cost to the Company of providing other benefits may vary depending on, for example, market practice and the cost of insuring certain benefits.

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Purpose & link to strategy	Operation & Performance Assessment	Opportunity
Short term incentives - Executive Annual Incentive Plan (EAIP)
To reward individuals with an award based on achievement of pre defined, Committee approved corporate objectives (the corporate scorecard) and the individual’s contributions toward achieving those objectives.  Key performance measures are set by the Committee both in the context of annual performance as well as to ensure progress towards our strategy - to grow our business and deliver value to our stakeholders by focusing on significant unmet patient need in specialist areas and providing more innovative treatments to more patients.	In determining EAIP awards for the Executive Directors, the Committee considers performance against each of the key performance measures within the corporate scorecard, taking into account the impact on the Company’s performance of strategic actions, as well as the Company’s response to external opportunities and events that could not have been predicted at the beginning of the year, together with performance against personal objectives. In addition, the Committee may amend the performance measures or targets in exceptional circumstances where it considers that they are no longer appropriate. The cash element (75% of any award) is paid in the first quarter of the year following the performance year, and the deferred shares element (25% of any award) is deferred and released after a period of three years, subject to the participant’s employment not being terminated for cause. The release of deferred shares includes dividend shares representing accumulated dividends. Clawback arrangements are in place for awards to cover  situations where results are materially misstated or in the event of serious misconduct.	90% and 80% of base salary is payable for target performance for the CEO and CFO respectively and up to 180% and 160% for maximum performance, although actual payouts can range from 0% (threshold performance) upwards. Each year the Committee determines the measures and weightings for the corporate scorecard within the following parameters: ·  At least 75% of the corporate scorecard will be based on financial performance. ·  Other corporate scorecard measures will comprise other strategic priorities such as: -Strengthening the commercial portfolio; -Expanding the development pipeline; and -Enhancing organizational effectiveness. The precise allocation between financial and non-financial measures (as well as the weightings within these measures), will depend on the strategic focus of the Company in any given year.
Long term incentives - Portfolio Share Plan
To incentivise individuals to achieve sustained growth through superior long term performance and create alignment with shareholders. The performance measures for the PSP awards are Non GAAP EBITDA1and Non GAAP Adjusted ROIC2. These measures were selected by the Committee as it believes that they represent meaningful and relevant measurements of our performance and are an important measure of our ability to meet our strategic objective to grow our business and deliver value to our stakeholders. The Committee reviews annually whether the performance matrix structure and metrics remain appropriate and challenging taking into account the Company’s strategic objectives and shareholder interests.	PSP grants for the Executive Directors comprise two types of award: ·SAR awards. AStock Appreciation Right (SAR) is the right to receive ordinary shares or ADSs linked to the increase in value of ordinary shares or ADSs from grant to exercise. · PSA awards. A Performance Share Award (PSA) is the right to receive a specified number of ordinary shares or ADSs. SAR and PSA awards granted to Executive Directors vest three years from the date of grant, subject to the satisfaction of performance conditions and are governed by the PSP rules. SAR awards can be exercised up to the seventh anniversary of the date of grant. These two types of award are made to ensure a balance between the emphasis on share price growth that the SAR awards provide and the retentive properties of the PSA awards. Vesting of awards requires the achievement of Non GAAP EBITDA and Non GAAP Adjusted ROIC targets within a performance matrix. The Committee reserves the right to make adjustments to the matrix to reflect significant one off items which occur during the vesting period (Significant Adjustment Events (SAEs)). Potential SAEs are reviewed by the Committee against pre existing guidelines3. The Committee will make full and clear disclosure of any such adjustments in the Directors’ Remuneration Report (DRR), together with the Non GAAP Adjusted ROIC performance, at the end of the performance period. In addition, awards only vest if the Committee determines that the underlying performance of the Company is sufficient to justify the vesting of the award. Performance targets are set by the Committee to ensure alignment with the Company’s current long range plans and strategy, the Company’s weighted average cost of capital and recent broker forecasts. Clawback arrangements are in place for awards to cover situations where results are materially misstated or in the event of serious misconduct.	The Committee has established the following target levels of award in face value terms: For the CEO: ·400% of base salary for SAR awards; and ·300% of base salary for PSA awards. For the CFO: ·300% of base salary for SAR awards; and ·220% of base salary for PSA awards. The Committee’s policy is that each year, awards will be made to Executive Directors of between 80% and 120% of these target levels, depending on performance and consideration of appropriate benchmarks. In doing so, the Committee gives consideration to the expected value of the award, which enables comparison to other Shire employees (whose long term incentives are determined in expected value terms) as well as to the external market. Threshold vesting under the performance matrix is equal to 25% of any award made, with maximum vesting being equal to 100% of any award made.

1 Non GAAP EBITDA growth is defined as the CAGR of Non GAAP EBITDA, as derived from the Group’s Non GAAP financial results included in its full year earnings releases, over the three year vesting period.

2 Non GAAP Adjusted ROIC reflects the definition used by the Company in its corporate scorecard. This definition aims to measure true underlying economic performance of the Company, by making a number of adjustments to ROIC as derived from the Company’s Non GAAP financial results including:

·   Adding back to Non GAAP operating income all R&D expenses and operating lease costs incurred in the period;

·   Capitalizing on the Group’s balance sheet historical, cumulative R&D, in process R&D and intangible asset impairment charges and operating lease costs which previously have been expensed;

·   Deducting from Non GAAP operating income an amortization charge for the above capitalized costs based on the estimated commercial lives of the relevant products;

·   Excluding the income statement and balance sheet impact of non operating assets (such as surplus cash and non-strategic investments); and

·   Taxing the resulting adjusted operating income at the underlying Non GAAP tax rate.

3The Significant Adjustment Events pre-existing guidelines consist of the following:

·   The event results from a strategic action that has a short term impact on Non GAAP Adjusted ROIC or Non GAAP EBITDA growth, but is in the long term interest of shareholders or the event was external and results in a significant change to the Company’s operating environment;

·   The event is a one off (as opposed to recurring) in nature;

·   The event is “significant” which is defined by reference to its impact on Non GAAP EBITDA relative to a materiality threshold; and

·   The event was not taken into account when the performance matrix was set.

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Legacy matters in relation to Executive Director remuneration

The Committee will honour remuneration and related commitments to current and former directors (including the exercise of any discretions available to the Committee in relation to such commitments) where the terms were agreed prior to the approval and implementation of the remuneration policy detailed in this report.

b) Chairman and Non-Executive Director remuneration policy

Purpose and link to strategy	Operation	Opportunity
Overall remuneration
To attract and retain high calibre individuals by offering market competitive fee levels.	The Chairman is paid a single fee for all of his/her responsibilities. The Non-Executive Directors are paid a basic fee. The members and chairmen of the main Board committees and the Senior Independent Director are paid a committee fee to reflect their extra responsibilities. The Non-Executive Directors receive 25% of their total fees in the form of shares. Given his significant shareholding in Shire, the current Chairman receives his fee in the form of cash only. The Company reimburses reasonably incurred expenses and Non-Executive Directors are also paid an additional fee in respect of each transatlantic trip made for Board meetings. The fees paid to the Chairman and the Non-Executive Directors are not performance related. The Non-Executive Directors do not participate in any of the Group share plans, pension plans or other employee benefit schemes (with the exception of the current Chairman only who is provided with private family medical coverage to which both he and the Company contribute).	Fees are determined by the Executive Directors and the Chairman, with the exception of the Chairman’s fee which is determined by the Committee. They are benchmarked against a blend of US and UK companies, similar to those used for benchmarking the Executive Directors’ remuneration (the Mid-Atlantic peer group). In addition, the fees for the Chairman also take into account the anticipated time commitment for the role and experience of the incumbent. Benchmarking of Non-Executive Directors’ fees takes place on an annual basis.

 c) Recruitment remuneration policy

The following table sets out the various components which would be considered for inclusion in the remuneration package for the appointment of an Executive Director and the approach to be adopted by the Committee in respect of each component. The Committee will review this policy as part of the planned 2014 remuneration review, in particular it will reflect further on whether some additional flexibility would be prudent to facilitate the recruitment of a new Executive Director. Any changes envisaged as a result of the 2014 review will be discussed with shareholders and will be included in the recruitment remuneration policy that will be put to shareholders for a binding vote at the 2015 AGM.

Area	Policy and operation
Overall	·The Committee’s approach when considering the overall remuneration arrangements in the recruitment of a member of the Board from an external party is to take account of the Executive Director’s remuneration package in their prior role, the market positioning of the remuneration package, and to not pay more than necessary to facilitate the recruitment of the individual in question.
Fixed elements (Base salary, retirement and other benefits)	·The salary level will be consistent with the Company’s Mid-Atlantic peer group. ·The Executive Director shall be eligible to participate in Shire’s employee benefit plans, including coverage under all executive and employee pension and benefit programs in accordance with the terms and conditions of such plans, as may be amended by the Company in its sole discretion from time to time. ·  The Company may meet certain mobility costs, including relocation support, expatriate allowances, temporary living and transportation expenses in line with the prevailing mobility policy and practice for senior executives.
Short term incentives	·The appointed Executive Director will be eligible to earn a discretionary annual incentive award in accordance with the rules and terms of Shire’s Executive Annual Incentive Plan or successor bonus plan. ·The level of opportunity will be consistent with that stated in Part 2(a) of this report.
Long term incentives	·The Executive Director will be eligible for performance-based equity awards in accordance with the rules and terms of Shire’s Portfolio Share Plan or successor long term incentive plan. ·The quantum will be consistent with that stated in Part 2(a) of this report; the Committee reserves the right to exceed target ranges in exceptional circumstances (within the limits set out in the plan rules).

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Area

Policy and operation

Replacement awards

·The Committee will consider what replacement awards (if any) are reasonably necessary to facilitate the recruitment of a new hire Executive Director in all circumstances. This includes an assessment of the awards and any other compensation or benefits item that would be forfeited on leaving their current employer. ·The Committee will seek to structure any replacement awards such that overall they are not significantly more generous in terms of quantum or vesting period than the awards due to be forfeited. ·In determining quantum and structure of these commitments, the Committee will seek to provide broadly equivalent value and replicate, as far as practicable, the timing and performance requirements of remuneration foregone. ·The Committee will seek to ensure that a meaningful proportion of the replacement awards which are not attributable to long-term incentives foregone will be delivered in Shire deferred shares, released at a later date and subject to continued employment. ·If the Executive Director’s prior employer pays any portion of the remuneration that was deemed foregone, the replacement payments shall be reduced by an equivalent amount. ·Replacement share awards, if used, will be granted using the Company’s existing long term incentive plan to the extent possible, although awards may also be granted outside of this plan if necessary and as permitted under the Listing Rules. ·In the case of an internal hire, any outstanding awards made in relation to the previous role will be allowed to pay out according to their original terms. If promotion is part way through the year, an additional top-up award may be made to bring the Executive Director’s opportunity to a level that is appropriate in the circumstances.

d) Service contracts and termination arrangements

Executive Directors

The Committee’s policy on service contracts and termination arrangements for Executive Directors is set out below. As an overriding principle, it is the Committee's policy that there should be no element of reward for failure. The Committee’s approach when considering payments in the event of termination is to take account of the individual circumstances including the reason for termination, performance, contractual obligations of both parties as well as share plan and pension scheme rules.

Notice period	·The Committee’s policy is that Executive Directors’ service contracts should provide for a notice period of 12 months from the Company and the Executive Director. ·The Committee believes this policy provides an appropriate balance between the need to retain the services of key individuals for the benefit of the business and the need to limit the potential liabilities of the Company in the event of termination. The contracts for Flemming Ornskov and Graham Hetherington do not have a fixed term but provide for a notice period of 12 months in line with this policy. Their contracts are dated October 24, 2012 and July 2, 2008 respectively.
Contractual payments	·Executive Directors’ contracts allow for termination with contractual notice from the Company or termination by way of payment in lieu of notice, at the Company’s discretion. Neither notice nor a payment in lieu of notice will be given in the event of gross misconduct. ·Payments in lieu of notice could potentially include up to 12 months’ base salary and the cash equivalent of 12 months’ pension contributions, car allowance and other contractual benefits. There is no contractual entitlement to annual incentive payments in respect of the notice period - any award is at the Committee’s absolute discretion, performance-related and capped at the contractual target level. ·Payment in lieu of notice would be made where circumstances dictate that the Executive Directors’ services are not required for the full 12 months of their notice period. Contracts also allow for phased payments on termination, which allow for further reduction in payments if the individual finds alternative employment outside of the Company during the notice period.
Retirement benefits	·Normal treatment to apply as governed by the rules of the relevant pension plan; no enhancement for leavers will be made.
Short term incentives	·Where an Executive Director’s employment is terminated after the end of a performance year but before the payment is made, the executive will remain eligible for an annual incentive award for that performance year subject to an assessment based on performance achieved over the period. No award will be made in the event of gross misconduct. ·Where an Executive Director’s employment is terminated during a performance year, a prorata annual incentive award for the period worked in that performance year may be payable subject to an assessment based on performance achieved over the period. ·The Committee’s policy is not to award an annual incentive for any portion of the notice period not served. ·The relevant plan rules provide that any outstanding deferred shares will vest in accordance with the regular vesting period, except for where an Executive Director’s employment is terminated for cause.

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Long term incentives

·The treatment of unvested long term incentive awards is governed by the rules of the relevant incentive plan, as approved by shareholders. ·Where an individual’s employment terminates, the current PSP rules provide for unvested long term incentive awards to lapse except as set out below. ·Under the current PSP rules, where an individual is determined to be a “good” leaver, unvested long term incentive awards vest upon termination subject to performance against applicable performance conditions and, unless the Committee determines otherwise, prorating for time. Any Committee determination will take into account a number of considerations, in particular performance and other circumstances relating to their termination of employment. ·Good leaver reasons include retirement in accordance with the Company’s retirement policy, ill health, injury or disability, and redundancy or in other circumstances that the Committee determines. ·Prorating for time will be calculated on the basis of the number of complete weeks in the relevant period during which the executive was employed (or would have been employed had the executive remained in employment throughout the notice period) as a proportion of the number of complete weeks in the relevant period. ·Where an Executive Director’s employment is terminated or an Executive Director is under notice of termination for any reason at the date of award of any long term incentive awards, no long term incentive awards will be made.

Change in control

·In relation to unvested long term incentive awards, the current PSP rules provide that unvested awards will normally only vest on a change in control to the extent that any performance condition has been satisfied, unless the Committee determines otherwise, and would be reduced where less than 2 years have elapsed from the relevant grant date. ·The Committee’s policy is that contracts of employment should not provide additional compensation on severance as a result of change in control.

External appointments

Executive Directors are permitted to hold external non-executive directorships, subject to prior approval by the Board. Any fees received from such appointments are retained by the Executive Director.

Dr. Ornskov resigned from his position as Non-Executive Chairman of Evotec AG in June 2013. For his services as Non-Executive Chairman from January 1, 2013 to the date of resignation, he was paid fees of €35,048. Mr. Russell is a Non-Executive Director of Intermune, Inc. In respect of this position he was paid fees of $20,000, in respect of such service whilst serving as Chief Executive Officer of Shire plc. Dr. Ornskov and Mr. Russell both retained the fees paid in respect to their external appointments.

Chairman and Non-Executive Directors

Non-Executive Directors have letters of appointment and are appointed by the Board ordinarily for a term of two years. Their initial appointment and any subsequent re-appointment are subject to election, and thereafter annual re-election by shareholders. Non-Executive Directors are not entitled to compensation for loss of office.

Details of the letters of appointment and length of service for each Non-Executive Director are as follows:

Director1	Date of current letter of appointment	Expiry of current term
Matthew Emmens	June 18, 2012	June 17, 2014
David Kappler	April 5, 2012	April 4, 2014
William Burns	March 15, 2012	March 14, 2014
Steven Gillis	October 1, 2012	September 30, 2014
David Ginsburg	June 16, 2012	June 15, 2014
Susan Kilsby	September 1, 2013	August 31, 2015
Anne Minto	June 16, 2012	June 15, 2014
David Stout	October 31, 2013	October 30, 2015
Dominic Blakemore	January 1, 2014	December 31, 2015

1 All Non-Executive Directors are subject to a three-month notice period.

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e) Remuneration scenarios

The composition and value of the Executive Directors’ remuneration packages in three performance scenarios are set out in the charts below. These show that the proportion of the package delivered through long term incentives supports the long term nature of the business and changes significantly across the performance scenarios. The level of remuneration is in accordance with the Executive Director remuneration policy set out in Part 2(a) of this report.

The scenarios are defined as follows:

	Fixed only	On target performance	Maximum performance
Fixed elements	Fixed elements do not vary with performance and comprise: ·2014 annualised base salary; ·Benefits included in the summary of 2013 remunerationtable on page 95 (excluding any one-off items); and ·Retirement benefits is the cash value of the total Company contributions to the Company plans (by way of a contribution and/or by way of a cash allowance). This represents 30% of base salary for the CEO and 25% of base salary for the CFO. These definitions are consistent with the Schedule 8 Regulations.
Short term incentives - EAIP (% of maximum opportunity)	0%	50%	100%
Long term incentives - PSP (% of maximum vesting)1	0%	50% vesting2	100% vesting

1In accordance with the Schedule 8 Regulations, no allowance has been made for share price appreciation. SAR awards are valued with the same Black-Scholes model that is used to determine the share based compensation cost included in the Company’s consolidated statements of income. Any dividend shares receivable have been ignored.

2A level of 50% vesting for ‘on-target’ performance reflects the midpoint of the performance range under the PSP performance matrix, which the Committee believes to be a fair assumption for ‘on-target’ performance.

The Executive Directors’ remuneration package promotes the achievement of superior long term performance and aligns the interests of the Executive Directors with those of shareholders

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f) Shareholder engagement

The Committee takes the views of shareholders very seriously and is committed to ongoing dialogue with the Company’s shareholder base, which has a significant transatlantic element. This can take a variety of forms including meetings with major shareholders to consider significant potential changes to policy or specific issues of interest to particular shareholder groups, other dialogue to update shareholders and receive their feedback on planned refinements to arrangements, and annual voting on the DRR.

In light of the new Schedule 8 Regulations and the first binding vote on remuneration policy scheduled for the 2014 AGM, the Committee carried out a shareholder consultation exercise in late 2013 / early 2014 which included meetings with many of the Company’s largest shareholders as well as key shareholder advisory bodies. Key topics discussed included:

·   Application of the binding policy from January 1, 2015;

·   Approach to key new disclosures such as the recruitment remuneration policy and service contracts and termination arrangements; and

·   Disclosure of prospective and retrospective annual incentive award targets.

These discussions have informed the disclosures in this report, in particular the disclosure of 2013 EAIP outcomes. The Committee is also aware of shareholder views on a number of other issues including holding periods in relation to long term incentives. The Committee will take these views as well as market practice into account during the planned 2014 remuneration review.

g) Remuneration of other employees

The Committee recognises that remuneration has an important role to play in supporting the implementation and achievement of the Company’s strategy and ongoing performance. When making remuneration decisions in respect of the Executive Directors, the Committee is sensitive to pay and employment conditions across the Company, in particular in relation to base salary decisions where the Committee considers the broader employee salary increase budget. The Committee approves the overall annual bonus funding for the Company each year and has oversight over the grant of all PSP awards across the Company. In addition, annual performance for the Executive Directors is measured against the backdrop of the same corporate scorecard that is appropriately cascaded across the organization.

Given Shire’s diverse employee base, employing over 5,000 people in 30 locations, the Committee does not consider it appropriate to consult with employees over the remuneration policy for Executive Directors. However, many of the Company’s employees are shareholders through the Company’s all-employee share plans, and are therefore able to express their views on director remuneration at each general meeting. The Company also periodically carries out an employee engagement survey which provides employees the opportunity to feedback their views on a variety of employment-related matters, including remuneration.

The diagram set out on the following page illustrates how our remuneration policy and arrangements reinforce the achievement of Shire’s success and ensures that executives and employees are focused on delivering the same core objectives.

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The Shire Remuneration Policy

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Part 3 - Annual Report on Remuneration

a) Implementation of Directors’ Remuneration Policy in 2014

In 2014, the Executive Director and Non-Executive Director remuneration policies will be implemented as follows:

Executive Director remuneration policy

Fixed elements - Base salary

Following the year end review, the Committee made the following 2014 base salary decisions (effective January 1, 2014) which are in line with the disclosed policy in Part 2(a) of this report:

	2013 salary	2014 salary	% change
Flemming Ornskov	$1,200,0001	$1,300,000	8.3%
Graham Hetherington	£480,000	£480,000	0%

1 Upon appointment to CEO effective April 30, 2013

Flemming Ornskov: In light of strong corporate performance and excellent leadership, the Committee decided to award Dr. Ornskov a base salary increase of 8.3% to $1,300,000. In accordance with our remuneration policy and the recruitment arrangements disclosed in last year’s DRR, this brings his base salary in line with the median for comparable roles. It is also consistent with the pattern of increases across the organization where strong performers are given above average increases to achieve appropriate market positioning.

Graham Hetherington: The Committee decided that no increase would be applied to Mr. Hetherington’s base salary this year, given his announced departure from the Company on March 1, 2014 (see Graham Hetherington – Departure Arrangements section below for further details).

Fixed elements - Retirement and other benefits

The implementation of policy in relation to pension and benefits is unchanged and in line with the disclosed policy in Part 2(a) of this report.

Short term incentives - EAIP

There is no change to the level of EAIP award opportunity for Executive Directors.

The 2014 EAIP will continue to use a scorecard approach and will be comprised of 75% financial and 25% non-financial performance measures. This weighting recognises the critical importance of financial results to our shareholders, bonus affordability and the important role that non-financial performance plays in the success and growth of the Company. These measures are aligned with and support the budget and strategic focus for 2014 approved by the Board. In particular, for 2014, there is considerable activity related to the One Shire transformation, which is reflected in both the financial and non financial measures below.

The targets themselves are considered to be commercially sensitive on the grounds that disclosure could damage the Company’s commercial interests. However, retrospective disclosure of the targets and performance against them will be provided in next year’s DRR to the extent that they do not remain commercially sensitive at that time. Financial and non financial targets are set at the start of the performance year and are approved by the Committee, which believes the targets are suitably stretching, relevant and measurable. The 2014 corporate scorecard is set out below:

Strategic priorities	Weighting	Financial KPIs
Financial1	75%	·Net product sales ·Non GAAP EBITA ·Non GAAP Adjusted ROIC ·Cost management
Strategic priorities	Weighting	Examples of Non Financial KPIs
Pipeline	15%	·KPIs built around the strategic priority of developing our future assets which will enable us to deliver innovation and value for the future. These include clinical milestones, regulatory filings and other critical pipeline expansion and advancement targets that will support our continued growth and future financial performance
Organizational effectiveness	10%	·Execute against priority actions identified in relation to supporting a high performance culture ·Execute against key financial and non financial success factors in relation to the integration of ViroPharma ·Complete new organization structure

1 Financial targets are underpinned by a series of KPIs relating to our In-Line products

Long term incentives - PSP

Following the year end review, the Committee made the following 2014 PSP award decisions which are in line with the disclosed policy in Part 2(a) of this report:

	Award type	Face value of base award / threshold vesting (% of 2014 salary) (1.0x vesting under performance matrix)	Face value of total award / maximum vesting (% of 2014 salary) (4.0x vesting under performance matrix)	Face value of total award / maximum vesting (000’s) (4.0x vesting under performance matrix)
Flemming Ornskov	SAR	111%	443%	$5,761
	PSA	83%	332%	$4,320

The face value allocation between SARs and PSAs is estimated as it is determined on an expected value basis upon grant.

Given his announced departure from the Company on March 1, 2014, the Committee determined that no 2014 PSP award would be made to Graham Hetherington (see Graham Hetherington – Departure Arrangements section below for further details).

The base award is one quarter of the total award made (1.0x vesting under the matrix) and is payable for threshold performance. There is nil vesting below this performance level. Up to four times the base award (4.0x vesting under the matrix) is payable for maximum performance, which would result in the total award vesting, with straight line vesting within this performance range. In all cases, awards will only vest if the Committee determines that the underlying performance of the Company is sufficient to justify the vesting of the award.

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The Committee reviewed the performance matrix and determined that the structure and performance measures will be retained in their current form for 2014. The performance targets have been adjusted to maintain appropriate alignment with the Company’s current long range plans and strategy, the Company’s weighted average cost of capital and recent broker forecasts. The 2014 performance matrix is set out below:

Non GAAP Adjusted ROIC	Non GAAP EBITDA growth (CAGR 2013-2016)
Change in bp p.a.	9%	10%	11%	12%	13%
-100	1.0x	1.3x	1.7x	2.1x	2.5x
-80	1.3x	1.6x	2.0x	2.4x	2.8x
-60	1.6x	1.9x	2.4x	2.7x	3.1x
-40	1.9x	2.3x	2.6x	3.1x	3.5x
-20	2.2x	2.6x	3.1x	3.6x	4.0x
0	2.5x	3.0x	3.5x	4.0x	4.0x

For Non GAAP EBITDA growth, the Non GAAP EBITDA in the final performance year (2016) is compared to the Non GAAP EBITDA in the reference year (2013). A compound annual growth rate of Non GAAP EBITDA is then calculated. For Non GAAP Adjusted ROIC, the Non GAAP Adjusted ROIC in the final performance year is compared to the Non GAAP Adjusted ROIC in the reference year. The change in these two numbers is then divided by three and expressed in basis points (one hundredth of a percentage point) to give an average per annum change in Non GAAP Adjusted ROIC basis points.

The acquisition of ViroPharma in January 2014 will add approximately $4 billion to the denominator used to calculate Shire’s Non GAAP Adjusted ROIC. As a result, in the short term, including over the measurement period for the 2014 PSP awards, Non GAAP Adjusted ROIC is expected decline from the 15.6%1 achieved in 2013. The performance matrix reflects this, by awarding higher vesting for lower declines in Non GAAP Adjusted ROIC.

Clawback arrangements are in place for awards to cover situations where results are materially misstated or in the event of serious misconduct.

1 Including results from DERMAGRAFT operations

 

Graham Hetherington – Departure Arrangements

Mr. Hetherington has agreed with the Board that he will be stepping down from Shire’s Board of Directors and his role as CFO on March 1, 2014.

In line with the Committee’s policy, the Committee considered the overall circumstances of the departure as well as performance, contractual obligations and plan rules. In particular, the Committee considered Mr. Hetherington’s sustained performance and contribution to the Company over a period of almost six years, the excellent 2013 financial results and confident outlook for 2014. The Committee’s determinations, which are consistent with the Committee’s termination policy, are set out below.

Mr. Hetherington will not receive any payment in respect of salary or benefits (or compensation in lieu) in respect of any period after March 1, 2014 or receive any compensation for loss of office.

As set out above, the Committee determined that no 2014 base salary increase or 2014 PSP grant would be appropriate given Mr. Hetherington’s scheduled departure date. In addition, he will not receive any 2014 short term incentive in respect of his period of employment to, or in respect of any period after, March 1, 2014.

Those elements of Mr. Hetherington’s EAIP awards from previous years that were compulsorily deferred into shares under the EAIP will vest in accordance with the plan rules at the end of the relevant three year vesting periods (see table below).

The Committee determined that the 2012 PSP award will vest on the departure date in line with the terms of the plan rules taking into account the applicable performance conditions and the proportion of the performance period (approximately two thirds) during which Mr. Hetherington remained in employment (see table below). The 2013 PSP awards will lapse on the departure date.

Award	Number of shares under original award1	Number of shares vesting1	Illustrative Share Price2	Estimated value	Vesting / release date
2012 PSP3 (SAR element)	55,554	27,915	£33.68	£319,906	March 1, 2014
2012 PSP3 (PSA element)	40,740	20,471	£33.68	£689,463	March 1, 2014
2011 deferral (2010 EAIP award)	6,504	6,504	£33.68	£219,055	March 31, 2014
2012 deferral (2011 EAIP award)	4,552	4,552	£33.68	£153,311	March 30, 2015
2013 deferral (2012 EAIP award)	4,504	4,504	£33.68	£151,695	March 31, 2016
2014 deferral (2013 EAIP award)	Shares to the value of £106,250 will be purchased on March 31, 2014				March 31, 2017

The release of PSA awards and deferred shares under the EAIP will include dividend shares representing any accrued dividends, in accordance with the relevant plan rules.

1.   Awards are over Ordinary Shares.

2.   Closing share price as at February 21, 2014.

3.   The figures shown above represent the number of shares vesting taking into account the applicable performance conditions (resulting in the vesting of 75% of the shares under the original award) and, in addition, the proportion of the performance period (approximately two thirds) in which Mr. Hetherington remained in employment.

Vested SAR awards will, in accordance with the terms of the PSP, remain exercisable for a period of 12 months after the departure date, and if not exercised will lapse.

All other unvested equity awards, namely the 2013 PSP award and 2013 Sharesave, will lapse when Mr. Hetherington ceases to be employed.

Mr. Hetherington was employed throughout the relevant performance periods for the 2013 EAIP and 2011 PSP, therefore payments under the 2013 EAIP and vesting of the 2011 PSP will be made as normal.

The Committee determined that it would be appropriate to continue the same level of medical cover under the Company’s private medical scheme until December 31, 2014 and to pay his reasonable legal costs incurred in connection with his departure arrangements.

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Chairman and Non-Executive Director remuneration policy

Details of fees levels for 2014 compared to 2013 are set out below. Taking into account market positioning and the need to be able to attract high quality, appropriately qualified individuals, it was agreed to increase the basic fee payable to Non-Executive Directors to £93,000. In addition, the Non-Executive Directors will continue to receive 25% of their total fees in the form of shares. Given his significant shareholding in Shire, the current Chairman will continue to receive his fee in the form of cash only.

Basic fees (effective January 1, 2014)	2014	2013
Chairman (inclusive of all committees)	£390,0001	£390,000
Deputy Chairman and Senior Independent Non-Executive Director (inclusive of Non-Executive Director fee)	£98,000	£98,000
Non-Executive Director	£93,000	£86,400

1 Given that the current Chairman (Matthew Emmens) will retire from the Board at the Company’s AGM on April 29, 2014, no increase will be made to the Chairman’s fee for 2014. The Chairman designate (Susan Kilsby) who will resume the role of Chairman after the conclusion of the AGM will be paid an annualised Chairman fee of £365,000 (effective April 29, 2014) to reflect that she is new in role.

In addition to the basic fee, a committee fee will be paid to the members and Chairman of the following Committees:

Committee fees (effective January 1, 2014)	Chairman		Member
	2014	2013	2014	2013
Audit, Compliance & Risk	£20,000	£20,000	£10,000	£10,000
Remuneration	£18,000	£18,000	£9,000	£9,000
Science & Technology	£15,000	£15,000	£7,500	£7,500
Nomination	£12,500	£12,500	£5,750	£5,750

Non-Executive Directors will also continue to receive an additional fee of £5,000 for each transatlantic trip made for Board meetings.

b) 2013 single total figure of remuneration for Executive Directors

The summary table of 2013 remuneration for the Executive Directors comprises a number of key components which are set out in further detail in the relevant sections that follow.

In both 2012 and 2013, the totals were significantly impacted by share price growth between the PSP grant and vesting dates. This alignment with shareholders and the significant role that long term variable remuneration plays in the overall remuneration package is consistent with our remuneration policy and the long term nature of our business. In relation to 2013, stock price growth on the 2011 PSP awards from £17.23 to £27.00 (the average Ordinary Share price over the last quarter of 2013) accounts for 40% of the total remuneration figure for Mr. Hetherington.

		Fixed elements				Variable elements				Other payments	Total
		Base salary	Retirement benefits	Other benefits	Total fixed pay	Short term incentives - EAIP		Long term incentives - PSP	Total variable pay
						Cash element	Deferred share element
		$'000	$'000	$'000	$'000	$'000	$'000	$'000	$'000	$'000	$'000
Flemming Ornskov	2013	1,071	207	74	1,352	1,200	400	-	1,600	450	3,402
	2012	-	-	-	-	-	-	-	-	-	-
Angus Russell	2013	422	110	99	631	150	50	4,928	5,128	-	5,759
	2012	1,290	387	88	1,765	845	281	10,5391	11,665	-	13,430
		£'000	£'000	£'000	£'000	£'000	£'000	£'000	£'000	£'000	£'000
Graham Hetherington	2013	480	120	28	628	319	106	2,4752	2,900	-	3,528
	2012	465	116	21	602	270	90	2,9343	3,294	-	3,896

Dr. Ornskov's and Mr. Russell's remuneration, which is paid through the US payroll, is reported in US dollars.

Average exchange rates for the year to December 31, 2013 were $1.56:£1.00.

1 Actual vesting value of $10,539,158 is calculated using the closing share price at the date of vesting of $96.29 (March 1, 2013). Estimated vesting value as disclosed in the Company’s 2012 DRR of $9,032,545 was calculated using the average share price over the last quarter of 2012 (in line with the methodology prescribed in the Schedule 8 Regulations).

2 The 2013 vesting value is calculated using the average share price over the last quarter of 2013 of £27.00.

3 Actual vesting value of £2,933,841 is calculated using the closing share price at the date of vesting of £20.75 (March 1, 2013). Estimated vesting value as disclosed in the Company’s 2012 DRR of £2,341,017 was calculated using the average share price over the last quarter of 2012 (in line with the methodology prescribed in the Schedule 8 Regulations).

Base salary

Corresponds to the amounts received during the year

·   Dr. Ornskov’s base salary comprises his CEO designate salary of $900,000 received from January 2, 2013 to April 29, 2013 and his CEO salary of $1,200,000 received upon appointment to CEO from April 30, 2013.

·   Mr. Russell’s base salary comprises his annual salary of $1,290,000 prorated for his worked notice period (January 1, 2013 to April 30, 2013).

·   Mr. Hetherington’s base salary reflects his annual salary of £480,000.

Retirement benefits

Represents the cash value of the total Company contributions towards retirement benefit provision

·   Dr. Ornskov received a contribution at a rate of 30% of his base salary through a combination of contributions to the Company’s 401(k) Plan and credits to his SERP account. In accordance with the terms of the SERP, he received credits on the basis of his CEO designate base salary for the three calendar quarters in 2013 for which he was eligible.

·   Mr. Russell received a similar contribution of 30% of base salary into Company plans in respect of his worked notice period. As part of Mr. Russell’s retirement arrangements, he received a distribution of his SERP account balance, and was eligible to withdraw funds from his deferred UK pension due to his early retirement. These actions were in accordance with the rules of the relevant plan without any form of enhancement being made. The distribution of his SERP account balance has not been included in the retirement benefits figure above as it reflects remuneration paid and disclosed in prior years. However, it has been included in the disclosure in Part 3(e) of this report.

·   Mr. Hetherington received a contribution of 25% of base salary by way of a cash allowance.

Other benefits

Corresponds to the taxable value of all other benefits paid in respect of the year. The 2013 figures for Executive Directors principally include car allowance, financial and tax advisory support, long term disability and life cover and private medical cover

·   For Dr. Ornskov, the 2013 figure also includes $28,519 principally in relation to immigration support and temporary living expenses, in accordance with the Company’s mobility policy and the recruitment arrangements disclosed in last year’s DRR.

·   For Mr. Russell, the 2013 figure includes $58,550 for advice in relation to US and UK tax return preparation and related tax advice, as provided for in his contract.

·   For both Mr. Russell and Mr. Hetherington, the 2012 and 2013 figures include a reimbursement reflecting a lower level of Company paid private medical cover (and dental cover in the case of Mr. Russell) in prior years than provided for in their contracts.

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Short term incentives

Corresponds to the annual incentive award earned under the EAIP in respect of 2013 performance and comprises a cash element (75%) and a deferred share element (25%)

2013 corporate scorecard for Executive Directors

The 2013 EAIP continued to use a scorecard approach with key corporate performance measures supporting Shire’s strategic goals as set out below. The non financial targets are considered by the Company to be commercially sensitive on the grounds that the disclosure of these targets could damage the Company’s commercial interests.

Financial goals:	Net product sales1 - $4.9B (Actual: $4.847B)	Non GAAP operating income1 - $1.6B (Actual: $1.755B)	Non GAAP Adjusted ROIC1 - 14.9% (Actual: 15.6%)
Other strategic priorities:	Strengthening the commercial portfolio	Expanding the development pipeline	Enhancing organizational effectiveness

Performance outcomes

Performance against financial goals:

Net product sales1

·Strong revenues from net product sales in 2013 being up 10% to $4.8 billion; and

·Six of our products delivered double digit growth year on year, with further detail set out in the Product sales section on page 51 and 52.

Non GAAP operating income1

·Non GAAP operating income was up 19% to $1.755 billion (2012: $1.474 billion), demonstrating the progress made against our strategy to grow our business in an efficient manner, delivering value to stakeholders and also giving us the ability to provide more innovative treatments to more patients.

Non GAAP Adjusted ROIC1

·Non GAAP Adjusted ROIC grew by 180 basis points in 2013 over 2012 as higher product sales (up 10%) and continued operating leverage led to an increase in margins.

Performance against other strategic priorities:

Strengthening the commercial portfolio

Strategic priority: Drive optimum performance from our currently marketed products to optimize revenue growth and cash generation.

Achievements against this objective in 2013 include:

·Acquisition of  ViroPharma (adding CINRYZE, prophylactic treatment of Hereditary Angioedema);

·Geographic expansion in Asia (office opened in Japan and presence established in South Korea and China);

·Launch of ELVANSE (marketed as VYVANSE in the US) in a further four European countries; and

·Positive opinion received on the VPRIV Summary of Product Characteristics from the Committee for Medicinal Products for Human Use of the European Medicines Agency.

Expanding the development pipeline

Strategic priority: Build our future assets through both R&D and Business Development to deliver innovation and value for the future.

Achievements against the 2013 objective include:

·Prioritization of the pipeline to focus on the development of innovative specialist medicines that have the best chance of clinical and commercial success together with early stage research in rare diseases;

·Positive top-line results evaluating the efficacy and safety of LDX versus placebo in adults with BED;

·Top-line data results announced from OPUS-2 study for lifitegrast;

·Acquisition of SARcode Bioscience Inc. (Dry Eye Disease); Premacure AB (Retinopathy of Prematurity) and Lotus Tissue Repair, Inc. (Dystrophic Epidermolysis Bullosa); and

·Enrolment of the first patient in its Phase 2 clinical program for VASCUGEL.

Enhancing organizational effectiveness

Achievements against the 2013 objective include:

·Implementation of our revised governance model (In-Line and Pipeline Committees) to ensure enterprise-wide decision making and resource allocation that is overseen by the Executive Committee; and

·Simplification of our business model which has reset our cost base and generated the capacity to invest in future growth.

1 Net product sales / Non GAAP operating income / Non GAAP Adjusted ROIC include results from DERMAGRAFT operations.

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2013 EAIP award decisions

In determining 2013 EAIP awards for the Executive Directors, the Committee considered performance against the key corporate performance measures, including the achievements set out above, as well as performance against personal objectives. The Committee approved the awards set out in the following table.

Executive Director	Award	% of 2013 base salary	% of target opportunity	% of maximum opportunity
Flemming Ornskov1	$1,600,000	145%	162%	81%
Angus Russell2	$200,000	44%	52%	26%
Graham Hetherington	£425,000	89%	111%	55%

EAIP award figures are rounded to the nearest whole percentage.

75% of the award is payable in cash (non-pensionable) and 25% is deferred into shares and released after a period of three years (subject to the participant’s employment not being terminated for cause).

The release of deferred shares will include dividend shares representing any accrued dividends.

1.   Dr. Ornskov’s EAIP opportunity was based on his prevailing salary for periods in the CEO designate and CEO role during 2013.

2.   The Committee had previously determined that Mr. Russell should receive no EAIP award relating to the portion of his contractual notice period not served. The EAIP award therefore reflects time proration and an assessment of performance to the date of his retirement. The figures in the table above are expressed as percentages of actual 2013 base salary (the value included in the 2013 summary remuneration table) and the EAIP opportunity actually available taking into account the portion of his contractual notice period served in 2013. This EAIP award is also set out in Part 3(e) in the context of Angus Russell’s retirements arrangements.

Long term incentives

The value represents the market value of the 2011 PSP awards for Graham Hetherington (vesting in February 2014) and the market value of the 2011 and 2012 PSP awards for Angus Russell that vested following his retirement.

In accordance with the Schedule 8 Regulations, the summary of 2013 remuneration figure includes the value of the 2011 PSP awards (performance period 2010 - 2013), which vest in February 2014. For Angus Russell, the 2013 remuneration figure includes both the value of his 2011 and 2012 PSP awards, which vested on June 5, 2013 following an assessment of performance to his retirement date by the Committee in accordance with the PSP plan rules.

As previously disclosed, the Committee reserves the right to make adjustments to the performance conditions to reflect significant one off items which occur during the performance period. In respect of the 2011 PSP awards, the Committee carried out a comprehensive review of potential adjusting events (SAEs) against pre-existing guidelines.

Consistent with the adjustments made in respect of the 2010 PSP awards (as disclosed in last year’s DRR), the Committee determined that the same two 2012 SAE adjustments would be appropriate for the 2011 PSP awards:

1.   To exclude the impact of the acquisition of Advanced BioHealing which had a short term negative impact on Non GAAP EBITDA and Non GAAP Adjusted ROIC performance in 2013. This acquisition was completed in June 2011 after the 2011 performance matrix had been set and led to the creation of a new Regenerative Medicine business unit centered around the DERMAGRAFT product. In line with our refined strategy to prioritize investments that have the greatest clinical and commercial value, the Company subsequently announced on January 17, 2014 that it had sold its DERMAGRAFT assets. Without DERMAGRAFT and its assets, Regenerative Medicine will no longer be one of the Company’s Business Units; and

2.   To exclude the impact of the Japanese tsunami on Fosrenol sales in that market which benefited Shire’s Non GAAP EBITDA and Non GAAP Adjusted ROIC performance in 2012: The Company’s royalty and licensing revenue for Fosrenol benefited from increased sales made by the Company’s partner in Japan, following the Tsunami which disrupted a key competitor’s supply chain.

The Committee noted that these adjustments did not in fact result in a change in the vesting outcome under the performance conditions applicable to the 2011 PSP awards (either individually or taken together).

Graham Hetherington - vesting of 2011 PSP awards

The table below sets out a summary of the performance outcome and the resulting gross estimated vesting value for the 2011 PSP awards for Mr. Hetherington. This estimate is on the basis of an average share price over the last quarter of 2013 of £27.00, given that the 2011 PSP awards (2011 - 2014 performance period) vest following the date of this report. There is no scheduled vesting of PSP awards for Dr. Ornskov until 2016 when his 2013 PSP awards (2013 - 2016 performance period) vest subject to the achievement of applicable performance conditions.

Performance conditions	Performance outcome	Resulting estimated vesting
2011 performance matrix: Performance period ended on December 31, 2013 with vesting in February 2014.	18.2%1 CAGR in Non GAAP EBITDA; and 220 bp1 p.a. increase in Non GAAP Adjusted ROIC, between 2010 and 2013. Resulting in a vesting multiplier of 4.0x. (100% of the total award made)	£2,475,272 (value included in 2013 summary remuneration table)

1 Excluding results for DERMAGRAFT operations.

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Angus Russell - vesting of 2011 and 2012 PSP awards

Under the PSP rules approved by shareholders in respect of a retiree, unvested share awards vest on retirement on a prorata basis and subject to the early assessment of performance against the relevant performance conditions, which were measured as at the date of retirement. This treatment was applied to Mr. Russell’s outstanding 2011 and 2012 PSP grants.

Angus Russell - Performance outcome for the 2011 and 2012 PSP awards

For the 2011 and 2012 PSP awards, performance was assessed over the period from the grant date up until April 30, 2013 (being the date of retirement) with the awards vesting on June 5, 2013.

In respect of the 2011 PSP awards, the Committee concluded that the same two 2012 SAE adjustments would be appropriate for Mr. Russell. These SAEs were not relevant to Mr. Russell’s 2012 PSP awards as the events were known at the time of setting targets for the 2012 PSP awards.

Taking into account performance against the performance matrices as well as an overall assessment of the underlying performance of the Company, the Committee determined that, in respect of the 2011 and 2012 PSP awards, an aggregate number of shares with a value on the date of vesting of $4,928,432 would vest.

Other payments

Represents the value of any other payments received during the year

·   Dr. Ornskov received a cash award of $450,000 to replace cash payments foregone from his former employment. This award forms part of his recruitment arrangements previously disclosed.

c) 2013 single total figure of remuneration for the Chairman and Non-Executive Directors

Details of the total fees paid to the Chairman and Non-Executive Directors during 2013 are set out in the table below.

	Date of current letter of appointment	Board fees		Committee fees				Total 2013 fees	Total 2012 fees
		Basic fee	Additional fees1	Remuneration Committee	Audit, Compliance & Risk Committee	Nomination Committee	Science & Technology Committee
Matthew Emmens2	June 18, 2012	£407,782	£15,000	-	-	-	-	£422,782	£395,135
David Kappler3	April 5, 2012	£98,000	£10,000		£13,086	£12,500	-	£133,586	£135,000
William Burns4	March 15, 2012	£86,400	£10,000	£9,000	-	£5,750	£7,500	£118,650	£109,212
Steven Gillis5	October 1, 2012	£88,868	£15,000	£9,000	-	-	£7,500	£120,368	£28,750
David Ginsburg6	June 16, 2012	£86,400	£15,000	-	-	-	£11,250	£112,650	£102,500
Susan Kilsby3	September 1, 2013	£86,400	£10,000	-	£13,086	-	-	£109,486	£100,000
Anne Minto7	June 16, 2012	£86,400	£10,000	£18,000	-	£5,750	-	£120,150	£109,474
David Stout	October 31, 2013	£86,400	£15,000	£9,000	£10,000	-	-	£120,400	£112,500

1.   Non-Executive Directors receive an additional fee of £5,000 for each transatlantic trip made for Board meetings.

2.   Mr. Emmen’s 2012 and 2013 fees include private medical insurance.

3.   Ms Kilsby succeeded Mr. Kappler as Chair of the Audit, Compliance & Risk Committee on May 2, 2013. Mr. Kappler remains a member of the Audit, Compliance & Risk Committee.

4.   Mr. Burns was appointed as a member of the Science & Technology Committee on February 8, 2012.

5.   Dr. Gillis was appointed as a Non-Executive Director and as a member of the Remuneration Committee and the Science & Technology Committee on October 1, 2012. His 2013 fees include an amount in relation to adjusting taxes paid on historical fees.

6.   Dr. Ginsburg was appointed Chair of the Science & Technology Committee on May 2, 2013.

7.   Ms Minto was appointed as a member of the Nomination Committee on February 8, 2012.

d) Executive Directors’ interests under long term incentives awarded during 2013

The following tables set out details of the PSA and SAR awards granted to Executive Directors under the PSP during 2013. Vesting of the 2013 PSP awards will be determined by the Committee in Q1 2016 taking into account performance against the 2013 performance matrix and any SAEs that are relevant, as well as an overall assessment of the underlying performance of the Company.

2013 PSP awards:

2013 PSP awards	Award type	Share price on grant / Exercise price	Face value of base award / threshold vesting (% of 2013 salary)	Face value of total award /  maximum vesting (% of 2013 salary)	Face value of total award /  maximum vesting ('000)
Flemming Ornskov1	SAR2	$95.04	90%	361%	$4,334
	PSA2		68%	271%	$3,250
Graham Hetherington	SAR	£20.88	73%	290%	£1,393
	PSA		53%	213%	£1,021

2013 Performance matrix:

Non GAAP Adjusted ROIC	Non GAAP EBITDA growth (CAGR 2012-2015)
Increase bp p.a.	10%	12%	14%	16%	18%
100	1.0x	1.3x	1.7x	2.1x	2.5x
120	1.3x	1.6x	2.0x	2.4x	2.8x
140	1.6x	1.9x	2.4x	2.7x	3.1x
160	1.9x	2.3x	2.6x	3.1x	3.5x
180	2.2x	2.6x	3.1x	3.6x	4.0x
200	2.5x	3.0x	3.5x	4.0x	4.0x

The base award is one quarter of the total award made (1.0x vesting under the matrix) and is payable for threshold performance. There is nil vesting below this performance level. Up to four times the base award (4.0x vesting under the matrix) is payable for maximum performance, which would result in the total award vesting, with straight line vesting within this performance range.

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The same definitions and measurement approach apply for the following performance matrices as set out in the earlier policy section of this report.

The maximum SAR and PSA awards are granted and, subject to the achievement of performance conditions, adjusted at the date of vesting.

The number of SARs and PSAs as well as the exercise price for SAR awards is calculated using an approach based on the average three-day closing mid-market share price at the time of grant.

1.   Based on Dr. Ornskov's 2013 annualised CEO base salary.

2.  Denotes an award over ADS. One ADS is equal to three Ordinary Shares.  All other awards are over Ordinary Shares.

e) Retirement arrangements for Angus Russell

As disclosed in last year’s DRR, the following tables set out the payments received by Angus Russell in respect of his retirement arrangements. All payments have been made in accordance with the Company’s policy on termination arrangements as set out in Part 2(d) of this report. Details of the performance conditions for the EAIP and PSP awards and performance against these conditions are contained in the relevant sections above. Where relevant, the amounts have been included in the 2013 summary of remuneration table.

Remuneration in respect of qualifying services	Amount	Description
Short term incentives - EAIP
EAIP payment in respect of 2013 performance	$200,0001	Reflects a time prorated award for January to April 2013 (the “worked” notice period). This is comprised of a cash element (75% of the award) and a deferred share element (25% of the award) which is deferred into shares in the normal way. Further details of the performance outcome are set out on pages 96 and 97. Those elements of Mr. Russell’s EAIP awards from previous years that were compulsorily deferred into shares under the EAIP will vest in accordance with the plan rules at the end of the relevant three-year vesting periods.
Long term incentives - PSP
2011 PSP award & 2012 PSP award	$4,928,4321	Awards prorated through the end of the unworked notice period in accordance with the plan rules. The value is based on the final level of vesting set out on page 98 as determined by the Committee and has been calculated using the share price on the date of vesting (June 5, 2013). In determining the vesting level of these awards, the Committee took account of performance against the performance matrices as well as an overall assessment of the underlying performance of the Company. The plan rule provisions relating to retirement have been applied in respect of all unexercised SAR awards previously granted to Mr. Russell under the PSP. These require the SARs to be exercised within 12 months of retirement.
Other payments	Amount	Description
Payment in lieu of notice
Contractual payment in lieu of the remainder of the contractual notice period	$866,686	Payment represents six months’ salary ($645,000), SERP contribution (30% of base for relevant period) ($193,500), car allowance ($14,580) and other contractual benefits ($13,606).
Retirement benefits
SERP balance	$1,410,207	Reflects remuneration paid and disclosed in prior years. Specifically, this amount represents a distribution of his SERP account balance in accordance with the rules of the plan.

1 Value included in 2013 summary remuneration table.

f) Payments to past Directors

No payments (other the payments made to Angus Russell set out above) have been made to past Directors for the relevant financial year for the purposes of the Schedule 8 Regulations.

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g) Directors’ shareholdings and scheme interests

Employee share ownership is an important means to support alignment of employee interests with those of shareholders

The Committee believes that employee share ownership is an important means to support long term commitment to the Company and the alignment of employee interests with those of shareholders.

The interests of the Executive Directors and other senior executives are closely aligned with those of other shareholders in this regard through the operation of the Company’s long term incentive plan and, for the Executive Committee, the deferral of one quarter of any EAIP award into shares for a period of three years. These remuneration elements constitute a significant proportion of their individual remuneration packages.

The CEO, CFO and other members of the Executive Committee are encouraged to own shares in the Company equivalent to 200%, 150% and 100% of base salary, respectively, within a five-year period following their appointment. All shares beneficially owned by an executive or deferred under the EAIP count towards achieving these guidelines. The Committee reviews share ownership levels annually for this group. Current shareholding levels for Directors are set out in the table below.

Summary of Directors’ shareholdings and scheme interests

	Security type 1	Shareholding as at Dec 31, 20132	Scheme interests as at Dec 31, 20132					Total shares held which count towards the shareholding guidelines (as a % of 2013 salary)
			Total Deferred shares3	Total PSAs unvested4	Total SARs / Options unvested5	Total SARs / Options vested but unexercised6	Total scheme interests
Flemming Ornskov	ADS	-	15,286	44,482	64,585	-	124,353	69%
	Ord Shares	22,000	-	-	-	-	-
Angus Russell7	ADS	45,936	10,024	83,240	110,987	105,616	309,867	1,237%
	Ord Shares	261,991	-	-	-	-
Graham Hetherington	Ord Shares	92,089	15,560	150,428	205,602	134,814	506,404	514%
Matthew Emmens	ADS	6,289	-	-	-	-	-	-
	Ord Shares	92,874	-	-	-	-	-
David Kappler	Ord Shares	11,016	-	-	-	-	-	-
Anne Minto	Ord Shares	3,206	-	-	-	-	-	-
William Burns	Ord Shares	975	-	-	-	-	-	-
Steven Gillis	ADS	309	-	-	-	-	-	-
David Ginsburg	ADS	297	-	-	-	-	-	-
Susan Kilsby	ADS	289	-	-	-	-	-	-
David Stout	ADS	307	-	-	-	-	-	-

1   One ADS is equal to three Ordinary Shares.

2   With the exception of Mr. Emmens and Mr. Hetherington selling 36,100 and 40,000 Ordinary Shares respectively, there were no changes in shareholdings in the period from December 31, 2013 and February 24, 2014.

3   This represents unvested shares deferred under the EAIP plan which are forfeited in the case of termination for cause and, in the case of Dr. Ornskov, deferred shares granted to him which are subject to continued service.

4   This represents unvested PSAs which are subject to the achievement of performance conditions, adjusted at the date of vesting.

5   This represents unvested SARs which are subject to the achievement of performance conditions, adjusted at the date of vesting and options granted under the Shire Sharesave Scheme.

6   This represents vested SARs which are no longer subject to the achievement of performance conditions, but are unexercised as at December 31, 2013.

7   All information is presented as at April 30, 2013 (being the date of Mr. Russell’s retirement).

The Company also operates broad-based share plans (a Sharesave scheme in the UK and an ESPP in the US and other countries) to encourage wider share ownership among the Company’s employees.

Awards under the Company’s long term incentive plans and broad-based share plans are satisfied either by market purchased shares which are held in an employee benefit trust or the issue of new shares within the limits agreed by shareholders when the plans were approved. These limits comply with the Association of British Insurers’ guidelines which require that no more than 10% of a company’s issued share capital may be used for employee share plans in any 10-year period. Within the 10% limit, up to 5% may be used for discretionary employee share plans under these guidelines.

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Directors’ scheme interests

Details of Directors’ interests under share based plans which were outstanding, awarded, lapsed or exercised during the year are set out in the table below. The market price of the Company’s Ordinary Shares at December 31, 2013 was £28.52 and the range during the year was £18.53 to £29.39. The market price of the Company’s ADSs at December 31, 2013 was $141.29 and the range during the year was $86.01 to $141.29.

Award type1	Date of award	As at Jan 1, 2013	Shares awarded2,3	Dividend shares4	Lapsed	Exercised / released	At Dec 31, 2013	Share price on grant / Exercise price5	Share price on exercise / release	Normal exercise period/ vesting date
Flemming Ornskov6
SAR (ADS)	Feb 28, 2013	-	45,601	-	-	-	45,601	$95.04	-	Feb 28, 2016 to Feb 28, 2020
PSA (ADS)	Feb 28, 2013	-	34,201	-	-	-	34,201	$93.66	-	Feb 28, 2016
SAR (ADS)	May 2, 2013	-	18,984	-	-	-	18,984	$91.59	-	May 2, 2016 to May 2, 2020
PSA (ADS)	May 2, 2013	-	10,281	-	-	-	10,281	$87.75	-	May 2, 2016
Deferred Shares (ADS)	May 2, 2013	-	15,286	-	-	-	15,286	$87.75	-	Feb 28, 2015
Angus Russell7
SAR (ADS)	Mar 01, 2010	105,616	-	-	-	-	105,616	$64.91	-	Mar 01, 2013 to Mar 01, 2017
PSA (ADS)	Mar 01, 2010	73,948	-	1,085	-	75,033	-	$64.91	$96.29	Mar 01, 2013
EAIP (ADS)	Mar 31, 2010	7,421	-	-	-	7,421	-	$66.01	$91.03	Mar 31, 2013
SAR (ADS)7	Feb 28, 2011	63,126	-	-	-	-	63,126	$83.79	-	Feb 28, 2014 to Feb 28, 2018
PSA (ADS)7	Feb 28, 2011	47,344	-	-	-	-	47,344	$85.01	-	Feb 28, 2014
EAIP (ADS)	Mar 31, 2011	3,994	-	-	-	-	3,994	$87.03	-	Mar 31, 2014
SAR (ADS)7	Feb 28, 2012	47,861	-	-	-	-	47,861	$105.50	-	Feb 28, 2015 to Feb 28, 2019
PSA (ADS)7	Feb 28, 2012	35,896	-	-	-	-	35,896	$105.53	-	Feb 28, 2015
EAIP (ADS)	Mar 30, 2012	2,907	-	-	-	-	2,907	$94.75	-	Mar 30, 2015
EAIP (ADS)	Mar 31, 2013		3,123	-	-	-	3,123	$90.00	-	Mar 31, 2016
Graham Hetherington
SAR	Mar 01, 2010	134,814	-	-	-	-	134,814	£14.43	-	Mar 01, 2013 to Mar 01, 2017
PSA	Mar 01, 2010	98,864	-	450	-	100,314	-	£14.43	£20.75	Mar 01, 2013
EAIP	Mar 31, 2010	12,569	-	-	-	12,569	-	£14.54	£19.87	Mar 31, 2013
SAR	Feb 28, 2011	82,873	-	-	-	-	82,873	£17.23	-	Feb 28, 2014 to Feb 28, 2018
PSA	Feb 28, 2011	60,769	-	-	-	-	60,769	£17.41	-	Feb 28, 2014
EAIP	Mar 31, 2011	6,504	-	-	-	-	6,504	£18.11	-	Mar 31, 2014
SAR	Feb 28, 2012	55,554	-	-	-	-	55,554	£22.22	-	Feb 28, 2015 to Feb 28, 2019
PSA	Feb 28, 2012	40,740	-	-	-	-	40,740	£22.16	-	Feb 28, 2015
EAIP	Mar 30, 2012	4,552	-	-	-	-	4,552	£20.20	-	Mar 30, 2015
SAR	Feb 28, 2013	-	66,708	-	-	-	66,708	£20.88	-	Feb 28, 2016 to Feb 28, 2020
PSA	Feb 28, 2013	-	48,919	-	-	-	48,919	£20.65	-	Feb 28, 2016
EAIP	Mar 31, 2013	-	4,504	-	-	-	4,504	£19.94	-	Mar 31, 2016
Sharesave	Sep 28, 2013	-	467	-	-	-	467	£19.24	-	Dec 1, 2016 to May 31, 2017

The number of PSA and SAR awards granted in 2011 and subsequently is calculated using an approach based on the average three day closing mid-market share price at the time of grant. The number of PSA and SAR awards granted in 2010 is calculated using an approach based on the average closing mid-market share price over the prior 12 month period.

1.   Awards are over Ordinary Shares, except where the award type is marked as an ADS award. One ADS is equal to three Ordinary Shares.

2.   The maximum SAR and PSA awards are granted and, subject to the achievement of performance conditions, adjusted at the date of vesting.

3.   Performance conditions attached to SAR and PSA awards granted from 2010 onwards are Non GAAP Adjusted ROIC and Non GAAP EBITDA. Further information on the 2011 and 2013 performance matrices can be found on pages 97 and 98 respectively. For reference, the performance matrices for the 2010 and 2012 awards are set out below. In all cases, awards will only vest if the Committee determines that the underlying performance of the Company is sufficient to justify the vesting of the award.

2010 performance matrix						2012 performance matrix
Non GAAP Adjusted ROIC	Non GAAP EBITDA growth (CAGR 2009-2012)					Non GAAP Adjusted ROIC	Non GAAP EBITDA growth (CAGR 2011-2014)
Increase bp p.a.	8%	10%	12%	14%	16%	Increase bp p.a.	8%	10%	12%	14%	16%
10	1.0x	1.3x	1.7x	2.1x	2.5x	60	1.0x	1.3x	1.7x	2.1x	2.5x
20	1.3x	1.6x	2.0x	2.4x	2.8x	80	1.3x	1.6x	2.0x	2.4x	2.8x
40	1.6x	1.9x	2.4x	2.7x	3.1x	100	1.6x	1.9x	2.4x	2.7x	3.1x
60	1.9x	2.3x	2.6x	3.1x	3.5x	120	1.9x	2.3x	2.6x	3.1x	3.5x
80	2.2x	2.6x	3.1x	3.6x	4.0x	140	2.2x	2.6x	3.1x	3.6x	4.0x
100	2.5x	3.0x	3.5x	4.0x	4.0x	160	2.5x	3.0x	3.5x	4.0x	4.0x

4.   In accordance with the plan rules, the vested PSA awards have been increased to reflect the dividends paid by Shire in the period from the grant date to the vesting date.

5.   The exercise price for SAR awards granted in 2011 and subsequently is equal to the three day average, up to and including the date of award, of the closing mid-market share price. The exercise price for SAR awards granted in 2010 is the closing mid-market share price on the date of award. The grant price for all PSA awards is the closing mid-market share price on the date of award.

6.   On November 1, 2013, Dr. Ornskov was granted an option over ADSs pursuant to the Shire ESPP. Dr. Ornskov elected to save $480.76 per fortnight. In accordance with the plan rules, the option price is the lower of 85% of the fair market value of an ADS on November 1, 2013, and 85% of the fair market value of an ADS on the exercise date, October 31, 2014.

7.   All information is presented as at April 30, 2013 (being the date of Mr. Russell’s retirement). The 2011 and 2012 PSP awards vested on June 5, 2013 following Mr. Russell’s retirement. The vesting outcome is set out on page 98 of this report.

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h) TSR performance graph

The graph below shows the Total Shareholder Return (TSR) for Shire and the FTSE 100 Index over the five year period ending December 31, 2013. TSR is calculated as the change (indexed) between the fourth quarter TSR in the relevant year and the base year. The FTSE 100 Index reflects the 100 largest quoted companies by market capitalisation in the United Kingdom and has been chosen because the FTSE 100 represents the broad market Index within which the Company’s shares are traded.

Total Shareholder Return - change in value of a hypothetical £100 holding over five years

Rebased to 100 (GBP)

The historical total remuneration for the person undertaking the role of CEO is set out in the table below.

	2009	2010	2011	2012	2013
					Dr. Ornskov	Mr. Russell
Short term incentive (% of maximum)	70%	65%	50%	48%	81%	26%
Long term incentive (% of maximum)	84%	88%	100%	100%	-	50%
Total remuneration ($’000)	$4,781	$9,634	$17,506	$13,430	$3,402	$5,759

These calculations are based on the methodology prescribed in the Schedule 8 Regulations. In particular, the long term incentive figures relate to any awards that vest following the end of each financial year.

i) Percentage change in CEO remuneration

The following table shows the percentage change in the base salary, taxable benefits and annual bonus of the CEO between the current and previous financial year compared to the average percentage change for all other employees.

	Percentage change between 2012 to 2013
	Salary and fees	Taxable benefits	Short term incentives
CEO1	-17%	-16%	+42%
All other employees2	+6%	0%	+45%

1 Reflects the 2012 remuneration for Angus Russell and 2013 remuneration for Flemming Ornskov as reported in the single total figure of remuneration table in section 3(a).

2Reflects the average change in remuneration for all other employees globally that were annual bonus eligible. To help minimise distortions in the underlying data, certain adjustments have been made, in particular the figures have been prepared on the basis of permanent employees who have been employed with the Company for the two preceding calendar years.

j) Relative importance of spend on pay

The Company considers employee remuneration costs in the context of the general financial performance and position of the Company, including when determining the annual salary increase budget, the annual equity grant budget and annual bonus funding for the organization.

The following graphs set out for 2012 and 2013 the overall spend on pay, shareholder distributions (dividends and share buybacks) and for further context, Non GAAP EBITDA (from continuing operations).

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k) Remuneration Committee

Terms of reference

The Committee is responsible for agreeing the broad remuneration policy for the organization and the individual packages for the Chairman, Executive Directors, and certain other senior leadership roles. Within the agreed policy, the Committee determines the terms and conditions to be included in service agreements, including termination payments and compensation commitments, where applicable. The Committee also determines performance targets applicable to the Company’s annual bonus and long term incentive plans, and has oversight of the Company’s share incentive schemes. In October 2013, the Committee reviewed its terms of reference and a number of minor changes were made to reflect various governance developments. The revised terms of reference were approved by the Board in December 2013 and are available in full on the Company’s website www.shire.com. Other information included on or accessible through our website does not constitute a part of this report and the reference to our website does not constitute incorporation by reference of such information, and should not be relied upon.

Membership and attendance

The Board considers all members of the Committee to be independent. The Directors in the table below served as members of the Committee during the period within which remuneration for the relevant financial year was under consideration.

Committee member	Meeting attendance1
Anne Minto (Chairman)	7(7)
William Burns	7(7)
Steven Gillis	7(7)
David Stout	7(7)

The number in brackets denotes the number of meetings that Committee members were eligible to attend.

1There were five scheduled and two ad hoc Committee meetings held during 2013.

The Chairman and the CEO attend meetings of the Committee by invitation, but neither is present in any discussions relating to their own remuneration.

Remuneration Committee activities in 2013

In 2013, the Committee discussed the key agenda items set out in the following table:

Key agenda items
Overall remuneration	·Approval of 2012 performance and remuneration decisions for the CEO, CEO designate, CFO and the Executive Committee ·Approval of final retirement arrangements for the former CEO ·Review of the 2013 year end compensation process and budgets for all employees ·Preliminary discussion of 2013 performance and remuneration decisions for the CEO, CFO and the Executive Committee
Short term incentives	·Assessment of Company performance against the 2012 annual bonus funding scorecard ·Approval of the 2013 corporate scorecard ·Preliminary review of the 2014 corporate scorecard
Long term incentives	·Determination of the vesting percentage of the 2010 PSP awards granted under the PSP for Executive Directors ·Approval of the 2013 performance matrix for PSP awards to Executive Directors ·Approval of annual offerings of Sharesave and ESPP awards ·Approval of the vesting outcome for Angus Russell’s 2011 and 2012 PSP awards ·Preliminary review of the 2014 performance matrix for PSP awards to Executive Directors ·Consideration of potential SAEs in relation to outstanding PSP performance cycles
Governance and other matters	·Approval of the 2012 DRR ·Consideration of trends in executive remuneration and corporate governance developments ·Preparation of preliminary 2013 DRR including consideration of the Schedule 8 Regulations and review of shareholder and proxy advisory firm feedback on the 2012 DRR ·Approval of approach to Autumn shareholder consultation exercise and review of shareholder and proxy advisory firm feedback ·Review of the Committee’s term of reference ·Review of the CEO, CFO and the Executive Committee’s shareholdings

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Shareholder context for the Committee’s activities

The table below shows how shareholders voted on the advisory vote in relation to the 2012 DRR at the AGM on April 30, 2013. This endorsement of the current remuneration approach informed the Committee’s activities and decision-making in 2013.

For (including discretionary votes)	%	Against	%	Votes cast as a % of relevant shares in issue	Withheld1
361,222,372	96.26%	14,042,536	3.74%	67.56%	12,225,569

1 Votes withheld are not a vote in law and are not counted in the calculation of the proportion of votes validly cast.

Advisors

In discharging its responsibilities in 2013, the Committee was materially assisted by those employees performing the roles of Human Resources Director and Vice President, Total Rewards. In addition, PricewaterhouseCoopers LLP (PwC), appointed by the Committee, continued to serve as independent external advisor to the Committee, following a competitive tendering process in early 2012. PwC also provided global consultancy services to the Company in 2013, primarily in respect of tax matters. Fees paid to PwC in relation to remuneration services provided to the Committee, totalled £201,200 in 2013 and were determined based on the scope and nature of the projects undertaken for the Committee.

The Committee is satisfied that the advice received by PwC in relation to executive remuneration matters during the year was independent. The Committee reviewed the potential for conflicts of interest and judged that there were appropriate safeguards against any potential conflicts. PwC is a member of the Remuneration Consultants’ Group which operates a code of conduct in relation to executive remuneration consulting in the UK.

Approval

This report was approved by the Board on February 24, 2014 and signed on its behalf by:

Anne Minto

Chairman of the Remuneration Committee

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Non GAAP measures used in the Directors’ Remuneration Report

The Directors’ Remuneration Report contains financial measures not prepared in accordance with US GAAP. These measures are referred to as “Non GAAP” measures and include “Non GAAP EBITDA”, “EBITDA Growth”, and “Non GAAP operating income from continuing operations”. Non GAAP measures exclude the effect of certain cash and non-cash items, which Shire's management believes are not related to the core performance of Shire’s business. Shire’s Remuneration Committee uses these Non GAAP measures when assessing the performance and compensation of employees, including Shire’s Executive Directors. The most directly comparable measure under US GAAP for Non GAAP EBITDA and Non GAAP Operating Income from continuing operations is US GAAP Net Income.

The following table reconciles US GAAP Net Income to Non GAAP EBITDA:

	For the Year Ended December 31,			For the Year Ended December 31,			For the Year Ended December, 31
	(US$ in millions)
	2013			2012			2011
US GAAP  Net Income		665.1			745.4			865.0
(Deduct) / add back:
Loss from discontinued operations net of tax		754.5			60.3			17.7
Equity in earnings of equity method investees, net of taxes		(3.9	)		(1.0	)		(2.5	)
Income taxes		277.9			203.1			236.9
Other expense/ (income), net		3.9			2.2			(18.5	)
Interest expense		38.1			38.2			39.1
Interest income		(2.1	)		(3.0	)		(1.9	)
US GAAP Operating Income from continuing operations		1,733.5			1,045.2			1,135.8
Amortization		152.0			153.6			145.0
Depreciation		127.6			109.0			119.5
Asset impairments		27.0			197.9			16.0
Integration and acquisition costs		(134.1	)		36.5			0.1
Divestments, reorganizations and discontinued operations		72.3			(18.1	)		41.6
Legal and litigation costs		9.0			94.1			-
Non GAAP EBITDA		1987.3			1,618.2			1,458.0
Depreciation		(127.6	)		(109.0	)		(119.5	)
Non GAAP Operating Income from continuing operations		1,859.7			1,509.2			1,338.5

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ITEM 12: Security ownership of certain beneficial owners and management and related stockholder matters

Set forth in the following table is the beneficial ownership of ordinary shares on February 14, 2014 for (i) each person (or group of affiliated persons) known to the Company to be the beneficial owner of more than 5% of ordinary shares, (ii) all current directors, and (iii) all current directors and executive officers of the Company as a group.  As a foreign private issuer incorporated in Jersey (Channel Islands) with its principal listing on the London Stock Exchange, Shire follows its “home country” regulations with respect to executive compensation disclosure in Item 11 of this annual report on Form 10-K and is not required thereunder to identify any “named executive officers”. Except as indicated by the notes to the following table, the holders listed below have sole voting power and investment power over the shares beneficially held by them. The address of each of Shire’s directors and executive officers is that of Shire.

Name	Number of ordinary shares beneficially owned on February 14, 2014		Percent of ordinary shares (1)
Beneficial owner
BlackRock Inc. - 40 East 52nd Street, New York NY 10022		54,030,642		9.2	%
Management
Matthew Emmens		110,490		*
Susan Kilsby		867		-
Dr. Flemming Ornskov		22,000		*
Graham Hetherington (2)		226,992		*
David Kappler		11,016		-
Dominic Blakemore		-		-
William Burns		975		*
Dr. Steven Gillis		927		*
Dr David Ginsburg		891		*
Anne Minto		3,206		*
David Stout		921		*
All Directors and Executive Officers of the Company (11 persons)		378,285		*

* Less than 1%

1.   For the purposes of this table, a person or a group of persons is deemed to have “beneficial ownership” of any shares, which that person has the right to acquire as of April 14, 2014 (being 60 days after February 14, 2014) through the release of restricted shares and the exercise of any vested stock options and awards.

2.   Includes 87,744 restricted shares and 47,159 shares that could be acquired upon the exercise of vested but unexercised Stock Appreciation Right awards, assuming a share price of £32.19, the closing price on February 14, 2014.

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Equity Compensation Plan Information

Set forth in the following table are the details, for the year to December 31, 2013, in respect of compensation plans (including individual compensation arrangements) under which equity securities of the Company are authorized for issuance.

Plan category	Number of securities to be issued upon exercise of outstanding equity awards		Weighted-average price of outstanding equity awards		Number of securities remaining available for future issuance under equity compensation plans(1)
	(a)		(b)		(c)
Equity compensation plans approved by security holders		17,730,481		18.84		6,410,625
Equity compensation plans not approved by security holders		-		-		-
Total		17,730,481				6,410,625

(1) This number reflects the maximum number of ordinary shares remaining available for issuance (excluding the number of ordinary shares reflected in column (a)) upon the exercise of options that may be issued under the Shire Employee Stock Purchase Plan.  In addition, certain of the Company’s plans provide for the award of options, share appreciation rights (“SARs”) and performance shares awards (“PSAs”) without limitation of the number of shares that can be awarded.

ITEM 13: Certain relationships and related transactions

None.

ITEM 14: Principal accountant fees and services

The Audit, Compliance & Risk Committee reviews the scope and results of the audit and non-audit services, including tax advisory and compliance services, provided by the Company’s Independent Registered Public Accountants, Deloitte LLP, and the cost effectiveness and the independence and objectivity of the Registered Public Accountants. In recognition of the importance of maintaining the independence of Deloitte LLP, a process for pre-approval has been in place since July 1, 2002 and has continued through to the end of the period covered by this Annual Report.

The following table provides an analysis of the amount paid to the Company’s Independent Registered Public Accountants, Deloitte LLP, all fees having been pre-approved by the Audit, Compliance & Risk Committee.

Year to December 31,	2013		2012
		$’M		$’M
Audit fees (1)		4.0		3.0
Audit related fees(2)		-		0.1
Tax fees(3)		0.2		0.1
All other fees(4)		0.4		0.4
Total fees		4.6		3.6

(1)   Audit fees consisted of audit work only the Independent Registered Public Accountant can reasonably be expected to perform, such as statutory audits.

(2)   Audit-related fees consist of work generally only the Independent Registered Public Accountant can reasonably be expected to perform, such as procedures relating to regulatory filings.

(3)   Tax fees consisted principally of assistance with matters related to compliance and advice in various tax jurisdictions.

(4)   All other fees relate to advisory services provided to the Company’s Human Resources and Sales functions.

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Policy on Audit, Compliance & Risk Committee pre-approval of audit and permissible non-audit services of Independent Registered Public Accountant

Consistent with SEC policies regarding auditor independence, the Audit, Compliance & Risk Committee has responsibility for appointing, setting compensation and overseeing the work of the Independent Registered Public Accountant. In recognition of this responsibility, the Audit, Compliance & Risk Committee pre-approves all audit and permissible non-audit services provided by the Independent Registered Public Accountant.

Certain services have been pre-approved by the Audit, Compliance & Risk Committee as part of its pre-approval policy, including:

·   audit services, such as audit work performed in the preparation of consolidated financial statements, as well as work that generally only the Independent Registered Public Accountant can reasonably be expected to provide, including comfort letters, statutory audits and consultation regarding financial accounting and/or reporting standards;

·   audit-related services, such as the audit of employee benefit plans, and special procedures required to meet certain regulatory requirements; and

·   tax services, such as tax compliance services and tax advice on employee remuneration strategies.

Where it is necessary to engage the Independent Registered Public Accountant for services not contemplated in the pre-approval policy, the Audit, Compliance & Risk Committee must pre-approve the proposed service before engaging the Independent Registered Public Accountant. For this purpose, the Audit, Compliance & Risk Committee has delegated pre-approval authority to the Chairman of the Audit, Compliance & Risk Committee. The pre-approval policy is reviewed and updated periodically and was last updated in December 2012. The Chairman must report any pre-approval decisions to the Audit, Compliance & Risk Committee at its next scheduled meeting.

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PART IV

ITEM 15: Exhibits, financial statement schedules

The following documents are included as part of this Annual Report on Form 10-K

Index to the consolidated financial statements

Report of Independent Registered Public Accounting Firm

Consolidated Balance Sheets as at December 31, 2013 and 2012

Consolidated Statements of Income for each of the three years in the period ended December 31, 2013

Consolidated Statements of Comprehensive Income for each of the three years in the period ended

December 31, 2013

Consolidated Statements of Changes in Equity for each of the three years in the period ended

December 31, 2013

Consolidated Statements of Cash Flows for each of the three years in the period ended December 31, 2013

Notes to the Consolidated Financial Statements

Index to the Shire Income Access Share Trust financial statements

Report of Independent Registered Public Accounting Firm

Balance Sheets as at December 31, 2013 and 2012

Statements of Income for each of the three years in the period ended December 31, 2013

Statements of Changes in Equity for each of the three years in the period ended December 31, 2013

Statements of Cash Flows for each of the three years in the period ended December 31, 2013

Notes to the Shire Income Access Share Trust Financial Statements

Financial statement schedule

The following schedule is filed as part of this Form 10-K:

Schedule II – Valuation and Qualifying Accounts for each of the three years in the period ended December 31, 2013.

All other schedules are omitted as the information required is inapplicable or the information is presented in the consolidated financial statements or the related notes.

Exhibits

Exhibit number	Description
2.01	Agreement and Plan of Merger by and among Shire Pharmaceuticals Group plc, Transkaryotic Therapies, Inc. and Sparta Acquisition Corporation, dated as of April 21, 2005.(1)
2.02	Agreement of Merger dated as of February 20, 2007 among Shire plc, Shuttle Corporation and New River Pharmaceuticals, Inc.(2)
2.03	Business Combination Agreement dated as of July 3, 2008 between Maia Elfte Vermögensverwaltungs GmbH and Jerini AG. (3)
2.04	Heads of Agreement by and among Shire plc and Movetis NV relating to a friendly tender offer, dated August 3, 2010. (4)

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2.05	Agreement and Plan of Merger, dated as of May 17, 2011, by and among Shire Pharmaceuticals Inc., ABH Merger Sub Inc., Advanced Biohealing, Inc., and solely for the limited purposes set forth therein, Canaan VII L.P. and Shire plc. (5)
2.06	Agreement and Plan of Merger, dated as of March 14, 2012, by and among Shire Pharmaceuticals LLC, Pelegrina Corporation, FerroKin BioSciences, Inc. and Shareholder Representative Services LLC, solely for the limited purposes set forth therein. (6)
2.07	Agreement and Plan of Merger dated as of November 11, 2013 among Shire Pharmaceutical Holdings Ireland Limited, Venus Newco, Inc., ViroPharma Incorporated and Shire plc. (7)
2.08	Asset Purchase Agreement dated as of January 16, 2014 among Shire US Holdings, Inc., Shire Regenerative Medicine, Inc. and Organogenesis Inc. (8)
3.01	Form of Memorandum of Association of Shire plc as adopted by a special resolution passed on April 10, 2008 and amended by a special resolution passed on September 24, 2008. (9)
3.02	Form of Article of Association of Shire plc as amended by a special resolution passed on April 26, 2011 and adopted by a special resolution passed on April 26, 2011. (10)
4.01	Form of Assignment and Novation Agreement between Shire Limited, Shire plc, JPMorgan Chase Bank, N.A. dated April 16, 2008 relating to the Deposit Agreement among Shire plc, JPMorgan Chase Bank, N.A. as depositary and all holders from time to time of ADRs issued thereunder dated November 21, 2005.(11)
4.02	Form of Deposit Agreement among Shire plc, JPMorgan Chase Bank, N.A. as depositary and all holders from time to time of ADRs issued thereunder dated November 21, 2005. (12)
4.03	Form of Ordinary Share Certificate of Shire Limited. (13)
4.04	Form of American Depositary Receipt Certificate of Shire Limited. (14)
4.05	Trust Deed for the New Shire Income Access Trust, dated August 29, 2008. (15)
4.06	Form of Amended and Restated Deposit Agreement among Shire plc, Citibank, N.A. as successor depositary, and all holders from time to time of ADRs thereunder dated May 23, 2011 (16)
10.01	Tender and Support Agreement dated as of February 20, 2007 among Shire plc, Mr. Randal J. Kirk and the other parties named therein. (17)
10.02	Multicurrency Term and Revolving Facilities Agreement as of February 20, 2007 by and among Shire plc, ABN AMRO Bank N.V., Barclays Capital, Citigroup Global Markets Limited, The Royal Bank of Scotland plc, and Barclays Bank plc. (18)
10.03	Accession and Amendment Deed dated April 15, 2008 between Shire Limited, Shire plc, certain subsidiaries of Shire plc and Barclays Bank PLC as Facility Agent relating to a US $1,200,000,000 facility agreement dated February 20, 2007 (as amended by a syndication and amendment agreement dated July 19, 2007). (19)
10.04	Subscription Agreement dated May 2, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and others. (20)
10.05	Amending Subscription Agreement dated May 8, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and ABN AMRO Bank N.V. and NM Rothschild & Sons Limited (trading together as ABN AMRO Rothschild, an unincorporated equity capital markets joint venture) and Barclays Bank PLC and Citigroup Global Markets Limited and Goldman Sachs International and Morgan Stanley & Co. International plc and others. (21)
10.06	Trust Deed dated May 9, 2007 relating to the 2.75% Convertible Bonds due 2014 between Shire plc and BNY Corporate Trustee Services Limited. (22)
10.07	Supplemental Trust Deed dated April 15, 2008 between Shire Limited, Shire plc and BNY Corporate Trustee Services Limited relating to a trust deed dated May 9, 2007 relating to US $1,100,000,000 2.75% Convertible Bonds due 2014. (23)
10.08	Accession and Amendment Agreement dated April 15, 2008 between Shire Limited, Shire plc, BNY Corporate Trustee Services Limited and The Bank of New York relating to a paying and conversion agency agreement dated May 9, 2007 relating to US $1,100,000,000 2.75% Convertible Bonds due 2014. (24)

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10.09*	Revised and Restated Master License Agreement dated November 20, 1995 among Shire BioChem Inc (f/k/a BioChem Pharma Inc.), Glaxo Group Limited, Glaxo Wellcome Inc. (formerly Glaxo Canada Inc.), Glaxo Wellcome Inc. (formerly Glaxo Inc.), Tanaud Holdings (Barbados) Limited, Tanaud International B.V. and Tanaud LLC. (25)
10.10*	Settlement Agreement, dated August 14, 2006 by and between Shire Laboratories Inc. and Barr. (26)
10.11*	Product Development and License Agreement, dated August 14, 2006 by and between Shire LLC and Duramed Pharmaceuticals, Inc. (27)
10.12*	Product Acquisition and License Agreement, dated August 14, 2006 by and among Shire LLC, Shire plc and Duramed Pharmaceuticals, Inc. (28)
10.13	Novation Agreement dated November 21, 2005 relating to the Employment Agreement of Angus Russell dated March 10, 2004. (29)
10.14	Novation Agreement dated April 11, 2008 relating to the Employment Agreement of Angus Russell dated March 10, 2004, as previously novated on November 21, 2005. (30)
10.15	Form of Amended and Restated Employment Agreement between Shire plc and Mr Matthew Emmens, dated March 12, 2004. (31)
10.16	Amendment Agreement dated November 21, 2005 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (32)
10.17	Ratification and Guaranty dated November 21, 2005 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (33)
10.18	Amendment Agreement dated May 20, 2008 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004, as amended on November 21, 2005. (34)
10.19	Ratification and Guaranty dated May 20, 2008 relating to the Amended and Restated Employment Agreement of Matthew Emmens dated March 12, 2004. (35)
10.20	Form of Indemnity Agreement for Directors of Shire Limited. (36)
10.21	Service Agreement between Shire Limited and Mr Graham Hetherington, dated July 2, 2008. (37)
10.22	Form of Settlement Agreement and Mutual Release in re: Transkaryotic Therapies, Inc., by and between Shire Human Genetic Therapies, Inc., Shire plc and the parties set forth therein. (38)
10.23	Amended Agreement dated February 24, 2009 relating to the Product Development and License Agreement dated August 14, 2006. (39)
10.24	Amendment to the Shire Portfolio Share Plan as approved by the Annual General meeting held on April 27, 2010. (40)
10.25	Multicurrency revolving and swingline facilities agreement as at November 23, 2010 by and among Shire plc & with a number of financial institutions, for which Abbey National Treasury Services Plc (trading as Santander Global Banking and Markets), Bank of America Securities Limited, Barclays Capital, Citigroup Global Markets Limited, Lloyds TSB Bank plc and The Royal Bank of Scotland plc acted as mandated lead arrangers and bookrunners and Credit Suisse AG, London Branch, Deutsche Bank AG, London Branch, Goldman Sachs International, Morgan Stanley Bank, N.A. and Sumitomo Mitsui Banking Corporation, Brussels Branch acted as arrangers. (41)
10.26	Service Agreement between Shire plc and Mr. Flemming Ornskov, dated October 24, 2012. (42)
10.27	Facilities Agreement dated November 11, 2013 among Shire plc, Morgan Stanley Bank International Limited, as mandated lead arranger, bookrunner and agent, and the other parties thereto. (43)
10.28	Letter agreement dated December 13, 2013 among Shire plc, Morgan Stanley Bank International Limited, as agent, and the other parties thereto. (44)
10.29	Letter agreement dated February 18, 2014 between Shire plc and Barclays Bank plc, as agent. (45)
21	List of Subsidiaries
23.1	Consent of Deloitte LLP
23.2	Consent of Deloitte LLP
31.1	Certification of Flemming Ornskov pursuant to Rule 13a - 14 under The Exchange Act.
31.2	Certification of Graham Hetherington pursuant to Rule 13a - 14 under The Exchange Act.

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32.1	Certification of Flemming Ornskov and Graham Hetherington pursuant to Section 906 of the Sarbanes - Oxley Act of 2002.
101.INS XBRL Instance Document
101.SCH XBRL Taxonomy Extension Schema Document
101.CAL XBRL Taxonomy Extension Calculation Linkbase Document
101.DEF XBRL Taxonomy Definition Linkbase Document
101.LAB XBRL Taxonomy Extension Label Linkbase Document
101.PRE XBRL Taxonomy Extension Presentation Linkbase Document
*	Certain portions of this exhibit have been omitted intentionally, subject to a confidential treatment request. A complete version of this agreement has been filed separately with the Securities and Exchange Commission.
(1)	Incorporated by reference to Exhibit 99.02 to Shire's Form 8-K filed on April 25, 2005.
(2)	Incorporated by reference to Exhibit 2.1 to Shire's Form 8-K filed on February 23, 2007.
(3)	Incorporated by reference to Exhibit 2.1 to Shire's Form 8-K filed on July 10, 2008.
(4)	Incorporated by reference to Exhibit 2.04 to Shire's Form 10-Q filed on November 5, 2010.
(5)	Incorporated by reference to Exhibit 2.1 to Shire's Form 8-K filed on June 30, 2011.
(6)	Incorporated by reference to Exhibit 2.06 to Shire's Form 10-Q filed on May 23, 2012.
(7)	Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on November 12, 2013.
(8)	Incorporated by reference to Exhibit 2.1 to Shire’s Form 8-K filed on January 22, 2014.
(9)	Incorporated by reference to Exhibit 99.02 to Shire's Form 8-K filed on October 1, 2008.
(10)	Incorporated by reference to Exhibit 3.1 to Shire's Form 8-K filed on April 29, 2011.
(11)	Incorporated by reference to Exhibit 4.01 to Shire's Form 8-K filed on May 23, 2008.
(12)	Incorporated by reference to Exhibit 4.02 to Shire's Form 8-K filed on May 23, 2008.
(13)	Incorporated by reference to Exhibit 4.03 to Shire's Form 8-K filed on May 23, 2008.
(14)	Incorporated by reference to Exhibit 4.04 to Shire's Form 8-K filed on May 23, 2008.
(15)	Incorporated by reference to Exhibit 4.05 to Shire's Form 10-K filed on February 27, 2009.
(16)	Incorporated by reference to Exhibit (a) to Shire's Form F-6 filed on April 27, 2011.
(17)	Incorporated by reference to Exhibit 99.1 to Shire's Form 8-K filed on February 23, 2007.
(18)	Incorporated by reference to Exhibit 10.2 to Shire's Form 10-Q filed on May 1, 2007.
(19)	Incorporated by reference to Exhibit 10.01 to Shire's Form 8-K filed on May 23, 2008.
(20)	Incorporated by reference to Exhibit 10.1 to Shire's Form 10-Q filed on August 2, 2007.
(21)	Incorporated by reference to Exhibit 10.2 to Shire's Form 10-Q filed on August 2, 2007.
(22)	Incorporated by reference to Exhibit 10.3 to Shire's Form 10-Q filed on August 2, 2007.
(23)	Incorporated by reference to Exhibit 10.02 to Shire's Form 8-K filed on May 23, 2008.
(24)	Incorporated by reference to Exhibit 10.03 to Shire's Form 8-K filed on May 23, 2008.
(25)	Incorporated by reference to Exhibit 10.09 to Shire's Form 10-K/A filed on May 30, 2008.
(26)	Incorporated by reference to Exhibit 10.1 to Shire's Form 10-Q filed on November 7, 2006.
(27)	Incorporated by reference to Exhibit 10.2 to Shire's Form 10-Q filed on November 7, 2006.
(28)	Incorporated by reference to Exhibit 10.3 to Shire's Form 10-Q filed on November 7, 2006.
(29)	Incorporated by reference to Exhibit 10.03 to Shire's Form 8-K filed on November 25, 2005.
(30)	Incorporated by reference to Exhibit 10.06 to Shire's Form 8-K filed on May 23, 2008.
(31)	Incorporated by reference to Exhibit 10.13 to Shire's Form 10-K filed on March 12, 2004.

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(32)	Incorporated by reference to Exhibit 10.01 to Shire's Form 8-K filed on November 25, 2005.
(33)	Incorporated by reference to Exhibit 10.02 to Shire's Form 8-K filed on November 25, 2005.
(34)	Incorporated by reference to Exhibit 10.04 to Shire's Form 8-K filed on May 23, 2008.
(35)	Incorporated by reference to Exhibit 10.05 to Shire's Form 8-K filed on May 23, 2008.
(36)	Incorporated by reference to Exhibit 10.07 to Shire's Form 8-K filed on May 23, 2008.
(37)	Incorporated by reference to Exhibit 10.23 to Shire's Form 10-Q filed on November 10, 2008.
(38)	Incorporated by reference to Exhibit 10.24 to Shire's Form 10-Q filed on November 10, 2008.
(39)	Incorporated by reference to Exhibit 10.25 to Shire's Form 10-Q filed on May 7, 2009.
(40)	Incorporated by reference to Exhibit 10.27 to Shire's Form 10-Q filed on May 6, 2010.
(41)	Incorporated by reference to Exhibit 10.28 to Shire's Form 10-K filed on February 23, 2011.
(42)	Incorporated by reference to Exhibit 10.29 to Shire's Form 10-K filed on February 25, 2013.
(43)	Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on November 12, 2013.
(44)	Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on December 16, 2013.
(45)	Incorporated by reference to Exhibit 10.1 to Shire’s Form 8-K filed on February 21, 2014.

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INDEX TO THE CONSOLIDATED FINANCIAL STATEMENTS AND SUPPLEMENTARY SCHEDULE

Report of Independent Registered Public Accounting Firm	F2
Consolidated Balance Sheets as at December 31, 2013 and 2012	F4
Consolidated Statements of Income for each of the three years in the period to December 31, 2013	F6
Consolidated Statements of Comprehensive Income for each of the three years in the period to December 31, 2013	F8
Consolidated Statements of Changes in Equity for each of the three years in the period to December 31, 2013	F9
Consolidated Statements of Cash Flows for each of the three years in the period to December 31, 2013	F12
Notes to the Consolidated Financial Statements	F14
Schedule:
Schedule II - Valuation and Qualifying Accounts for each of the three years in the period to December 31, 2013	S1

F-1

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of Shire plc

We have audited the accompanying consolidated balance sheets of Shire plc and subsidiaries (the "Company") as at December 31, 2013 and 2012, and the related consolidated statements of income, comprehensive income, changes in equity and cash flows for each of the three years in the period ended December 31, 2013. Our audits also included the financial statement schedule listed in the Index at ITEM 15. These consolidated financial statements and the financial statement schedule are the responsibility of the Company's management. Our responsibility is to express an opinion on these consolidated financial statements and the financial statement schedule based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

In our opinion, such consolidated financial statements present fairly, in all material respects, the financial position of Shire plc and subsidiaries as at December 31, 2013 and 2012, and the results of their operations and their cash flows for each of the three years in the period ended December 31, 2013, in conformity with accounting principles generally accepted in the United States of America. Also, in our opinion, such financial statement schedule, when considered in relation to the consolidated financial statements taken as a whole, presents fairly, in all material respects, the information set forth therein.

We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the Company's internal control over financial reporting as at December 31, 2013, based on the criteria established in Internal Control—Integrated Framework (1992), by the Committee of Sponsoring Organizations of the Treadway Commission and our report dated February 24, 2014 expressed an unqualified opinion on the Company's internal control over financial reporting.

/s/ Deloitte LLP

DELOITTE LLP

London, United Kingdom

February 24, 2014

F-2

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To the Board of Directors and Stockholders of Shire plc

We have audited the internal control over financial reporting of Shire plc and subsidiaries (the "Company") as at December 31, 2013, based on criteria established in Internal Control — Integrated Framework (1992), by the Committee of Sponsoring Organizations of the Treadway Commission.  The Company's management is responsible for maintaining effective internal control over financial reporting and for its assessment of the effectiveness of internal control over financial reporting, included in the accompanying Management’s Report on Internal Control over Financial Reporting. Our responsibility is to express an opinion on the Company's internal control over financial reporting, including those controls applicable to the Income Access Share Trust (the “Trust”) based on our audits.

We conducted our audits in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether effective internal control over financial reporting was maintained in all material respects. Our audit included obtaining an understanding of internal control over financial reporting, assessing the risk that a material weakness exists, testing and evaluating the design and operating effectiveness of internal control based on the assessed risk, and performing such other procedures as we considered necessary in the circumstances. We believe that our audits provide a reasonable basis for our opinion.

A company's internal control over financial reporting is a process designed by, or under the supervision of, the company's principal executive and principal financial officers, or persons performing similar functions, and effected by the company's board of directors, management, and other personnel to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles. A company's internal control over financial reporting includes those policies and procedures that (1) pertain to the maintenance of records that, in reasonable detail, accurately and fairly reflect the transactions and dispositions of the assets of the company; (2) provide reasonable assurance that transactions are recorded as necessary to permit preparation of financial statements in accordance with generally accepted accounting principles and that receipts and expenditures of the company are being made only in accordance with authorizations of management and directors of the company; and (3) provide reasonable assurance regarding prevention or timely detection of unauthorized acquisition, use, or disposition of the company's assets that could have a material effect on the financial statements.

Because of the inherent limitations of internal control over financial reporting, including the possibility of collusion or improper management override of controls, material misstatements due to error or fraud may not be prevented or detected on a timely basis. Also, projections of any evaluation of the effectiveness of the internal control over financial reporting to future periods are subject to the risk that the controls may become inadequate because of changes in conditions, or that the degree of compliance with the policies or procedures may deteriorate.

In our opinion, the Company maintained, in all material respects, effective internal control over financial reporting, including those controls applicable to the Trust, as at December 31, 2013, based on the criteria established in Internal Control — Integrated Framework (1992) by the Committee of Sponsoring Organizations of the Treadway Commission.

We have also audited, in accordance with the standards of the Public Company Accounting Oversight Board (United States), the consolidated financial statements and financial statement schedule as at and for the year ended December 31, 2013 of the Company and the Trust and our reports dated February 24, 2014 expressed an unqualified opinion on those financial statements and financial statement schedule.

/s/ Deloitte LLP

DELOITTE LLP

London, United Kingdom

February 24, 2014

F-3

SHIRE PLC

CONSOLIDATED BALANCE SHEETS

		December 31,		December 31,
		2013		2012
	Notes		$’M		$’M
ASSETS
Current assets:
Cash and cash equivalents			2,239.4		1,482.2
Restricted cash			22.2		17.1
Accounts receivable, net	6		961.2		824.2
Inventories	7		455.3		436.9
Assets held for sale	8		31.6		-
Deferred tax asset	26		315.6		229.9
Prepaid expenses and other current assets	9		263.0		221.8
Total current assets			4,288.3		3,212.1
Non-current assets:
Investments			31.8		38.7
Property, plant and equipment, net	10		891.8		955.8
Goodwill	11		624.6		644.5
Other intangible assets, net	12		2,312.6		2,388.1
Deferred tax asset	26		141.1		46.5
Other non-current assets			32.8		31.5
Total assets			8,323.0		7,317.2
LIABILITIES AND EQUITY
Current liabilities:
Accounts payable and accrued expenses	13		1,688.4		1,501.5
Other current liabilities	14		119.5		144.1
Total current liabilities			1,807.9		1,645.6
Non-current liabilities:
Convertible bonds	15		-		1,100.0
Deferred tax liability	26		560.6		520.8
Other non-current liabilities	17		588.5		241.6
Total liabilities			2,957.0		3,508.0
Commitments and contingencies	18		-		-

F-4

SHIRE PLC

CONSOLIDATED BALANCE SHEETS (continued)

		December 31,			December 31,
		2013			2012
	Notes		$’M			$’M
Equity:
Common stock of 5p par value; 1,000 million shares authorized; and 597.5 million shares issued and outstanding (2012: 1,000 million shares authorized; and 562.5 million shares issued and outstanding)	22		58.6			55.7
Additional paid-in capital			4,186.3			2,981.5
Treasury stock: 13.4 million shares (2012: 10.7 million shares)	22		(450.6	)		(310.4	)
Accumulated other comprehensive income	19		110.2			86.9
Retained earnings			1,461.5			995.5
Total equity			5,366.0			3,809.2
Total liabilities and equity			8,323.0			7,317.2

The accompanying notes are an integral part of these consolidated financial statements.

F-5

SHIRE PLC

CONSOLIDATED STATEMENTS OF INCOME

		2013			2012			2011
Revenues:	Notes		$’M			$’M			$’M
Product sales			4,757.5			4,252.9			3,844.9
Royalties			153.7			241.6			283.5
Other revenues			23.1			32.9			29.7
Total revenues			4,934.3			4,527.4			4,158.1
Costs and expenses:
Cost of product sales			670.8			585.8			551.7
Research and development(1)			933.4			953.0			764.5
Selling, general and administrative (1)			1,651.3			1,948.0			1,675.7
Goodwill impairment charge	11		7.1			-			-
(Gain)/loss on sale of product rights	4		(15.9	)		(18.1	)		6.0
Reorganization costs	5		88.2			-			24.3
Integration and acquisition costs	3		(134.1	)		13.5			0.1
Total operating expenses			3,200.8			3,482.2			3,022.3
Operating income from continuing operations			1,733.5			1,045.2			1,135.8
Interest income			2.1			3.0			1.9
Interest expense			(38.1	)		(38.2	)		(39.1	)
Other (expense)/income, net			(3.9	)		(2.2	)		18.5
Total other expense, net			(39.9	)		(37.4	)		(18.7	)
Income from continuing operations before income taxes and equity in earnings of equity method investees			1,693.6			1,007.8			1,117.1
Income taxes	26		(277.9	)		(203.1	)		(236.9	)
Equity in earnings of equity method investees, net of taxes			3.9			1.0			2.5
Income from continuing operations, net of taxes			1,419.6			805.7			882.7
Loss from discontinued operations, net of  taxes1	8		(754.5	)		(60.3	)		(17.7	)
Net income			665.1			745.4			865.0

(1)  Research and development (“R&D”) includes intangible asset impairment charges of $19.9 million (2012: $71.2 million, 2011: $16.0 million) for the year to December 31, 2013. Selling, general and administrative (“SG&A”) costs include amortization and impairment charges of intangible assets relating to intellectual property rights acquired of $152.0 million for the year to December 31, 2013 (2012: $280.3 million, 2011: $145.0 million).

F-6

SHIRE PLC

CONSOLIDATED STATEMENTS OF INCOME (continued)

	Notes	2013			2012			2011
Earnings per ordinary share - basic
Earnings from continuing operations			257.2	c		145.1	c		160.1	c
Loss from discontinued operations	1		(136.7c	)		(10.9c	)		(3.2c	)
Earnings per ordinary share - basic			120.5	c		134.2	c		156.9	c
Earnings per ordinary share - diluted
Earnings from continuing operations			245.3	c		141.0	c		153.9	c
Loss from discontinued operations	1		(127.8c	)		(10.1c	)		(3.0c	)
Earnings per ordinary share - diluted			117.5	c		130.9	c		150.9	c
Weighted average number of shares (millions):
Basic	23		552.0			555.4			551.1
Diluted	23		590.3			593.5			595.4

The accompanying notes are an integral part of these consolidated financial statements.

F-7

SHIRE PLC

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME

		2013			2012		2011
		$'M			$'M		$'M
Net income			665.1			745.4		865.0
Other comprehensive income:
	Foreign currency translation adjustments		25.3			23.7		(24.0	)
	Unrealized holding (loss)/gain on available-for-sale securities (net of taxes of $0.1 million, $2.5 million and $0.2 million)		(2.0	)		2.9		16.2
	Other than temporary impairment of available-for-sale securities (net of taxes of $nil in all periods)		-			-		2.4
1	Realized gain on divestment of available-for-sale securities (net of taxes of $nil, $nil and $3.5 million)		-			-		(20.0	)
Comprehensive income			688.4			772.0		839.6

The components of accumulated other comprehensive income as at December 31, 2013 and December 31, 2012 are as follows:

	December 31,			December 31,
	2013			2012
		$’M			$’M
Foreign currency translation adjustments		110.4			85.1
Unrealized holding (loss)/gain on available-for-sale securities, net of taxes		(0.2	)		1.8
Accumulated other comprehensive income		110.2			86.9

The accompanying notes are an integral part of these consolidated financial statements.

F-8

SHIRE PLC

CONSOLIDATED STATEMENT OF CHANGES IN EQUITY

(In millions of US dollars except share data)

	Shire plc shareholders' equity
	Common stock Number of shares M's		Common stock $'M		Additional paid-in capital $’M		Treasury stock $'M			Accumulated other comprehensive income $'M		Retained earnings $'M			Total equity $'M
As at January 1, 2013		562.5		55.7		2,981.5		(310.4	)		86.9		995.5			3,809.2
Net income		-		-		-		-			-		665.1			665.1
Other comprehensive income, net of tax		-		-		-		-			23.3		-			23.3
Options exercised		1.2		0.1		16.1		-			-		-			16.2
Convertible Bonds conversion to Ordinary Shares		33.8		2.8		1,098.7		-			-		-			1,101.5
Share-based compensation		-		-		78.1		-			-		-			78.1
Tax benefit associated with exercise of stock options		-		-		11.9		-			-		-			11.9
Shares purchased by employee benefit trust ("EBT")		-		-		-		(50.0	)		-		-			(50.0	)
Shares purchased under share buy-back program		-		-		-		(193.8	)		-		-			(193.8	)
Shares released by EBT  to satisfy exercise of stock options		-		-		-		103.6			-		(102.7	)		0.9
Dividends		-		-		-		-			-		(96.4	)		(96.4	)
As at December 31, 2013		597.5		58.6		4,186.3		(450.6	)		110.2		1,461.5			5,366.0

The accompanying notes are an integral part of these consolidated financial statements.

Dividends per share

During the year to December 31, 2013 Shire plc declared and paid dividends of 17.60 US cents per ordinary share (equivalent to 52.80 US cents per ADS) totalling $96.4 million.

F-9

CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY (continued)

(In millions of US dollars except share data)

	Common stock Number of shares M's		Common stock $'M		Additional paid-in capital $’M		Treasury stock $'M			Accumulated other comprehensive income $'M		Retained earnings $'M			Total equity $'M
As at January 1, 2012		562.5		55.7		2,853.3		(287.2	)		60.3		502.9			3,185.0
Net income		-		-		-		-			-		745.4			745.4
Other comprehensive income, net of tax		-		-		-		-			26.6		-			26.6
Options exercised		-		-		0.1		-			-		-			0.1
Share-based compensation		-		-		88.0		-			-		-			88.0
Tax benefit associated with exercise of stock options		-		-		40.1		-			-		-			40.1
Shares purchased by EBT		-		-		-		(99.3	)		-		-			(99.3	)
Shares purchased under Share buy-back program		-		-		-		(106.5	)		-		-			(106.5	)
Shares released by EBT to satisfy exercise of stock options		-		-		-		182.6			-		(166.5	)		16.1
Dividends		-		-		-		-			-		(86.3	)		(86.3	)
As at December 31, 2012		562.5		55.7		2,981.5		(310.4	)		86.9		995.5			3,809.2

The accompanying notes are an integral part of these consolidated financial statements.

Dividends per share

During the year to December 31, 2012 Shire plc declared and paid dividends of 15.32 US cents per ordinary share (equivalent to 45.96 US cents per ADS) totaling $86.3 million.

F-10

CONSOLIDATED STATEMENTS OF CHANGES IN EQUITY (continued)

(In millions of US dollars except share data)

	Common stock Number of shares M's		Common stock $'M		Additional paid-in capital $’M		Treasury stock $'M			Accumulated other comprehensive income $'M			Accumulated deficit $'M			Total equity $'M
As at January 1, 2011		562.2		55.7		2,746.4		(276.1	)		85.7			(160.3	)		2,451.4
Net income		-		-		-		-			-			865.0			865.0
Other comprehensive income, net of tax		-		-		-		-			(25.4	)		-			(25.4	)
Options exercised		0.3		-		0.7		-			-			-			0.7
Share-based compensation		-		-		76.8		-			-			-			76.8
Tax benefit associated with exercise of stock options		-		-		29.4		-			-			-			29.4		1
Shares purchased by EBT		-		-		-		(151.8	)		-			-			(151.8	)
Shares released by EBT  to satisfy exercise of stock options		-		-		-		140.7			-			(128.0	)		12.7
Dividends		-		-		-		-			-			(73.8	)		(73.8	)
As at December 31, 2011		562.5		55.7		2,853.3		(287.2	)		60.3			502.9			3,185.0

The accompanying notes are an integral part of these consolidated financial statements.

Dividends per share

During the year to December 31, 2011 Shire plc declared and paid dividends of 13.33 US cents per ordinary share (equivalent to 39.99 US cents per ADS) totaling $73.8 million.

F-11

SHIRE PLC

CONSOLIDATED STATEMENTS OF CASH FLOWS

	2013			2012			2011
		$’M			$’M			$’M
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income		665.1			745.4			865.0
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization		324.4			308.6			294.8
Share based compensation		77.4			87.1			75.7
Change in fair value of contingent consideration		(159.1	)		9.2			-
Impairment of intangible assets		19.9			197.9			16.0
Goodwill impairment charge1		198.9			-			-
Impairment of assets held for sale		636.9			-			-
Write down of assets		58.2			0.9			-
Gain on sale of non-current investments		-			-			(23.5	)
(Gain)/loss on sale of product rights		(15.9	)		(18.1	)		6.0
Other, net		8.3			7.4			16.1
Movement in deferred taxes		(349.9	)		(58.3	)		(14.5	)
Equity in earnings of equity method investees		(3.9	)		(1.0	)		(2.5	)
Changes in operating assets and liabilities:
(Increase)/decrease in accounts receivable		(148.3	)		22.2			(134.0	)
Increase in sales deduction accruals		177.5			42.7			80.5
Increase in inventory		(36.6	)		(88.2	)		(64.4	)
Increase in prepayments and other assets		(60.9	)		(14.5	)		(36.8	)
Increase/(decrease) in accounts payable and other liabilities		67.9			136.7			(10.0	)
Returns on investment from joint venture		3.1			4.9			5.2
Net cash provided by operating activities (A)		1,463.0			1,382.9			1,073.6
CASH FLOWS FROM INVESTING ACTIVITIES:
Movements in restricted cash		(5.3	)		3.5			6.2
Purchases of subsidiary undertakings and businesses, net of cash acquired		(227.8	)		(97.0	)		(725.0	)
Purchases of non-current investments		(10.6	)		(18.0	)		(10.7	)
Purchases of property, plant and equipment ("PP&E")		(157.0	)		(149.6	)		(194.3	)
Purchases of intangible assets		-			(43.5	)		(5.2	)
Proceeds from disposal of non-current investments and PP&E		12.1			7.2			106.0
Proceeds received on sale of product rights		19.2			17.8			12.0
Return on equity investments		5.4			-			-
Other, net		3.1			8.6			1.8
Net cash used in investing activities (B)		(360.9	)		(271.0	)		(809.2	)

F-12

SHIRE PLC

CONSOLIDATED STATEMENTS OF CASH FLOWS (continued)

	2013			2012			2011
		$’M			$’M			$’M
CASH FLOWS FROM FINANCING ACTIVITIES:
Payments to acquire shares under share buy-back program		(193.8	)		(106.5	)		-
Payment of dividend		(96.4	)		(86.3	)		(73.8	)
Payments to acquire shares by the Employee Benefit Trust ("EBT")		(50.0	)		(99.3	)		(151.8	)
Proceeds from exercise of options		17.2			16.2			13.4
Proceeds from drawing of revolving credit facility ("RCF")		-			-			30.0
Repayment of RCF		-			-			(30.0	)
Repayment of debt acquired through business combinations		(6.0	)		-			(13.1	)
Facility arrangement fee		(13.9	)		-			-
Excess tax benefit associated with exercise of stock options		13.4			40.7			31.4
Contingent consideration payments		(14.1	)		(5.8	)		-
Other, net		(1.0	)		(3.3	)		(1.5	)
Net cash used in financing activities(C)		(344.6	)		(244.3	)		(195.4	)
Effect of foreign exchange rate changes on cash and cash equivalents (D)		(0.3	)		(5.4	)		0.4
Net increase in cash and cash equivalents (A+B+C+D)		757.2			862.2			69.4
Cash and cash equivalents at beginning of period		1,482.2			620.0			550.6
Cash and cash equivalents at end of period		2,239.4			1,482.2			620.0

Supplemental information associated with continuing
operations:
	2013			2012			2011
		$’M			$’M			$’M
Interest paid		(29.9	)		(34.6	)		(33.3	)
Income taxes paid		(290.2	)		(199.2	)		(286.1	)

The accompanying notes are an integral part of these consolidated financial statements.

F-13

NOTES TO THE CONSOLIDATED FINANCIAL STATEMENTS

(In millions of US dollars, except where indicated)

1.  Description of operations

Shire plc and its subsidiaries (collectively referred to as either “Shire”, or the “Company”) is a leading specialty biopharmaceutical company that focuses on developing and marketing innovative specialty medicines that address significant unmet patient needs.

The Company has grown through acquisition, completing a series of major transactions that have brought therapeutic, geographic and pipeline growth and diversification. The Company will continue to evaluate companies, products and pipeline opportunities that offer a good strategic fit and have the potential to deliver demonstrable value to all of the Company’s stakeholders: patients, physicians, policy makers, payors, investors and employees.

2.  Summary of significant accounting policies

(a)  Basis of preparation

The accompanying consolidated financial statements include the accounts of Shire plc, all of its subsidiary undertakings and the Income Access Share trust, after elimination of inter-company accounts and transactions. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for annual reporting.

(b)  Use of estimates in consolidated financial statements

The preparation of consolidated financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestments, contingent consideration payable in respect of business combinations and asset purchases and assets held for sale. If actual results differ from the Company’s estimates, or to the extent these estimates are adjusted in future periods, the Company’s results of operations could either benefit from, or be adversely affected by, any such change in estimate.

(c)  Revenue recognition

The Company recognizes revenue when all of the following conditions are met:

•  there is persuasive evidence of an agreement or arrangement;

•  delivery of products has occurred or services have been rendered;

•  the seller’s price to the buyer is fixed or determinable; and

•  collectability is reasonably assured.

Where applicable, all revenues are stated net of value added and similar taxes, and trade discounts. No revenue is recognized for consideration, the value or receipt of which is dependent on future events or future performance.

The Company’s principal revenue streams and their respective accounting treatments are discussed below:

Product sales

Revenue for the sale of products is recognized when delivery has occurred and substantially all the risks and rewards of ownership have been transferred to the customer. Provisions for rebates, product returns and discounts to customers are provided for as reductions to revenue in the same period as the related sales are recorded. The provisions made at the time of revenue recognition are based on historical experience and updated for changes in facts and circumstances including the impact of new legislation. The provisions are recognized as a reduction to revenues.

F-14

Royalty income

Royalty income relating to licensed technology is recognized when the licensee sells the underlying product, with the amount of royalty income recorded based on sales information received from the relevant licensee. The Company estimates sales amounts and related royalty income based on the historical product information for any period that the sales information is not available from the relevant licensee.

Licensing revenues

Other revenue includes revenues derived from product out-licensing arrangements, which typically consist of an initial upfront payment on inception of the license and subsequent milestone payments contingent on the achievement of certain clinical and sales milestones. Product out-licensing arrangements often require the Company to provide multiple deliverables to the licensee.

Initial license fees received in connection with product out-licensing agreements entered into prior to January 1, 2011 are deferred and recognized over the period in which the Company has continuing substantive performance obligations, typically the period over which the Company participates in the development of the out-licensed product, even where such fees are non-refundable and not creditable against future royalty payments.

For product out-licensing arrangements entered into, or subject to material modification, after January 1, 2011, consideration received is allocated between each of the separable elements in the arrangement using the relative selling price method. An element is considered separable if it has value to the customer on a stand-alone basis. The selling price used for each separable element will be based on vendor specific objective evidence (“VSOE”) if available, third party evidence if VSOE is not available, or estimated selling price if neither VSOE nor third party evidence is available. Revenue is then recognized as each of the separable elements to which the revenue has been allocated is delivered.

Milestone payments which are non-refundable, non creditable and contingent on achieving certain clinical milestones are recognized as revenues either on achievement of such milestones if the milestones are considered substantive or over the period the Company has continuing substantive performance obligations, if the milestones are not considered substantive. If milestone payments are creditable against future royalty payments, the milestones are deferred and released over the period in which the royalties are anticipated to be paid.

(d)  Sales deductions

(i)  Rebates

Rebates primarily consist of statutory rebates to state Medicaid agencies and contractual rebates with health-maintenance organizations. These rebates are based on price differentials between a base price and the selling price. As a result, rebates generally increase as a percentage of the selling price over the life of the product (as prices increase). Provisions for rebates are recorded as reductions to revenue in the same period as the related sales are recorded, with the amount of the rebate based on the Company’s best estimate if any uncertainty exists over the unit rebate amount, and with estimates of future utilization derived from historical trends.

(ii)  Returns

The Company estimates the proportion of recorded revenue that will result in a return, based on historical trends and when applicable, specific factors affecting certain products at the balance sheet date. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded.

(iii)  Coupons

The Company uses coupons as a form of sales incentive. An accrual is established based on the Company's expectation of the level of coupon redemption, estimated using historical trends. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded or the date the coupon is offered, if later than the date the related sales are recorded.

(iv)  Discounts

The Company offers cash discounts to customers for the early payment of receivables which are recorded as reductions to revenue and accounts receivable in the same period as the related sale is recorded.

(v)  Wholesaler chargebacks

The Company has contractual agreements whereby it supplies certain products to third parties at predetermined prices. Wholesalers acting as intermediaries in these transactions are reimbursed by the Company if the predetermined prices

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are less than the prices paid by the wholesaler to the Company. Accruals for wholesaler chargebacks, which are based on historical trends, are recorded as reductions to revenue in the same period as the related sales are recorded.

(e)  Collaborative arrangements

The Company enters into collaborative arrangements to develop and commercialize drug candidates. These collaborative arrangements often require up-front, milestone, royalty or profit share payments, or a combination of these, with payments often contingent upon the success of the related development and commercialization efforts. Collaboration agreements entered into by the Company may also include expense reimbursements or other such payments to the collaborating partner.

The Company reports costs incurred and revenue generated from transactions with third parties as well as payments between parties to collaborative arrangements either on a gross or net basis, depending on the characteristics of the collaborative relationship.

(f)  Cost of product sales

Cost of product sales includes the cost of purchasing finished product for sale, the cost of raw materials and manufacturing for those products that are manufactured by the Company, shipping and handling costs, depreciation and amortization of intangible assets in respect of favorable manufacturing contracts. Royalties payable on products to which the Company does not own the rights are also included in Cost of product sales.

(g)  Leased assets

The costs of operating leases are charged to operations on a straight-line basis over the lease term, even if rental payments are not made on such a basis.

Assets acquired under capital leases are included in the consolidated balance sheet as property, plant and equipment and are depreciated over the shorter of the period of the lease or their useful lives. The capital element of future lease payments is recorded as a liability, while the interest element is charged to operations over the period of the lease to produce a level yield on the balance of the capital lease obligation.

(h)  Advertising expense

The Company expenses the cost of advertising as incurred. Advertising costs amounted to $60.9 million, $85.8 million and $122.5 million for the years to December 31, 2013, 2012 and 2011 respectively and were included within Selling, general and administrative (“SG&A”) expenses.

(i)  Research and development (“R&D”) expense

R&D costs are expensed as incurred. Upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified are also expensed as incurred.

Milestone payments made to third parties on and subsequent to regulatory approval are capitalized as intangible assets, and amortized over the remaining useful life of the related product.

(j)  Valuation and impairment of long-lived assets other than goodwill, indefinite lived intangible assets and investments

The Company evaluates the carrying value of long-lived assets other than goodwill, indefinite lived intangible assets and investments for impairment whenever events or changes in circumstances indicate that the carrying amounts of the relevant assets may not be recoverable. When such a determination is made, management’s estimate of undiscounted cash flows to be generated by the use and ultimate disposition of these assets is compared to the carrying value of the assets to determine whether the carrying value is recoverable. If the carrying value is deemed not to be recoverable, the amount of the impairment recognized in the consolidated financial statements is determined by estimating the fair value of the relevant assets and recording an impairment loss for the amount by which the carrying value exceeds the estimated fair value. This fair value is usually determined based on estimated discounted cash flows.

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(k)  Finance costs of debt

Finance costs relating to debt issued are recorded as a deferred charge and amortized to the consolidated statements of income over the period to the earliest redemption date of the debt, using the effective interest rate method. On extinguishment of the related debt, any unamortized deferred financing costs are written off and charged to interest expense in the consolidated statements of income.

(l)  Foreign currency

Monetary assets and liabilities in foreign currencies are translated into the functional currency of the relevant subsidiary in which they arise at the rate of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into the relevant functional currency at the rate of exchange ruling at the date of the transaction. Transaction gains and losses, other than those related to current and deferred tax assets and liabilities, are recognized in arriving at income from operations before income taxes and equity in earnings of equity method investees. Transaction gains and losses arising on foreign currency denominated current and deferred tax assets and liabilities are included within income taxes in the consolidated statements of income.

The results of operations for subsidiaries, whose functional currency is not the US dollar, are translated into the US dollar at the average rates of exchange during the period, with the subsidiaries’ balance sheets translated at the rates ruling at the balance sheet date. The cumulative effect of exchange rate movements is included in a separate component of Other comprehensive income.

Foreign currency exchange transaction losses included in consolidated statements of income in the years to December 31, 2013, 2012 and 2011 amounted to $8.7 million, $3.5 million and $2.1 million, respectively.

(m)  Income taxes

Uncertain tax positions are recognized in the consolidated financial statements for positions which are considered more likely than not of being sustained, based on the technical merits of the position on audit by the tax authorities. The measurement of the tax benefit recognized in the consolidated financial statements is based upon the largest amount of tax benefit that, in management’s judgment, is greater than 50% likely of being realized based on a cumulative probability assessment of the possible outcomes. The Company recognizes interest relating to unrecognized tax benefits and penalties within income taxes.

Deferred tax assets and liabilities are recognized for differences between the carrying amounts of assets and liabilities in the consolidated financial statements and the tax bases of assets and liabilities that will result in future taxable or deductible amounts. The deferred tax assets and liabilities are measured using the enacted tax laws and rates applicable to the periods in which the differences are expected to affect taxable income.

Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized.

(n)  Earnings per share

Basic earnings per share is based upon net income attributable to Shire plc divided by the weighted average number of ordinary shares outstanding during the period. Diluted earnings per share is based upon net income attributable to Shire plc adjusted for the impact of interest expense on convertible debt on an “if-converted” basis (when the effect is dilutive and prior to the actual conversion or redemption of debt) divided by the weighted average number of ordinary share equivalents outstanding during the period, adjusted for the dilutive effect of all potential ordinary shares equivalents that were outstanding during the year. Such potentially dilutive shares are excluded when the effect would be to increase diluted earnings per share or reduce the diluted loss per share.

(o)  Share-based compensation

Share-based compensation represents the cost of share-based awards granted to employees. The Company measures share-based compensation cost for awards classified as equity at the grant date, based on the estimated fair value of the award. Predominantly all of the Company’s awards have service and/or performance conditions and the fair values of these awards are estimated using a Black-Scholes valuation model.

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For share-based compensation awards which cliff vest, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the employee’s requisite service period. For those share-based compensation awards with a graded vesting schedule, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the requisite service period for the entire award (that is, over the requisite service period for the last separately vesting portion of the award). The share based compensation expense is recorded in Cost of product sales, R&D, and SG&A in the consolidated statements of income based on the employees’ respective functions.

The Company records deferred tax assets for awards that result in deductions on the Company’s income tax returns, based on the amount of compensation cost recognized and the Company’s statutory tax rate in the jurisdiction in which it will receive a deduction. Differences between the deferred tax assets recognized for financial reporting purposes and the actual tax deduction reported on the Company’s income tax return are recorded in additional paid-in capital (if the tax deduction exceeds the deferred tax asset) or in the consolidated statements of income (if the deferred tax asset exceeds the tax deduction and no additional paid-in capital exists from previous awards).

The Company’s share-based compensation plans are described more fully in Note 27.

(p)  Cash and cash equivalents

Cash and cash equivalents are defined as short term highly liquid investments with original maturities of ninety days or less.

(q)  Financial instruments - derivatives

The Company uses derivative financial instruments to manage its exposure to foreign exchange risk associated with intercompany financing. These instruments consist of swap and forward foreign exchange contracts. The Company does not apply hedge accounting for these instruments. The fair values of these instruments are included on the balance sheet in current assets / liabilities, with changes in the fair value recognized in the consolidated statements of income. The cash flows relating to these instruments are presented within net cash provided by operating activities in the consolidated statement of cash flows, unless the derivative instruments are economically hedging specific investing or financing activities.

(r)  Inventories

Inventories are stated at the lower of cost or market. Cost incurred in bringing each product to its present location and condition is based on purchase costs calculated on a first-in, first-out basis, including transportation costs.

Inventories include costs relating to both marketed products and, for certain products, cost incurred prior to regulatory approval. Inventories are capitalized prior to regulatory approval if the Company considers that it is probable that the US Food and Drug Administration (“FDA”) or another regulatory body will grant commercial and manufacturing approval for the relevant product, and it is probable that the value of capitalized inventories will be recovered through commercial sale.

Inventories are written down for estimated obsolescence or unmarketable inventory equal to the difference between the cost of inventory and estimated market value based upon assumptions about future demand and market conditions. If actual market conditions are less favorable than those anticipated, inventory adjustments may be required.

(s)  Assets held-for-sale

An asset or asset disposal group is classified as held-for-sale when, amongst other things, the Company has committed to a plan of disposition, the asset or asset disposal group is available for immediate sale, and the plan is not expected to change significantly. Assets held-for-sale are carried at the lower of their carrying amount or fair value less cost to sell.

The Company does not record depreciation or amortization on assets classified as held-for-sale.

(t)  Investments

The Company has certain investments in pharmaceutical and biotechnology companies.

Investments are accounted for using the equity method of accounting if the investment gives the Company the ability to exercise significant influence, but not control over, the investee. Significant influence is generally deemed to exist if the Company has an ownership interest in the voting stock of the investee between 20% and 50%, although other factors

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such as representation on the investee’s Board of Directors and the nature of commercial arrangements, are considered in determining whether the equity method of accounting is appropriate. Under the equity method of accounting, the Company records its investments in equity-method investees in the consolidated balance sheet under Investments and its share of the investees’ earnings or losses together with other-than-temporary impairments in value under equity in earnings of equity method investees in the consolidated statements of income.

All other equity investments, which consist of investments for which the Company does not have the ability to exercise significant influence, are accounted for under the cost method or at fair value. Investments in private companies are carried at cost, less provisions for other-than-temporary impairment in value. For public companies that have readily determinable fair values, the Company classifies its equity investments as available-for-sale and, accordingly, records these investments at their fair values with unrealized holding gains and losses included in the consolidated statement of comprehensive income, net of any related tax effect. Realized gains and losses, and declines in value of available-for-sale securities judged to be other-than-temporary, are included in other income, net. The cost of securities sold is based on the specific identification method. Interest on securities classified as available-for-sale are included as interest income.

(u)  Property, plant and equipment

Property, plant and equipment is shown at cost reduced for impairment losses, net of accumulated depreciation. The cost of significant assets includes capitalized interest incurred during the construction period. Depreciation is recorded on a straight-line basis at rates calculated to write off the cost less estimated residual value of each asset over its estimated useful life as follows:

Buildings	15 to 50 years
Office furniture, fittings and equipment	3 to 10 years
Warehouse, laboratory and manufacturing equipment	3 to 15 years

The cost of land is not depreciated. Assets under the course of construction are not depreciated until the relevant assets are available and ready for their intended use.

Expenditures for maintenance and repairs are charged to the consolidated statements of income as incurred. The costs of major renewals and improvements are capitalized. At the time property, plant and equipment is retired or otherwise disposed of, the cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts. The profit or loss on such disposition is reflected in operating income.

(v)  Goodwill and other intangible assets

(i)  Goodwill

In business combinations completed subsequent to January 1, 2009, goodwill represents the excess of the fair value of the consideration given and the fair value of any non-controlling interest in the acquiree over the fair value of the identifiable assets and liabilities acquired. For business combinations completed prior to January 1, 2009 goodwill represents the excess of the fair value of the consideration given over the fair value of the identifiable assets and liabilities acquired.

Goodwill is not amortized, but instead is reviewed for impairment, at least annually or whenever events or changes in circumstances indicate that the carrying value may not be recoverable. For the purpose of assessing the carrying value of goodwill for impairment, goodwill is allocated at the Company’s reporting unit level. Events or changes in circumstances which could trigger an impairment review include but are not limited to: significant underperformance of a reporting unit relative to expected historical or projected future operating results; significant changes in the manner of the Company's use of acquired assets or the strategy for the overall business; and significant negative industry trends.

Goodwill is reviewed for impairment by comparing the carrying value of the reporting unit's net assets (including allocated goodwill) to the fair value of the reporting unit. If the reporting unit's carrying amount is greater than its fair value, a second step is performed whereby the portion of the reporting unit’s fair value relating to goodwill is compared to the carrying value of the reporting unit’s goodwill. The Company recognizes a goodwill impairment charge for the amount by which the carrying value of goodwill exceeds its estimated fair value. In the year to December 31, 2013 the Company has recorded an impairment charge of $198.9 million related to the goodwill allocated to the Company’s former Regenerative Medicine (“RM”) reporting unit. See Note 11 for further details.

(ii)  Other intangible assets

Other intangible assets principally comprise intellectual property rights for products with a defined revenue stream, acquired product technology and IPR&D.  Intellectual property rights for currently marketed products and acquired product

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technology are recorded at fair value and amortized over the estimated useful life of the related product, which ranges from 1 to 20 years (weighted average 10.1 years). IPR&D acquired through a business combination is capitalized as an indefinite lived intangible asset until the completion or abandonment of the associated R&D efforts. IPR&D is reviewed for impairment using a “one-step” approach which compares the fair value of the IPR&D asset with its carrying amount. An impairment loss is recognized to the extent that the carrying value exceeds the fair value of the IPR&D asset. Once the R&D efforts are completed the useful life of the relevant assets will be determined, and the IPR&D asset amortized over this useful economic life.

The following factors, where applicable, are considered in estimating the useful lives of Other intangible assets:

· expected use of the asset;

· regulatory, legal or contractual provisions, including the regulatory approval and review process, patent issues and actions by government agencies;

· the effects of obsolescence, changes in demand, competing products and other economic factors, including the stability of the market, known technological advances, development of competing drugs that are more effective clinically or economically;

· actions of competitors, suppliers, regulatory agencies or others that may eliminate current competitive advantages; and

· historical experience of renewing or extending similar arrangements.

When a number of factors apply to an intangible asset, these factors are considered in combination when determining the appropriate useful life for the relevant asset.

(w)  Non-monetary transactions

The Company enters into certain non-monetary transactions that involve either the granting of a license over the Company’s patents or the disposal of an asset or group of assets in exchange for a non–monetary asset, usually equity. The Company accounts for these transactions at fair value if the Company is able to determine the fair value within reasonable limits. To the extent the Company concludes that it is unable to determine the fair value of a transaction that transaction is accounted for at the recorded amounts of the assets exchanged. Management is required to exercise its judgment in determining whether or not the fair value of the asset received or given up can be determined.

(x)  New accounting pronouncements

Adopted during the period

Indefinite-Lived Intangible Assets (Other than Goodwill) Impairment Testing

In July 2012 the Financial Accounting Standard Board (“FASB”) issued guidance on the testing of indefinite-lived intangible assets for impairment. The guidance permits an entity to first assess qualitative factors to determine whether the existence of events or circumstances leads to a determination that it is more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount. If, after assessing the totality of events or circumstances, an entity determines it is not more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount, performing the impairment test is unnecessary. The more-likely-than-not threshold is defined as a likelihood of more than 50 percent. An entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the impairment test and may resume performing the qualitative assessment in any subsequent period. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company’s consolidated financial position, results of operations or cash flows.

Disclosure about offsetting assets and liabilities

In December 2011 the FASB issued guidance on disclosures about offsetting assets and liabilities. In January 2013 the FASB amended the previous guidance to clarify the scope of guidance issued in December 2011. The amended guidance requires entities to disclose both gross and net information about derivatives including bifurcated embedded derivatives, repurchase agreements and reverse repurchase agreements, and securities borrowing and securities lending transactions that are either offset in accordance with FASB guidance on topics “Balance Sheet” and “Derivatives and Hedging” or subject to an enforceable master netting arrangement or similar agreement; to enable users of financial statements to understand the effects or potential effects of those arrangements on its financial position. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company’s consolidated financial

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position, results of operations or cash flows. Enhanced disclosure of balance sheet offsetting as required by this guidance is included in Note 20.

Amounts reclassified out of Comprehensive Income

In February 2013 the FASB issued guidance on reporting amounts reclassified out of accumulated other comprehensive income. The guidance requires entities to provide information about the amount reclassified out of comprehensive income by component and present either on the face of the financial statements or in the notes, significant amounts reclassified out of other comprehensive income by the respective line items of net income, but only if the amount reclassified is required under US GAAP to be reclassified to net income in its entirety in the same reporting period. For other amounts that are not required under US GAAP to be reclassified in their entirety to net income, an entity is required to cross-reference to other disclosures required under US GAAP that provide additional detail about those amounts. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company’s consolidated financial position, results of operations or cash flows.

Presentation of an unrecognized tax benefit

In July 2013 the FASB issued guidance on the financial statement presentation of an unrecognized tax benefit when a net operating loss carry forward, a similar tax loss, or a tax credit carry forward exists. The guidance requires entities to present an unrecognized tax benefit or a portion of an unrecognized tax benefit in the financial statements as a reduction to a deferred tax asset for a net operating loss carry forward, a similar tax loss, or a tax credit carry forward, except as follows: to the extent a net operating loss carry forward, a similar tax loss, or a tax credit carry forward is not available at the reporting date under the tax law of the applicable jurisdiction to settle any additional income taxes that would result from the disallowance of a tax position or the tax law of the applicable jurisdiction does not require the entity to use, and the entity does not intend to use, the deferred tax asset for such purpose, the unrecognized tax benefit should be presented in the financial statements as a liability and should not be combined with deferred tax assets. The assessment of whether a deferred tax asset is available is based on the unrecognized tax benefit and deferred tax asset that exist at the reporting date and should be made presuming disallowance of the tax position at the reporting date. The guidance will be effective for fiscal years, and interim periods within those years, beginning after December 15, 2013, with early adoption permitted. The Company has adopted this guidance in the period. The adoption of the guidance did not materially impact the Company’s consolidated financial position, results of operations or cash flows.

(y)  Statutory accounts

The consolidated financial statements as at December 31, 2013 and 2012, and for each of the three years in the period to December 31, 2013 do not comprise statutory accounts within the meaning of Section 434 of the UK Companies Act 2006 or Article 104 of the Companies (Jersey) Law 1991.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2012 prepared under UK GAAP and in compliance with Jersey law have been delivered to the Registrar of Companies for Jersey. The consolidated accounts of the Company for the year ended December 31, 2012 prepared in accordance with US GAAP, in fulfillment of the Company’s United Kingdom Listing Authority (“UKLA”) annual reporting requirements were filed with the UKLA. The auditor’s reports on these accounts were unqualified.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2013 prepared under UK GAAP and in compliance with Jersey law will be delivered to the Registrar of Companies in Jersey in 2014. The Company further expects to file the consolidated accounts of the Company for the year to December 31, 2013, prepared in accordance with US GAAP, in fulfillment of the Company’s UKLA annual reporting requirements with the UKLA in 2014.

3.  Business combinations

Acquisition of ViroPharma Inc. (“ViroPharma”)

On November 11, 2013, Shire signed a definitive agreement to acquire all of the outstanding share capital of ViroPharma for $50 per share in cash or approximately $4,200 million. The transaction was completed on January 24, 2014 at which time ViroPharma became a wholly-owned subsidiary.

ViroPharma is a high growth, rare disease biopharmaceutical company, whose commercial product CINRYZE (C1 esterase inhibitor [human]), is a leading brand for the prophylactic treatment of Hereditary Angioedema (“HAE”).

The acquisition of ViroPharma will be accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ViroPharma will be recorded at the date of acquisition, at their fair value. Shire’s

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consolidated financial statements will reflect these fair values at, and the results of ViroPharma will be included in Shire’s consolidated statement of income from, January 24, 2014. As the initial accounting for the business combination has not yet been completed, further disclosure relating to this acquisition will be included in the Company’s Form 10-Q for the three months ended March 31, 2014.

In the year to December 31, 2013 the Company expensed costs of $12.8 million (2012: $nil) relating to the acquisition of ViroPharma, which have been recorded within integration and acquisition costs in the Company’s consolidated income statement.

Acquisition of SARcode Bioscience Inc. (“SARcode”)

On April 17, 2013 Shire completed the acquisition of 100% of the outstanding share capital of SARcode. The acquisition date fair value of consideration totaled $368 million, comprising cash consideration paid on closing of $151 million and the acquisition date fair value of contingent consideration payable of $217 million. Following top-line Phase 3 study results in December 2013, the maximum amount of contingent cash consideration which may now be payable by Shire in future periods is $225 million dependent upon achievement of certain net sales milestones.

This acquisition brings the global rights of a new Phase 3 compound, Lifitegrast, currently under development for the treatment of Dry Eye disease, into Shire’s portfolio. Top-line results from OPUS-2, a Phase 3 efficacy and safety study of 5.0% Lifitegrast ophthalmic solution, were announced on December 6, 2013. Shire intends to investigate the full data from OPUS-2 and is planning further interactions with the FDA in the first half of 2014 in order to advance this program.

The acquisition of SARcode has been accounted as a business combination using the acquisition method. The assets and liabilities assumed from SARcode have been recorded at their fair values at the date of acquisition, being April 17, 2013. The Company’s consolidated financial statements and results of operations include the results of SARcode from April 17, 2013. In the year to December 31, 2013 the Company’s consolidated income statement includes pre-tax losses of $26.0 million in relation to the post acquisition results of SARcode.

The purchase price has been allocated to acquired in process research and development (“IPR&D”) in respect of Lifitegrast ($412 million), net current liabilities assumed ($8.2 million), net non-current liabilities assumed, including deferred tax liabilities ($122.4 million) and goodwill ($86.6 million). This acquisition resulted in goodwill of $86.6 million, which is not deductible for tax purposes. Goodwill includes the value of the assembled workforce and the related scientific expertise in ophthalmology which allows for potential expansion into a new therapeutic area.

In the year to December 31, 2013 the Company recorded a net credit of $170.7 million (2012: $nil) within Integration and acquisition costs relating to the acquisition of SARcode. This amount principally comprises a credit of $176.0 million on re-measuring the fair value of the contingent consideration payable following OPUS-2 trial results. In addition, acquisition and integration costs related to SARcode amounted to $5.3 million. 

Acquisition of Premacure AB (“Premacure”)

On March 8, 2013 Shire completed the acquisition of 100% of the outstanding share capital of Premacure. The acquisition date fair value of the consideration totaled $140.2 million, comprising cash consideration paid on closing of $30.6 million, and the fair value of contingent consideration payable of $109.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods, dependent upon the successful completion of certain development and commercial milestones, is $169 million. Shire will also pay royalties on relevant net sales.

Premacure is developing a protein replacement therapy (“PREMIPLEX”), currently in Phase 2 development, for the prevention of Retinopathy of Prematurity (“ROP”). ROP is a rare and potentially blinding eye disorder that primarily affects premature infants and is one of the most common causes of visual loss in childhood. Together, the acquisitions of SARcode and Premacure build Shire’s presence in the ophthalmology therapeutic area.

The acquisition of Premacure has been accounted for as a business combination using the acquisition method. The assets and the liabilities assumed from Premacure have been recorded at their fair values at the date of acquisition, being March 8, 2013. The Company’s consolidated financial statements and results of operations include the results of Premacure from March 8, 2013.

The purchase price has been allocated to acquired IPR&D in respect of PREMIPLEX ($151.8 million), net current liabilities assumed ($11.7 million), net non-current liabilities assumed, including deferred tax liabilities ($29.5 million) and goodwill ($29.6 million). This acquisition resulted in goodwill of $29.6 million, which is not deductible for tax purposes.

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In the year to December 31, 2013 the Company expensed costs of $9.5 million (2012: nil) relating to the acquisition of Premacure (including charges related to the change in fair value of contingent consideration payable), which have been recorded within integration and acquisition costs in the Company’s consolidated income statement.

Acquisition of Lotus Tissue Repair, Inc. (“Lotus Tissue Repair”)

On February 12, 2013 Shire completed the acquisition of 100% of the outstanding share capital of Lotus Tissue Repair. The acquisition date fair value of consideration totaled $174.2 million, comprising cash consideration paid on closing of $49.4 million, and the fair value of contingent consideration payable of $124.8 million.  The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $275 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon achievement of certain pre-clinical and clinical development milestones.

Lotus Tissue Repair is developing a proprietary recombinant form of human collagen Type VII (“rC7”) as the first and only intravenous protein replacement therapy currently being investigated for the treatment of Dystrophic Epidermolysis Bullosa (“DEB”).  DEB is a devastating orphan disease for which there is no currently approved treatment option other than palliative care. The acquisition adds to Shire’s pipeline a late stage pre-clinical product for the treatment of DEB with global rights.

The acquisition of Lotus Tissue Repair has been accounted for as a business combination using the acquisition method. The assets and the liabilities assumed from Lotus Tissue Repair have been recorded at their fair values at the date of acquisition, being February 12, 2013. The Company’s consolidated financial statements and results of operations include the results of Lotus Tissue Repair from February 12, 2013.

The purchase price has been allocated to acquired IPR&D in respect of rC7 ($176.7 million), net current assets assumed ($6.8 million), net non-current liabilities assumed, including deferred tax liabilities ($63.4 million) and goodwill ($54.1 million). This acquisition resulted in goodwill of $54.1 million, which is not deductible for tax purposes.

In the year to December 31, 2013 the Company expensed costs of $2.3 million (2012: $0.5 million) relating to the acquisition of Lotus Tissue Repair, which have been recorded within integration and acquisition costs in the Company’s consolidated income statement.

Acquisition of FerroKin BioSciences, Inc. (“FerroKin”)

On April 2, 2012 Shire completed the acquisition of 100% of the outstanding share capital of FerroKin. The acquisition-date fair value of consideration totalled $159.3 million, comprising cash consideration paid on closing of $94.5 million and the fair value of contingent consideration payable of $64.8 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $225.0 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon the achievement of certain clinical development, regulatory and net sales milestones.

The acquisition of FerroKin adds global rights to a Phase 2 product, SHP 602 (formerly referred to as FBS0701), to Shire’s pipeline. SHP 602 is intended to serve a chronic patient need for treatment of iron overload following numerous blood transfusions. Together with the Company’s collaboration with Sangamo Biosciences Inc. (“Sangamo”), this acquisition is a strategic step in building Shire’s hematology business, which already includes XAGRID and a growing development pipeline.

The acquisition of FerroKin has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from FerroKin have been recorded at their fair values at the date of acquisition, being April 2, 2012. The Company’s consolidated financial statements and results of operations include the results of FerroKin from April 2, 2012. In the year to December 31, 2012 the Company included pre-tax losses of $19.1 million, for FerroKin within its consolidated statement of income.

The purchase price has been allocated to acquired in-process research and development (“IPR&D”) in respect of SHP602 ($166.0 million), net current liabilities assumed ($6.6 million), net non-current liabilities assumed (including deferred tax liabilities) ($46.2 million) and goodwill ($46.1 million). Goodwill arising of $46.1 million is not deductible for tax purposes.

In the year to December 31, 2013 the Company expensed costs of $10.4 million (2012: $12.1 million) relating to the FerroKin acquisition, which have been recorded within Integration and acquisition costs in the Company’s consolidated statement of income.

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Acquisition of certain assets & liabilities of Pervasis Therapeutics, Inc. (“Pervasis”)

On April 19, 2012 Shire acquired substantially all the assets and certain liabilities of Pervasis. The acquisition date fair value of the consideration totaled $26.1 million, comprising cash consideration paid on closing of $2.5 million and the fair value of contingent consideration payable of $23.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is up to $169.5 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon achievement of certain clinical development, regulatory and net sales milestones. The acquisition adds SHP613 (formerly VASCUGEL) to Shire’s pipeline. SHP613 is currently in Phase 2 development for acute vascular repair, focused on improving hemodialysis access for patients with end-stage renal disease.

The acquisition has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from Pervasis have been recorded at their fair values at the date of acquisition, being  April 19, 2012. The Company’s consolidated financial statements and results of operations include the results of the assets acquired and the liabilities assumed from Pervasis from April 19, 2012. The purchase price has been allocated to acquired IPR&D (principally for VASCUGEL) ($24.3 million), current liabilities assumed ($0.2 million) and goodwill ($2.0 million). Goodwill arising of $2.0 million is not deductible for tax purposes.

Acquisition of Advanced BioHealing, Inc. (“ABH”)

On June 28, 2011 Shire completed its acquisition of 100% of the outstanding shares and other equity instruments of ABH. The fair value of cash consideration paid by the Company during 2011 was $739.6 million.

On January 16, 2014, the Company sold and transferred certain of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc. For further information, see Note 8, “Results of discontinued operations and other assets held for sale” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

The acquisition of ABH was accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ABH have been recorded at their fair values at the date of acquisition, being June 28, 2011. The determination of final fair values was completed on June 28, 2012. The Company’s consolidated financial statements and results of operations include the results of ABH from June 28, 2011. The amount of ABH’s revenues and pre-tax losses included in the Company’s consolidated statement of income for the year ended December 31, 2011 were $105.3 million and $15.3 million (after intangible asset amortization of $20.0 million) respectively.

F-24

The Company’s allocation of the purchase price to the assets acquired and liabilities assumed is outlined below:

	Fair value
		$’M
ASSETS
Current assets:
Cash and cash equivalents		14.6
Accounts receivable		30.1
Inventories		30.7
Deferred tax assets		51.1
Other current assets		7.9
Total current assets		134.4
Non-current assets:
Property, plant and equipment		16.6
Goodwill		197.0
Other intangible assets
- DERMAGRAFT product technology		710.0
- other intangible assets		1.5
Other non-current assets		0.2
Total assets		1,059.7
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities		52.4
Non-current liabilities:
Long term debt, less current portion		9.1
Deferred tax liabilities		258.5
Other non-current liabilities		0.1
Total liabilities		320.1
Fair value of identifiable assets acquired and liabilities assumed		739.6
Consideration
Cash consideration paid		739.6

Supplemental disclosure of pro forma information

The unaudited pro forma financial information to present the combined results of the operations of Shire, SARcode, Premacure and Lotus Tissue Repair are not provided as the impacts of these acquisitions were not material to the Company’s results of continuing operations for any period presented.

4.  Divestment of product rights

On October 1, 2010 the Company completed the divestment of DAYTRANA to Noven (Noven developed and manufactures DAYTRANA, and Shire licensed DAYTRANA from Noven in 2003). No consideration was received at the time of divestment, however consideration is receivable from Noven dependent on DAYTRANA’s performance in the period subsequent to divestment. On divestment Shire recorded the fair value of contingent consideration receivable from

F-25

Noven within current and non-current assets. During the year to December 31, 2013 the Company recognized a gain of $15.9 million (2012: gain of $18.1 million, 2011: loss of $6.0 million) due to changes in the fair value of this contingent consideration. At December 31, 2013 the Company has recorded a receivable based on the fair value of future contingent consideration totaling $36.1 million (2012: $39.2 million), split between current assets $9.6 million (2012: $11.6 million) and non-current assets $26.5 million (2012: $27.6 million).

5.  Reorganization costs

Turnhout, Belgium Site Closure

On January 23, 2013 Shire announced that it had decided to proceed with a collective dismissal and business closure at its site in Turnhout, Belgium. This decision follows the conclusion of an information and consultation process. Shire will continue to sell RESOLOR in Europe and the supply of RESOLOR for patients in Europe who rely on the medicine will not be affected. The closure of the Turnhout site was completed during 2013. In the year to December 31, 2013 the Company incurred reorganization costs totaling $23.6 million, relating to employee involuntary termination benefits and other re-organization costs.

One Shire business reorganization

On May 2, 2013, the Company announced that there would be a reorganization of the business to integrate the three divisions into a simplified One Shire organization in order to drive future growth and innovation.

On November 7, 2013 the Company announced that, as part of the One Shire reorganization, the Company had undertaken a review of all of Shire’s pipeline programs to identify those projects that fit with Shire’s new strategic direction and have an acceptable likelihood of success. Shire’s pre-clinical investments will now be primarily focused on Rare Diseases, meaning that the majority of other pre-clinical projects will not continue. Several clinical programs have also been discontinued. The impact of the prioritization and rationalization of the Company’s development portfolio means many of the R&D programs currently run from Basingstoke, UK will cease. Taken together with the overall streamlining of the R&D organization, this has resulted in a significant number of R&D roles in Basingstoke being eliminated and some positions being re-located. A small number of functional roles that support R&D in Basingstoke have also been affected.

In addition the Company also announced plans to relocate its international commercial hub from Nyon, Switzerland to Zug, Switzerland. All Nyon-based employees have been impacted by the One Shire transition and the proposed move to Zug. Shire is planning for the new Zug office to be ready for occupancy in summer 2014, and will phase out the Nyon office over a reasonable period of time to enable employees and their families to manage their re-locations.

In the year to December 31, 2013 the Company incurred reorganization costs totaling $64.6 million, relating to employee involuntary termination benefits and other reorganization costs. The One Shire reorganization is expected to be substantially completed by the end of 2014. Currently, the Company estimates that further costs in respect of the One Shire reorganization of approximately $150 million will be expensed as incurred during 2014.

The liability for reorganization costs arising on the closure of Company’s site in Turnhout, Belgium and the One Shire business reorganization at December 31, 2013 is as follows:

	Opening liability		Amount					Closing liability at
	at January 1,		charged to re-					December 31,
	2013		organization		Paid/Utilized			2013
	$'M		$'M		$'M			$'M
Involuntary termination benefits		-		44.7		(29.4	)		15.3
Other reorganization costs		-		43.5		(34.0	)		9.5
		-		88.2		(63.4	)		24.8

F-26

At December 31, 2013 the closing reorganization cost liability was recorded within accounts payable and accrued expenses ($24.8 million).

6.  Accounts receivable, net

Accounts receivable at December 31, 2013 of $961.2 million (December 31, 2012: $824.2 million), are stated net of a provision for discounts and doubtful accounts of $47.9 million (December 31, 2012: $41.7 million, December 31, 2011: $31.1 million).

Provision for discounts and doubtful accounts:

	2013			2012			2011
		$’M			$’M			$’M
As at January 1,		41.7			31.1			23.4
Provision charged to operations		306.8			283.3			240.8
Provision utilization		(300.6	)		(272.7	)		(233.1	)
As at December 31,		47.9			41.7			31.1

At December 31, 2013 accounts receivable included $37.8 million (December 31, 2012: $38.5 million) related to royalty income.

7.  Inventories

Inventories are stated at the lower of cost or market and comprise:

	December 31,		December 31,
	2013		2012
		$’M		$’M
Finished goods		156.6		124.4
Work-in-progress		240.5		220.6
Raw materials		58.2		91.9
		455.3		436.9

8.  Results of discontinued operations and assets held for sale

On January 16, 2014 the Company entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”) with Organogenesis Inc. (the “Purchaser” or “Organogenesis”), pursuant to which, on January 16, 2014 the Company sold and transferred to the Purchaser certain of the assets (the “Transferred Assets”) relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT (the “Business”), and the Purchaser assumed certain of the liabilities relating to the Business. The Company will receive no upfront payment from the Purchaser but is entitled to receive total milestone payments of up to $300 million in cash if the Purchaser meets certain annual net sales targets during the five consecutive calendar years ending with the calendar year ending December 31, 2018.

The Transferred Assets include intellectual property relating to DERMAGRAFT, including patents, trademarks and know-how, regulatory filings and registrations relating to DERMAGRAFT ($611.4 million), certain manufacturing plant, equipment and materials relating to the Business ($29.1 million), and DERMAGRAFT product inventory ($16.2 million) and accounts receivable ($11.8 million). The Company is generally retaining liabilities incurred prior to the date of the Asset Purchase Agreement relating to the DERMAGRAFT business, including the previously disclosed investigation by the US Department of Justice relating to the sales and marketing practices of Advanced Biohealing, Inc. (“ABH”).

The Transferred Assets have been measured at their fair value less costs to sell, amounting to $31.6 million, and are presented within “Assets held-for-sale” in the consolidated balance sheet as at December 31, 2013. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs (see Note 21 for further details).

F-27

On October 22, 2013 Shire announced that it had decided to discontinue the construction of its new manufacturing facility in San Diego. Shire is currently assessing disposal options for this facility. In the year to December 31, 2013, the Company recorded charges of $99.6 million, comprising charges to write down the carrying value of the assets related to this manufacturing facility, accruals for non-cancellable contractual costs in relation to the construction, and a provision for the onerous land lease. These costs have been presented within discontinued operations in the consolidated income statement.

The operating results associated with the DERMAGRAFT business, including the costs of discontinuing the second manufacturing facility, have been classified as discontinued operations in the consolidated statements of income for all periods presented.

The components of discontinued operations which relate to the DERMAGRAFT business are as follows:

	2013			2012			2011
Revenues:		$’M			$’M			$’M
Product revenues		89.8			153.8			105.3
Loss from discontinued operations before income taxes		(1,080.9	)		(96.4	)		(27.0	)
Income taxes		326.4			36.1			9.3
Loss from discontinued operations, net of taxes		(754.5	)		(60.3	)		(17.7	)

The loss from discontinued operations before income taxes in 2013 includes: $191.8 million, being the proportion of the RM reporting unit goodwill impairment charge (recorded in the first quarter of 2013) that relates to the DERMAGRAFT business, $636.9 million being the impairment charge recorded upon re-measurement of the divested assets to their fair value less costs to sell in the fourth quarter of 2013, and $99.6 million being amounts previously recorded to Reorganization costs in relation to the DERMAGRAFT business.

9.  Prepaid expenses and other current assets

	December 31,		December 31,
	2013		2012
		$’M		$’M
Prepaid expenses		29.4		31.7
Income tax receivable		177.4		130.6
Value added taxes receivable		14.5		20.9
Other current assets		41.7		38.6
		263.0		221.8

F-28

10.  Property, plant and equipment, net

	December 31,			December 31,
	2013			2012
		$’M			$’M
Land and buildings		695.0			701.2
Office furniture, fittings and equipment		467.0			383.8
Warehouse, laboratory and manufacturing equipment		276.2			287.2
Assets under construction		45.6			93.8
		1,483.8			1,466.0
Less: Accumulated depreciation		(592.0	)		(510.2	)
		891.8			955.8

Depreciation expense for the years to December 31, 2013, 2012 and 2011 was $127.6 million, $109.0 million, and $119.5 million respectively.

11.  Goodwill

	December 31,		December 31,
	2013		2012
		$’M		$’M
Goodwill arising on businesses acquired		624.6		644.5

In the year to December 31, 2013 the Company completed the acquisitions of SARcode, Premacure and Lotus Tissue Repair, which resulted in goodwill of $86.6 million, $29.6 million and $54.1 million, respectively (see Note 3 for details).

As a result of the re-alignment of the business into a simplified One Shire organization, the Company now comprises one operating and one reportable segment (see note 24 for further details).

	2013			2012
		$’M			$’M
As at January 1,		644.5			592.6
Acquisitions		170.3			48.1
Goodwill impairment charge related to continuing operations		(7.1	)		-
Goodwill impairment charge related to DERMAGRAFT business and transferred to discontinued operations		(191.8	)		-
Foreign currency translation		8.7			3.8
As at December 31,		624.6			644.5

Goodwill is tested for impairment at least annually as at October 1 each year. This assessment is also performed whenever there is a change in circumstances that indicates the carrying value of these assets may not be recoverable.

In the first quarter of 2013 the Company identified circumstances which indicated that the carrying value of goodwill in the Company’s former RM reporting unit may not be recoverable, which triggered an impairment test in advance of the annual testing date.

F-29

Those circumstances included the results of an independent market research study of the DERMAGRAFT sales potential, commissioned by the Company, which was finalized late in the first quarter of 2013. In addition, the recently completed restructuring of the RM sales and marketing organization and the implementation of a new commercial model had a more pronounced impact than previously expected. As a result of those and other factors forecast future sales were lower than at the time of acquisition.

The results of the Company’s March 31, 2013 impairment test showed that the carrying amount of the former RM reporting unit exceeded its fair value and the implied value of the goodwill was $nil. As a result the Company recorded an impairment charge of $198.9 million related to the goodwill allocated to the former RM reporting unit. The RM goodwill impairment charge is not deductible for tax purposes. Accumulated goodwill impairment as at December 31, 2013 was $198.9 million (December 31, 2012: $nil).

The Company determined the estimated fair value of the former RM reporting unit using discounted cash flow analyses, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, expected cash flows for the period from March 31, 2013 to December 31, 2023 and the associated discount rate of 15.1%, which was derived from management’s best estimate of the after-tax weighted average cost of capital for the RM reporting unit.

Discounted cash flow analyses are dependent upon a number of quantitative and qualitative factors including estimates of forecasted revenue, profitability, earnings before interest, taxes, depreciation and amortization, and terminal values. The discount rates applied in the discounted cash flow analyses also have an impact on the estimates of fair value, as use of a higher rate will result in a lower estimate of fair value.

Following the divestment of DERMAGRAFT (see Note 8) the Company has reclassified the Goodwill and related accumulated impairment of $191.8 million (being the portion of the former RM reporting unit goodwill impairment charge that relates to the DERMAGRAFT business) to discontinued operations.

12.  Other intangible assets, net

	December 31,			December 31,
	2013			2012
		$’M			$’M
Amortized intangible assets
Intellectual property rights acquired for currently marketed products		2,573.3			2,462.0
Acquired product technology		-			710.0
Other intangible assets		46.1			44.5
		2,619.4			3,216.5
Unamortized intangible assets
Intellectual property rights acquired for IPR&D		951.5			231.0
		3,570.9			3,447.5
Less: Accumulated amortization		(1,258.3	)		(1,059.4	)
		2,312.6			2,388.1

F-30

The change in the net book value of other intangible assets for the year to December 31, 2013 and 2012 is shown in the table below:

	Other intangible assets
	2013			2012
		$’M			$’M
As at January 1,		2,388.1			2,493.0
Acquisitions		731.8			281.6
Amortization charged		(152.0	)		(153.6	)
Amortization charged on DERMAGRAFT product technology, presented within discontinued operations in the consolidated income statement		(39.4	)		(40.5	)
Impairment charges		(19.9	)		(197.9	)
Reclassification of DERMAGRAFT product technology to assets held for sale		(611.4	)		-
Foreign currency translation		15.4			5.5
As at December 31,		2,312.6			2,388.1

In the year to December 31, 2013 the Company acquired intangible assets totaling $731.8 million, relating to intangible assets acquired with SARcode, Premacure and Lotus Tissue Repair (see Note 3 for further details).

In the second quarter of 2013 the Company reviewed certain intangible assets acquired through Movetis N.V. (“Movetis”) for impairment and recognized an impairment charge of $19.9 million (2012: $197.9 million) in the consolidated income statement, to write-down these assets to their fair value. The fair values of these assets were determined using the income approach, which used significant unobservable (Level 3) inputs (see Note 21 for further details).

Following the divestment of DERMAGRAFT (see Note 8) the Company has reclassified $611.4 million of intangible assets related to the DERMAGRAFT product technology to assets held for sale.

Management estimates that the annual amortization charge in respect of intangible assets held at December 31, 2013 will be approximately $127 million for each of the five years to December 31, 2018. Estimated amortization expense can be affected by various factors including future acquisitions, disposals of product rights, regulatory approval and subsequent amortization of acquired IPR&D projects, foreign exchange movements and the technological advancement and regulatory approval of competitor products.

13.  Accounts payable and accrued expenses

	December 31,		December 31,
	2013		2012
		$’M		$’M
Trade accounts payable and accrued purchases		202.6		208.1
Accrued rebates – Medicaid		549.1		455.6
Accrued rebates – Managed care		258.1		184.9
Sales return reserve		98.8		90.5
Accrued bonuses		130.9		109.0
Accrued employee compensation and benefits payable		79.4		64.5
R&D accruals		69.6		73.5
Provisions for litigation losses and other claims		71.7		118.2
Other accrued expenses		228.2		197.2
		1,688.4		1,501.5

F-31

14.  Other current liabilities

	December 31,		December 31,
	2013		2012
		$’M		$’M
Income taxes payable		69.0		78.4
Value added taxes		15.8		23.6
Contingent consideration payable		12.9		16.0
Other current liabilities		21.8		26.1
		119.5		144.1

15.  Convertible bonds

Shire 2.75% Convertible Bonds due 2014

On May 9, 2007 Shire issued $1,100 million in principal amount of 2.75% convertible bonds due in 2014 and convertible into fully paid ordinary shares of Shire plc (the “Bonds”). As of December 31, 2013 all of the Bonds had been converted or redeemed as described below.

On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed to the holders of the Bonds. The aggregate outstanding principal amount of the Bonds on November 25, 2013, the last practicable date prior to the date of the optional redemption notice, was $1,075,070,000. The last day on which holders were able to exercise their conversion rights was December 13, 2013. Those Bonds which were not voluntarily converted by holders were redeemed by the Company on December 27, 2013 at par together with interest accrued to that date. As at December 31, 2013, Bonds in an aggregate principal amount of the $1,099,050,000 had been voluntarily converted into 33,806,464 fully paid ordinary shares at a conversion price of US$32.51 per ordinary share, in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principal amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. Following the redemption of all the outstanding Bonds, the Company cancelled the listing of the Bonds on the Official List maintained by the UK Listing Authority and the admission to trading of the Bonds on the Professional Securities Market of the London Stock Exchange.

16.  Other long term debt

Term Loan Agreement

On November 11, 2013, Shire entered into a $2.60 billion Facilities Agreement with, among others, Morgan Stanley Bank International Limited (acting as lead arranger and agent) (the “Facilities Agreement”).  The Facilities Agreement comprises two credit facilities: (i) a $1.75 billion term loan facility and (ii) a $0.85 billion term loan facility.  

On December 13, 2013 and on February 21, 2014, the Company cancelled part of the $2.60 billion term loan facility. The revised Facilities Agreement of $1.40 billion now comprises two credit facilities: (i) a $0.55 billion term loan facility and (ii) a $0.85 billion term loan facility. All other terms and conditions remain unchanged.

The $0.55 billion term loan facility, which matures on November 10, 2014, may be used only to finance the purchase price payable in respect of Shire’s proposed acquisition of ViroPharma (including certain related costs) and for the redemption of Shire’s Bonds.  Shire has the option to extend the maturity of the $0.55 billion term loan facility once by a further 364 days.

The $0.85 billion term loan facility, which matures on November 11, 2015, may be used only to finance the purchase price payable in respect of Shire’s proposed acquisition of ViroPharma (including certain related costs).

Interest on any loans made under the facilities will be payable on the last day of each interest period, which may be one week or one, two, three or six months at the election of Shire, or as otherwise agreed with the lenders.  The interest rate applicable to the $0.55 billion term loan facility is LIBOR plus 0.75% per annum and increases by 0.25% per annum on August 11, 2014 and on three-month intervals thereafter.

The interest rate applicable to the $0.85 billion term loan facility commenced at LIBOR plus 1.15% per annum until delivery of the compliance certificate for the year ending December 31, 2013 and thereafter is subject to change depending upon the prevailing ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement), in respect of the most recently completed financial year or financial half year.

F-32

Shire shall also pay a commitment fee on the available but unutilized commitments under the $0.55 billion term loan facility and the $0.85 billion term loan facility for the availability period applicable to each facility. With effect from first utilization, the commitment fee rate will be 35% of the applicable margin. Before first utilization, the commitment fee rate will increase in stages from 0% to 35% of the applicable margin over a period of 3 months.

The Facilities Agreement includes customary representations and warranties, covenants and events of default, including requirements that the ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement) must not, at any time, exceed 3.5:1 for the Relevant Period (as defined in the Facilities Agreement), except that following certain acquisitions, including the ViroPharma acquisition, Shire may elect to increase the ratio to 4.0:1 in the relevant period in which the acquisition was completed and the immediately following relevant period.  In addition, for each 12-month period ending December 31 or June 30, the ratio of EBITDA of the Group to Net Interest (each as defined in the Facilities Agreement) must not be less than 4.0:1.

The Facilities Agreement restricts (subject to certain covenants) Shire’s ability to incur additional financial indebtedness, grant security over its assets or provide or guarantee loans.  Further, any lender may require mandatory prepayment of its participation if there is a change of control of Shire. In addition, in certain circumstances, the net proceeds of certain shares, undertakings or business disposals by Shire must be applied towards the mandatory prepayment of the facilities, subject to certain exceptions.

Events of default under the facilities include: (i) non-payment of any amounts due under the facilities, (ii) failure to satisfy any financial covenants, (iii) material misrepresentation in any of the finance documents, (iv) failure to pay, or certain other defaults, under other financial indebtedness, (v) certain insolvency events or proceedings, (vi) material adverse changes in the business, operations, assets or financial condition of Shire and its subsidiaries, (vii) if it becomes unlawful for Shire or any of its subsidiaries that are parties to the Facilities Agreement to perform their obligations or (viii) if Shire or any subsidiary of Shire which is a party to the Facilities Agreement repudiates the Facilities Agreement or any other finance document, among others.The Facilities Agreement is governed by English law.

17.  Other non-current liabilities

	December 31,		December 31,
	2013		2012
		$’M		$’M
Income taxes payable		115.7		58.9
Deferred revenue		9.8		11.4
Deferred rent		11.3		11.9
Insurance provisions		1.0		12.3
Contingent consideration payable		393.0		120.4
Other non-current liabilities		57.7		26.7
		588.5		241.6

18.  Commitments and contingencies

(a)  Leases

Future minimum lease payments under operating leases at December 31, 2013 are presented below:

	Operating
	leases
		$’M
2014		44.9
2015		33.6
2016		23.9
2017		17.9
2018		12.2
Thereafter		83.4
		215.9

F-33

The Company leases land, facilities, motor vehicles and certain equipment under operating leases expiring through 2032. Lease and rental expense amounted to $44.0 million, $43.2 million and $37.6 million for the year to December 31, 2013, 2012 and 2011 respectively, which is predominately included in SG&A expenses in the Company’s consolidated income statement.

(b)  Letters of credit and guarantees

At December 31, 2013 the Company had irrevocable standby letters of credit and guarantees with various banks and insurance companiestotaling $51.0 million, providing security for the Company’s performance of various obligations. These obligations are primarily in respect of the recoverability of insurance claims, lease obligations and supply commitments.

(c)  Collaborative arrangements

Details of significant updates in collaborative arrangements are included below:

In-licensing arrangements

(i)  Research Collaboration with Santaris Pharma A/S (“Santaris”) on Locked Nucleic Acid (“LNA”) Drug Platform

On August 24, 2009 Shire announced that it had entered into a research collaboration with Santaris, to develop its proprietary LNA technology in a range of rare diseases. LNA technology has the benefit of shortened target validation and proof of concept, potentially increasing the speed and lowering the cost of development. As part of the joint research project Santaris will design, develop and deliver pre-clinical LNA oligonucleotides for Shire-selected orphan disease targets, and Shire will have the exclusive right to further develop and commercialize these candidate compounds on a worldwide basis.

In the year to December 31, 2013 Shire paid success milestones and other support costs of $1.5 million (2012: $3.0 million; 2011: $2.5 million) and $4.5 million (2012: $8.1 million; 2011: $5.3 million) to Santaris respectively, which were expensed to R&D. Shire has remaining obligations to pay Santaris development and sales milestones up to a maximum of $71.0 million for each current indication. Shire will also pay single or double digit tiered royalties on net sales of the product.

Shire and Santaris have formed a joint research committee to monitor R&D activities through preclinical lead candidate selection at which point all development and commercialization costs will be the responsibility of Shire.

(ii)  Collaboration and license agreement with Sangamo to develop therapeutics for hemophilia

On February 1, 2012 Shire and Sangamo announced that they had entered into a collaboration and license agreement to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo’s ZFP technology. Sangamo is responsible for all activities through submission of Investigational New Drug Applications and European Clinical Trial Applications for each product and Shire will reimburse Sangamo for its internal and external research program-related costs. Shire is responsible for clinical development and commercialization of products arising from the collaboration. 

In the year to December 31, 2012 Shire made an upfront payment to Sangamo of $13.0 million, for technology access and R&D funding, which was expensed to R&D.

In the year to December 31, 2013 Shire’s share of R&D costs under this collaboration agreement was $15.2 million (2012: $8.9 million; 2011: $nil) which were expensed to R&D. Shire may be required to pay research, regulatory, development and commercial milestone payments up to a maximum of $213.5 million and to pay royalties on net sales of the product.

Out-licensing arrangements

Shire has entered into various collaborative arrangements under which the Company has out-licensed certain product or intellectual property rights for consideration such as up-front payments, development milestones, sales milestones and/or royalty payments. In some of these arrangements Shire and the licensee are both actively involved in the development and commercialization of the licensed product and have exposure to risks and rewards dependent on its commercial success. Under the terms of these arrangements, the Company may receive development milestone payments up to an aggregate amount of $39.0 million and sales milestones up to an aggregate amount of $71.5 million. The receipt of these substantive milestones is uncertain and contingent on the achievement of certain development milestones or the achievement of a specified level of annual net sales by the licensee. In the year to December 31, 2013 Shire received up-front and milestone payments totaling $3.0 million (2012: $18.3 million, 2011: $11.5 million). In the year to December 31, 2013 Shire recognized milestone income of $5.0 million (2012: $19.4 million, 2011: $17.5 million) in other revenues and $58.3 million (2012: $83.8 million, 2011: $65.2 million) in product sales for shipment of product to the relevant licensee.

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(d)  Commitments

(i)  Clinical testing

At December 31, 2013 the Company had committed to pay approximately $346 million (December 31, 2012: $425 million) to contract vendors for administering and executing clinical trials. The timing of these payments is dependent upon actual services performed by the organizations as determined by patient enrollment levels and related activities.

(ii)  Contract manufacturing

At December 31, 2013 the Company had committed to pay approximately $109 million (December 31, 2012: $125 million) in respect of contract manufacturing. The Company expects to pay $109 million of these commitments in 2014.

(iii)  Other purchasing commitments

At December 31, 2013 the Company had committed to pay approximately $128 million (December 31, 2012: $145 million) for future purchases of goods and services, predominantly relating to active pharmaceutical ingredients sourcing. The Company expects to pay $121 million of these commitments in 2014.

(iv)  Investment commitments

At December 31, 2013 the Company had outstanding commitments to subscribe for interests in companies and partnerships for amounts totaling $14 million (December 31, 2012: $15 million) which may all be payable in 2014, depending on the timing of capital calls. The investment commitments include additional funding to Nimbus Neptune, Inc., a variable interest entity of which Shire is not the primary beneficiary. Under the terms of the agreement Nimbus Neptune, Inc. controls and conducts all related research up to achievement of drug candidate status at which point Shire will have an exclusive option to acquire the program.  Shire will then be responsible for all clinical development and future commercialization activities. Nimbus Neptune Inc. will be eligible to receive further consideration contingent upon achievement of certain development and commercial milestones.

(v)  Capital commitments

At December 31, 2013 the Company had committed to spend $12 million (December 31, 2012: $97 million) on capital projects.

(e)  Legal and other proceedings

The Company expenses legal costs as they are incurred.

The Company recognizes loss contingency provisions for probable losses when management is able to reasonably estimate the loss. When the estimated loss lies within a range, the Company records a loss contingency provision based on its best estimate of the probable loss. If no particular amount within that range is a better estimate than any other amount, the minimum amount is recorded.  Estimates of losses may be developed substantially before the ultimate loss is known, and are therefore refined each accounting period as additional information becomes known. In instances where the Company is unable to develop a reasonable estimate of loss, no loss contingency provision is recorded at that time. As information becomes known a loss contingency provision is recorded when a reasonable estimate can be made. The estimates are reviewed quarterly and the estimates are changed when expectations are revised. An outcome that deviates from the Company’s estimate may result in an additional expense or release in a future accounting period. At December 31, 2013 provisions for litigation losses, insurance claims and other disputes totaled $72.7 million (December 31, 2012: $130.5 million).

The Company’s principal pending legal and other proceedings are disclosed below. The outcomes of these proceedings are not always predictable and can be affected by various factors. For those legal and other proceedings for which it is considered at least reasonably possible that a loss has been incurred, the Company discloses the possible loss or range of possible loss in excess of the recorded loss contingency provision, if any, where such excess is both material and estimable.

VYVANSE

In May and June 2011, Shire was notified that six separate Abbreviated New Drug Applications ("ANDAs") were submitted under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of VYVANSE. The

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notices were from Sandoz, Inc. ("Sandoz"); Amneal Pharmaceuticals LLC ("Amneal"); Watson Laboratories, Inc.; Roxane Laboratories, Inc. ("Roxane"); Mylan Pharmaceuticals, Inc.; and Actavis Elizabeth LLC and Actavis Inc. (collectively, "Actavis").  Within the requisite 45 day period, Shire filed lawsuits for infringement of certain of Shire's VYVANSE patents in the US District Court for the District of New Jersey against each of Sandoz, Roxane, Amneal and Actavis; in the US District Court for the Central District of California against Watson Laboratories, Inc.; and in the US District Court for the Eastern District of New York against Mylan Pharmaceuticals, Inc. and Mylan Inc. (collectively "Mylan"). In February 2013, Shire withdrew its lawsuit against Watson following Watson’s withdrawal of its ANDA. On December 9, 2011, the District Court of New Jersey consolidated the Sandoz, Roxane, Amneal and Actavis cases. The filing of the lawsuits triggered a stay of approval of all six ANDAs for up to 30 months from the expiration of the new chemical entity exclusivity, which will expire on August 23, 2014. In December 2011 and February 2012, Shire received additional notifications that Mylan had filed further certifications challenging other VYVANSE patents listed in the Orange Book.  Within the requisite 45 day period, Shire filed a new lawsuit against Mylan, Johnson Matthey Pharmaceutical Materials and Johnson Matthey Inc. in New Jersey. In May 2012, the Mylan case that was filed in the Eastern District of New York was transferred and consolidated with the Mylan, Sandoz, Roxane, Amneal and Actavis cases in New Jersey. In December 2012, the parties completed a Markman briefing. A Markman hearing took place on August 5, 2013 and a ruling was rendered on August 8, 2013. No trial dates have been set.

INTUNIV

Between March 2010 and March 2011, Shire was notified that seven separate ANDAs had been submitted to the FDA under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of INTUNIV. The ANDA filers were Actavis Inc., Teva Pharmaceuticals USA, Inc., Anchen, Inc., Watson Pharmaceuticals, Inc., Impax Laboratories, Inc., Mylan Pharmaceuticals, Inc., Sandoz, Inc., and certain of their respective affiliates.  Shire filed lawsuits against each of these ANDA filers.  All of the lawsuits have now been settled.  Under the terms of the Actavis settlement, Actavis has a license to make and market Actavis' generic versions of INTUNIV in the United States on December 1, 2014.  Such sales will require the payment of a royalty of 25% of gross profits to Shire during the 180 day period of Actavis' exclusivity. All other parties with whom Shire has settled will be able to enter the market with their respective ANDA-approved products after Actavis’ 180 day exclusivity period has expired.  Each of the settlements included a consent judgment confirming that the proposed ANDA products infringe the patents-in-suit, U.S. Patents 6,287,599 and 6,811,794, and that those patents are valid and enforceable with respect to their respective proposed ANDA products.   U.S. Patent 5,854,290, which was originally asserted in some of the litigations, has been dedicated to the public.

FOSRENOL

Between February 2009 and December 2010 Shire was notified that four separate ANDAs had been submitted to the FDA under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of FOSRENOL. The ANDA filers were Barr Laboratories, Inc.; Mylan, Inc.; Natco Pharma Limited and Alkem Laboratories Ltd., and certain of their respective affiliates. Shire filed lawsuits against each of these ANDA filers.  In April 2011, Shire and Barr reached a settlement and the lawsuit against Barr was dismissed.  The settlement provides Barr with a license to market its own generic version of FOSRENOL upon receiving FDA approval in the US on the earlier of the date of entry of another company’s generic version of FOSRENOL to the US market, or October 1, 2021.  Shire’s lawsuits against Mylan, Alkem and Natco have each been dismissed, and consequently, each of Mylan, Alkem and Natco may enter the US market upon FDA approval of their respective ANDA products.

LIALDA

In May 2010 Shire was notified that Zydus Pharmaceuticals USA, Inc. (“Zydus”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of Delaware against Zydus and Cadila Healthcare Limited, doing business as Zydus Cadila. As of February 22, 2013, the case has been administratively closed.  No further activity will take place until after one of the parties files a motion to reopen the case.

In February 2012, Shire was notified that Osmotica Pharmaceutical Corporation ("Osmotica") had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA.  Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Northern District of Georgia against Osmotica. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. The court has appointed a special master to assist with a Markman hearing and to preside over any discovery disputes. A Markman hearing took place on August 22, 2013 but no ruling has been rendered. No trial date has been set.

In March 2012, Shire was notified that Watson Laboratories Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Southern District of Florida against Watson Laboratories Inc.-Florida and Watson Pharmaceuticals, Inc. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. In August 2012, Shire filed an amended complaint adding Watson Pharma, Inc. and Watson Laboratories, Inc. as defendants. A

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Markman hearing was held on December 20, 2012 and a written Markman decision was given by the court on January 17, 2013. A trial took place in April, 2013 and on May 9, 2013 the trial court issued a decision finding that the proposed generic product infringes the patent-in-suit and that the patent is not invalid.  Watson has appealed the trial court’s ruling to the Court of Appeals of the Federal Circuit (“CAFC”) and a hearing took place on December 2, 2013. No ruling has been issued by the CAFC.

In April 2012, Shire was notified that Mylan Pharmaceuticals, Inc. (“Mylan”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Middle District of Florida against Mylan. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. No date for a Markman hearing has been set. A trial is scheduled to occur in September, 2014.

ADDERALL XR

On November 1, 2010 Impax Laboratories, Inc. (“Impax”) filed suit against Shire in the US District Court for the Southern District of New York claiming that Shire was in breach of its supply contract for the authorized generic version of ADDERALL XR. On February 7, 2013 Shire and Impax settled this dispute and agreed to discontinue all court and related proceedings. Under the terms of the settlement Shire made a one-time cash payment to Impax of $48 million in the first quarter of 2013. Also as part of the settlement, the parties have entered into an amended supply agreement which will govern the supply of authorized generic ADDERALL XR from Shire to Impax until the end of the supply term on September 30, 2014.

In February 2011, Shire was notified that Watson Laboratories, Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of all approved strengths of ADDERALL XR. Shire filed a lawsuit in the U.S. District Court for the Southern District of New York against Watson Pharmaceuticals, Inc. and certain of its affiliates for infringement of certain of Shire’s ADDERALL XR patents. Par Pharmaceutical, Inc. (the successor in interest to Watson's ANDA for ADDERALL XR) has withdrawn its ANDA, and the litigation was dismissed on January 23, 2013 by agreement between Shire, Watson and Par Pharmaceutical, Inc..

In February 2013, Shire was notified that Neos Therapeutics, Inc. had submitted a New Drug Application under section 505(b)(2) of the Hatch Waxman Act (“505(b)(2) Application”). The 505(b)(2) Application was submitted with a paragraph IV certification for U.S. Reissued Patent Nos. RE41,148 and 42,096 listed in the Orange Book.  Within the requisite 45 day period, Shire filed a lawsuit in the Northern District of Texas against Neos Therapeutics, Inc. for infringement of those patents. The filing of the lawsuit triggered a stay of final approval of the 505(b)(2) Application for 30 months.  No trial date has been set.

Subpoena related to ADDERALL XR, DAYTRANA and VYVANSE

On September 23, 2009 the Company received a civil subpoena from the US Department of Health and Human Services Office of Inspector General in coordination with the US Attorney for the Eastern District of Pennsylvania seeking production of documents related to the sales and marketing of ADDERALL XR, DAYTRANA and VYVANSE. The investigation covered whether Shire engaged in off-label promotion and other conduct that may implicate the civil False Claims Act.

On February 1, 2013 the Company announced it had reached an agreement in principle to resolve this matter.  The agreement also addresses sales and marketing practices relating to LIALDA and PENTASA pursuant to a subsequent voluntary disclosure made by the Company. Shire cooperated with the US Government throughout the process that led to this agreement in principle.

The Company has recorded a $57.5 million charge comprised of the agreement in principle amount, interest and costs, which has been charged to SG&A in the fourth quarter of 2012.  The agreement in principle is subject to change until this matter is finally resolved.  Discussions between the Company and the US Government are ongoing to establish a final resolution to the investigation.

Louisiana Complaint related to ADDERALL, ADDERALL XR, DAYTRANA, VYVANSE and INTUNIV

On July 22 and July 23, 2013, the State of Louisiana served Shire LLC and Shire US Inc., respectively, with a civil complaint filed in the 19th Judicial District Court for the Parish of East Baton Rouge. The complaint alleges that Shire’s sales, marketing, and promotion of ADDERALL, ADDERALL XR, DAYTRANA, VYVANSE and INTUNIV violated state law. The State is seeking monetary relief for its claims of fraud, redhibition, and unjust enrichment, as well as violations of Louisiana’s Medical Assistance Programs Integrity Law, Unfair Trade Practices Act, and anti-trust laws. Shire intends vigorously to defend these claims. Shire is not in a position at this time to predict the timing, result or outcome of these claims.

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Investigation related to DERMAGRAFT

Shire understands that the Department of Justice, including the US Attorney’s Office for the Middle District of Florida, Tampa Division and the US Attorney’s Office for Washington, DC, is conducting civil and criminal investigations into the sales and marketing practices of Advanced BioHealing Inc. (“ABH”) relating to DERMAGRAFT. Shire is cooperating fully with these investigations. Shire is not in a position at this time to predict the scope, duration or outcome of these investigations.

Civil Investigative Demand for ADDERALL XR, ADDERALL XR Authorized Generics and VYVANSE

On April 5, 2012 Shire received a Civil Investigative Demand (“CID”) from the United States Federal Trade Commission (“FTC”) requesting that Shire provide it with certain information regarding the supply and reported shortages of ADDERALL XR and its authorized generics and the marketing and sale of ADDERALL XR, its authorized generics and VYVANSE. Shire believes the CID was triggered by reports of product shortages of ADDERALL XR and the authorized generic products in 2011. Shire responded to the CID in 2012. On August 29, 2013, the FTC informed Shire that it was closing the investigation without taking any further action.

19.  Accumulated Other ComprehensiveIncome

The changes in accumulated other comprehensive income, net of their related tax effects, in the year to to December 31, 2013 are included below:

	Foreign currency translation adjustment		Unrealized holding gain/(loss) on available-for-sale securities			Accumulated other comprehensive income
		$M		$M			$M
As at January 1, 2013		85.1		1.8			86.9
Current period change:
Other Comprehensive income before reclassification		25.3		1.5			26.8
Gain transferred to the income statement (within Other (expense)/income, net) on disposal of available-for-sale securities		-		(3.5	)		(3.5	)
Net current period other comprehensive income		25.3		(2.0	)		23.3
As at December 31, 2013		110.4		(0.2	)		110.2

20.  Financial instruments

Treasury policies and organization

The Company’s principal treasury operations are coordinated by its corporate treasury function. All treasury operations are conducted within a framework of policies and procedures approved annually by the Board. As a matter of policy, the Company does not undertake speculative transactions that would increase its currency or interest rate exposure.

Interest rate risk

The Company is exposed to interest rate risk on its $1,200 million Revolving Credit Facility, its $0.55 billion term loan facility, its $0.85 billion term loan facility (the “Facilities”), to the extent the Facilities are utilized, restricted cash, cash and cash equivalents and on foreign exchange contracts on which interest is at floating rates. This exposure is primarily to US dollar, Pounds sterling, Euro and Canadian dollar interest rates. The Company has evaluated the interest rate risk on its debt facilities and considers the floating rate as appropriate. As the Company maintains all of its cash, liquid investments and foreign exchange contracts on a short term basis for liquidity purposes, this risk is not actively managed. In the year to to December 31, 2013 the average interest rate received on cash and liquid investments was less than 1% per annum.

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The largest proportion of these cash and liquid investments was in US dollar money market and liquidity funds. At December 31, 2013 the Facilities were not utilized.

The Company incurred interest at a fixed rate of 2.75% on its $1,100 million in principal amount convertible bonds which were converted and redeemed at December 31, 2013.

No derivative instruments were entered into during the year to December 31, 2013 to manage interest rate exposure. The Company continues to review its interest rate risk and the policies in place to manage the risk.

Credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor’s and by Moody’s credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company’s revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2013 there were three customers in the US that accounted for 52% of the Company’s product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these wholesalers to honor their debts to the Company could have an adverse effect on the Company’s financial condition and results of operations.

A substantial portion of the Company’s accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company’s recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments.  In recent years the creditworthiness and general economic condition of a number of Eurozone countries (including Greece, Italy, Portugal and Spain (the “Relevant Countries”)) has deteriorated. As a result, in some of these countries the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers. The Company continued to receive remittances in relation to government-owned or government-supported healthcare providers in all the Relevant Countries in the year to December 31, 2013, including receipts of $116.8 million and $144.7 million in respect of Spanish and Italian receivables, respectively.

To date the Company has not incurred significant losses on accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable. The Company will continue to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company’s financial condition and results of operations.

Foreign exchange risk

The Company trades in numerous countries and as a consequence has transactional and translational foreign exchange exposures.

Transactional exposure arises where transactions occur in currencies different to the functional currency of the relevant subsidiary. The main trading currencies of the Company are the US dollar, Pounds Sterling, Swiss Franc and the Euro. It is the Company’s policy that these exposures are minimized to the extent practicable by denominating transactions in the subsidiary’s functional currency.

Where significant exposures remain, the Company uses foreign exchange contracts (being spot, forward and swap contracts) to manage the exposure for balance sheet assets and liabilities that are denominated in currencies different to the functional currency of the relevant subsidiary. These assets and liabilities relate predominantly to intercompany financing. The foreign exchange contracts have not been designated as hedging instruments. Cash flows from derivative

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instruments are presented within net cash provided by operating activities in the consolidated cash flow statement, unless the derivative instruments are economically hedging specific investing or financing activities.

Translational foreign exchange exposure arises on the translation into US dollars of the financial statements of non-US dollar functional subsidiaries.

At December 31, 2013 the Company had 29 swap and forward foreign exchange contracts outstanding to manage currency risk.  The swap and forward contracts mature within 90 days. The Company did not have credit risk related contingent features or collateral linked to the derivatives.  The Company has master netting agreements with a number of  counterparties to these foreign exchange contracts and on the occurrence of specified events, the Company has the ability to terminate contracts and settle them with a net payment by one party to the other. The Company has elected to present derivative assets and derivative liabilities on a gross basis in the consolidated balance sheet. As at December 31, 2013  the potential effect of rights of set off associated with the foreign exchange contracts would be an offset to both assets and liabilities of $0.7 million, resulting in net derivative assets and derivative liabilities of $3.3 million and $2.1 million, respectively. Further details are included below:

		Fair value		Fair value
		December 31,		December 31,
		2013		2012
			$’M		$’M
Assets	Prepaid expenses and other current assets		4.0		1.3
Liabilities	Other current liabilities		2.8		3.0

Net (losses)/ gains (both realized and unrealized) arising on foreign exchange contracts have been classified in the consolidated statements of income as follows:

	Location of net (loss)/gain recognized in income	Amount of net (loss)/gain recognized in income
In the year to		December 31,			December 31,		December 31,
		2013			2012		2011
			$’M			$’M		$’M
Foreign exchange contracts	Other income, net		(1.8	)		6.2		21.3

These net foreign exchange (losses)/gains are offset within Other income, net by net foreign exchange losses arising on the balance sheet items that these contracts were put in place to manage.

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21.  Fair value measurement

Assets and liabilities that are measured at fair value on a recurring basis

As at December 31, 2013 and December 31, 2012 the following financial assets and liabilities are measured at fair value on a recurring basis using quoted prices in active markets for identical assets (Level 1); significant other observable inputs (Level 2); and significant unobservable inputs (Level 3).

	Carrying		Fair value
	value
			Total		Level 1		Level 2		Level 3
At December 31, 2013	$'M		$'M		$'M		$'M		$'M
Financial assets:
Available-for-sale securities(1)		6.7		6.7		6.7		-		-
Contingent consideration receivable (2)		36.1		36.1		-		-		36.1
Foreign exchange contracts		4.0		4.0		-		4.0		-
Financial liabilities:
Foreign exchange contracts		2.8		2.8		-		2.8		-
Contingent consideration payable(3)		405.9		405.9		-		-		405.9
			Total		Level 1		Level 2		Level 3
At December 31, 2012	$'M		$'M		$'M		$'M		$'M
Financial assets:
Available-for-sale securities(1)		14.2		14.2		14.2		-		-
Contingent consideration receivable (2)		38.3		38.3		-		-		38.3
Foreign exchange contracts		1.3		1.3		-		1.3		-
Financial liabilities:
Foreign exchange contracts		3.0		3.0		-		3.0		-
Contingent consideration payable(3)		136.4		136.4		-		-		136.4

(`) Available-for-sale securities are included within Investments in the consolidated balance sheet.

(2) Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3) Contingent consideration payable is included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company’s intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

· Available-for-sale securities – the fair values of available-for-sale securities are estimated based on quoted market prices for those investments.

· Contingent consideration receivable – the fair value of the contingent consideration receivable has been estimated using the income approach (using a probability weighted discounted cash flow method).

· Foreign exchange contracts – the fair values of the swap and forward foreign exchange contracts have been determined using an income approach based on current market expectations about the future cash flows.

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· Contingent consideration payable – the fair value of the contingent consideration payable has been estimated using the income approach (using a probability weighted discounted cash flow method).

Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

The change in the fair value of the Company’s contingent consideration receivable and payables, which are measured at fair value on a recurring basis using significant unobservable inputs (Level 3), are as follows:

Contingent consideration receivable
	2013			2012
	$'M			$'M
Balance at January 1,		38.3			37.8
Gain recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period		15.9			18.1
Reclassification of amounts to Other receivables within Other current assets		(19.5	)		(18.7	)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)		1.4			1.1
Balance at December 31,		36.1			38.3
Contingent consideration payable
		2013			2012
	$'M			$'M
Balance at January 1,		136.4			-
Initial recognition of contingent consideration payable		451.4			127.8
Change in fair value during the period with the corresponding adjustment recognized as a gain in the income statement (within Integration and acquisition costs)		(159.1	)		9.2
Reclassification of amounts to Other current liabilities		(13.9	)		(8.8	)
Change in fair value during the period with corresponding adjustment to the associated intangible asset		(8.9	)		8.2
Balance at December 31,		405.9			136.4

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Quantitative Information about Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

Quantitative information about the Company’s recurring Level 3 fair value measurements is included below:

Financial assets:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
Contingent consideration receivable ("CCR")	36.1	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast royalties receivable at relevant contractual royalty rates • Assumed market participant discount rate	• 10 to 45% • $40 million to $148 million • 6.2%
Financial liabilities:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
Contingent consideration payable	405.9	Income approach (probability weighted discounted cash flow)	• Cumulative probability of  milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 18 to 57% (Weighted average) • 2.9 to 15% (Weighted average) • 2014 to 2025 • $2.4 to $7.6 million

The Company re-measures the CCR (relating to contingent consideration due to the Company following divestment of one of the Company’s products) at fair value at each balance sheet date, with the fair value measurement based on forecast cash flows, over a number of scenarios which vary depending on the expected performance outcome of the product following divestment. The forecast cash flows under each of these differing outcomes have been included in probability weighted estimates used by the Company in determining the fair value of the CCR.

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Contingent consideration payable represents future milestones the Company may be required to pay in conjunction with various business combinations and future royalties payable as a result of certain business combinations and licenses. The amount ultimately payable by Shire in relation to business combinations is dependent upon the achievement of specified future milestones, such as the achievement of certain future development, regulatory and sales milestones. The Company assesses the probability, and estimated timing, of these milestones being achieved and re-measures the related contingent consideration to fair value each balance sheet date. The amount of contingent consideration which may ultimately be payable by Shire in relation to future royalties is dependent upon future net sales of the relevant products over the life of the royalty term. The Company assesses the present value of forecast future net sales of the relevant products and re-measures the related contingent consideration to fair value each balance sheet date.

The fair value of the Company’s contingent consideration receivable and payable could significantly increase or decrease due to changes in certain assumptions which underpin the fair value measurements. Each set of assumptions and milestones are specific to the individual contingent consideration receivable or payable. The assumptions include, among other things, the probability and expected timing of certain milestones being achieved, the forecast future net sales of the relevant products and related future royalties payable, the probability weightings applied to different sales scenarios of one of the Company’s divested products and forecast future royalties receivable under scenarios developed by the Company, and the discount rates used to determine the present value of contingent future cash flows. The Company regularly reviews these assumptions, and makes adjustments to the fair value measurements as required by facts and circumstances.

Assets Measured At Fair Value on a Non-Recurring Basis in the period using Significant Unobservable Inputs (Level 3)

In the second quarter of 2013 the Company reviewed certain IPR&D intangible assets acquired through Movetis for impairment and recognized an impairment charge of $19.9 million, recorded within R&D in the consolidated income statement, to write-down these assets to their fair value. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, risk-adjusted forecast future cash flows to be generated by these assets and the determination of an appropriate discount rate to be applied in calculating the present value of forecast future cash flows. The fair value of these assets, determined at the time of the impairment review, was $20.3 million.

On January 16, 2014, the Company sold and transferred certain of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc (see Note 8 for details). The Transferred Assets include intellectual property relating to DERMAGRAFT, including patents, trademarks and know-how, regulatory filings and registrations relating to DERMAGRAFT, certain manufacturing plant, equipment and materials relating to the Business, and DERMAGRAFT product inventory and accounts receivable. The Transferred Assets have been measured at their fair value less costs to sell as at December 31, 2013. An impairment charge of $636.9 million was recorded within discontinued operations in the consolidated income statement upon re-measurement of the divested assets to their fair value less costs to sell. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, risk-adjusted forecast future cash flows to be generated by Shire following the divestment of these assets and the determination of an appropriate discount rate to be applied in calculating the present value of forecast future cash flows. The fair value of these assets at the date the held-for-sale conditions were met amounted to $31.6 million.

F-44

Quantitative information about Non-Recurring Level 3 Fair Value Measurements which occurred in the period is included below:

	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Rate used
	$'M
Movetis-related IPR&D intangible assets	20.3	Income approach (discounted cash flow)	• Decline in forecast peak sales since last impairment test • Assumed market participant discount rate	• 50% • 8.9%
DERMAGRAFT assets held-for-sale	31.6	Income approach (discounted cash flow)	• Future forecast milestones to be received • Assumed market participant discount rate	• $15 -$95 million • 11.5%

Financial assets and liabilities that are not measured at fair value on a recurring basis

The carrying amounts and estimated fair values as at December 31, 2013 and December 31, 2012 of the Company’s financial assets and liabilities which are not measured at fair value on a recurring basis are as follows:

	December 31, 2013				December 31, 2012
	Carrying				Carrying
	amount		Fair value		amount		Fair value
		$’M		$’M		$’M		$’M
Financial liabilities:
Convertible bonds (Level 1)		-		-		1,100.0		1,228.2
Building financing obligation (Level 3)		7.8		10.1		8.0		10.3

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company’s intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

· Building finance obligations - the fair value of building finance obligations are estimated based on the present value of future cash flows, and an estimate of the residual value of the underlying property at the end of the lease term, associated with these obligations.

The carrying amounts of other financial assets and liabilities materially approximate to their fair value because of the short term maturity of these amounts.

F-45

22.  Shareholders’ equity

Authorized common stock

The authorized stock of Shire plc as at December 31, 2013 was 1,000,000,000 ordinary shares and 2 subscriber ordinary shares.

Dividends

Under Jersey law, Shire plc is entitled to make payments of dividends from its accumulated profits and other distributable reserves. At December 31, 2013 Shire plc’s distributable reserves were approximately $10.4 billion.

Treasury stock

The Company records the purchase of its own shares by the EBT and under share buy-back program as a reduction of shareholders’ equity based on the price paid for the shares. At December 31, 2013, the EBT held 2.4 million ordinary shares (2012: 3.8 million; 2011: 4.6 million) and 0.4 million ADSs (2012: 1.1 million; 2011: 2.4 million) and shares held under share buy-back program were 7.1 million ordinary shares (2012: 2.7 million; 2011: nil) and 0.9 million ADSs (2012: 0.3 million; 2011: nil). During the year to December 31, 2013 a total of 4.2 million (2012: 4.5 million; 2011: 2.7 million) ordinary shares and 0.8 million (2012: 0.9 million; 2011: 0.8 million) ADSs had been purchased for total consideration of $243.8 million (2012: $205.8 million; 2011: $151.8 million), including stamp duty and broker commission.

Share buy-back Program

In 2012 the Company commenced a share buy-back program of up to $500 million through both direct purchases of ordinary shares and through the purchase of ordinary shares underlying ADRs. The purchases have been made through independent third parties who have made trading decisions independently of, and uninfluenced by, the Company. The independence of the third parties enabled the Company to purchase ordinary shares (including ordinary shares underlying ADRs) during close periods and other prohibited periods, should they arise. The amount, timing or prices of purchases, varied based on market conditions and other factors. The shares purchased to date are held as treasury shares.

During the year ending December 31, 2013, the Company made on-market repurchases totaling 6,191,965 ordinary shares at a cost of $193 million (excluding transaction costs). This represents 1.0% of the issued share capital of the Company as at the end of the quarter. Ordinary shares purchased may be cancelled or be held as treasury shares, in accordance with the authority renewed by shareholders at the Company’s Annual General Meeting (“AGM”).  At its AGM on April 24, 2012 the Company was authorized to make market purchases of up to 56,253,208 of its own ordinary shares. That authority expired at the AGM held on April 30, 2013 and was renewed. Under the new authority, which expires on the earlier of July 29, 2014 or the conclusion of the 2014 AGM, the Company was authorized to make market purchases of up to 55,741,587 of its own ordinary shares.

On November 11, 2013, contemporaneous with Shire’s announcement of its acquisition of ViroPharma, the Company’s share buyback program was terminated. Since the inception of the share buyback program the Company had purchased $300 million of ordinary shares and ordinary shares underlying ADRs.

Conversion of Shire’s 2.75% Convertible Bonds

On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed dated May 9, 2007 to holders of the Company’s Bonds. Consequently, as of December 31, 2013, Bondholders had voluntarily converted the Bonds into 33,806,464 fully paid ordinary shares. See Note 15 for further details.

Income Access Share Arrangements (“IAS Trust”)

Shire has put into place income access arrangements which enable ordinary shareholders, other than ADS holders, to choose whether they receive their dividends from Shire, a company tax resident in the Republic of Ireland, or from Shire Biopharmaceutical Holdings (“Old Shire”), a Shire group company tax resident in the UK.

Old Shire has issued one income access share to the Income Access Trust (the “IAS Trust”) which is held by the trustee of the IAS Trust (the “Trustee”). The mechanics of the arrangements are as follows:

i)   If a dividend is announced or declared by Shire plc on its ordinary shares, an amount is paid by Old Shire by way of a dividend on the income access share to the Trustee, and such amount is paid by the Trustee to ordinary shareholders who have elected (or are deemed to have elected) to receive dividends under these

F-46

arrangements. The dividend which would otherwise be payable by Shire plc to its ordinary shareholders will be reduced by an amount equal to the amount paid to its ordinary shareholders by the Trustee.

ii)   If the dividend paid on the income access share and on-paid by the Trustee to ordinary shareholders is less than the total amount of the dividend announced or declared by Shire plc on its ordinary shares, Shire plc will be obliged to pay a dividend on the relevant ordinary shares equivalent to the amount of the shortfall. In such a case, any dividend paid on the ordinary shares will generally be subject to Irish withholding tax at the rate of 20% or such lower rate as may be applicable under exemptions from withholding tax contained in Irish law.

iii)   An ordinary shareholder is entitled to make an income access share election such that she/he will receive his/her dividends (which would otherwise be payable by Shire plc) under these arrangements from Old Shire.

iv)   An ordinary shareholder who holds 25,000 or fewer ordinary shares at the first record date after she/he first becomes an ordinary shareholder, and who does not make a contrary election, will be deemed to have made an election (pursuant to the Shire plc articles of association) such that she/he will receive his/her dividends under these arrangements from Old Shire.

The ADS Depositary has made an election on behalf of all holders of ADSs such that they will receive dividends from Old Shire under the income access share arrangements. Dividends paid by Old Shire under the income access share arrangements will not, under current legislation, be subject to any UK or Irish withholding taxes. If a holder of ADSs does not wish to receive dividends from Old Shire under the income access share arrangements, she/he must withdraw his/her ordinary shares from the ADS program prior to the dividend record date set by the Depositary and request delivery of the Shire plc ordinary shares. This will enable him/her to receive dividends from Shire plc (if necessary, by making an election to that effect).

It is the expectation, although there can be no certainty, that Old Shire will distribute dividends on the income access share to the Trustee for the benefit of all ordinary shareholders who make (or are deemed to make) an income access share election in an amount equal to what would have been such ordinary shareholders’ entitlement to dividends from Shire plc in the absence of the income access share election. If any dividend paid on the income access share and or paid to the ordinary shareholders is less than such ordinary shareholders’ entitlement to dividends from Shire plc in the absence of the income access share election, the dividend on the income access share will be allocated pro rata among the ordinary shareholders and Shire plc will pay the balance to these ordinary shareholders by way of dividend. In such circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

Shire will be able to suspend or terminate these arrangements at any time, in which case the full Shire plc dividend will be paid directly by Shire plc to those ordinary shareholders (including the Depositary) who have made (or are deemed to have made) an income access share election. In such circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

In the year ended December 31, 2013 Old Shire paid dividends totaling $91.1 million (2012: $81.5 million; 2011: $67.6 million) on the income access share to the Trustee in an amount equal to the dividend Shire ordinary shareholders would have received from Shire.

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23.  Earnings per share

The following table reconciles net income and the weighted average ordinary shares outstanding for basic and diluted earnings per share for the periods presented:

	2013			2012			2011
		$’M			$’M			$’M
Income from continuing operations, net of taxes		1,419.6			805.7			882.7
Loss from discontinued operations1		(754.5	)		(60.3	)		(17.7	)
Numerator for basic earnings per share		665.1			745.4			865.0
Interest on convertible bonds, net of tax		28.3			31.3			33.6
Numerator for diluted earnings per share		693.4			776.7			898.6
Weighted average number of shares:
	Millions			Millions			Millions
Basic 1		552.0			555.4			551.1
Effect of dilutive shares:
Share based awards to employees 2		4.8			4.6			10.9
Convertible bonds 2.75% due 2014 3		33.5			33.5			33.4
Diluted		590.3			593.5			595.4

1. Excludes shares purchased by the EBT and under the share buy-back program and presented by Shire as treasury stock.

2. Calculated using the treasury stock method.

3. At December 31, 2013, Bondholders had voluntarily converted $1,099,050,000 aggregate principal amount of the Bonds into 33,806,464 fully paid Ordinary Shares. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the option redemption notice issued on November 26, 2013. The Company has calculated the impact of the Bonds on diluted EPS from the beginning of the period to the actual date of Bonds conversion using the ‘if-converted’ method.

Year to December 31,	2013			2012			2011
Earnings per ordinary share - basic
Earnings from continuing operations		257.2	c		145.1	c		160.1	c
Loss from discontinued operations		(136.7c	)		(10.9c	)		(3.2c	)
Earnings per ordinary share - basic		120.5	c		134.2	c		156.9	c
Earnings per ordinary share - diluted
Earnings from continuing operations		245.3	c		141.0	c		153.9	c
Loss from discontinued operations		(127.8c	)		(10.1c	)		(3.0c	)
Earnings per ordinary share  – diluted		117.5	c		130.9	c		150.9	c

F-48

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

	2013		2012		2011
	No. of shares		No. of shares		No. of shares
	Millions		Millions		Millions
Share based awards to employees1		0.5		6.7		2.9

1.   Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc’s average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

F-49

24.  Segmental reporting

Historically the Company had three business units and three reportable segments: Specialty Pharmaceuticals (“SP”), Human Genetic Therapies (“HGT”) and RM.

On May 2, 2013 the Company announced that there would be a reorganization of the Company’s business to integrate the operation of these business units into a simplified One Shire organization in order to drive future growth and innovation. Consequently the SP, HGT and RM segments no longer exist.

Shire now comprises a single operating and reportable segment, consistent with the One Shire approach that underpins the business simplification. This segment is engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs.

This segment is supported by several key functions: a Pipeline group, consisting of R&D and Business Development, will prioritize its activities towards late stage development programs across a variety of therapeutic areas, while focusing its pre-clinical development activities primarily in rare diseases; a Technical Operations group will be responsible for the Company’s global supply chain; and an In-Line marketed products group will focus on commercialized products. The In-Line marketed products group currently consists of four commercial units focused exclusively on commercial delivery to drive optimum performance of currently marketed products. The business is also supported by a simplified, centralized corporate function group. None of these functional groups meets all of the criteria to be an operating segment.

The reorganization to a single operating and reportable segment is consistent with the financial information regularly reviewed by the Executive Committee (which is Shire’s chief operating decision maker) for the purposes of evaluating performance, allocating resources, and planning and forecasting future periods.

F-50

Geographic information

Revenues (based on the geographic location from which the sale originated):

	2013		2012		2011
Year to December 31,		$’M		$’M		$’M
Ireland		22.5		20.6		21.1
United Kingdom		206.7		207.0		219.9
North America		3,386.2		3,006.1		2,761.8
Rest of World		1,318.9		1,293.7		1,155.3
Total revenues		4,934.3		4,527.4		4,158.1

Long-lived assets comprise all non-current assets, (excluding goodwill and other intangible assets, deferred contingent consideration assets, deferred tax assets, investments and financial instruments) based on the geographic location within which the economic benefits arise:

	2013		2012
Year to December 31,		$’M		$’M
Ireland		5.8		5.2
United Kingdom		70.3		72.2
North America		802.9		861.0
Rest of World		13.8		18.8
Total		892.8		957.2

Material customers

In the periods set out below, certain customers, accounted for greater than 10% of the Company’s product revenues:

	2013		2013		2012		2012		2011		2011
Year to December 31,		$’M	% product revenue			$’M	% product revenue			$’M	% product revenue
McKesson Corp.		902.9		19		835.9		20		742.9		19
Cardinal Health Inc.		853.7		18		1,035.7		24		923.9		24
AmerisourceBergen Corp		721.0		15		307.4		7		276.4		7

Amounts outstanding as at December 31, in respect of these material customers were as follows:

	2013		2012
December 31,		$’M		$’M
McKesson Corp.		161.3		127.4
Cardinal Health Inc.		149.5		166.1
AmerisourceBergen Corp		164.6		47.4

F-51

In the periods set out below, revenues by major product were as follows:

	2013		2012		2011
		$’M		$’M		$’M
VYVANSE		1,227.8		1,029.8		805.0
ELAPRASE		545.6		497.6		464.9
LIALDA/MEZAVANT		528.9		399.9		372.1
REPLAGAL		467.9		497.5		475.2
ADDERALL XR		375.4		429.0		532.8
VPRIV		342.7		306.6		256.2
INTUNIV		334.9		287.8		223.0
PENTASA		280.6		265.8		251.4
FIRAZYR		234.8		116.3		33.0
FOSRENOL		183.4		172.0		166.9
XAGRID		99.4		97.2		90.6
Other product sales		136.1		153.4		173.8
Total product sales		4,757.5		4,252.9		3,844.9

25.  Retirement benefits

The Company makes contributions to defined contribution retirement plans that together cover substantially all employees. The level of the Company’s contribution is fixed at a set percentage of employee’s pay.

Company contributions to personal defined contribution pension plans totaled $45.7 million, $46.4 million and $44.4 million for the years to December 31, 2013, 2012 and 2011, respectively, and were charged to operations as they became payable.

26.  Taxation

The components of pre tax income from continuing operations are as follows:

	2013			2012			2011
Year to December 31,		$’M			$’M			$’M
Republic of Ireland		(47.8	)		(74.7	)		(65.9	)
UK		10.9			30.7			45.4
US		1,153.3			683.8			774.6
Other jurisdictions		577.2			368.0			363.0
		1,693.6			1,007.8			1,117.1

F-52

The provision for income taxes by location of the taxing jurisdiction for the years to December 31, 2013, 2012 and 2011 consisted of the following:

Year to December 31,
	2013			2012			2011
		$’M			$’M			$’M
Current income taxes:
Republic of Ireland		-			-			(1.8	)
US federal tax		274.3			230.0			201.4
US state and local taxes		17.9			11.3			9.2
Other		63.4			29.0			40.0
Total current taxes		355.6			270.3			248.8
Deferred taxes:
US federal tax		23.8			(63.8	)		23.3
US state and local taxes		(8.3	)		(6.5	)		(4.6	)
UK corporation tax		11.5			13.1			(1.0	)
Other		(104.7	)		(10.0	)		(29.6	)
Total deferred taxes		(77.7	)		(67.2	)		(11.9	)
Total income taxes		277.9			203.1			236.9

The operating results associated with the DERMAGRAFT business have been classified as discontinued operations for all periods presented.

The Group has determined the amount of income tax expense or benefit allocable to continuing operations using the incremental approach described in ASC 740-20-45-8 and the relevant examples. As a result $9 million of income tax expense associated with the US operations was allocated to income from continuing operations for 2013 based on the primacy of continuing operations, due to changes in circumstances that caused a change in judgment about the realization of deferred tax assets in future years, and in accordance with the rules prescribed under ASC 740-20-45.  

The amount of Income tax attributed to discontinued operations is disclosed in Note 8.

The reconciliation of income from continuing operations before income taxes, noncontrolling interests and equity in earnings/(losses) of equity method investees at the statutory tax rate to the provision for income taxes is shown in the table below:

F-53

Year to December 31,
	2013			2012			2011
		$’M			$’M			$’M
Income from continuing operations before income taxes and equity in earnings of equity method investees		1,693.6			1,007.8			1,117.1
Statutory tax rate(1)		25.0	%		25.0	%		25.0	%
Adjustments to derive effective rate:
Non-deductable items:
US R&D credit		(4.5	%)		(2.6	%)		(4.5	%)
Effect of the convertible bond		0.5	%		0.8	%		0.8	%
Intra-group items(2)		(9.2	%)		(16.0	%)		(7.5	%)
Recognition of foreign tax credits		-			(6.6	%)		-
Other permanent items		(0.7	%)		0.8	%		(0.5	%)
Other items:
Change in valuation allowance		0.9	%		3.4	%		3.2	%
Impact of RESOLOR impairment		-			4.9	%		-
Difference in taxation rates		7.8	%		7.6	%		4.6	%
Change in provisions for uncertain tax positions		3.8	%		1.1	%		(1.2	%)
Prior year adjustment		(3.4	%)		0.8	%		0.8	%
Change in fair value of contingent consideration		(3.6	%)		-			-
Change in tax rates		(0.2	%)		0.8	%		0.2	%
Other		0.0	%		0.1	%		0.3	%
Provision for income taxes on continuing operations		16.4	%		20.1	%		21.2	%

(1) In addition to being subject to the Irish Corporation tax rate of 25%, in 2013 the Company is also subject to income tax in other territories in which the Company operates, including: Canada (15%); France (33.3%); Germany (15%); Italy (27.5%); Luxembourg (21.0%); the Netherlands (25%); Belgium (33.99%); Spain (30%); Sweden (22%); Switzerland (8.5%); United Kingdom (23.25%) and the US (35%). The rates quoted represent the statutory federal income tax rates in each territory, and do not include any state taxes or equivalents or surtaxes or other taxes charged in individual territories, and do not purport to represent the effective tax rate for the Company in each territory.

(2) Intra-group items principally relate to the effect of inter-company dividends, capital receipts (either taxable or non-taxable) and other intra-territory eliminations, the pre-tax effect of which has been eliminated in arriving at the Company’s consolidated income from continuing operations before income taxes, noncontrolling interests and equity in earnings/(losses) of equity method investees.

Provisions for uncertain tax positions

The Company files income tax returns in the Republic of Ireland, the UK, the US (both federal and state) and various other jurisdictions (see footnote (1) to the table above for major jurisdictions). With few exceptions, the Company is no longer subject to income tax examinations by tax authorities for years before 1999. Tax authorities in various jurisdictions are in the process of auditing the Company’s tax returns for fiscal periods from 1999; these tax audits cover a range of issues, including transfer pricing, potential restrictions on the utilization of net operating losses, potential taxation of overseas dividends and controlled foreign companies’ rules.

While tax audits remain open, the Company also considers it reasonably possible that issues may be raised by tax authorities resulting in increases to the balance of unrecognized tax benefits, however, an estimate of such increase cannot be made.

The Company is required in certain tax jurisdictions to make advance deposits to tax authorities on receipt of tax assessments. These payments have been offset against the income tax liability within the balance sheet but have not reduced the provision for unrecognized tax benefits.

F-54

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:

	2013			2012			2011
		$’M			$’M			$’M
Balance at January 1		278.7			265.5			290.8
Increases based on tax positions related to the current year		56.8			20.5			18.2
Decreases based on tax positions taken in the current year		(0.5	)		-			(2.5	)
Increases for tax positions taken in prior years		34.5			0.4			1.4
Decreases for tax positions taken in prior years		(0.8	)		(3.3	)		(12.0	)
Decreases resulting from settlements with the taxing authorities		-			(10.6	)		(25.7	)
Decreases as a result of expiration of the statute of limitations		(0.6	)		(0.3	)		(0.5	)
Foreign currency translation adjustments(1)		(12.9	)		6.5			(4.2	)
Balance at December 31(2)		355.2			278.7			265.5

(1) Recognized within Other Comprehensive Income

(2) The full amount of which would affect the effective rate if recognized

The Company considers it reasonably possible that certain audits currently being conducted will be concluded in the next twelve months, and as a result the total amount of unrecognized tax benefits recorded at December 31, 2013 could decrease by up to approximately $210 million.  As at the balance sheet date, the Company believes that its reserves for uncertain tax positions are adequate to cover the resolution of these audits. However, the resolution of these audits could have a significant impact on the financial statements if the settlement differs from the amount reserved.

The Company recognizes interest and penalties accrued related to unrecognized tax benefits within income taxes. During the years ended December 31, 2013, 2012 and 2011, the Company recognized $0.4 million, $5.1 million and $4.0 million in interest and penalties and the Company had a liability of $112.2 million, $119.6 million and $114.5 million for the payment of interest and penalties accrued at December 31, 2013, 2012 and 2011, respectively.

F-55

Deferred taxes

The significant components of deferred tax assets and liabilities and their balance sheet classifications, as at December 31, are as follows:

	December 31,			December 31,
	2013			2012
		$’M			$’M
Deferred tax assets:
Deferred revenue		5.2			5.5
Inventory & warranty provisions		48.6			52.5
Losses carried forward (including tax credits)1		500.6			425.7
Provisions for sales deductions and doubtful accounts		151.8			144.9
Intangible assets		10.7			36.7
Share-based compensation		25.5			32.7
Excess of tax value over book value of assets		22.1			-
Accruals and provisions		55.1			44.1
Other		2.6			21.6
Gross deferred tax assets		822.2			763.7
Less: valuation allowance		(282.4	)		(268.6	)
		539.8			495.1
Deferred tax liabilities:
Intangible assets		(586.8	)		(702.7	)
Excess of book value over tax value of assets and investments		(56.9	)		(36.8	)
Net deferred tax liabilities		(103.9	)		(244.4	)
Balance sheet classifications:
Deferred tax assets - current		315.6			229.9
Deferred tax assets - non-current		141.1			46.5
Deferred tax liabilities - non-current		(560.6	)		(520.8	)
		(103.9	)		(244.4	)

1.   Excluding $15.0 million of deferred tax assets at December 31, 2013 (2012: $6.8 million), related to the net operating losses that result from excess stock based compensation and for which any benefit realized will be recorded to stockholders’ equity.

At December 31, 2013, the Company had a valuation allowance of $282.4 million (2012: $268.6 million) to reduce its deferred tax assets to estimated realizable value. These valuation allowances related primarily to operating loss, capital loss and tax-credit carry-forwards in Ireland (2013: $78.8 million; 2012: $73.9 million); the US (2013: $60.9 million; 2012: $37.2 million); Germany (2013: $30.8 million; 2012: $96.9 million); and other foreign tax jurisdictions (2013: $111.9 million; 2012: $60.6 million).

Management is required to exercise judgement in determining whether deferred tax assets will more likely than not be realized. A valuation allowance is established where there is an expectation that on the balance of probabilities management considers it is more likely than not that the relevant deferred tax assets will not be realized. In assessing the need for a valuation allowance, management weighs all available positive and negative evidence including cumulative losses in recent years, projection of future taxable income, carry forward and carry back potential under relevant tax law, expiration period of tax attributes, taxable temporary differences, and prudent and feasible tax-planning strategies.

The net increase in valuation allowances of $13.8 million includes (i) increases of $104.5 million primarily in respect of losses and other temporary differences in various jurisdictions where management consider that there is insufficient

F-56

positive evidence in respect of the factors described above to overcome cumulative losses and therefore it is more likely than not that the relevant deferred tax assets will not be realized in full, and (ii) a decrease of $90.7 million primarily in respect of German tax losses ($67.4m), which based on the assessment of the factors described above now provides sufficient positive evidence to support that the losses are more likely than not to be realized. The release of this valuation allowance has been recorded in the current period due to changes in the financing of the German subsidiary.

At December 31, 2013, based upon a consideration of the factors described above management believes it is more likely than not that the Company will realize the benefits of these deductible differences, net of the valuation allowances. However, the amount of the deferred tax asset considered realizable could be adjusted in the future if these factors are revised in the future periods.

The approximate tax effect of NOLs, capital losses and tax credit carry-forwards as at December 31, are as follows:

	2013		2012
		$’M		$’M
US federal tax NOLs		32.2		26.1
US state tax NOLs		61.5		31.4
UK NOLs		6.7		20.7
Republic of Ireland NOLs		78.8		72.6
Foreign tax jurisdictions		273.1		208.8
R&D and other tax credits		48.3		66.2

The approximate gross value of NOLs and capital losses at December 31, 2013 is $2,583.7 million (2012: $1,783.5 million). The tax effected NOLs, capital losses and tax credit carry-forwards shown above have the following expiration dates:

	December 31,
	2013
		$’M
Within 1 year		0.9
Within 1 to 2 years		1.1
Within 2 to 3 years		0.7
Within 3 to 4 years		2.9
Within 4 to 5 years		3.0
Within 5 to 6 years		35.6
After 6 years		142.7
Indefinitely		313.7

The Company does not provide for deferred taxes on the excess of the financial reporting over the tax basis in investments in foreign subsidiaries that are essentially permanent in duration.  At December 31, 2013, that excess totalled approximately $8.5 billion. The determination of additional deferred taxes is not practicable and is not provided.

F-57

27.  Share-based compensation plans

The following table shows the total share-based compensation expense (see below for types of share-based awards) included in the consolidated statements of income:

	2013			2012			2011
		$’M			$’M			$’M
Cost of product sales		4.4			6.3			8.8
Research and development		22.8			25.8			21.8
Selling, general and administrative		46.9			55.0			45.1
Reorganization costs		3.3			-			-
Total		77.4			87.1			75.7
Less tax		(18.1	)		(23.8	)		(23.6	)
		59.3			63.3			52.1

There were no capitalized share-based compensation costs at December 31, 2013 and 2012.

At December 31, 2013 $97.0 million (2012: $102.3 million) of total unrecognized compensation cost relating to non-vested awards is expected to be recognized over a period of 3 years.

At December 31, 2013 $90.3 million (2012: $74.6 million) of total unrecognized compensation cost relating to non-vested in the money awards (based on the average share price during the year) is expected to be recognized over a weighted average period of 1.7 years (2012: 1.7 years). The total fair value of in the money awards vested during the year to December 31, 2013 was $70.5 million (2012: $113.9 million).

Share-based compensation plans

The Company grants stock-settled share appreciation rights (“SARs”) and performance share awards over ordinary shares and ADSs to Executive Directors and employees under the Shire Portfolio Share Plan (Parts A and B). The SARs and PSAs granted under the Shire Portfolio Share Plan (Part A & B) to Executive Directors are exercisable subject to performance and service criteria.

The principal terms and conditions of SARs and PSAs are as follows: (i) the contractual life of SARs is seven years, (ii) the vesting period of SARs and PSAs granted to employees below the level of Executive Vice President allows for graded vesting, and (iii) awards granted to Executive Directors contain performance conditions based on growth in adjusted return on invested capital (“Adjusted ROIC”) and earnings before interest, taxation, depreciation and amortization (“Non GAAP EBITDA”).

The Company also operates an Employee Share Purchase Plan and a Sharesave Scheme.

The following awards were outstanding as at December 31, 2013:

F-58

	Compensation type	Number of awards*	Expiration period from date of issue	Vesting period
Portfolio Share Plan - Part A	SARs	14,083,748	5 - 7 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
Sharesave Scheme	Stock options	243,783	6 months after vesting	3 or 5 years
Stock Purchase Plan	Stock options	568,828	On vesting date	1 to 5 years
Legacy Plans	Stock options	132,823	7 to 10 years	3-10 years, subject to market or performance criteria
Stock-settled SARs and stock options		15,029,182
Portfolio Share Plan - Part B	Performance share awards	2,701,299	3 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
Performance share awards		2,701,299

* Number of awards are stated in terms of ordinary share equivalents.

Stock settled SARs and stock options

(a)  Portfolio Share Plan – Part A

Stock-settled share appreciation rights granted under the Portfolio Share Plan – Part A are exercisable subject to performance and service criteria.

In respect of any award made to Executive Directors performance criteria are based on Non GAAP EBITDA and Adjusted ROIC targets. These performance measures provide increased alignment to the core activities and strategy of the Company.

Awards granted to employees below Executive Director level are not subject to performance conditions and are only subject to service conditions.

Once awards have vested, participants will have until the seventh anniversary of the date of grant to exercise their awards.

F-59

(b)  Shire Sharesave Scheme (Sharesave Scheme)

Options granted under the Sharesave Scheme are granted with an exercise price equal to 80% and 75% of the mid-market price on the day before invitations are issued to UK and Ireland employees, respectively. Employees may enter into three or five year savings contracts. No performance conditions apply.

(c)  Shire Employee Stock Purchase Plan (Stock Purchase Plan)

Under the Stock Purchase Plan, options are granted with an exercise price equal to 85% of the fair market value of a share on the enrolment date (the first day of the offering period) or the exercise date (the last day of the offering period), whichever is the lower. Employees agree to save for a period up to 12 months. No performance conditions apply.

(d)  Legacy plans – principally the Shire 2000 Executive Share Option Scheme

Options granted under this scheme were subject to certain performance criteria, which were based on the Company’s share price or diluted EPS growth compared to a fixed growth rate.  At December 31, 2013 all stock options outstanding under this scheme had met the required conditions and were exercisable.

A summary of the status of the Company’s SARs and stock options as at December 31, 2013 and of the related transactions during the period then ended is presented below:

	Weighted average exercise price £
Year to December 31, 2013			Number of shares*			Intrinsic Value £’ M
Outstanding as at beginning of period		16.66		18,536,947
Granted		20.05		6,914,026
Exercised		22.09		(8,302,740	)
Forfeited		18.30		(2,119,051	)
Outstanding as at end of period		18.88		15,029,182			143.9
Exercisable as at end of period		15.67		3,670,446			46.9

* Number of awards are stated in terms of ordinary share equivalents

The weighted average grant date fair value of SARs and stock options granted in the year ended December 31, 2013 was £3.37.

F-60

SARs and stock options outstanding as at December 31, 2013 have the following characteristics:

Number of awards outstanding*	Exercise prices		Weighted Average remaining contractual term (Years)		Weighted average exercise price of awards outstanding		Number of awards exercisable		Weighted average exercise price of awards exercisable
	£				£					£
104,658		3.38-7.00		1.1		5.56		104,658		5.56
810,822		7.01-14.00		2.8		11.27		804,402		11.25
14,113,702		14.01-28.00		4.9		18.07		2,761,386		17.34
15,029,182								3,670,446

* Number of awards are stated in terms of ordinary share equivalents

Performance shares

Portfolio Share Plan – Part B

Performance share awards granted to Executive Directors under the Portfolio Share Plan – Part B are exercisable subject to certain market, performance and service criteria.

In respect of any award granted to Executive Directors, the performance criteria are based on Non GAAP EBITDA and Adjusted ROIC targets.

Awards granted to employees below Executive Director level are not subject to performance conditions and are only subject to service conditions.

A summary of the status of the Company’s performance share awards as at December 31, 2013 and of the related transactions during the period then ended is presented below:

Performance share awards	Number of shares*			Aggregate intrinsic value £’M		Weighted average remaining life
Outstanding as at beginning of period		3,518,138
Granted		1,508,631
Exercised		(1,826,648	)
Forfeited		(498,822	)
Outstanding as at end of period		2,701,299			76.9		5.5
Exercisable as at end of period		-			N/A		N/A

* Number of awards are stated in terms of ordinary share equivalents

The weighted-average grant date fair value of performance share awards granted in the year to December 31, 2013 is £19.71.

F-61

Exercises of employee share-based awards

The total intrinsic values of share-based awards exercised for the years to December 31, 2013, 2012 and 2011 were $298.3 million, $224.1 million and $189.3 million, respectively. The total cash received from employees as a result of employee share option exercises for the period to December 31, 2013, 2012 and 2011 was approximately $17.2 million, $16.2 million and $13.4 million, respectively. In connection with these exercises, the tax benefit credited to additional paid-in capital for the years to December 31, 2013, 2012 and 2011 was $11.9 million, $40.1 million and $29.4 million respectively.

The Company will settle future employee share award exercises with either newly listed common shares or with shares held in the EBT. The number of shares to be purchased by the EBT during 2013 will be dependent on the number of employee share awards granted and exercised during the year and Shire plc’s share price. At December 31, 2013 the EBT held 2.4 million ordinary shares and 0.4 million ADSs.

Valuation methodologies

The Company estimates the fair value of its share-based awards using a Black-Scholes valuation model. Key input assumptions used to estimate the fair value of share–based awards include the grant price of the award, the expected stock-based award term, volatility of the Company’s share price, the risk-free rate and the Company’s dividend yield. The Company believes that the valuation technique and the approach utilized to develop the underlying assumptions are appropriate in estimating the fair values of Shire’s stock-based awards. Estimates of fair value are not intended to predict actual future events or the value ultimately realized by employees who receive equity awards, and subsequent events are not indicative of the reasonableness of the original estimates of fair value made by the Company under guidance issued by the FASB on share based payment transactions.

The fair value of share awards granted was estimated using the following assumptions:

Period ended December 31,	2013	2012	2011
Risk-free interest rate1	0.1-0.9%	0.2-1%	0.1-2.5%
Expected dividend yield	0.4-0.6%	0-0.6%	0-0.5%
Expected life	1-4 years	1-4 years	1-5 years
Volatility	23-26%	24-32%	19-33%
Forfeiture rate	5-9%	5-7%	5-7%

(1) Risk free interest rate is for UK and US grants

The following assumptions were used to value share-based awards:

· risk-free interest rate – for awards granted over ADSs, the US Federal Reserve treasury constant maturities rate with a term consistent with the expected life of the award is used. For awards granted over ordinary shares, the yield on UK government bonds with a term consistent with the expected life of the award is used;

· expected dividend yield – measured as the average annualized dividend estimated to be paid by the Company over the expected life of the award as a percentage of the share price at the grant date;

· expected life – estimated based on the contractual term of the awards and the effects of employees’  expected exercise and post-vesting employment termination behaviour;

· expected volatility – measured using historical daily price changes of the Company’s share price over the respective expected life of the share-based awards at the date of the award; and

· the forfeiture rate is estimated using historical trends of the number of awards forfeited prior to vesting.

F-62

Quarterly results of operations (Unaudited)

The following tables reconcile previously reported data with current year quarterly data which has been updated for discontinued operations related to the DERMAGRAFT business (see Note 8 for details):

	First quarter of 2013									Second quarter of 2013
	Previously			Adjusted for			As			Previously			Adjusted for			As
	reported			DERMAGRAFT			reported			reported			DERMAGRAFT			reported
		$’M			$’M			$’M			$’M			$’M			$’M
Total revenues		1,161.9			(18.5	)		1,143.4			1,274.5			(22.3	)		1,252.2
Cost of product sales		155.9			(8.5	)		147.4			175.7			(11.4	)		164.3
Income from continuing operations, net of taxes		64.8			216.2			281.0			258.1			32.8			290.9
Loss from discontinued operations, net of taxes		-			(216.2	)		(216.2	)		-			(32.8	)		(32.8	)
Net income		64.8			-			64.8			258.1			-			258.1
Earnings per ordinary share - basic
Earnings from continuing operations		11.7	c		39.3	c		51.0	c		46.9	c		6.0	c		52.9	c
Loss from discontinued operations		-			(39.3c	)		(39.3c	)		-			(6.0c	)		(6.0c	)
Earnings per share - basic		11.7	c		-			11.7	c		46.9	c		-			46.9	c
Earnings per ordinary share - diluted
Earnings from continuing operations		11.7	c		36.7	c		49.0	c		45.3	c		5.6c			50.9	c
Loss from discontinued operations		-			(36.7c	)		(36.7c	)		-			(5.6c	)		(5.6c	)
Earnings per share - diluted		11.7	c		-			12.3	c		45.3	c		-			45.3	c

F-63

	Third quarter of 2013									Fourth quarter of 2013
	Previously			Adjusted for			As			Memo (prior			Adjusted for			As
	reported			DERMAGRAFT			reported			to adjustment)			DERMAGRAFT			reported
		$’M			$’M			$’M			$’M			$’M			$’M
Total revenues		1,236.6			(23.9	)		1,212.7			1,351.1			(25.1	)		1,326.0
Cost of product sales		197.1			(16.6	)		180.5			196.5			(17.9	)		178.6
Income from continuing operations, net of taxes		278.2			22.9			301.1			64.0			482.6			546.6
Loss from discontinued operations, net of taxes		-			(22.9	)		(22.9	)		-			(482.6	)		(482.6	)
Net income		278.2			-			278.2			64.0			-			64.0
Earnings per ordinary share - basic
Earnings from continuing operations		50.7	c		4.2	c		54.9	c		11.5	c		86.5	c		98.0	c
Loss from discontinued operations		-			(4.2c	)		(4.2c	)		-			(86.5c	)		(86.5c	)
Earnings per share - basic		50.7	c		-			50.7	c		11.5	c		-			11.5	c
Earnings per ordinary share - diluted
Earnings from continuing operations		48.8	c		3.9	c		52.7	c		11.7	c		81.7	c		93.4	c
Loss from discontinued operations		-			(3.9c	)		(3.9c	)		-			(81.7c	)		(81.7c	)
Earnings per share - diluted		48.8	c		-			48.8	c		11.7	c		-			11.7	c

F-64

	First quarter of 2012									Second quarter of 2012
	Previously			Adjusted for			As			Previously			Adjusted for			As
	reported			DERMAGRAFT			reported			reported			DERMAGRAFT			reported
		$’M			$’M			$’M			$’M			$’M			$’M
Total revenues		1,171.8			(48.8	)		1,123.0			1,207.8			(52.4	)		1,155.4
Cost of product sales		158.4			(10.0	)		148.4			152.5			(17.0	)		135.5
Income from continuing operations, net of taxes		238.4			7.4			245.8			237.8			10.7			248.5
Loss from discontinued operations, net of taxes		-			(7.4	)		(7.4	)		-			(10.7	)		(10.7	)
Net income		238.4			-			238.4			237.8			-			237.8
Earnings per ordinary share - basic
Earnings from continuing operations		43.1	c		1.3	c		44.4	c		42.7	c		1.9	c		44.6	c
Loss from discontinued operations		-			(1.3c	)		(1.3c	)		-			(1.9c	)		(1.9c	)
Earnings pershare - basic		43.1	c		-			43.1	c		42.7	c		-			42.7	c
Earnings per ordinary share - diluted
Earnings from continuing operations		41.4	c		1.3	c		42.7	c		41.3	c		1.8	c		43.1	c
Loss from discontinued operations		-			(1.3c	)		(1.3c	)		-			(1.8c	)		(1.8c	)
Earnings per share - diluted		41.4	c		-			41.4	c		41.3	c		-			41.3	c

F-65

	Third quarter of 2012									Fourth quarter of 2012
	Previously			Adjusted for			As			Previously			Adjusted for			As
	reported			DERMAGRAFT			reported			reported			DERMAGRAFT			reported
		$’M			$’M			$’M			$’M			$’M			$’M
Total revenues		1,100.4			(33.7	)		1,066.7			1,201.2			(18.9	)		1,182.3
Cost of product sales		167.9			(16.0	)		151.9			166.6			(16.6	)		150.0
Income from continuing operations, net of taxes		227.2			16.2			243.4			42.0			26.0			68.0
Loss from discontinued operations, net of taxes		-			(16.2	)		(16.2	)		-			(26.0	)		(26.0	)
Net income		227.2			-			227.2			42.0			-			42.0
Earnings per ordinary share - basic
Earnings from continuing operations		40.9	c		2.9	c		43.8	c		7.5	c		4.7	c		12.2	c
Loss from discontinued operations		-			(2.9c	)		(2.9c	)		-			(4.7c	)		(4.7c	)
Earnings per share - basic		40.9	c		-			40.9	c		7.5	c		-			7.5	c
Earnings per ordinary share - diluted
Earnings from continuing operations		39.6	c		2.7	c		42.3	c		7.4	c		4.7	c		12.1	c
Loss from discontinued operations		-			(2.7c	)		(2.7c	)		-			(4.7c	)		(4.7c	)
Earnings per share - diluted		39.6	c		-			39.6	c		7.4	c		-			7.4	c

F-66

INDEX TO THE SHIRE INCOME ACCESS SHARE TRUST FINANCIAL STATEMENTS

Report of Independent Registered Public Accounting Firm	F-68
Balance Sheets as at December 31, 2013 and 2012	F-69
Statements of Income for each of the three years in the period ended December 31, 2013	F-70
Statements of Changes in Equity for each of the three years in the period ended December 31, 2013	F-70
Statements of Cash Flows for each of the three years in the period ended December 31, 2013	F-71
Notes to the Shire Income Access Share Trust Financial Statements	F-72

F-67

REPORT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

To Equinity Trust (Jersey) Limited, Trustee of the Shire Income Access Share Trust and the Board of Directors and Stockholders of Shire plc

We have audited the accompanying balance sheets of the Shire Income Access Share Trust (the “Trust”) as at December 31, 2013 and 2012 and the related statements of income, statements of changes in equity and statements of cash flows for each of the three years in the period ended December 31, 2013. These financial statements are the responsibility of the Trustee and Shire plc’s management. Our responsibility is to express an opinion on these financial statements based on our audits.

We conducted our audit in accordance with the standards of the Public Company Accounting Oversight Board (United States). Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the financial statements are free of material misstatement. The Trust is not required to have an audit of its internal control over financial reporting.Our audit included consideration of internal control over financial reporting as a basis for designing audit procedures that are appropriate in the circumstances, but not for the purpose of expressing an opinion on the Trust’s internal control over financial reporting. Accordingly, we express no such separate opinion. Our audit of the financial statements included examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements, assessing the accounting principles used and significant estimates made by management, and evaluating the overall financial statement presentation. We believe that our audit provides a reasonable basis for our opinion.

In our opinion, the financial statements referred to above present fairly, in all material respects, the financial position of the Shire Income Access Share Trust at December 31, 2013 and 2012, and the results of its operations and cash flows for each of the three years in the period ended December 31, 2013, in conformity with accounting principles generally accepted in the United States of America.

/s/ Deloitte LLP

DELOITTE LLP

London, United Kingdom

February 24, 2014

F-68

SHIRE INCOME ACCESS SHARE TRUST

BALANCE SHEETS

	Notes	December 31, 2013		December 31, 2012
			$’M		$’M
ASSETS
Total assets			-		-
LIABILITIES AND EQUITY
Total liabilities			-		-
Equity:
Total equity			-		-
Total liabilities and equity			-		-

The notes on pages F-72 to F-73 are an integral part of these financial statements.

F-69

SHIRE INCOME ACCESS SHARE TRUST

STATEMENTS OF INCOME

		Year to		Year to		Year to
	Notes	December 31, 2013		December 31, 2012		December 31, 2011
			$’M		$’M		$’M
Dividend income			91.1		81.5		67.6
Net income			91.1		81.5		67.6

The notes on page F-72 to F-73 are an integral part of these financial statements.

SHIRE INCOME ACCESS SHARE TRUST

STATEMENTS OF CHANGES IN EQUITY

	Capital account		Revenue account			Total equity
		$’M		$’M			$’M
At December 31, 2010		-		-			-
Net income for the year		-		67.6			67.6
Distributions made		-		(67.6	)		(67.6	)
As at December 31, 2011		-		-			-
Net income for the year		-		81.5			81.5
Distributions made		-		(81.5	)		(81.5	)
As at December 31, 2012		-		-			-
Net income for the year		-		91.1			91.1
Distributions made		-		(91.1	)		(91.1	)
As at December 31, 2013		-		-			-

The notes on page F-72 to F-73 are an integral part of these financial statements.

F-70

SHIRE INCOME ACCESS SHARE TRUST

STATEMENTS OF CASHFLOWS

		Year to			Year to			Year to
	Notes	December 31, 2013			December 31, 2012			December 31, 2011
			$’M			$’M			$’M
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income			91.1			81.5			67.6
Net cash provided from operating activities(A)			91.1			81.5			67.6
CASH FLOWS FROM INVESTING ACTIVITIES:
Net cash provided by investing activities(B)			-			-			-
CASH FLOWS FROM FINANCING ACTIVITIES:
Distributions made			(91.1	)		(81.5	)		(67.6	)
Net cash used in financing activities(C)			(91.1	)		(81.5	)		(67.6	)
Net increase in cash and cash equivalents (A+B+C)			-			-			-
Cash and cash equivalents at beginning of period			-			-			-
Cash and cash equivalents at end of period			-			-			-

The notes on page F-72 to F-73 are an integral part of these financial statements.

F-71

NOTES TO THE SHIRE INCOME ACCESS SHARE TRUST FINANCIAL STATEMENTS

(a)  The Trust

The Shire Income Access Share Trust (the “Trust”) was established on August 29, 2008 by Shire Biopharmaceuticals Holdings (formerly Shire plc). The Trust is governed by the applicable laws of England and Wales and is resident in Jersey. The Trustee of the Trust is Equiniti Trust (Jersey) Limited, 26 New Street, St Helier, Jersey, JE4 3RA.

The Trust was established as part of the Income Access Share mechanism, as outlined in Note 22 in this Annual Report on Form 10-K of Shire plc and its subsidiaries (collectively referred to as either “Shire” or the “Company”).

(b)  Basis of preparation

The financial statements of the Trust have been prepared in accordance with accounting principles generally accepted in the United States of America (“US GAAP”). The financial statements have been prepared under the historical cost convention.

The preparation of financial statements in conformity with US GAAP requires the use of certain accounting estimates. It also requires management to exercise its judgment in the process of applying the Trust’s accounting policies. Actual results may differ from these estimates.

The results of operations, and the financial position and cash flows of the Trust are also consolidated in the Company’s financial statements, as contained on pages F-1 to F-66.

(c)  Summary of significant accounting policies

i)  Functional currency

The functional currency of the Trust is US dollars.

ii)  Foreign currency translation

Income and expense items denominated in currencies other than the functional currency are translated into the functional currency at the rate ruling on their transaction date. Monetary assets and liabilities recorded in currencies other than the functional currency have been expressed in the functional currency at the rates of exchange ruling at the respective balance sheet dates. Differences on translation are included in the consolidated statements of income.

iii)  Dividend income

Interim dividends declared on the Income Access Share are recognized on a paid basis unless the dividend has been confirmed by a general meeting of Shire, in which case income is recognized on the record date of the dividend by Shire on its ordinary shares.

(d)  Capital account

The Capital account is represented by the Income Access Share of 5 pence settled in the Trust by Old Shire.

(e)  Distributions made

Distributions are made to those shareholders of Shire who have elected to receive dividends from the Trust in accordance with the Trust Deed. Unclaimed dividends are not included in distributions made. There were no unclaimed dividends at December 31, 2013. Amounts are recorded as distributed once a wire transfer or check is issued. All checks are valid for one year from the date of issue. Any wire transfers that are not completed are replaced by checks. To the extent that checks expire or are returned unrepresented, the Trust records a liability for unclaimed dividends and a corresponding amount of cash.

F-72

(f)  Financial instruments

The Trust, in its normal course of business, is not subject to market risk, credit risk or liquidity risk. The Trustees do not consider that any foreign exchange exposure will materially affect the operations of the Trust.

F-73

Schedule II – Valuation and Qualifying Accounts

	Beginning balance		Provision charged to income(1)		Costs incurred/ utilization(1)			Ending balance
Provision for sales rebates, returns and coupons		$’M		$’M		$’M			$’M
2013 :
Accrued rebates – Medicaid and HMOs		640.5		1,626.6		(1,460.6	)		806.5
Sales returns reserve		90.5		34.5		(27.1	)		97.9
Accrued coupons		8.0		107.4		(94.7	)		20.7
		739.0		1,768.5		(1,582.4	)		925.1
2012 :
Accrued rebates – Medicaid and HMOs		612.6		1,228.0		(1,200.1	)		640.5
Sales returns reserve		88.8		40.8		(39.1	)		90.5
Accrued coupons		8.1		71.7		(71.8	)		8.0
		709.5		1,340.5		(1,311.0	)		739.0
2011 :
Accrued rebates – Medicaid and HMOs		549.9		1,123.2		(1,060.5	)		612.6
Sales returns reserve		69.8		51.2		(32.2	)		88.8
Accrued coupons		5.2		60.5		(57.6	)		8.1
		624.9		1,234.9		(1,150.3	)		709.5

(1) In the analysis above, due to systems limitations, it is not practical and has not been necessary to break out current versus prior year activity. When applicable, Shire has performed general ledger reviews of sales deduction provisions charged to income, and the utilization of these provisions in subsequent years. Shire has determined that adjustments made in each year as a result of changes to estimates that related to prior year sales, and adjustments made as a result of differences between prior period provisions and actual payments, did not have a material impact on the Company’s financial performance or position either in each individual year, or in the Company’s performance over the reported period.

S-1

SIGNATURES

Pursuant to the requirements of Section 13 or 15(d) of the Securities and Exchange Act of 1934, the Company has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.

SHIRE PLC

(the “Registrant”)

Date: February 24, 2014

By: /s/ Flemming Ornskov

Flemming Ornskov, Chief Executive Officer

Pursuant to the requirements of the Securities Exchange Act of 1934, this report has been signed below by the following persons on behalf of the Registrant and in the capacities and on the date indicated.

Signature	Title	Date
/s/ Matthew Emmens MATTHEW EMMENS	Non-Executive Chairman	February 24, 2014
/s/ Susan Kilsby SUSAN KILSBY	Non-Executive Chairman Designate	February 24, 2014
/s/ Dr. Flemming Ornskov FLEMMING ORNSKOV	Chief Executive Officer	February 24, 2014
/s/ Graham Hetherington GRAHAM HETHERINGTON	Chief Financial Officer and Principal Accounting Officer	February 24, 2014
/s/ David Kappler DAVID KAPPLER	Non-Executive Director	February 24, 2014
/s/ Dominic Blakemore DOMINIC BLAKEMORE	Non-Executive Director	February 24, 2014
/s/ William Burns WILLIAM BURNS	Non-Executive Director	February 24, 2014
/s/ Dr. Steven Gillis STEVEN GILLIS	Non-Executive Director	February 24, 2014
/s/ Dr. David Ginsburg DAVID GINSBURG	Non-Executive Director	February 24, 2014
/s/ Anne Minto ANNE MINTO	Non-Executive Director	February 24, 2014
/s/ David Stout DAVID STOUT	Non-Executive Director	February 24, 2014

EX-21

EXHIBIT 21

LIST OF SUBSIDIARIES                                                                                                                     

Subsidiary/undertaking	Jurisdiction of incorporation
3829359 Canada Inc.	Canada
Advanced Biohealing Corp	US
FerroKin BioSciences, Inc.	United States
Jerini Holding Limited	Malta
Jerini Ophthalmic Holding GmbH	Germany
Jerini Ophthalmic, Inc.	United States
Jerini Trading Limited	Malta
JPT Peptide Technologies, Inc.	United States
Lotus Tissue Repair Inc	US
Monmouth Pharmaceuticals Limited	United Kingdom
Movetis GmbH	Germany
Movetis Limited	United Kingdom
Pharma International Insurance Limited	Ireland
Rybar Laboratories Limited	United Kingdom
Premacure AB	Sweden/ Luxembourg
Premacure Uppsala AB	Sweden
SARcode Bioscience Inc	US
SHGT Executive Services, Inc.	United States
Shire (Shanghai) Pharmaceuticals Consultancy Co. Ltd	China
Shire 2005 Investments Limited	Cayman Islands
Shire Acquisition, Inc.	Canada
Shire Australia Pty Limited	Australia
Shire Belgium BVBA	Belgium
Shire Biopharmaceuticals Holdings	United Kingdom
Shire Biopharmaceuticals Holdings Ireland Limited	Jersey
Shire Biopharmaceuticals Ireland Limited	Ireland
Shire Brandywine LLC	United States
Shire Canada, Inc.	Canada
Shire Colombia S.A.S.	Colombia
Shire Czech S.R.O.	Czech Republic
Shire Denmark ApS	Denmark
Shire Deutschland GmbH	Germany
Shire Deutschland Investments GmbH	Germany
Shire Development, LLC.	United States
Shire Europe Finance	United Kingdom
Shire Europe Limited	United Kingdom
Shire Executive Services LLC	United States
Shire Farmacêutica Brasil LTDA	Brazil
Shire Finance Limited	Cayman Islands

Shire Finland Oy	Finland
Shire France S.A.	France
Shire Global Finance	United Kingdom
Shire GmbH	Germany
Shire Hellas Pharmaceuticals Import Export and Marketing S.A.	Greece
Shire Holdings Europe B.V.	Netherlands
Shire Holdings Europe Limited	United Kingdom
Shire Holdings Europe No.2 S.a.r.l.	Luxembourg
Shire Holdings Ireland	Ireland
Shire Holdings Ireland No.2 Limited	Ireland
Shire Holdings Limited	Bermuda
Shire Holdings Luxembourg S.a r.l.	Luxembourg
Shire Holdings UK Canada Limited	United Kingdom
Shire Holdings UK Limited	United Kingdom
Shire Holdings US AG	United States
Shire Human Genetic Therapies (Canada) Inc.	Canada
Shire Human Genetic Therapies AB	Sweden
Shire Human Genetic Therapies Limited	United Kingdom
Shire Human Genetic Therapies S.A.	Argentina
Shire Human Genetic Therapies Securities Corporation	United States
Shire Human Genetic Therapies UK Limited	United Kingdom
Shire Human Genetic Therapies, Inc.	United States
Shire Incorporated	United States
Shire Intellectual Property 2 SRL	Barbados
Shire Intellectual Property Ireland Limited	Ireland
Shire Intellectual Property SRL	Barbados
Shire International GmbH	Switzerland
Shire International Licensing BV	Netherlands
Shire Investement Inc	US
Shire Investments & Finance (U.K.) Company	United Kingdom
Shire IP Services Corporation	Canada
Shire Ireland Finance Limited	Ireland
Shire Italia S.p.A.	Italy
Shire Ireland Investement Limited	Ireland
Shire Ireland Premacure Investment	Ireland
Shire Japan KK	Japan
Shire Jersey Limited	Jersey
Shire LLC	United States
Shire Luxembourg Finance S.a.r.l.	Luxembourg
Shire Luxembourg Intellectual Property No.2 S.a r.l.	Luxembourg
Shire Luxembourg Intellectual Property No.3 S.a.r.l.	Luxembourg
Shire Luxembourg Intellectual Property S.a r.l.	Luxembourg
Shire Luxembourg S.a r.l.	Luxembourg

Shire-Movetis NV	Belgium
Shire North American Group Inc.	United States
Shire Norway AS	Norway
Shire Orphan Therapies GmbH	Germany
Shire Orphan Therapies, Inc.	United States
Shire Orphan and Rare Diseases GmbH	Switzerland
Shire Pharma Korea Yuhan Hoesa	Korea
Shire Pharmaceutical Contracts Limited	United Kingdom
Shire Pharmaceutical Development Limited	United Kingdom
Shire Pharmaceutical Development, Inc.	United States
Shire Pharmaceutical Holdings Ireland Limited	Ireland
Shire Pharmaceutical Investment Holdings Limited	Malta
Shire Pharmaceutical Investment Limited	Malta
Shire Pharmaceutical Investment Trading Ireland	Ireland
Shire Pharmaceutical Investments 2008	Ireland
Shire Pharmaceuticals Group	United Kingdom
Shire Pharmaceuticals Iberica S.L.	Spain
Shire Pharmaceuticals International	Ireland
Shire Pharmaceuticals Investments (British Virgin Islands) Limited	Virgin Islands, British
Shire Pharmaceuticals Investments 2007	Ireland
Shire Pharmaceuticals Ireland Limited	Ireland
Shire Pharmaceuticals Limited	United Kingdom
Shire Pharmaceuticals LLC	United States
Shire Pharmaceuticals Mexico SA de CV	Mexico
Shire Pharmaceuticals Portugal, Lda	Portugal
Shire Pharmaceuticals Services Limited	United Kingdom
Shire Pharmaceuticals Trading Limited Company	Turkey
Shire Polska Sp. z o. o.	Poland
Shire Properties US	United States
Shire Regulatory, Inc.	United States
Shire Regenerative Medicine, Inc.	United States
Shire Rus Limited Liability Company	Russia
Shire Supplies U.S. LLC	United States
Shire Sinagpore Pte. Ltd	Singapore
Shire Sweden AB	Sweden
Shire Sweden Holdings S.a.r.l.	Sweden
Shire UK Investments Limited	United Kingdom
Shire US Holdings, Inc.	United States
Shire US Investments	United Kingdom
Shire US Manufacturing, Inc.	United States
Shire US, Inc.	United States
Sparkleflame Limited	United Kingdom
Tanaud International BV	Netherlands

Tanaud Ireland Inc.	Ireland
The Endocrine Centre Limited	United Kingdom
TKT Argentina S.R.L.	Argentina
Venus NewCo Inc	US

All subsidiary undertakings of Shire plc are beneficially owned (directly or indirectly) as to 100% and are all consolidated in the consolidated financial statements of Shire plc.

EX-23.1

EXHIBIT 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in Shire plc’s Registration Statements on Form S-8 (Nos. 333-09168, 333-93543, 333-60952, 333-91552, 333-111579, 333-129961, 333-129960 and 333-111108), Form S-4 (No. 333-55696) and Form S-3 (Nos. 333-72862-01, 333-38662 and 333-39702) of our reports dated February 24, 2014 relating to the consolidated financial statements and financial statement schedule of Shire plc and the effectiveness of Shire plc’s internal control over financial reporting appearing in this Annual Report on Form 10-K of Shire plc for the year ended December 31, 2013.

/s/ Deloitte LLP

DELOITTE LLP

London, United Kingdom

February 24, 2014

EX-23.2

EXHIBIT 23.2

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We consent to the incorporation by reference in Shire plc’s Registration Statements on Form S-8 (Nos. 333-09168, 333-93543, 333-60952, 333-91552, 333-111579, 333-129961, 333-129960 and 333-111108), Form S-4 (No. 333-55696) and Form S-3 (Nos. 333-72862-01, 333-38662 and 333-39702) of our report dated February 24, 2014 relating to the financial statements of the Shire Income Access Share Trust appearing in this Annual Report on Form 10-K of Shire plc for the year ended December 31, 2013.

/s/ Deloitte LLP

DELOITTE LLP

London, United Kingdom

February 24, 2014

EX-31.1

EXHIBIT 31.1

CERTIFICATION OF FLEMING ORNSKOV RELATING TO

FORM 10-K FOR THE YEAR TO

DECEMBER 31, 2013 OF

SHIRE PLC

I, Fleming Ornskov, certify that:

1.   I have reviewed this Annual Report on Form 10-K of Shire plc;

2.   Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.   Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as at, and for, the periods presented in this report;

4.   The Registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

(a)   designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)   designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)   evaluated the effectiveness of the Registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as at the end of the period covered by this report based on such evaluation; and

(d)   disclosed in this report any change in the Registrant's internal control over financial reporting that occurred during the Registrant's most recent fiscal quarter (the Registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the Registrant's internal control over financial reporting; and

5.   The Registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant's auditors and the audit committee of Registrant's board of directors (or persons performing the equivalent functions):

(a)   all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant's ability to record, process, summarize and report financial information; and

(b)   any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal control over financial reporting.

Date: February 24, 2014

/s/ Fleming Ornskov

Fleming Ornskov

Chief Executive Officer

EX-31.2

EXHIBIT 31.2

CERTIFICATION OF GRAHAM HETHERINGTON RELATING TO

FORM 10-K FOR THE YEAR TO

DECEMBER 31, 2013 OF

SHIRE PLC

I, Graham Hetherington, certify that:

1.   I have reviewed this Annual Report on Form 10-K of Shire plc;

2.   Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

3.   Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the Registrant as at, and for, the periods presented in this report;

4.   The Registrant's other certifying officer(s) and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the Registrant and have:

(a)   designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the Registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

(b)   designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

(c)   evaluated the effectiveness of the Registrant's disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as at the end of the period covered by this report based on such evaluation; and

(d)   disclosed in this report any change in the Registrant's internal control over financial reporting that occurred during the Registrant's most recent fiscal quarter (the Registrant's fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the Registrant's internal control over financial reporting; and

5.   The Registrant's other certifying officer(s) and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the Registrant's auditors and the audit committee of Registrant's board of directors (or persons performing the equivalent functions):

(a)   all significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the Registrant's ability to record, process, summarize and report financial information; and

(b)   any fraud, whether or not material, that involves management or other employees who have a significant role in the Registrant's internal control over financial reporting.

Date: February 24, 2014

/s/ Graham Hetherington

Graham Hetherington

Chief Financial Officer

EX-32.1

EXHIBIT 32.1

The certification set forth below is being submitted in connection with this Annual Report on Form 10-K of Shire plc for the year ended December 31, 2013 (the “Report”) for the purpose of complying with Rule 13a-14(b) or Rule 15d-14(b) of the Securities Exchange Act of 1934 (the “Exchange Act”) and Section 1350 of Chapter 63 of Title 18 of the United States Code.

Flemming Ornskov, the Chief Executive Officer and Graham Hetherington, the Chief Financial Officer of Shire plc, each certifies that, to the best of his knowledge:

1. the Report fully complies with the requirements of Section 13(a) or 15(d) of the Exchange Act; and

2.   the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of Shire plc.

Date: February 24, 2014

/s/ Flemming Ornskov

Flemming Ornskov

Chief Executive Officer

/s/ Graham Hetherington

Graham Hetherington

Chief Financial Officer

XML

Retirement Benefits

12 Months Ended

Dec. 31, 2013

Compensation and Retirement Disclosure [Abstract]

Retirement Benefits Disclosure

25.Retirement benefits

The Company makes contributions to defined contribution retirement plans that together cover substantially all employees. The level of the Company's contribution is fixed at a set percentage of employee's pay.

Company contributions to personal defined contribution pension plans totaled $45.7 million, $46.4 million and $44.4 million for the years to December 31, 2013, 2012 and 2011, respectively, and were charged to operations as they became payable.

XML

Share-based Compensation Plans (Fair Value Assumptions) (Details)	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Minimum
Fair Value Assumptions and Methodology
Risk-free interest rate, minimum	0.10%	0.20%	0.10%
Expected dividend yield	0.40%	0.00%	0.00%
Expected life	1 year	1 year	1 year
Volatility, minimum	23.00%	24.00%	19.00%
Forfeiture rate	5.00%	5.00%	5.00%
Maximum
Fair Value Assumptions and Methodology
Risk-free interest rate, maximum	0.90%	1.00%	2.50%
Expected dividend yield	0.60%	0.60%	0.50%
Expected life	4 years	4 years	5 years
Volatility, maximum	26.00%	32.00%	33.00%
Forfeiture rate	9.00%	7.00%	7.00%

XML

Other Intangible Assets, Net (Tables)

12 Months Ended

Dec. 31, 2013

Intangible Assets, Net (Excluding Goodwill) [Abstract]

Schedule of Other Intangible Assets

		December 31,	December 31,
		2013	2012
		$’M	$’M
		________________	________________
Amortized intangible assets
	Intellectual property rights acquired for currently marketed products	2,573.3	2,462.0
	Acquired product technology	-	710.0
	Other intangible assets	46.1	44.5
		________________	________________
		2,619.4	3,216.5
Unamortized intangible assets
	Intellectual property rights acquired for IPR&D	951.5	231.0
		________________	________________
		3,570.9	3,447.5
Less: Accumulated amortization		(1,258.3)	(1,059.4)
		________________	________________
		2,312.6	2,388.1
		________________	________________

Intangible Assets (Excluding Goodwill) Roll Forward

	Other intangible assets
	2013	2012
	$’M	$’M
	________________	________________
As at January 1,	2,388.1	2,493.0
Acquisitions	731.8	281.6
Amortization charged	(152.0)	(153.6)
Amortization charged on DERMAGRAFT product technology, presented within discontinued operations in the consolidated income statement	(39.4)	(40.5)
Impairment charges	(19.9)	(197.9)
Reclassification of DERMAGRAFT product technology to assets held for sale	(611.4)	-
Foreign currency translation	15.4	5.5
	________________	________________
As at December 31,	2,312.6	2,388.1
	________________	________________

XML

Accounts Receivable, Net (Tables)

12 Months Ended

Dec. 31, 2013

Receivables [Abstract]

Provision for discounts and doubtful accounts

	2013	2012	2011
	$’M	$’M	$’M
	_____________	_____________	_____________
As at January 1,	41.7	31.1	23.4
Provision charged to operations	306.8	283.3	240.8
Provision utilization	(300.6)	(272.7)	(233.1)
	_____________	_____________	_____________
As at December 31,	47.9	41.7	31.1
	_____________	_____________	_____________

XML

Business Combinations (ABH) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended			1 Months Ended	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Jun. 28, 2011 ABH	Dec. 31, 2011 ABH	Jun. 28, 2011 ABH DERMAGRAFT Product Technology	Jun. 28, 2011 ABH Other Intangible Assets
Business Acquisition [Line Items]
Percentage of voting interests acquired				100.00%
Cash consideration paid				$ 739.6
Current assets:
Cash and cash equivalents				14.6
Accounts receivable				30.1
Inventories				30.7
Deferred tax assets				51.1
Other current assets				7.9
Total current assets				134.4
Non-current assets:
Property, plant and equipment				16.6
Goodwill	624.6	644.5	592.6	197.0
Other intangible assets, net						710.0	1.5
Other non-current assets				0.2
Total assets				1,059.7
Current liabilities:
Accounts payable and other current liabilities				52.4
Non-current liabilities:
Long term debt, less current portion				9.1
Deferred tax liabilities				258.5
Other non-current liabilities				0.1
Total liabilities				320.1
Fair value of identified assets acquired and liabilities assumed				739.6
Pro Forma Information
Post acquisition revenues included in consolidated statement of income					105.3
Post acquisition pre-tax losses included in consolidated statement of income					15.3
Post acquisition amortization of intangible assets included in consolidated statement of income					20.0
Integration and acquisition costs	$ (134.1)	$ 13.5	$ 0.1

XML

Accounts Payable and Accrued Expenses (Tables)

12 Months Ended

Dec. 31, 2013

Accounts Payable and Accrued Liabilities, Current [Abstract]

Schedule of Accounts Payable and Accrued Expenses

	December 31,	December 31,
	2013	2012
	$’M	$’M
	________________	________________
Trade accounts payable and accrued purchases	202.6	208.1
Accrued rebates – Medicaid	549.1	455.6
Accrued rebates – Managed care	258.1	184.9
Sales return reserve	98.8	90.5
Accrued bonuses	130.9	109.0
Accrued employee compensation and benefits payable	79.4	64.5
R&D accruals	69.6	73.5
Provisions for litigation losses and other claims	71.7	118.2
Other accrued expenses	228.2	197.2
	________________	________________
	1,688.4	1,501.5
	________________	________________

XML

Goodwill (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended						0 Months Ended		0 Months Ended	12 Months Ended		1 Months Ended	0 Months Ended	12 Months Ended	3 Months Ended		12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2013 Continung operations	Dec. 31, 2012 Continung operations	Dec. 31, 2013 Discontinued operations	Dec. 31, 2012 Discontinued operations	Apr. 02, 2012 FerroKin	Jun. 28, 2011 ABH	Feb. 12, 2013 Lotus	Dec. 31, 2013 Lotus	Dec. 31, 2013 Premacure AB	Apr. 19, 2012 Pervasis	Apr. 17, 2013 SARcode Biosciences Inc	Dec. 31, 2013 SARcode Biosciences Inc	Mar. 31, 2013 Former RM reporting unit	Dec. 31, 2013 Former RM reporting unit	Dec. 31, 2013 One Shire number
Goodwill [Line Items]
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net							$ 159.3	$ 739.6	$ 174.2			$ 26.1	$ 368.0
Goodwill arising on business acquired	170.3	48.1					46.1		54.1	54.1	29.6	2.0	86.6	86.6	0
Goodwill facts and circumstances leading to impairment	Goodwill is tested for impairment at least annually as at October 1 each year. This assessment is also performed whenever there is a change in circumstances that indicates the carrying value of these assets may not be recoverable. In the first quarter of 2013 the Company identified circumstances which indicated that the carrying value of goodwill in the Company’s former RM reporting unit may not be recoverable, which triggered an impairment test in advance of the annual testing date. Those circumstances included the results of an independent market research study of the DERMAGRAFT sales potential, commissioned by the Company, which was finalized late in the first quarter of 2013. In addition, the recently completed restructuring of the RM sales and marketing organization and the implementation of a new commercial model had a more pronounced impact than previously expected. As a result of those and other factors forecast future sales were lower than at the time of acquisition.
Discount Rate	15.10%
Goodwill impairment method for fair value determination	The results of the Company’s March 31, 2013 impairment test showed that the carrying amount of the former RM reporting unit exceeded its fair value and the implied value of the goodwill was $nil. As a result the Company recorded an impairment charge of $198.9 million related to the goodwill allocated to the former RM reporting unit. The RM goodwill impairment charge is not deductible for tax purposes. Accumulated goodwill impairment as at December 31, 2013 was $198.9 million (December 31, 2012: $nil). The Company determined the estimated fair value of the former RM reporting unit using discounted cash flow analyses, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, expected cash flows for the period from March 31, 2013 to December 31, 2023 and the associated discount rate of 15.1%, which was derived from management’s best estimate of the after-tax weighted average cost of capital for the RM reporting unit. Discounted cash flow analyses are dependent upon a number of quantitative and qualitative factors including estimates of forecasted revenue, profitability, earnings before interest, taxes, depreciation and amortization, and terminal values. The discount rates applied in the discounted cash flow analyses also have an impact on the estimates of fair value, as use of a higher rate will result in a lower estimate of fair value
Accumulated Goodwill Impairment	198.9	0
Goodwill [Roll Forward]
As at January 1,	644.5	592.6						197.0
Acquisition	170.3	48.1					46.1		54.1	54.1	29.6	2.0	86.6	86.6	0
Goodwill impairment charge			(7.1)	0	(191.8)	0										198.9
Foreign currency translation	8.7	3.8
As at December 31,	$ 624.6	$ 644.5						$ 197.0
Operating segments																	1
Reportable segments																	1

XML

Taxation (Effective Income Tax Rate Reconciliation, and Statutory Tax Rates) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Effective Income Tax Rate Reconciliation
Income from continuing operations before income taxes and equity in earnings of equity method investees	$ 1,693.6		$ 1,007.8		$ 1,117.1
Statutory tax rate	25.00%	[1]	25.00%	[1]	25.00%	[1]
Other permanent differences:
US R&D credit	(4.50%)		(2.60%)		(4.50%)
Effect of the convertible bond	0.50%		0.80%		0.80%
Intra-group items	(9.20%)	[2]	(16.00%)	[2]	(7.50%)	[2]
Recognition of foreign tax credits			(6.60%)		0.00%
Other permanent items	(0.70%)		0.80%		(0.50%)
Change in valuation allowance	0.90%		3.40%		3.20%
Impact of Resolor impairment	0.00%		4.90%		0.00%
Differences in taxation rates	7.80%		7.60%		4.60%
Change in provisions for uncertain tax positions	3.80%		1.10%		(1.20%)
Prior year adjustment	(3.40%)		0.80%		0.80%
Change in fair value of contingent consideration	(3.60%)		0.00%		0.00%
Change in tax rates	(0.20%)		0.80%		0.20%
Other	0.00%		0.10%		0.30%
Provision for income taxes on continuing operations	16.40%		20.10%		21.20%
Statutory Tax Rates
Statutory tax rate	25.00%
Canada
Statutory Tax Rates
Statutory tax rate	15.00%
France
Statutory Tax Rates
Statutory tax rate	33.30%
Germany
Statutory Tax Rates
Statutory tax rate	15.00%
Italy
Statutory Tax Rates
Statutory tax rate	27.50%
Luxembourg
Statutory Tax Rates
Statutory tax rate	21.00%
The Netherlands
Statutory Tax Rates
Statutory tax rate	25.00%
Belgium
Statutory Tax Rates
Statutory tax rate	33.99%
Spain
Statutory Tax Rates
Statutory tax rate	30.00%
Sweden
Statutory Tax Rates
Statutory tax rate	22.00%
Switzerland
Statutory Tax Rates
Statutory tax rate	8.50%
United Kingdom
Statutory Tax Rates
Statutory tax rate	23.25%
United States
Statutory Tax Rates
Statutory tax rate	35.00%

[1] In addition to being subject to the Irish Corporation tax rate of 25%, in 2013 the Company is also subject to income tax in other territories in which the Company operates, including: Canada (15%); France (33.3%); Germany (15%); Italy (27.5%); Luxembourg (21.0%); the Netherlands (25%); Belgium (33.99%); Spain (30%); Sweden (22%); Switzerland (8.5%); United Kingdom (23.25%) and the US (35%). The rates quoted represent the statutory federal income tax rates in each territory, and do not include any state taxes or equivalents or surtaxes or other taxes charged in individual territories, and do not purport to represent the effective tax rate for the Company in each territory

[2] Intra-group items principally relate to the effect of inter-company dividends, capital receipts (either taxable or non-taxable) and other intra-territory eliminations, the pre-tax effect of which has been eliminated in arriving at the Company’s consolidated income from continuing operations before income taxes, noncontrolling interests and equity in earnings/(losses) of equity method investees

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Business Combinations (Tables) (ABH)

12 Months Ended

Dec. 31, 2013

ABH

Business Acquisition [Line Items]

Schedule of Purchase Price Allocation

	Fair value
	$’M
ASSETS
Current assets:
Cash and cash equivalents	14.6
Accounts receivable	30.1
Inventories	30.7
Deferred tax assets	51.1
Other current assets	7.9
	_______________
Total current assets	134.4
Non-current assets:
Property, plant and equipment	16.6
Goodwill	197.0
Other intangible assets
- DERMAGRAFT product technology	710.0
- other intangible assets	1.5
Other non-current assets	0.2
	_______________
Total assets	1,059.7
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	52.4
Non-current liabilities:
Long term debt, less current portion	9.1
Deferred tax liabilities	258.5
Other non-current liabilities	0.1
	_______________
Total liabilities	320.1
	_______________
Fair value of identifiable assets acquired and liabilities assumed	739.6
Consideration	_______________
Cash consideration paid	739.6
	_______________

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Accumulated Other Comprehensive Income

12 Months Ended

Dec. 31, 2013

Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]

Accumulated Other Comprehensive Income (Loss)

19.Accumulated Other ComprehensiveIncome

The changes in accumulated other comprehensive income, net of their related tax effects, in the year to to December 31, 2013are included below:

		Foreign currency translation adjustment	Unrealized holding gain/(loss) on available-for-sale securities	Accumulated other comprehensive income
		$M	$M	$M
As at January 1, 2013		85.1	1.8	86.9
Current period change:
	Other Comprehensive income before reclassification	25.3	1.5	26.8
	Gain transferred to the income statement (within Other (expense)/income, net) on disposal of available-for-sale securities	0	(3.5)	(3.5)
Net current period other comprehensive income		25.3	(2.0)	23.3
As at December 31, 2013		110.4	(0.2)	110.2

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Other Intangible Assets, Net (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	$ 2,619.4	$ 3,216.5
Other intangible assets, gross	3,570.9	3,447.5
Less: Accumulated amortization	(1,258.3)	(1,059.4)
Other intangible assets, net	2,312.6	2,388.1	2,493.0
Estimates of Annual Amortization
2014	127
2015	127
2016	127
2017	127
2018	127
Currently Marketed Products
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	2,573.3	2,462.0
Acquired Product Technology
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	0	710.0
Other Intangible Assets
Intangible Assets (Excluding Goodwill) [Line Items]
Amortized intangible assets	46.1	44.5
IPR&D
Intangible Assets (Excluding Goodwill) [Line Items]
Unamortized intangible assets	$ 951.5	$ 231.0

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Accounts Receivable, Net (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Provision for discounts and doubtful accounts
As at January 1,	$ 41.7	$ 31.1	$ 23.4
Provision charged to operations	306.8	283.3	240.8
Provision utilization	(300.6)	(272.7)	(233.1)
As at December 31,	47.9	41.7	31.1
Accounts receivable, net	961.2	824.2
Accounts receivable related to royalty income	$ 37.8	$ 38.5

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Accumulated Other Comprehensive Income (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Accumulated Other Comprehensive Income (Loss)
As at January 1, 2013	$ 86.9
Other comprehensive income, net of tax	23.3	26.6	(25.4)
As at December 31, 2013	110.2	86.9
Foreign currency translation adjustment
Accumulated Other Comprehensive Income (Loss)
As at January 1, 2013	85.1
Other Comprehensive income before reclassification	25.3
Gain transferred to the income statement (within Other (expense)/income,net) on disposal of available-for-sale-securities	0
Other comprehensive income, net of tax	25.3
As at December 31, 2013	110.4
Unrealized holding gain/(loss) on available-for-sale securities
Accumulated Other Comprehensive Income (Loss)
As at January 1, 2013	1.8
Other Comprehensive income before reclassification	1.5
Gain transferred to the income statement (within Other (expense)/income,net) on disposal of available-for-sale-securities	(3.5)
Other comprehensive income, net of tax	(2.0)
As at December 31, 2013	(0.2)
Accumulated other comprehensive income
Accumulated Other Comprehensive Income (Loss)
As at January 1, 2013	86.9
Other Comprehensive income before reclassification	26.8
Gain transferred to the income statement (within Other (expense)/income,net) on disposal of available-for-sale-securities	(3.5)
Other comprehensive income, net of tax	23.3	26.6	(25.4)
As at December 31, 2013	$ 110.2	$ 86.9

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Other Non-current Liabilities (Tables)

12 Months Ended

Dec. 31, 2013

Other Liabilities, Noncurrent [Abstract]

Schedule of Other Noncurrent Liabilities

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Income taxes payable	115.7	58.9
Deferred revenue	9.8	11.4
Deferred rent	11.3	11.9
Insurance provisions	1.0	12.3
Contingent consideration payable	393.0	120.4
Other non-current liabilities	57.7	26.7
	____________	____________
	588.5	241.6
	____________	____________

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Share-based Compensation Plans (by Share-based Payment Award) (Details)				12 Months Ended												12 Months Ended
	Dec. 31, 2013 SARs and Stock Options	Dec. 31, 2012 SARs and Stock Options	Dec. 31, 2013 Portfolio Share Plan - Part A SARs and Stock Options	Dec. 31, 2013 Portfolio Share Plan - Part A SARs	Dec. 31, 2013 Portfolio Share Plan - Part A SARs Minimum	Dec. 31, 2013 Portfolio Share Plan - Part A SARs Maximum	Dec. 31, 2013 Sharesave Scheme Stock Options	Dec. 31, 2013 Sharesave Scheme Stock Options United Kingdom	Dec. 31, 2013 Sharesave Scheme Stock Options Ireland	Dec. 31, 2013 Sharesave Scheme Stock Options Minimum	Dec. 31, 2013 Sharesave Scheme Stock Options Maximum	Dec. 31, 2013 Stock Purchase Plan Stock Options	Dec. 31, 2013 Stock Purchase Plan Stock Options Minimum	Dec. 31, 2013 Stock Purchase Plan Stock Options Maximum	Dec. 31, 2013 Legacy Plans Stock Options	Dec. 31, 2013 Legacy Plans Stock Options Minimum	Dec. 31, 2013 Legacy Plans Stock Options Maximum	Dec. 31, 2013 Portfolio Share Plan - Part B Performance Share Awards
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Award outstanding (in shares)	15,029,182	18,536,947	15,029,182	14,083,748			243,783					568,828			132,823			2,701,299
Award expiration period from the date of the issue					5 years	7 years	6 months									7 years	10 years	3 years
Vesting period				3 years						3 years	5 years		1 year	5 years		3 years	10 years	3 years
Exercise price of common stock, percent								80.00%	75.00%			85.00%

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Prepaid Expenses and Other Current Assets (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Prepaid Expense and Other Assets, Current [Abstract]
Prepaid expenses	$ 29.4	$ 31.7
Income tax receivable	177.4	130.6
Value added taxes receivable	14.5	20.9
Other current assets	41.7	38.6
Prepaid expenses and other current assets, total	$ 263.0	$ 221.8

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Commitments and Contingencies (Leases, and LC and Guarantees ) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Future Minimum Lease Payments under Operating Leases
2014	$ 44.9
2015	33.6
2016	23.9
2017	17.9
2018	12.2
Thereafter	83.4
Future minimum lease payments, total	215.9
Operating Leases, Rent Expense
Lease and rental expense	44.0	43.2	37.6
Letters of credit and guarantees
Irrevocable standby letters of credit and guarantees	$ 51.0

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Accounts Payable and Accrued Expenses (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Accounts Payable and Accrued Liabilities, Current [Line Items]
Trade accounts payable and accrued purchases	$ 202.6	$ 208.1
Accrued rebates - Medicaid	549.1	455.6
Accrued rebates - Managed care	258.1	184.9
Sales return reserve	98.8	90.5
Accrued bonuses	130.9	109.0
Accrued employee compensation and benefits payable	79.4	64.5
R&D accruals	69.6	73.5
Provisions for litigation losses and other claims	71.7	118.2
Other accrued expenses	228.2	197.2
Accounts payable and accrued expenses, total	$ 1,688.4	$ 1,501.5

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Commitments and Contingencies (Collaborative Arrangements) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
In-licensing arrangements
Research and development	$ 933.4	[1]	$ 953.0	[1]	$ 764.5	[1]
In-licensing Arrangement | Research Collaboration with Santaris
In-licensing arrangements
Maximum conditional obligation	71.0
Milestones payment	1.5		3.0		2.5
Support costs	4.5		8.1		5.3
In-licensing Arrangement | Collaboration and Licensse Agreement with Sangamo
In-licensing arrangements
Upfront payment			13.0
Maximum conditional obligation	213.5
Research and development	15.2		8.9		0
Out-licensing Arrangement
Out-licensing arrangements
Milestone payments received	3.0		18.3		11.5
Out-licensing Arrangement | Other Revenues
Out-licensing arrangements
Milestone revenues recognized	5.0		19.4		17.5
Out-licensing Arrangement | Product Sales
Out-licensing arrangements
Milestone revenues recognized	58.3		83.8		65.2
Out-licensing Arrangement | Development Milestone
Out-licensing arrangements
Maximum milestone payment receivable	39.0
Out-licensing Arrangement | Sales Milestone
Out-licensing arrangements
Maximum milestone payment receivable	$ 71.5

[1] Research and development (“R&D”) includes intangible asset impairment charges of $19.9 million (2012: $71.2 million, 2011: $16.0 million) for the year to December 31, 2013. Selling, general and administrative (“SG&A”) costs include amortization and impairment charges of intangible assets relating to intellectual property rights acquired of $152.0 million for the year to December 31, 2013 (2012: $280.3 million, 2011: $145.0 million).

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Property Plant and Equipment (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Property, Plant and Equipment, Net
Land and buildings	$ 695.0	$ 701.2
Office furniture, fittings and equipment	467.0	383.8
Warehouse, laboratory and manufacturing equipment	276.2	287.2
Assets under construction	45.6	93.8
Property, plant and equipment, gross	1,483.8	1,466.0
Less: Accumulated depreciation	(592.0)	(510.2)
Property, plant and equipment, net	891.8	955.8
Depreciation	$ 127.6	$ 109.0	$ 119.5

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Divestment of Product Rights (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Product Information [Line Items]
Total divestiture contingent consideration receivable	$ 300.0
DAYTRANA
Product Information [Line Items]
Gain (loss) on change in the fair value of divestiture contingent consideration receivable	15.9	18.1	(6.0)
Current divestiture contingent consideration receivable	9.6	11.6
Noncurrent divestiture contingent consideration receivable	26.5	27.6
Total divestiture contingent consideration receivable	$ 36.1	$ 39.2

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Goodwill

12 Months Ended

Dec. 31, 2013

Goodwill and Intangible Assets Disclosure [Abstract]

Goodwill Disclosure

11.Goodwill

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Goodwill arising on businesses acquired	624.6	644.5
	____________	____________

In the year to December 31, 2013 the Company completed the acquisitions of SARcode, Premacure and Lotus Tissue Repair, which resulted in goodwill of $86.6 million, $29.6 million and $54.1 million, respectively (see Note 3 for details).

As a result of the re-alignment of the business into a simplified One Shire organization, the Company now comprises one operating and one reportable segment (see note 24 for further details).

	2013	2012
	$’M	$’M
	____________	____________
As at January 1,	644.5	592.6
Acquisitions	170.3	48.1
Goodwill impairment charge related to continuing operations	(7.1)	-
Goodwill impairment charge related to DERMAGRAFT business and transferred to discontinued operations	(191.8)	-
Foreign currency translation	8.7	3.8
	____________	____________
As at December 31,	624.6	644.5
	____________	____________

Goodwill is tested for impairment at least annually as at October 1 each year. This assessment is also performed whenever there is a change in circumstances that indicates the carrying value of these assets may not be recoverable.

In the first quarter of 2013 the Company identified circumstances which indicated that the carrying value of goodwill in the Company's former RM reporting unit may not be recoverable, which triggered an impairment test in advance of the annual testing date.

Those circumstances included the results of an independent market research study of the DERMAGRAFT sales potential, commissioned by the Company, which was finalized late in the first quarter of 2013. In addition, the recently completed restructuring of the RM sales and marketing organization and the implementation of a new commercial model had a more pronounced impact than previously expected. As a result of those and other factors forecast future sales were lower than at the time of acquisition.

The results of the Company's March 31, 2013 impairment test showed that the carrying amount of the former RM reporting unit exceeded its fair value and the implied value of the goodwill was $nil. As a result the Company recorded an impairment charge of $198.9 million related to the goodwill allocated to the former RM reporting unit. The RM goodwill impairment charge is not deductible for tax purposes.Accumulated goodwill impairment as at December 31, 2013 was $198.9 million (December 31, 2012: $nil).

The Company determined the estimated fair value of the former RM reporting unit using discounted cash flow analyses, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, expected cash flows for the period from March 31, 2013 to December 31, 2023 and the associated discount rate of 15.1%, which was derived from management's best estimate of the after-tax weighted average cost of capital for the RM reporting unit.

Discounted cash flow analyses are dependent upon a number of quantitative and qualitative factors including estimates of forecasted revenue, profitability, earnings before interest, taxes, depreciation and amortization, and terminal values. The discount rates applied in the discounted cash flow analyses also have an impact on the estimates of fair value, as use of a higher rate will result in a lower estimate of fair value.

Following the divestment of DERMAGRAFT (see Note 8) the Company has reclassified the Goodwill and related accumulated impairment of $191.8 million (being the portion of the former RM reporting unit goodwill impairment charge that relates to the DERMAGRAFT business) to discontinued operations.

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Results of discontinued operations and other assets held for sale (Table)

12 Months Ended

Dec. 31, 2013

DiscontinuedOperationIncomeLossFromDiscontinuedOperationDisclosuresAbstract

Schedule Of Disposal Groups Including Discontinued Operations Income Statement Balance Sheet And Additional Disclosures (Table Text Block)

	2013	2012	2011
	$’M	$’M	$’M
Revenues:	_______________	_______________	_______________
Product revenues	89.8	153.8	105.3
	_______________	_______________	_______________
Loss from discontinued operations before income taxes	(1,080.9)	(96.4)	(27.0)
Income taxes	326.4	36.1	9.3
	_______________	_______________	_______________
Loss from discontinued operations, net of taxes	(754.5)	(60.3)	(17.7)
	_______________	_______________	_______________

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Quarterly Results of Operations (Unaudited)

12 Months Ended

Dec. 31, 2013

Quarterly Financial Information Disclosure [Abstract]

Quarterly Results of Operations (Unaudited)

Quarterly results of operations (Unaudited)

The following tables reconcile previously reported data with current year quarterly data which has been updated for discontinued operations related to the DERMAGRAFT business(see Note8 for details):

	First quarter of 2013				Second quarter of 2013
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,161.9	(18.5)	1,143.4		1,274.5	(22.3)	1,252.2
Cost of product sales	155.9	(8.5)	147.4		175.7	(11.4)	164.3
Income from continuing operations, net of taxes	64.8	216.2	281.0		258.1	32.8	290.9
Loss from discontinued operations, net of taxes	-	(216.2)	(216.2)		-	(32.8)	(32.8)
Net income	64.8	-	64.8		258.1	-	258.1
Earnings per ordinary share - basic
Earnings from continuing operations	11.7c	39.3c	51.0c		46.9c	6.0c	52.9c
Loss from discontinued operations	-	(39.3c)	(39.3c)		-	(6.0c)	(6.0c)
Earnings per share - basic	11.7c	-	11.7c	1.0	46.9c	-	46.9c
Earnings per ordinary share - diluted
Earnings from continuing operations	11.7c	36.7c	49.0c		45.3c	5.6c	50.9c
Loss from discontinued operations	-	(36.7c)	(36.7c)		-	(5.6c)	(5.6c)
Earnings per share - diluted	11.7c	-	12.3c	1.0	45.3c	-	45.3c
	Third quarter of 2013				Fourth quarter of 2013
	Previously	Adjusted for	As		Memo (prior	Adjusted for	As
	reported	DERMAGRAFT	reported		to adjustment)	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,236.6	(23.9)	1,212.7		1,351.1	(25.1)	1,326.0
Cost of product sales	197.1	(16.6)	180.5		196.5	(17.9)	178.6
Income from continuing operations, net of taxes	278.2	22.9	301.1		64.0	482.6	546.6
Loss from discontinued operations, net of taxes	-	(22.9)	(22.9)		-	(482.6)	(482.6)
Net income	278.2	-	278.2		64.0	-	64.0
Earnings per ordinary share - basic
Earnings from continuing operations	50.7c	4.2c	54.9c		11.5c	86.5c	98.0c
Loss from discontinued operations	-	(4.2c)	(4.2c)		-	(86.5c)	(86.5c)
Earnings per share - basic	50.7c	-	50.7c	1.0	11.5c	-	11.5c
Earnings per ordinary share - diluted
Earnings from continuing operations	48.8c	3.9c	52.7c		11.7c	81.7c	93.4c
Loss from discontinued operations	-	(3.9c)	(3.9c)		-	(81.7c)	(81.7c)
Earnings per share - diluted	48.8c	-	48.8c	1.0	11.7c	-	11.7c
	First quarter of 2012				Second quarter of 2012
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,171.8	(48.8)	1,123.0		1,207.8	(52.4)	1,155.4
Cost of product sales	158.4	(10.0)	148.4		152.5	(17.0)	135.5
Income from continuing operations, net of taxes	238.4	7.4	245.8		237.8	10.7	248.5
Loss from discontinued operations, net of taxes	-	(7.4)	(7.4)		-	(10.7)	(10.7)
Net income	238.4	-	238.4		237.8	-	237.8
Earnings per ordinary share - basic
Earnings from continuing operations	43.1c	1.3c	44.4c		42.7c	1.9c	44.6c
Loss from discontinued operations	-	(1.3c)	(1.3c)		-	(1.9c)	(1.9c)
Earnings per share - basic	43.1c	-	43.1c	1.0	42.7c	-	42.7c
Earnings per ordinary share - diluted
Earnings from continuing operations	41.4c	1.3c	42.7c		41.3c	1.8c	43.1c
Loss from discontinued operations	-	(1.3c)	(1.3c)		-	(1.8c)	(1.8c)
Earnings per share - diluted	41.4c	-	41.4c	1.0	41.3c	-	41.3c
	Third quarter of 2012				Fourth quarter of 2012
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,100.4	(33.7)	1,066.7		1,201.2	(18.9)	1,182.3
Cost of product sales	167.9	(16.0)	151.9		166.6	(16.6)	150.0
Income from continuing operations, net of taxes	227.2	16.2	243.4		42.0	26.0	68.0
Loss from discontinued operations, net of taxes	-	(16.2)	(16.2)		-	(26.0)	(26.0)
Net income	227.2	-	227.2		42.0	-	42.0
Earnings per ordinary share - basic
Earnings from continuing operations	40.9c	2.9c	43.8c		7.5c	4.7c	12.2c
Loss from discontinued operations	-	(2.9c)	(2.9c)		-	(4.7c)	(4.7c)
Earnings per share - basic	40.9c	-	40.9c	1.0	7.5c	-	7.5c
Earnings per ordinary share - diluted
Earnings from continuing operations	39.6c	2.7c	42.3c		7.4c	4.7c	12.1c
Loss from discontinued operations	-	(2.7c)	(2.7c)		-	(4.7c)	(4.7c)
Earnings per share - diluted	39.6c	-	39.6c	1.0	7.4c	-	7.4c

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Results of discontinued operations and other assets helf for sale (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Loss from discontinued operations, net of taxes	$ (754.5)	$ (60.3)	$ (17.7)
Loss on sale of discontinued operations before income taxes	0	0	0
Divestiture, Contingent Consideration Receivable	300.0
Impairment of assets held for sale	636.9	0	0
Goodwill impairment charge	7.1	0	0
Reorganization costs	88.2	0	24.3
Transferred assets held for sale	31.6	0
Reclassification of Dermagraft product technology to assets held for sale	(611.4)	0
DERMAGRAFT
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Product Revenues	89.8	153.8	105.3
Loss from discontinuing operations before income taxes	(1,080.9)	(96.4)	(27.0)
Income tax expense from discontinued operations	326.4	36.1	9.3
Loss from discontinued operations, net of taxes	(754.5)	(60.3)	(17.7)
Impairment of assets held for sale	636.9
Historical goodwill impairment charge presented within discontinued operations	191.8
Accounts receivable,net	11.8
Inventories	16.2
Property, plant and equipment, net	29.1
Reclassification of Dermagraft product technology to assets held for sale	611.4
Continung operations
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Goodwill impairment charge	7.1
Discontinued operations
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Goodwill impairment charge	191.8
Discontinued operations | DERMAGRAFT
Income Statement, Balance Sheet and Additional Disclosures by Disposal Groups, Including Discontinued Operations [Line Items]
Reorganization costs	$ 99.6

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Earnings Per Share (Details) (USD $)	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Schedule of Calculation of Numerator and Denominator in Earnings Per Share
Income from continuing operations, net of taxes	$ 1,419,600,000		$ 805,700,000		$ 882,700,000
Loss from discontinued operations, net of taxes	(754,500,000)		(60,300,000)		(17,700,000)
Net income	665,100,000		745,400,000		865,000,000
Interest on convertible bonds, net of tax (in USD)	28,300,000		31,300,000		33,600,000
Numerator for diluted earnings per share (in USD)	693,400,000		776,700,000		898,600,000
Schedule of Weighted Average Number of Shares
Basic (in shares)	552,000,000	[1]	555,400,000	[1]	551,100,000	[1]
Effect of dilutive shares:
Share based awards to employees	4,800,000	[2]	4,600,000	[2]	10,900,000	[2]
Convertible bonds 2.75% due 2014	33,500,000	[3]	33,500,000	[3]	33,400,000	[3]
Diluted (in shares)	590,300,000		593,500,000		595,400,000
Earning per ordinary share - basic
Earnings from continuing operations (in USD per share)	$ 2.572		$ 1.451		$ 1.601
Loss from discontinued operations (in USD per share)	$ (1.367)		$ (0.109)		$ (0.032)
Earnings per ordinary share - basic	$ 1.205		$ 1.342		$ 1.569
Earnings per ordinary share - diluted
Earnings from continuing operations (in USD per share)	$ 2.453		$ 1.410		$ 1.539
Loss from discontinued operations (in USD per share)	$ (1.278)		$ (0.101)		$ (0.030)
Earnings per ordinary share - diluted	$ 1.175		$ 1.309		$ 1.509
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Convertible bond, convertible into number of ordinary shares	33,806,464
Principal amount	1,100,000,000
Redemption terms	On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed to the Holders of the Bonds. The aggregate outstanding principal amount of the Bonds on November 25, 2013, the last practicable date prior to the date of the optional redemption notice, was $1,075,070,000. The last day on which Holders were able to exercise their conversion rights was December 13, 2013. Those Bonds which were not voluntarily converted by Holders were redeemed by the Company on December 27, 2013 at par together with interest accrued to that date. As at December 31, 2013, Holders had voluntarily converted $1,099,050,000 aggregate principal amount of the Convertible Bonds into 33,806,464 fully paid Ordinary Shares at a conversion price of US$32.51 per Ordinary Share, in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principal amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. Following the redemption of all the outstanding Bonds, the Company cancelled the listing of the Bonds on the Official List maintained by the UK Listing Authority and the admission to trading of the Bonds on the Professional Securities Market of the London Stock Exchange
Stated interest rate	2.75%
Principal amount extinguished	1,075,070,000
Shire 2.75% Convertible Bond due 2014
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Principal amount	1,100,000,000
Stated interest rate	2.75%
Cash redemption amount
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Principal amount extinguished	950,000.00
Share redemption amount
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Principal amount extinguished	$ 1,099,050,000
Share Awards
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share	500,000	[4]	6,700,000	[4]	2,900,000	[4]

[1] Excludes shares purchased by the EBT and under the share buy-back program and presented by Shire as treasury stock

[2] Calculated using the treasury stock method

[3] At December 31, 2013, Bondholders had voluntarily converted $1,099,050,000 aggregate principal amount of the Bonds into 33,806,464 fully paid Ordinary Shares. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the option redemption notice issued on November 26, 2013. The Company has calculated the impact of the Bonds on diluted EPS from the beginning of the period to the actual date of Bonds conversion using the ‘if-converted’ method.

[4] Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc’s average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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Earnings Per Share

12 Months Ended

Dec. 31, 2013

Earnings Per Share [Abstract]

Earnings Per Share Disclosure

23.Earnings per share

The following table reconciles net income and the weighted average ordinary shares outstanding for basic and diluted earnings per share for the periods presented:

	2013	2012	2011
	$’M	$’M	$’M
	_________________	_________________	_________________
Income from continuing operations, net of taxes	1,419.6	805.7	882.7
Loss from discontinued operations1	(754.5)	(60.3)	(17.7)
	_________________	_________________	_________________
Numerator for basic earnings per share	665.1	745.4	865.0
Interest on convertible bonds, net of tax	28.3	31.3	33.6
	_________________	_________________	_________________
Numerator for diluted earnings per share	693.4	776.7	898.6
	_________________	_________________	_________________
Weighted average number of shares:
	Millions	Millions	Millions
	_________________	_________________	_________________
Basic 1	552.0	555.4	551.1
Effect of dilutive shares:
Share based awards to employees 2	4.8	4.6	10.9
Convertible bonds 2.75% due 2014 3	33.5	33.5	33.4
	_________________	_________________	_________________
Diluted	590.3	593.5	595.4
	_________________	_________________	_________________

1. Excludes shares purchased by the EBT and under the share buy-back program and presented by Shire as treasury stock.

2. Calculated using the treasury stock method.

3. At December 31, 2013,Bondholders had voluntarily converted $1,099,050,000 aggregate principal amount of the Bonds into 33,806,464 fully paid Ordinary Shares. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the option redemption noticeissued on November 26, 2013. The Company has calculated the impact of the Bonds on diluted EPS from the beginning of the period to the actual date of Bonds conversion using the 'if-converted' method.

Year to December 31,	2013	2012	2011
	_______________	_______________	_______________
Earnings per ordinary share - basic
Earnings from continuing operations	257.2c	145.1c	160.1c
Loss from discontinued operations	(136.7c)	(10.9c)	(3.2c)
	_______________	_______________	_______________
Earnings per ordinary share - basic	120.5c	134.2c	156.9c
	_______________	_______________	_______________
Earnings per ordinary share - diluted
Earnings from continuing operations	245.3c	141.0c	153.9c
Loss from discontinued operations	(127.8c)	(10.1c)	(3.0c)
	_______________	_______________	_______________
Earnings per ordinary share – diluted	117.5c	130.9c	150.9c
	_______________	_______________	_______________

The share equivalents not included in the calculation of the diluted weighted average number of shares are shown below:

	2013	2012	2011
	No. of shares	No. of shares	No. of shares
	Millions	Millions	Millions
	_________________	_________________	_________________
Share based awards to employees1	0.5	6.7	2.9
	_________________	_________________	_________________

• Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc's average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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Property, Plant and Equipment, Net (Tables)

12 Months Ended

Dec. 31, 2013

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Land and buildings	695.0	701.2
Office furniture, fittings and equipment	467.0	383.8
Warehouse, laboratory and manufacturing equipment	276.2	287.2
Assets under construction	45.6	93.8
	____________	____________
	1,483.8	1,466.0
Less: Accumulated depreciation	(592.0)	(510.2)
	____________	____________
	891.8	955.8
	____________	____________

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Summary of Significant Accounting Policies (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Accounting Policies [Abstract]
Advertising costs	$ 60.9	$ 85.8	$ 122.5
Foreign currency exchange transaction gain (loss)	(8.7)	(3.5)	(2.1)
Former RM reporting unit
Goodwill and Intangible Assets
Goodwill impairment charge	$ 198.9
Minimum
Goodwill and Intangible Assets
Estimated useful life of intangible assets	1 year
Maximum
Goodwill and Intangible Assets
Estimated useful life of intangible assets	20 years
Weighted Average
Goodwill and Intangible Assets
Estimated useful life of intangible assets	10 years 1 month
Buildings | Minimum
Property, Plant and Equipment
Estimated useful life of PP&E	15 years
Buildings | Maximum
Property, Plant and Equipment
Estimated useful life of PP&E	50 years
Office furniture, fittings and equipment | Minimum
Property, Plant and Equipment
Estimated useful life of PP&E	3 years
Office furniture, fittings and equipment | Maximum
Property, Plant and Equipment
Estimated useful life of PP&E	10 years
Warehouse, laboratory and manufacturing equipment | Minimum
Property, Plant and Equipment
Estimated useful life of PP&E	3 years
Warehouse, laboratory and manufacturing equipment | Maximum
Property, Plant and Equipment
Estimated useful life of PP&E	15 years

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Share-based Compensation Plans (Performance Share Awards) (Details) In Millions, except Share data, unless otherwise specified	12 Months Ended											12 Months Ended
	Dec. 31, 2013 USD ($)	Dec. 31, 2012 USD ($)	Dec. 31, 2011 USD ($)	Dec. 31, 2013 Ordinary Shares	Dec. 31, 2012 Ordinary Shares	Dec. 31, 2011 Ordinary Shares	Dec. 31, 2013 ADS	Dec. 31, 2012 ADS	Dec. 31, 2011 ADS	Dec. 31, 2013 EBT Ordinary Shares	Dec. 31, 2013 EBT ADS	Dec. 31, 2013 Performance Share Awards GBP (£)
Performance Share Awards Outstanding [Roll Forward]
Outstanding as at beginning of period												3,518,138
Granted												1,508,631
Exercised												(1,826,648)
Forfeited												(498,822)
Outstanding as at end of period												2,701,299
Aggregate intrinsic value (in GBP)												£ 76.9
Weighted average remaining life	5 years 6 months
Weighted average grant date fair value (in GBP per share)												£ 19.71
Tax benefit associated with exercise of stock options (in US dollar)	11.9	40.1	29.4
Intrinsic values of share-based awards exercised (in US dollar)	298.3	224.1	189.3
Cash received from employees as a result of employee share option exercises (in US dollar)	$ 17.2	$ 16.2	$ 13.4
Treasury Stock
Treasury stock held (in shares)				4,200,000	4,500,000	2,700,000	800,000	900,000	800,000	2,400,000	400,000

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Fair Value Measurement (Tables)

12 Months Ended

Dec. 31, 2013

Fair Value Disclosures [Abstract]

Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis

		Carrying	Fair value
		value
			Total	Level 1	Level 2	Level 3
At December 31, 2013		$'M	$'M	$'M	$'M	$'M
		____________	____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		6.7	6.7	6.7	-	-
Contingent consideration receivable (2)		36.1	36.1	-	-	36.1
Foreign exchange contracts		4.0	4.0	-	4.0	-
Financial liabilities:
Foreign exchange contracts		2.8	2.8	-	2.8	-
Contingent consideration payable(3)		405.9	405.9	-	-	405.9
		____________	____________	___________	___________	___________
			Total	Level 1	Level 2	Level 3
At December 31, 2012		$'M	$'M	$'M	$'M	$'M
		____________	____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		14.2	14.2	14.2	-	-
Contingent consideration receivable (2)		38.3	38.3	-	-	38.3
Foreign exchange contracts		1.3	1.3	-	1.3	-
Financial liabilities:
Foreign exchange contracts		3.0	3.0	-	3.0	-
Contingent consideration payable(3)	1	136.4	136.4	-	-	136.4
		____________	____________	___________	___________	___________

(1)Available-for-sale securities are included within Investments in the consolidated balance sheet.

(2)Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3)Contingent consideration payableis included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Assets Measured at Fair Value on a Recurring Basis Using Significant Unobervable Inputs (Level 3)

Contingent consideration receivable
	2013	2012
	$'M	$'M
	____________	____________
Balance at January 1,	38.3	37.8
Gain recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period	15.9	18.1
Reclassification of amounts to Other receivables within Other current assets	(19.5)	(18.7)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	1.4	1.1
Balance at December 31,	36.1	38.3

Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobervable Inputs (Level 3)

Contingent consideration payable
	2013	2012
	$'M	$'M
	____________	____________
Balance at January 1,	136.4	-
Initial recognition of contingent consideration payable	451.4	127.8
Change in fair value during the period with the corresponding adjustment recognized as a gain in the income statement (within Integration and acquisition costs)	(159.1)	9.2
Reclassification of amounts to Other current liabilities	(13.9)	(8.8)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(8.9)	8.2
Balance at December 31,	405.9	136.4

Fair Value Inputs, Assets Quantitative Information Table

Financial assets:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration receivable ("CCR")	36.1	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast royalties receivable at relevant contractual royalty rates • Assumed market participant discount rate	• 10 to 45% • $40 million to $148 million • 6.2%
	____________	____________	____________	____________

	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Rate used
	$'M
	____________	___________	___________	___________
Movetis-related IPR&D intangible assets	20.3	Income approach (discounted cash flow)	• Decline in forecast peak sales since last impairment test • Assumed market participant discount rate	• 50% • 8.9%
DERMAGRAFT assets held-for-sale	31.6	Income approach (discounted cash flow)	• Future forecast milestones to be received • Assumed market participant discount rate	• $15 -$95 million • 11.5%
	____________	____________	____________	____________

Fair Value Inputs, Liabilities Quantitative Information Table

Financial liabilities:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration payable	405.9	Income approach (probability weighted discounted cash flow)	• Cumulative probability of milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 18 to 57% (Weighted average) • 2.9 to 15% (Weighted average) • 2014 to 2025 • $2.4 to $7.6 million
	____________	____________	____________	____________

Schedule of Fair Value, Assets and Liabilities Not Measured at Fair Value on Recurring Basis

	December 31, 2013		December 31, 2012
	Carrying		Carrying
	amount	Fair value	amount	Fair value
	$’M	$’M	$’M	$’M
	____________	____________	____________	___________
Financial liabilities:
Convertible bonds (Level 1)	-	-	1,100.0	1,228.2
Building financing obligation (Level 3)	7.8	10.1	8.0	10.3
	____________	____________	____________	___________

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Reorganization costs (Table)

12 Months Ended

Dec. 31, 2013

Restructuring and Related Activities [Abstract]

ScheduleOfRestructuringAndRelatedCostsTextBlock

	Opening liability	Amount		Closing liability at
	at January 1,	charged to re-		December 31,
	2013	organization	Paid/Utilized	2013
	$'M	$'M	$'M	$'M
	___________	____________	___________	___________
Involuntary termination benefits	-	44.7	(29.4)	15.3
Other reorganization costs	-	43.5	(34.0)	9.5
	___________	____________	___________	___________
	-	88.2	(63.4)	24.8
	___________	___________	___________	___________

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Consolidated Statements of Changes in Equity (Parenthetical) (USD $) In Millions, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Dividends paid (in USD)	$ 96.4	[1]	$ 86.3	[2]	$ 73.8	[3]
Ordinary Shares
Dividends per share declared	$ 0.176		$ 0.1532		$ 0.1333
Dividends per share paid	$ 0.176		$ 0.1532		$ 0.1333
ADS
Dividends per share declared	$ 0.528		$ 0.4596		$ 0.3999
Dividends per share paid	$ 0.528		$ 0.4596		$ 0.3999

[1] Dividends per share During the year to December 31, 2013 Shire plc declared and paid dividends of 17.60 US cents per ordinary share (equivalent to 52.80 US cents per ADS) totalling $96.4 million

[2] Dividends per share During the year to December 31, 2012 Shire plc declared and paid dividends of 15.32 US cents per ordinary share (equivalent to 45.96 US cents per ADS) totaling $86.3 million

[3] Dividends per share During the year to December 31, 2011 Shire plc declared and paid dividends of 13.33 US cents per ordinary share (equivalent to 39.99 US cents per ADS) totaling $73.8 million.

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Earnings Per Share (Tables)

12 Months Ended

Dec. 31, 2013

Earnings Per Share [Abstract]

Schedule of Calculation of Numerator and Denominator in Earnings Per Share

	2013	2012	2011
	$’M	$’M	$’M
	_________________	_________________	_________________
Income from continuing operations, net of taxes	1,419.6	805.7	882.7
Loss from discontinued operations1	(754.5)	(60.3)	(17.7)
	_________________	_________________	_________________
Numerator for basic earnings per share	665.1	745.4	865.0
Interest on convertible bonds, net of tax	28.3	31.3	33.6
	_________________	_________________	_________________
Numerator for diluted earnings per share	693.4	776.7	898.6
	_________________	_________________	_________________

Schedule of Weighted Average Number of Shares

Weighted average number of shares:
	Millions	Millions	Millions
	_________________	_________________	_________________
Basic 1	552.0	555.4	551.1
Effect of dilutive shares:
Share based awards to employees 2	4.8	4.6	10.9
Convertible bonds 2.75% due 2014 3	33.5	33.5	33.4
	_________________	_________________	_________________
Diluted	590.3	593.5	595.4
	_________________	_________________	_________________

1. Excludes shares purchased by the EBT and under the share buy-back program and presented by Shire as treasury stock.

2. Calculated using the treasury stock method.

3. At December 31, 2013,Bondholders had voluntarily converted $1,099,050,000 aggregate principal amount of the Bonds into 33,806,464 fully paid Ordinary Shares. The remaining outstanding Bonds in an aggregate principle amount of $950,000 were redeemed pursuant to the option redemption noticeissued on November 26, 2013. The Company has calculated the impact of the Bonds on diluted EPS from the beginning of the period to the actual date of Bonds conversion using the 'if-converted' method.

Schedule of Earnings Per Share, Basic and Diluted

Year to December 31,	2013	2012	2011
	_______________	_______________	_______________
Earnings per ordinary share - basic
Earnings from continuing operations	257.2c	145.1c	160.1c
Loss from discontinued operations	(136.7c)	(10.9c)	(3.2c)
	_______________	_______________	_______________
Earnings per ordinary share - basic	120.5c	134.2c	156.9c
	_______________	_______________	_______________
Earnings per ordinary share - diluted
Earnings from continuing operations	245.3c	141.0c	153.9c
Loss from discontinued operations	(127.8c)	(10.1c)	(3.0c)
	_______________	_______________	_______________
Earnings per ordinary share – diluted	117.5c	130.9c	150.9c
	_______________	_______________	_______________

Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share

	2013	2012	2011
	No. of shares	No. of shares	No. of shares
	Millions	Millions	Millions
	_________________	_________________	_________________
Share based awards to employees1	0.5	6.7	2.9
	_________________	_________________	_________________

• Certain stock options have been excluded from the calculation of diluted EPS because (a) their exercise prices exceeded Shire plc's average share price during the calculation period or (b) the required performance conditions were not satisfied as at the balance sheet date.

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Notes to the Shire Income Access Share Trust Financial Statements

12 Months Ended

Dec. 31, 2013

Income Access Share Trust Disclosure [Abstract]

Shire Income Access Share Trust Disclosure

(a)       The Trust

The Shire Income Access Share Trust (the “Trust”) was established on August 29, 2008 by Shire Biopharmaceuticals Holdings (formerly Shire plc). The Trust is governed by the applicable laws of England and Wales and is resident in Jersey. The Trustee of the Trust is Equiniti Trust (Jersey) Limited, 26 New Street, St Helier, Jersey, JE4 3RA.

The Trust was established as part of the Income Access Share mechanism, as outlined in Note 22 in this Annual Report on Form 10-K of Shire plc and its subsidiaries (collectively referred to as either “Shire” or the “Company”).

(b)       Basis of preparation

The financial statements of the Trust have been prepared in accordance with accounting principles generally accepted in the United States of America(“US GAAP”). The financial statements have been prepared under the historical cost convention.

The preparation of financial statements in conformity with US GAAP requires the use of certain accounting estimates. It also requires management to exercise its judgment in the process of applying the Trust's accounting policies. Actual results may differ from these estimates.

The results of operations, and the financial position and cash flows of the Trust are also consolidated in the Company's financial statements, as contained on pages F-1 to F-67.

(c)       Summary of significant accounting policies

i)       Functional currency

The functional currency of the Trust is US dollars.

ii)       Foreign currency translation

Income and expense items denominated in currencies other than the functional currency are translated into the functional currency at the rate ruling on their transaction date. Monetary assets and liabilities recorded in currencies other than the functional currency have been expressed in the functional currency at the rates of exchange ruling at the respective balance sheet dates. Differences on translation are included in the consolidated statements of income.

iii)       Dividend income

Interim dividends declared on the Income Access Share are recognized on a paid basis unless the dividend has been confirmed by a general meeting of Shire, in which case income is recognized on the record date of the dividend by Shire on its ordinary shares.

(d)       Capital account

The Capital account is represented by the Income Access Share of 5 pence settled in the Trust by Old Shire.

(e)       Distributions made

Distributions are made to those shareholders of Shire who have elected to receive dividends from the Trust in accordance with the Trust Deed. Unclaimed dividends are not included in distributions made. There were no unclaimed dividends at December 31, 2013. Amounts are recorded as distributed once a wire transfer or check is issued. All checks are valid for one year from the date of issue. Any wire transfers that are not completed are replaced by checks. To the extent that checks expire or are returned unrepresented, the Trust records a liability for unclaimed dividends and a corresponding amount of cash.

(f)       Financial instruments

The Trust, in its normal course of business, is not subject to market risk, credit risk or liquidity risk. The Trustees do not consider that any foreign exchange exposure will materially affect the operations of the Trust.

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Convertible Bonds

12 Months Ended

Dec. 31, 2013

Convertible Debt [Abstract]

Convertible Bonds Disclosure

15.Convertible bonds

Shire 2.75% Convertible Bonds due 2014

On May 9, 2007 Shire issued $1,100million in principal amount of 2.75% convertible bonds due in 2014 and convertible into fully paid ordinary shares of Shire plc (the “Bonds”).As of December 31, 2013 all of the Bonds had been converted or redeemed as described below.

On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed to the holders of the Bonds. The aggregate outstanding principal amount of the Bonds on November 25, 2013, the last practicable date prior to the date of the optional redemption notice, was $1,075,070,000. The last day on which holders were able to exercise their conversion rights was December 13, 2013. Those Bonds which were not voluntarily converted by holders were redeemed by the Company on December 27, 2013 at par together with interest accrued to that date. As at December 31, 2013, Bonds in an aggregate principal amount of the $1,099,050,000had been voluntarily converted into 33,806,464 fully paid ordinary shares at a conversion price of US$32.51 per ordinary share, in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principal amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. Following the redemption of all the outstanding Bonds, the Company cancelled the listing of the Bonds on the Official List maintained by the UK Listing Authority and the admission to trading of the Bonds on the Professional Securities Market of the London Stock Exchange.

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Other Current Liabilities

12 Months Ended

Dec. 31, 2013

Other Liabilities, Current [Abstract]

Other Current Liabilities

14.       Other current liabilities

	December 31,	December 31,
	2013	2012
	$’M	$’M
	_____________	_____________
Income taxes payable	69.0	78.4
Value added taxes	15.8	23.6
Contingent consideration payable	12.9	16.0
Other current liabilities	21.8	26.1
	_____________	_____________
	119.5	144.1
	_____________	_____________

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Segmental Reporting (Revenues and Accounts Receivable by Major Customers) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenue, Major Customer [Line Items]
Product sales	$ 4,757.5	$ 4,252.9	$ 3,844.9
Cardinal Health Inc.
Revenue, Major Customer [Line Items]
Product sales	853.7	1,035.7	923.9
Accounts receivable by major customer	149.5	166.1
Revenue by major customer, percent	18.00%	24.00%	24.00%
McKesson Corp.
Revenue, Major Customer [Line Items]
Product sales	902.9	835.9	742.9
Accounts receivable by major customer	161.3	127.4
Revenue by major customer, percent	19.00%	20.00%	19.00%
AmerisourceBergen Corp
Revenue, Major Customer [Line Items]
Product sales	721.0	307.4	276.4
Accounts receivable by major customer	$ 164.6	$ 47.4
Revenue by major customer, percent	15.00%	7.00%	7.00%

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Other Current Liabilities (Tables)

12 Months Ended

Dec. 31, 2013

Other Liabilities, Current [Abstract]

Schedule of Other Current Liabilities

	December 31,	December 31,
	2013	2012
	$’M	$’M
	_____________	_____________
Income taxes payable	69.0	78.4
Value added taxes	15.8	23.6
Contingent consideration payable	12.9	16.0
Other current liabilities	21.8	26.1
	_____________	_____________
	119.5	144.1
	_____________	_____________

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Schedule II - Valuation and Qualifying Accounts

12 Months Ended

Dec. 31, 2013

Valuation and Qualifying Accounts [Abstract]

Provision for sales rebates, returns and coupons

	Beginning balance	Provision charged to income(1)	Costs incurred/ utilization(1)	Ending balance
Provision for sales rebates, returns and coupons	$’M	$’M	$’M	$’M
	__________	__________	__________	__________
2013 :
Accrued rebates – Medicaid and HMOs	640.5	1,626.6	(1,460.6)	806.5
Sales returns reserve	90.5	34.5	(27.1)	97.9
Accrued coupons	8.0	107.4	(94.7)	20.7
	__________	__________	__________	__________
	739.0	1,768.5	(1,582.4)	925.1
	__________	__________	__________	__________
2012 :
Accrued rebates – Medicaid and HMOs	612.6	1,228.0	(1,200.1)	640.5
Sales returns reserve	88.8	40.8	(39.1)	90.5
Accrued coupons	8.1	71.7	(71.8)	8.0
	__________	__________	__________	__________
	709.5	1,340.5	(1,311.0)	739.0
	__________	__________	__________	__________
2011 :
Accrued rebates – Medicaid and HMOs	549.9	1,123.2	(1,060.5)	612.6
Sales returns reserve	69.8	51.2	(32.2)	88.8
Accrued coupons	5.2	60.5	(57.6)	8.1
	__________	__________	__________	__________
	624.9	1,234.9	(1,150.3)	709.5
	__________	__________	__________	__________

(1)In the analysis above, due to systems limitations, it is not practical and has not been necessary to break out current versus prior year activity. When applicable, Shire has performed general ledger reviews of sales deduction provisions charged to income, and the utilization of these provisions in subsequent years. Shire has determined that adjustments made in each year as a result of changes to estimates that related to prior year sales, and adjustments made as a result of differences between prior period provisions and actual payments, did not have a material impact on the Company's financial performance or position either in each individual year, or in the Company's performance over the reported period.

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Other Long-Term Debt

12 Months Ended

Dec. 31, 2013

LongTermDebtAbstract

Term Loan Agreeement

16.       Other longterm debt

Term Loan Agreement

On November 11, 2013, Shire entered into a $2.60 billion Facilities Agreement with, among others, Morgan Stanley Bank International Limited (acting as lead arranger and agent) (the “Facilities Agreement”).  The Facilities Agreement comprises two credit facilities: (i) a $1.75 billion term loan facility and (ii) a $0.85 billion term loan facility.  

On December 13, 2013 and on February 21, 2014, the Company cancelled part of the $2.60 billion term loan facility. The revised Facilities Agreement of $1.40 billion now comprises two credit facilities: (i) a $0.55 billion term loan facility and (ii) a $0.85 billion term loan facility. All other terms and conditions remain unchanged.

The $0.55 billion term loan facility, which matures on November 10, 2014, may be used only to finance the purchase price payable in respect of Shire's proposed acquisition of ViroPharma (including certain related costs) and for the redemption of Shire's Bonds.  Shire has the option to extend the maturity of the $0.55 billion term loan facility once by a further 364 days.

The $0.85 billion term loan facility, which matures on November 11, 2015, may be used only to finance the purchase price payable in respect of Shire's proposed acquisition of ViroPharma (including certain related costs).

Interest on any loans made under the facilities will be payable on the last day of each interest period, which may be one week or one, two, three or six months at the election of Shire, or as otherwise agreed with the lenders.  The interest rate applicable to the $0.55 billion term loan facility is LIBOR plus 0.75% per annum and increases by 0.25% per annum on August 11, 2014 and on three-month intervals thereafter.

The interest rate applicable to the $0.85 billion term loan facility commenced at LIBOR plus 1.15% per annum until delivery of the compliance certificate for the year ending December 31, 2013 and thereafter is subject to change depending upon the prevailing ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement), in respect of the most recently completed financial year or financial half year.

Shire shall also pay a commitment fee on the available but unutilized commitments under the $0.55 billion term loan facility and the $0.85 billion term loan facility for the availability period applicable to each facility. With effect from first utilization, the commitment fee rate will be 35% of the applicable margin. Before first utilization, the commitment fee rate will increase in stages from 0% to 35% of the applicable margin over a period of 3 months.

The Facilities Agreement includes customary representations and warranties, covenants and events of default, including requirements that the ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement) must not, at any time, exceed 3.5:1 for the Relevant Period (as defined in the Facilities Agreement), except that following certain acquisitions, including the ViroPharma acquisition, Shire may elect to increase the ratio to 4.0:1 in the relevant period in which the acquisition was completed and the immediately following relevant period.  In addition, for each 12-month period ending December 31 or June 30, the ratio of EBITDA of the Group to Net Interest (each as defined in the Facilities Agreement) must not be less than 4.0:1.

The Facilities Agreement restricts (subject to certain covenants) Shire's ability to incur additional financial indebtedness, grant security over its assets or provide or guarantee loans.  Further, any lender may require mandatory prepayment of its participation if there is a change of control of Shire. In addition, in certain circumstances, the net proceeds of certain shares, undertakings or business disposals by Shire must be applied towards the mandatory prepayment of the facilities, subject to certain exceptions.

Events of default under the facilities include: (i) non-payment of any amounts due under the facilities, (ii) failure to satisfy any financial covenants, (iii) material misrepresentation in any of the finance documents, (iv) failure to pay, or certain other defaults, under other financial indebtedness, (v) certain insolvency events or proceedings, (vi) material adverse changes in the business, operations, assets or financial condition of Shire and its subsidiaries, (vii) if it becomes unlawful for Shire or any of its subsidiaries that are parties to the Facilities Agreement to perform their obligations or (viii) if Shire or any subsidiary of Shire which is a party to the Facilities Agreement repudiates the Facilities Agreement or any other finance document, among others.The Facilities Agreement is governed by English law.

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Other Non-current Liabilities

12 Months Ended

Dec. 31, 2013

Other Liabilities, Noncurrent [Abstract]

Other Noncurrent Liabilities Disclosure

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Income taxes payable	115.7	58.9
Deferred revenue	9.8	11.4
Deferred rent	11.3	11.9
Insurance provisions	1.0	12.3
Contingent consideration payable	393.0	120.4
Other non-current liabilities	57.7	26.7
	____________	____________
	588.5	241.6
	____________	____________

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Consolidated Statements of Changes in Equity (USD $) In Millions, except Share data		Total	EBT	Share Buy-back Program	Common stock	Additional paid-in capital	Treasury stock	Treasury stock EBT	Treasury stock Share Buy-back Program	Accumulated other comprehensive income	Retained earnings/(accumulated deficit)	Retained earnings/(accumulated deficit) EBT
As at Dec. 31, 2010		$ 2,451.4			$ 55.7	$ 2,746.4	$ (276.1)			$ 85.7	$ (160.3)
Shares as at Dec. 31, 2010					562,200,000
Net income		865.0									865.0
Other comprehensive income, net of tax		(25.4)								(25.4)
Options exercised		0.7				0.7
Option exercised (in shares)					300,000
Share-based compensation		76.8				76.8
Tax benefit associated with exercise of stock options (in US dollar)		29.4				29.4
Shares repurchased			(151.8)					(151.8)
Shares released by EBT to satisfy exercise of stock options		12.7						140.7				(128.0)
Dividends	[1]	(73.8)									(73.8)
As at Dec. 31, 2011		3,185.0			55.7	2,853.3	(287.2)			60.3	502.9
Shares as at Dec. 31, 2011					562,500,000
Net income		745.4									745.4
Other comprehensive income, net of tax		26.6								26.6
Options exercised		0.1				0.1
Share-based compensation		88.0				88.0
Tax benefit associated with exercise of stock options (in US dollar)		40.1				40.1
Shares repurchased			(99.3)	(106.5)				(99.3)	(106.5)
Shares released by EBT to satisfy exercise of stock options		16.1						182.6			(166.5)
Dividends	[2]	(86.3)									(86.3)
As at Dec. 31, 2012		3,809.2			55.7	2,981.5	(310.4)			86.9	995.5
Shares as at Dec. 31, 2012		562,500,000			562,500,000
Net income		665.1									665.1
Other comprehensive income, net of tax		23.3								23.3
Options exercised		16.2			0.1	16.1
Option exercised (in shares)					1,200,000
Convertible Bonds, conversion to Ordinary shares		1,101.5			2.8	1,098.7
Convertible Bonds, conversion to Ordinary shares (in shares)					33,800,000
Share-based compensation		78.1				78.1
Tax benefit associated with exercise of stock options (in US dollar)		11.9				11.9
Shares repurchased			(50.0)	(193.8)				(50.0)	(193.8)
Shares released by EBT to satisfy exercise of stock options		0.9					103.6				(102.7)
Dividends	[3]	(96.4)									(96.4)
As at Dec. 31, 2013		$ 5,366.0			$ 58.6	$ 4,186.3	$ (450.6)			$ 110.2	$ 1,461.5
Shares as at Dec. 31, 2013		597,500,000			597,500,000

[1] Dividends per share During the year to December 31, 2011 Shire plc declared and paid dividends of 13.33 US cents per ordinary share (equivalent to 39.99 US cents per ADS) totaling $73.8 million.

[2] Dividends per share During the year to December 31, 2012 Shire plc declared and paid dividends of 15.32 US cents per ordinary share (equivalent to 45.96 US cents per ADS) totaling $86.3 million

[3] Dividends per share During the year to December 31, 2013 Shire plc declared and paid dividends of 17.60 US cents per ordinary share (equivalent to 52.80 US cents per ADS) totalling $96.4 million

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Commitments and Contingencies

12 Months Ended

Dec. 31, 2013

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies Disclosure

18.       Commitments and contingencies

(a)       Leases

Future minimum lease payments under operating leases at December 31, 2013 are presented below:

	Operating
	leases
	$’M
	_____________
2014	44.9
2015	33.6
2016	23.9
2017	17.9
2018	12.2
Thereafter	83.4
	_____________
	215.9
	_____________

The Company leases land, facilities, motor vehicles and certain equipment under operating leases expiring through 2032. Lease and rental expense amounted to $44.0million,$43.2millionand $37.6 million for the year toDecember 31, 2013,2012and 2011respectively, which is predominately included in SG&Aexpenses in the Company's consolidated income statement.

(b)       Letters of credit and guarantees

At December 31, 2013 the Company had irrevocable standby letters of credit and guarantees with various banks and insurance companiestotaling $51.0million, providing security for the Company's performance of various obligations. These obligations are primarily in respect of the recoverability of insurance claims, lease obligations and supply commitments.

(c)       Collaborative arrangements

Details of significant updates in collaborative arrangements are included below:

In-licensing arrangements

(i)       Research Collaboration with SantarisPharma A/S (“Santaris”) on Locked Nucleic Acid (“LNA”) Drug Platform

On August 24, 2009 Shire announced that it had entered into a research collaboration with Santaris, to develop its proprietary LNA technology in a range of rare diseases. LNA technology has the benefit of shortened target validation and proof of concept, potentially increasing the speed and lowering the cost of development. As part of the joint research project Santaris will design, develop and deliver pre-clinical LNA oligonucleotides for Shire-selected orphan disease targets, and Shire will have the exclusive right to further develop and commercialize these candidate compounds on a worldwide basis.

In the year to December 31, 2013 Shire paid success milestones and other support costs of $1.5 million (2012: $3.0 million; 2011: $2.5 million) and $4.5 million (2012: $8.1 million; 2011: $5.3 million) to Santaris respectively, which were expensed to R&D. Shire has remaining obligations to pay Santaris development and sales milestones up to a maximum of $71.0 million for each current indication. Shire will also pay single or double digit tiered royalties on net sales of the product.

Shire and Santaris have formed a joint research committee to monitor R&D activities through preclinical lead candidate selection at which point all development and commercialization costs will be the responsibility of Shire.

(ii)Collaboration and license agreement with Sangamo to develop therapeutics for hemophilia

On February 1, 2012 Shire and Sangamo announced that they had entered into a collaboration and license agreement to develop therapeutics for hemophilia and other monogenic diseases based on Sangamo'sZFP technology. Sangamo is responsible for all activities through submission of Investigational New Drug Applications and European Clinical Trial Applications for each product and Shire will reimburse Sangamo for its internal and external research program-related costs. Shire is responsible for clinical development and commercialization of products arising from the collaboration. 

In the year to December 31, 2012 Shire made an upfront payment to Sangamo of $13.0 million, for technology access and R&D funding, which was expensed to R&D.

In the year to December 31, 2013 Shire's share of R&D costs under this collaboration agreement was $15.2 million (2012: $8.9 million; 2011: $nil) which were expensed to R&D. Shire may be required to pay research, regulatory, development and commercial milestone payments up to a maximum of $213.5 million and to pay royalties on net sales of the product.

Out-licensing arrangements

Shire has entered into various collaborative arrangements under which the Company has out-licensed certain product or intellectual property rights for consideration such as up-front payments, development milestones, sales milestones and/or royalty payments. In some of these arrangements Shire and the licensee are both actively involved in the development and commercialization of the licensed product and have exposure to risks and rewards dependent on its commercial success. Under the terms of these arrangements, the Company may receive development milestone payments up to an aggregate amount of $39.0 million and sales milestones up to an aggregate amount of $71.5 million. The receipt of these substantive milestones is uncertain and contingent on the achievement of certain development milestones or the achievement of a specified level of annual net sales by the licensee. In the year to December 31, 2013 Shire received up-front and milestone payments totaling$3.0 million (2012: $18.3 million,2011: $11.5 million). In the year toDecember 31, 2013 Shire recognized milestone income of $5.0million (2012: $19.4 million,2011: $17.5 million) in other revenues and $58.3million (2012: $83.8 million, 2011: $65.2 million) in product sales for shipment of product to the relevant licensee.

(d)       Commitments

(i)       Clinical testing

At December 31, 2013 the Company had committed to pay approximately $ 346 million (December 31, 2012: $ 425 million) to contract vendors for administering and executing clinical trials. The timing of these payments is dependent upon actual services performed by the organizations as determined by patient enrollment levels and related activities.

(ii)       Contract manufacturing

At December 31, 2013 the Company had committed to pay approximately $ 109 million (December 31, 2012: $ 125 million) in respect of contract manufacturing. The Company expects to pay $ 109 million of these commitments in 2014.

(iii)       Other purchasing commitments

At December 31, 2013 the Company had committed to pay approximately $ 128 million (December 31, 2012: $ 145 million) for future purchases of goods and services, predominantly relating to active pharmaceutical ingredients sourcing. The Company expects to pay $ 121 million of these commitments in 2014.

(iv)       Investment commitments

At December 31, 2013 the Company had outstanding commitments to subscribe for interests in companies and partnerships for amounts totaling $ 14 million (December 31, 2012: $ 15 million) which may all be payable in 2014, depending on the timing of capital calls.The investment commitments include additional funding to Nimbus Neptune, Inc., a variable interest entity of which Shire is not the primary beneficiary. Under the terms of the agreement Nimbus Neptune, Inc. controls and conducts all related research up to achievement of drug candidate status at which point Shire will have an exclusive option to acquire the program.  Shire will then be responsible for all clinical development and future commercialization activities. Nimbus Neptune Inc. will be eligible to receive further consideration contingent upon achievement of certain development and commercial milestones.

(v)       Capital commitments

At December 31, 2013 the Company had committed to spend $ 12 million (December 31, 2012: $ 97 million) on capital projects.

(e)Legaland other proceedings

The Company expenses legal costs as they are incurred.

The Company recognizes loss contingency provisions for probable losses when management is able to reasonably estimate the loss. When the estimated loss lies within a range, the Company records a loss contingency provision based on its best estimate of the probable loss. If no particular amount within that range is a better estimate than any other amount, the minimum amount is recorded.  Estimates of losses may be developed substantially before the ultimate loss is known, and are therefore refined each accounting period as additional information becomes known. In instances where the Company is unable to develop a reasonable estimate of loss, no loss contingency provision is recorded at that time. As information becomes known a loss contingency provision is recorded when a reasonable estimate can be made. The estimates are reviewed quarterly and the estimates are changed when expectations are revised. An outcome that deviates from the Company's estimate may result in an additional expense or release in a future accounting period. At December 31, 2013 provisions for litigation losses, insurance claims and other disputes totaled $72.7million (December 31, 2012: $130.5million).

The Company's principal pending legal and other proceedings are disclosed below. The outcomes of these proceedings are not always predictable and can be affected by various factors. For those legal and other proceedings for which it is considered at least reasonably possible that a loss has been incurred, the Company discloses the possible loss or range of possible loss in excess of the recorded loss contingency provision, if any, where such excess is both material and estimable.

VYVANSE

In May and June 2011, Shire was notified that six separate Abbreviated New Drug Applications ("ANDAs") were submitted under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of VYVANSE. The notices were from Sandoz, Inc. ("Sandoz"); Amneal Pharmaceuticals LLC ("Amneal"); Watson Laboratories, Inc.; Roxane Laboratories, Inc. ("Roxane"); Mylan Pharmaceuticals, Inc.; and Actavis Elizabeth LLC and Actavis Inc. (collectively, "Actavis"). Within the requisite 45 day period, Shire filed lawsuits for infringement of certain of Shire's VYVANSE patents in the US District Court for the District of New Jersey against each of Sandoz, Roxane, Amneal and Actavis; in the US District Court for the Central District of California against Watson Laboratories, Inc.;and in the US District Court for the Eastern District of New York against Mylan Pharmaceuticals, Inc. and Mylan Inc. (collectively "Mylan"). In February 2013, Shire withdrew its lawsuit against Watson following Watson's withdrawal of its ANDA.On December 9, 2011, the District Court of New Jersey consolidated the Sandoz, Roxane, Amneal and Actavis cases. The filing of the lawsuits triggered a stay of approval of all six ANDAs for up to 30 months from the expiration of the new chemical entity exclusivity, which will expire on August 23, 2014. In December 2011 and February 2012, Shire received additional notifications that Mylan had filed further certifications challenging other VYVANSE patents listed in the Orange Book. Within the requisite 45 day period, Shire filed a new lawsuit against Mylan, Johnson Matthey Pharmaceutical Materials and Johnson Matthey Inc. in New Jersey. In May 2012, the Mylan case that was filed in the Eastern District of New York was transferred and consolidated with the Mylan, Sandoz, Roxane, Amneal and Actavis cases in New Jersey. In December 2012, the parties completed a Markman briefing. A Markman hearing took place on August 5, 2013 and a ruling was rendered on August 8, 2013. No trial dates have been set.

INTUNIV

Between March 2010 and March 2011, Shire was notified that seven separate ANDAs had been submitted to the FDA under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of INTUNIV. The ANDA filers were Actavis Inc., Teva Pharmaceuticals USA, Inc., Anchen, Inc., Watson Pharmaceuticals, Inc., Impax Laboratories, Inc., Mylan Pharmaceuticals, Inc., Sandoz, Inc., and certain of their respective affiliates.  Shire filed lawsuits against each of these ANDA filers.  All of the lawsuits have now been settled.  Under the terms of the Actavissettlement, Actavis has a license to make and market Actavis' generic versions of INTUNIV in the United States on December 1, 2014.  Such sales will require the payment of a royalty of 25% of gross profits to Shire during the 180 day period of Actavis' exclusivity. All other parties with whom Shire has settled will be able to enter the market with their respective ANDA-approved products after Actavis' 180 day exclusivity period has expired.  Each of the settlements included a consent judgment confirming that the proposed ANDA products infringe the patents-in-suit, U.S. Patents 6,287,599 and 6,811,794, and that those patents are valid and enforceable with respect to their respective proposed ANDA products.   U.S. Patent 5,854,290, which was originally asserted in some of the litigations, has been dedicated to the public.

FOSRENOL

Between February 2009 and December 2010 Shire was notified that four separate ANDAs had been submitted to the FDA under the Hatch-Waxman Act seeking permission to market generic versions of all approved strengths of FOSRENOL. The ANDA filers were Barr Laboratories, Inc.; Mylan, Inc.; NatcoPharma Limited and Alkem Laboratories Ltd., and certain of their respective affiliates. Shire filed lawsuits against each of these ANDA filers.  In April 2011, Shire and Barr reached a settlement and the lawsuit against Barr was dismissed.  The settlement provides Barr with a license to market its own generic version of FOSRENOL upon receiving FDA approval in the US on the earlier of the date of entry ofanother company's generic version of FOSRENOL to the US market, or October 1, 2021.  Shire's lawsuits against Mylan, Alkem and Natco have each been dismissed, and consequently, each of Mylan, Alkem and Natco may enter the US market upon FDA approval of their respective ANDA products.

LIALDA

In May 2010 Shire was notified that Zydus Pharmaceuticals USA, Inc. (“Zydus”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the District of Delaware against Zydus and Cadila Healthcare Limited, doing business as ZydusCadila. As of February 22, 2013, the case has been administratively closed. No further activity will take place until after one of the parties files a motion to reopen the case.

In February 2012, Shire was notified that Osmotica Pharmaceutical Corporation ("Osmotica") had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA.  Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Northern District of Georgia against Osmotica. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. The court has appointed a special master to assist with a Markman hearing and to preside over any discovery disputes. A Markman hearing took place on August 22, 2013 but no ruling has been rendered. No trial date has been set.

In March 2012, Shire was notified that Watson Laboratories Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Southern District of Florida against Watson Laboratories Inc.-Florida and Watson Pharmaceuticals, Inc. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. In August 2012, Shire filed an amended complaint adding Watson Pharma, Inc. and Watson Laboratories, Inc. as defendants. A Markman hearing was held on December 20, 2012 and a written Markman decision was given by the court on January 17, 2013. A trial took place in April, 2013 andon May 9, 2013 the trial court issued a decision finding that the proposed generic product infringes the patent-in-suit and that the patent is not invalid.  Watson has appealed the trial court's ruling to the Court of Appeals of the Federal Circuit (“CAFC”) and a hearing took place on December 2, 2013. No ruling has been issued by the CAFC.

In April 2012, Shire was notified that Mylan Pharmaceuticals, Inc. (“Mylan”) had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of LIALDA. Within the requisite 45 day period, Shire filed a lawsuit in the US District Court for the Middle District of Florida against Mylan. The filing of the lawsuit triggered a stay of approval of the ANDA for up to 30 months. No date for a Markman hearing has been set. A trial is scheduled to occur in September, 2014.

ADDERALL XR

On November 1, 2010 Impax Laboratories, Inc. (“Impax”) filed suit against Shire in the US District Court for the Southern District of New York claiming that Shire was in breach of its supply contract for the authorized generic version of ADDERALL XR. On February 7, 2013 Shire and Impax settled this dispute and agreed to discontinue all court and related proceedings. Under the terms of the settlement Shire made a one-time cash payment to Impax of $48 million in the first quarter of 2013. Also as part of the settlement, the parties have entered into an amended supply agreement which will govern the supply of authorized generic ADDERALL XR from Shire to Impax until the end of the supply term on September 30, 2014.

In February 2011, Shire was notified that Watson Laboratories, Inc.-Florida had submitted an ANDA under the Hatch-Waxman Act seeking permission to market a generic version of all approved strengths of ADDERALL XR. Shire filed a lawsuit in the U.S. District Court for the Southern District of New York against Watson Pharmaceuticals, Inc. and certain of its affiliates for infringement of certain of Shire's ADDERALL XR patents. Par Pharmaceutical, Inc. (the successor in interest to Watson's ANDA for ADDERALL XR) has withdrawn its ANDA, and the litigation was dismissed on January 23, 2013 by agreement between Shire, Watson and Par Pharmaceutical, Inc..

In February 2013, Shire was notified that Neos Therapeutics, Inc. had submitted a New Drug Application under section 505(b)(2) of the Hatch Waxman Act (“505(b)(2) Application”). The 505(b)(2) Application was submitted with a paragraph IV certification for U.S. Reissued Patent Nos. RE41,148 and 42,096listed in the Orange Book.  Within the requisite 45 day period, Shire filed a lawsuit in the Northern District of Texas against Neos Therapeutics, Inc. for infringement of those patents. The filing of the lawsuit triggered a stay of final approval of the 505(b)(2) Application for 30 months.  No trial date has been set.

Subpoena related to ADDERALL XR, DAYTRANA and VYVANSE

On September 23, 2009 the Company received a civil subpoena from the US Department of Health and Human Services Office of Inspector General in coordination with the US Attorney for the Eastern District of Pennsylvania seeking production of documents related to the sales and marketing of ADDERALL XR, DAYTRANA and VYVANSE. The investigation covered whether Shire engaged in off-label promotion and other conduct that may implicate the civil False Claims Act.

On February 1, 2013 the Company announced it had reached an agreement in principle to resolve this matter.  The agreement also addresses sales and marketing practices relating to LIALDA and PENTASA pursuant to a subsequent voluntary disclosure made by the Company. Shire cooperated with the US Government throughout the process that led to this agreement in principle.

The Company has recorded a $57.5 million charge comprised of the agreement in principle amount, interest and costs, which has been charged to SG&A in the fourth quarter of 2012.  The agreement in principle is subject to change until this matter is finally resolved.  Discussions between the Company and the US Government are ongoing to establish a final resolution to the investigation.

Louisiana Complaint related to ADDERALL, ADDERALL XR, DAYTRANA, VYVANSE and INTUNIV

On July 22 and July 23, 2013, the State of Louisiana served Shire LLC and Shire US Inc., respectively, with a civil complaint filed in the 19th Judicial District Court for the Parish of East Baton Rouge. The complaint alleges that Shire's sales, marketing, and promotion of ADDERALL, ADDERALL XR, DAYTRANA, VYVANSE and INTUNIV violated state law. The State is seeking monetary relief for its claims of fraud, redhibition, and unjust enrichment, as well as violations of Louisiana's Medical Assistance Programs Integrity Law, Unfair Trade Practices Act, and anti-trust laws. Shire intends vigorously to defend these claims. Shire is not in a position at this time to predict the timing, result or outcome of these claims.

Investigation related to DERMAGRAFT

Shire understands that the Department of Justice, including the US Attorney's Office for the Middle District of Florida, Tampa Division and the US Attorney's Office for Washington, DC, is conducting civil and criminal investigations into the sales and marketing practices of Advanced BioHealing Inc. (“ABH”) relating to DERMAGRAFT. Shire is cooperating fully with these investigations. Shire is not in a position at this time to predict the scope, duration or outcome of these investigations.

Civil Investigative Demand for ADDERALL XR, ADDERALL XR Authorized Generics and VYVANSE

On April 5, 2012 Shire received a Civil Investigative Demand (“CID”) from the United States Federal Trade Commission (“FTC”) requesting that Shire provide it with certain information regarding the supply and reported shortages of ADDERALL XR and its authorized generics and the marketing and sale of ADDERALL XR, its authorized generics and VYVANSE. Shire believes the CID was triggered by reports of product shortages of ADDERALL XR and the authorized generic products in 2011. Shire responded to the CID in 2012. On August 29, 2013, the FTC informed Shire that it was closing the investigation without taking any further action.

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Convertible Bonds (Details) (USD $)	12 Months Ended
	Dec. 31, 2013
Debt Instrument [Line Items]
Debt issuance date	May 09, 2007
Conversion price (in USD per share)	$ 32.51
Stated interest rate	2.75%
Principal amount	$ 1,100,000,000
Principal amount extinguished	1,075,070,000
Convertible bond, convertible into number of ordinary shares	33,806,464
Redemption terms	On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed to the Holders of the Bonds. The aggregate outstanding principal amount of the Bonds on November 25, 2013, the last practicable date prior to the date of the optional redemption notice, was $1,075,070,000. The last day on which Holders were able to exercise their conversion rights was December 13, 2013. Those Bonds which were not voluntarily converted by Holders were redeemed by the Company on December 27, 2013 at par together with interest accrued to that date. As at December 31, 2013, Holders had voluntarily converted $1,099,050,000 aggregate principal amount of the Convertible Bonds into 33,806,464 fully paid Ordinary Shares at a conversion price of US$32.51 per Ordinary Share, in the capital of the Company, with par value of £0.05 each. The remaining outstanding Bonds in an aggregate principal amount of $950,000 were redeemed pursuant to the Optional Redemption Notice issued on November 26, 2013. Following the redemption of all the outstanding Bonds, the Company cancelled the listing of the Bonds on the Official List maintained by the UK Listing Authority and the admission to trading of the Bonds on the Professional Securities Market of the London Stock Exchange
Optional redemption notice	Nov. 26, 2013
Final redemption date	Dec. 27, 2013
Shire 2.75% Convertible Bond due 2014
Debt Instrument [Line Items]
Stated interest rate	2.75%
Principal amount	1,100,000,000
Cash redemption amount
Debt Instrument [Line Items]
Principal amount extinguished	950,000.00
Share redemption amount
Debt Instrument [Line Items]
Principal amount extinguished	$ 1,099,050,000

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Schedule II - Valuation and Qualifying Accounts (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Valuation and Qualifying Accounts Disclosure [Line Items]
Beginning balance	$ 739.0		$ 709.5		$ 624.9
Provision charged to income	1,768.5	[1]	1,340.5	[1]	1,234.9	[1]
Costs incurred/utilization	(1,582.4)	[1]	(1,311.0)	[1]	(1,150.3)	[1]
Ending balance	925.1		739.0		709.5
Accrued rebates - Medicaid and HMOs
Valuation and Qualifying Accounts Disclosure [Line Items]
Beginning balance	640.5		612.6		549.9
Provision charged to income	1,626.6	[1]	1,228.0	[1]	1,123.2	[1]
Costs incurred/utilization	(1,460.6)	[1]	(1,200.1)	[1]	(1,060.5)	[1]
Ending balance	806.5		640.5		612.6
Sales returns reserve
Valuation and Qualifying Accounts Disclosure [Line Items]
Beginning balance	90.5		88.8		69.8
Provision charged to income	34.5	[1]	40.8	[1]	51.2	[1]
Costs incurred/utilization	(27.1)	[1]	(39.1)	[1]	(32.2)	[1]
Ending balance	97.9		90.5		88.8
Accrued coupons
Valuation and Qualifying Accounts Disclosure [Line Items]
Beginning balance	8.0		8.1		5.2
Provision charged to income	107.4	[1]	71.7	[1]	60.5	[1]
Costs incurred/utilization	(94.7)	[1]	(71.8)	[1]	(57.6)	[1]
Ending balance	$ 20.7		$ 8.0		$ 8.1

[1] In the analysis above, due to systems limitations, it is not practical and has not been necessary to break out current versus prior year activity. When applicable, Shire has performed general ledger reviews of sales deduction provisions charged to income, and the utilization of these provisions in subsequent years. Shire has determined that adjustments made in each year as a result of changes to estimates that related to prior year sales, and adjustments made as a result of differences between prior period provisions and actual payments, did not have a material impact on the Company’s financial performance or position either in each individual year, or in the Company’s performance over the reported period.

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Taxation

12 Months Ended

Dec. 31, 2013

Income Tax Disclosure [Abstract]

Income Tax Disclosure

26.       Taxation

The components of pre tax income from continuing operations are as follows:

	2013	2012	2011
Year to December 31,	$’M	$’M	$’M
	___________	___________	___________
Republic of Ireland	(47.8)	(74.7)	(65.9)
UK	10.9	30.7	45.4
US	1,153.3	683.8	774.6
Other jurisdictions	577.2	368.0	363.0
	___________	___________	___________
	1,693.6	1,007.8	1,117.1
	___________	___________	___________

The provision for income taxes by location of the taxing jurisdiction for the years to December 31,2013, 2012 and 2011consisted of the following:

Year to December 31,
	2013	2012	2011
	$’M	$’M	$’M
	__________	__________	__________
Current income taxes:
Republic of Ireland	-	-	(1.8)
US federal tax	274.3	230.0	201.4
US state and local taxes	17.9	11.3	9.2
Other	63.4	29.0	40.0
	__________	__________	__________
Total current taxes	355.6	270.3	248.8
	__________	__________	__________
Deferred taxes:
US federal tax	23.8	(63.8)	23.3
US state and local taxes	(8.3)	(6.5)	(4.6)
UK corporation tax	11.5	13.1	(1.0)
Other	(104.7)	(10.0)	(29.6)
	__________	__________	__________
Total deferred taxes	(77.7)	(67.2)	(11.9)
	__________	__________	__________
Total income taxes	277.9	203.1	236.9
	__________	__________	__________

The operating results associated with the DERMAGRAFT business have been classified as discontinued operations for all periods presented.

The Group has determined the amount of income tax expense or benefit allocable to continuing operations using the incremental approach described in ASC 740-20-45-8 and the relevant examples. As a result $9 million of income tax expense associated with the US operations was allocated to income from continuing operations for 2013 based on the primacy of continuing operations, due to changes in circumstances that caused a change in judgment about the realization of deferred tax assets in future years, and in accordance with the rules prescribed under ASC 740-20-45.  

The amount of Income tax attributed to discontinued operations is disclosed in Note 8.

The reconciliation of income from continuing operations before income taxes, noncontrolling interests and equity in earnings/(losses) of equity method investees at the statutory tax rate to the provision for income taxes is shown in the table below:

Year to December 31,
		2013	2012	2011
		$’M	$’M	$’M
		___________	___________	___________
Income from continuing operations before income taxes and equity in earnings of equity method investees		1,693.6	1,007.8	1,117.1
		___________	___________	___________
Statutory tax rate(1)		25.0%	25.0%	25.0%
Adjustments to derive effective rate:
Non-deductable items:
	US R&D credit	(4.5%)	(2.6%)	(4.5%)
	Effect of the convertible bond	0.5%	0.8%	0.8%
	Intra-group items(2)	(9.2%)	(16.0%)	(7.5%)
	Recognition of foreign tax credits	-	(6.6%)	-
	Other permanent items	(0.7%)	0.8%	(0.5%)
Other items:
Change in valuation allowance		0.9%	3.4%	3.2%
Impact of RESOLOR impairment		-	4.9%	-
Difference in taxation rates		7.8%	7.6%	4.6%
Change in provisions for uncertain tax positions		3.8%	1.1%	(1.2%)
Prior year adjustment		(3.4%)	0.8%	0.8%
Change in fair value of contingent consideration		(3.6%)	-	-
Change in tax rates		(0.2%)	0.8%	0.2%
Other		0.0%	0.1%	0.3%
		___________	___________	___________
Provision for income taxes on continuing operations		16.4%	20.1%	21.2%
		___________	___________	___________

(1)In addition to being subject to the Irish Corporation tax rate of 25%, in 2013 the Company is also subject to income tax in other territories in which the Company operates, including: Canada (15%); France (33.3%); Germany (15%); Italy (27.5%); Luxembourg (21.0%); the Netherlands (25%); Belgium (33.99%); Spain (30%); Sweden (22%); Switzerland (8.5%); United Kingdom (23.25%) and the US (35%). The rates quoted represent the statutory federal income tax rates in each territory, and do not include any state taxes or equivalents or surtaxes or other taxes charged in individual territories, and do not purport to represent the effective tax rate for the Company in each territory.

(2)Intra-group items principally relate to the effect of inter-company dividends, capital receipts (either taxable or non-taxable) and other intra-territory eliminations, the pre-tax effect of which has been eliminated in arriving at the Company's consolidated income from continuing operations before income taxes, noncontrolling interests and equity in earnings/(losses) of equity method investees.

Provisions for uncertain tax positions

The Company files income tax returns in the Republic of Ireland, the UK, the US (both federal and state) and various other jurisdictions (see footnote (1) to the table above for major jurisdictions). With few exceptions, the Company is no longer subject to income tax examinations by tax authorities for years before 1999. Tax authorities in various jurisdictions are in the process of auditing the Company's tax returns for fiscal periods from 1999; these tax audits cover a range of issues, including transfer pricing, potential restrictions on the utilization of net operating losses, potential taxation of overseas dividends and controlled foreign companies' rules.

While tax audits remain open, the Company also considers it reasonably possible that issues may be raised by tax authorities resulting in increases to the balance of unrecognized tax benefits, however, an estimate of such increase cannot be made.

The Company is required in certain tax jurisdictions to make advance deposits to tax authorities on receipt of tax assessments. These payments have been offset against the income tax liability within the balance sheet but have not reduced the provision for unrecognized tax benefits.

A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows:

	2013	2012	2011
	$’M	$’M	$’M
	___________	___________	___________
Balance at January 1	278.7	265.5	290.8
Increases based on tax positions related to the current year	56.8	20.5	18.2
Decreases based on tax positions taken in the current year	(0.5)	-	(2.5)
Increases for tax positions taken in prior years	34.5	0.4	1.4
Decreases for tax positions taken in prior years	(0.8)	(3.3)	(12.0)
Decreases resulting from settlements with the taxing authorities	-	(10.6)	(25.7)
Decreases as a result of expiration of the statute of limitations	(0.6)	(0.3)	(0.5)
Foreign currency translation adjustments(1)	(12.9)	6.5	(4.2)
	___________	___________	___________
Balance at December 31(2)	355.2	278.7	265.5
	___________	___________	___________

(1)Recognized within Other Comprehensive Income

(2)The full amount of which would affect the effective rate if recognized

The Company considers it reasonably possible that certain audits currently being conducted will be concluded in the next twelve months, and as a result the total amount of unrecognized tax benefits recorded at December 31, 2013 could decrease by up to approximately $210 million. As at the balance sheet date, the Company believes that its reserves for uncertain tax positions are adequate to cover the resolution of these audits. However, the resolution of these audits could have a significant impact on the financial statements if the settlement differs from the amount reserved.

The Company recognizes interest and penalties accrued related to unrecognized tax benefits within income taxes. During the years ended December 31, 2013, 2012 and 2011, the Company recognized $0.4million, $5.1million and $4.0million in interest and penalties and the Company had a liability of $112.2million, $119.6million and $114.5 million for the payment of interest and penalties accrued at December 31, 2013,2012 and 2011, respectively.

Deferred taxes

The significant components of deferred tax assets and liabilities and their balance sheet classifications, as at December 31, are as follows:

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Deferred tax assets:
Deferred revenue	5.2	5.5
Inventory & warranty provisions	48.6	52.5
Losses carried forward (including tax credits)1	500.6	425.7
Provisions for sales deductions and doubtful accounts	151.8	144.9
Intangible assets	10.7	36.7
Share-based compensation	25.5	32.7
Excess of tax value over book value of assets	22.1	-
Accruals and provisions	55.1	44.1
Other	2.6	21.6
	____________	____________
Gross deferred tax assets	822.2	763.7
Less: valuation allowance	(282.4)	(268.6)
	____________	____________
	539.8	495.1
Deferred tax liabilities:
Intangible assets	(586.8)	(702.7)
Excess of book value over tax value of assets and investments	(56.9)	(36.8)
	____________	____________
Net deferred tax liabilities	(103.9)	(244.4)
	____________	____________
Balance sheet classifications:
Deferred tax assets - current	315.6	229.9
Deferred tax assets - non-current	141.1	46.5
Deferred tax liabilities - non-current	(560.6)	(520.8)
	____________	____________
	(103.9)	(244.4)
	____________	____________

• Excluding $15.0 million of deferred tax assets at December 31, 2013 (2012: $6.8 million), related to the net operating losses that result from excess stock based compensation and for which any benefit realized will be recorded to stockholders' equity.

At December 31, 2013, the Company had a valuation allowance of $282.4 million (2012: $268.6 million) to reduce its deferred tax assets to estimated realizable value. These valuation allowances related primarily to operating loss, capital loss and tax-credit carry-forwards in Ireland (2013: $78.8million; 2012: $73.9million); the US (2013: $60.9million; 2012: $37.2million); Germany (2013: $30.8million; 2012: $96.9 million); and other foreign tax jurisdictions (2013: $111.9million; 2012: $60.6 million).

Management is required to exercise judgement in determining whether deferred tax assets will more likely than not be realized. A valuation allowance is established where there is an expectation that on the balance of probabilities management considers it is more likely than not that the relevant deferred tax assets will not be realized. In assessing the need for a valuation allowance, management weighs all available positive and negative evidence including cumulative losses in recent years, projection of future taxable income, carry forward and carry back potential under relevant tax law, expiration period of tax attributes, taxable temporary differences, and prudent and feasible tax-planning strategies.

The net increase in valuation allowances of $13.8million includes (i) increases of $104.5 million primarily in respect of losses and other temporary differences in various jurisdictions where management consider that there is insufficient positive evidence in respect of the factors described above to overcome cumulative losses and therefore it is more likely than not that the relevant deferred tax assets will not be realized in full, and (ii) a decrease of $90.7 million primarily in respect of German tax losses ($67.4m),which based on the assessment of the factors described above now provides sufficient positive evidence to support that the losses are more likely than not to be realized. The release of this valuation allowance has been recorded in the current period due to changes in the financing of the German subsidiary.

At December 31, 2013, based upon a consideration of the factors described above management believes it is more likely than not that the Company will realize the benefits of these deductible differences, net of the valuation allowances. However, the amount of the deferred tax asset considered realizable could be adjusted in the future if these factors are revised in the future periods.

The approximate tax effect of NOLs, capital losses and tax credit carry-forwards as at December 31, are as follows:

	2013	2012
	$’M	$’M
	____________	____________
US federal tax NOLs	32.2	26.1
US state tax NOLs	61.5	31.4
UK NOLs	6.7	20.7
Republic of Ireland NOLs	78.8	72.6
Foreign tax jurisdictions	273.1	208.8
R&D and other tax credits	48.3	66.2
	____________	____________

The approximate gross value of NOLs and capital losses at December 31, 2013 is $2,583.7million (2012: $1,783.5million). The tax effected NOLs, capital losses and tax credit carry-forwards shown above have the following expiration dates:

	December 31,
	2013
	$’M
	___________
Within 1 year	0.9
Within 1 to 2 years	1.1
Within 2 to 3 years	0.7
Within 3 to 4 years	2.9
Within 4 to 5 years	3.0
Within 5 to 6 years	35.6
After 6 years	142.7
Indefinitely	313.7

The Company does not provide for deferred taxes on the excess of the financial reporting over the tax basis in investments in foreign subsidiaries that are essentially permanent in duration. At December 31, 2013, that excess totalled approximately $8.5 billion. The determination of additional deferred taxes is not practicable and is not provided.

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Goodwill (Tables)

12 Months Ended

Dec. 31, 2013

Goodwill and Intangible Assets Disclosure [Abstract]

Schedule of Acquired Goodwill

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Goodwill arising on businesses acquired	624.6	644.5
	____________	____________

Schedule of Goodwill

	2013	2012
	$’M	$’M
	____________	____________
As at January 1,	644.5	592.6
Acquisitions	170.3	48.1
Goodwill impairment charge related to continuing operations	(7.1)	-
Goodwill impairment charge related to DERMAGRAFT business and transferred to discontinued operations	(191.8)	-
Foreign currency translation	8.7	3.8
	____________	____________
As at December 31,	624.6	644.5
	____________	____________

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Reorganization Costs (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Reorganization Costs
Reorganization costs	$ 88.2	$ 0	$ 24.3
Restructuring Reserve (Roll Forward)
Reorganization Reserve Opening liability	0
Amounts charged to re-organization	88.2	0	24.3
Reorganization liability, Paid and Utilized	(63.4)
Reorganization Reserve Closing liability	24.8	0
Reorganization liability, Current	24.8
Involuntary termination benefits
Reorganization Costs
Reorganization costs	44.7
Restructuring Reserve (Roll Forward)
Reorganization Reserve Opening liability	0
Amounts charged to re-organization	44.7
Reorganization liability, Paid and Utilized	(29.4)
Reorganization Reserve Closing liability	15.3
Other reorganization costs
Reorganization Costs
Reorganization costs	43.5
Restructuring Reserve (Roll Forward)
Reorganization Reserve Opening liability	0
Amounts charged to re-organization	43.5
Reorganization liability, Paid and Utilized	(34.0)
Reorganization Reserve Closing liability	9.5
Turnhout
Reorganization Costs
Reorganization costs	23.6
Restructuring Reserve (Roll Forward)
Amounts charged to re-organization	23.6
"One Shire" business re-alignment
Reorganization Costs
Reorganization costs	64.6
Restructuring Reserve (Roll Forward)
Amounts charged to re-organization	64.6
"One Shire" business re-alignment | Reorganization costs, high estimate
Reorganization Costs
Reorganizations costs, expected costs	$ 150.0

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Consolidated Balance Sheets (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Current assets:
Cash and cash equivalents	$ 2,239.4	$ 1,482.2
Restricted cash	22.2	17.1
Accounts receivable, net	961.2	824.2
Inventories	455.3	436.9
Assets held for sale	31.6	0
Deferred tax asset	315.6	229.9
Prepaid expenses and other current assets	263.0	221.8
Total current assets	4,288.3	3,212.1
Non-current assets:
Investments	31.8	38.7
Property, plant and equipment, net	891.8	955.8
Goodwill	624.6	644.5
Other intangible assets, net	2,312.6	2,388.1
Deferred tax asset	141.1	46.5
Other non-current assets	32.8	31.5
Total assets	8,323.0	7,317.2
Current liabilities:
Accounts payable and accrued expenses	1,688.4	1,501.5
Other current liabilities	119.5	144.1
Total current liabilities	1,807.9	1,645.6
Non-current liabilities
Convertible bonds	0	1,100.0
Deferred tax liability	560.6	520.8
Other non-current liabilities	588.5	241.6
Total liabilities	2,957.0	3,508.0
Commitments and contingencies
Equity:
Common stock of 5p par value; 1,000 million shares authorized; and 597.5 million shares issued and outstanding (2012: 1,000 million shares authorized; and 562.5 million shares issued and outstanding)	58.6	55.7
Additional paid-in capital	4,186.3	2,981.5
Treasury stock: 13.4 million shares (2012: 10.7 million shares)	(450.6)	(310.4)
Accumulated other comprehensive income	110.2	86.9
Retained earnings	1,461.5	995.5
Total equity	5,366.0	3,809.2
Total liabilities and equity	$ 8,323.0	$ 7,317.2

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Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2013

Basis of preparation

The accompanying consolidated financial statements include the accounts of Shire plc, all of its subsidiary undertakings and the Income Access Share trust, after elimination of inter-company accounts and transactions. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for annual reporting.

Use of estimates in consolidated financial statements

The preparation of consolidated financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestments,contingent consideration payable in respect of business combinations and asset purchasesand assets held for sale. If actual results differ from the Company's estimates, or to the extent these estimates are adjusted in future periods, the Company's results of operations could either benefit from, or be adversely affected by, any such change in estimate.

Revenue recognition

The Company recognizes revenue when all of the following conditions are met:

•       there is persuasive evidence of an agreement or arrangement;

•       delivery of products has occurred or services have been rendered;

•       the seller's price to the buyer is fixed or determinable; and

•       collectability is reasonably assured.

Where applicable, all revenues are stated net of value added and similar taxes, and trade discounts. No revenue is recognized for consideration, the value or receipt of which is dependent on future events or future performance.

The Company's principal revenue streams and their respective accounting treatments are discussed below:

Product sales

Revenue for the sale of products is recognized when delivery has occurred and substantially all the risks and rewards of ownership have been transferred to the customer. Provisions for rebates, product returns and discounts to customers are provided for as reductions to revenue in the same period as the related sales are recorded. The provisions made at the time of revenue recognition are based on historical experience and updated for changes in facts and circumstances including the impact of new legislation. The provisions are recognized as a reduction to revenues.

Royalty income

Royalty income relating to licensed technology is recognized when the licensee sells the underlying product, with the amount of royalty income recorded based on sales information received from the relevant licensee. The Company estimates sales amounts and related royalty income based on the historical product information for any period that the sales information is not available from the relevant licensee.

Licensing revenues

Other revenue includes revenues derived from product out-licensing arrangements, which typically consist of an initial upfront payment on inception of the license and subsequent milestone payments contingent on the achievement of certain clinical and sales milestones. Product out-licensing arrangements often require the Company to provide multiple deliverables to the licensee.

Initial license fees received in connection with product out-licensing agreements entered into prior to January 1, 2011 are deferred and recognized over the period in which the Company has continuing substantive performance obligations, typically the period over which the Company participates in the development of the out-licensed product, even where such fees are non-refundable and not creditable against future royalty payments.

For product out-licensing arrangements entered into, or subject to material modification, after January 1, 2011, consideration received is allocated between each of the separable elements in the arrangement using the relative selling price method. An element is considered separable if it has value to the customer on a stand-alone basis. The selling price used for each separable element will be based on vendor specific objective evidence (“VSOE”) if available, third party evidence if VSOE is not available, or estimated selling price if neither VSOE nor third party evidence is available. Revenue is then recognized as each of the separable elements to which the revenue has been allocated is delivered.

Milestone payments which are non-refundable, non creditable and contingent on achieving certain clinical milestones are recognized as revenues either on achievement of such milestones if the milestones are considered substantive or over the period the Company has continuing substantive performance obligations, if the milestones are not considered substantive. If milestone payments are creditable against future royalty payments, the milestones are deferred and released over the period in which the royalties are anticipated to be paid.

Sales deductions

(i)       Rebates

Rebates primarily consist of statutory rebates to state Medicaid agencies and contractual rebates with health-maintenance organizations. These rebates are based on price differentials between a base price and the selling price. As a result, rebates generally increase as a percentage of the selling price over the life of the product (as prices increase). Provisions for rebates are recorded as reductions to revenue in the same period as the related sales are recorded, with the amount of the rebate based on the Company's best estimate if any uncertainty exists over the unit rebate amount, and with estimates of future utilization derived from historical trends.

(ii)       Returns

The Company estimates the proportion of recorded revenue that will result in a return, based on historical trends and when applicable, specific factors affecting certain products at the balance sheet date. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded.

(iii)       Coupons

The Company uses coupons as a form of sales incentive. An accrual is established based on the Company's expectation of the level of coupon redemption, estimated using historical trends. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded or the date the coupon is offered, if later than the date the related sales are recorded.

(iv)       Discounts

The Company offers cash discounts to customers for the early payment of receivables which are recorded as reductions to revenue and accounts receivable in the same period as the related sale is recorded.

(v)       Wholesaler chargebacks

The Company has contractual agreements whereby it supplies certain products to third parties at predetermined prices. Wholesalers acting as intermediaries in these transactions are reimbursed by the Company if the predetermined prices are less than the prices paid by the wholesaler to the Company. Accruals for wholesaler chargebacks, which are based on historical trends, are recorded as reductions to revenue in the same period as the related sales are recorded.

Collaborative arrangements

The Company enters into collaborative arrangements to develop and commercialize drug candidates. These collaborative arrangements often require up-front, milestone, royalty or profit share payments, or a combination of these, with payments often contingent upon the success of the related development and commercialization efforts. Collaboration agreements entered into by the Company may also include expense reimbursements or other such payments to the collaborating partner.

The Company reports costs incurred and revenue generated from transactions with third parties as well as payments between parties to collaborative arrangements either on a gross or net basis, depending on the characteristics of the collaborative relationship.

Cost of product sales

Cost of product sales includes the cost of purchasing finished product for sale, the cost of raw materials and manufacturing for those products that are manufactured by the Company, shipping and handling costs, depreciation and amortization of intangible assets in respect of favorable manufacturing contracts. Royalties payable on products to which the Company does not own the rights are also included in Cost of product sales.

Leased assets

The costs of operating leases are charged to operations on a straight-line basis over the lease term, even if rental payments are not made on such a basis.

Assets acquired under capital leases are included in the consolidated balance sheet as property, plant and equipment and are depreciated over the shorter of the period of the lease or their useful lives. The capital element of future lease payments is recorded as a liability, while the interest element is charged to operations over the period of the lease to produce a level yield on the balance of the capital lease obligation.

Advertising expense

The Company expenses the cost of advertising as incurred. Advertising costs amounted to $60.9 million, $85.8 million and $122.5 million for the years to December 31, 2013, 2012 and 2011 respectively and were included within Selling, general and administrative (“SG&A”) expenses.

Research and development ("R&D") expense

R&D costs are expensed as incurred. Upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified are also expensed as incurred.

Milestone payments made to third parties on and subsequent to regulatory approval are capitalized as intangible assets, and amortized over the remaining useful life of the related product.

Valuation and impairment of long-lived assets other than goodwill, indefinite lived intangible assets and investments

The Company evaluates the carrying value of long-lived assets other than goodwill, indefinite lived intangible assets and investments for impairment whenever events or changes in circumstances indicate that the carrying amounts of the relevant assets may not be recoverable. When such a determination is made, management's estimate of undiscounted cash flows to be generated by the use and ultimate disposition of these assets is compared to the carrying value of the assets to determine whether the carrying value is recoverable. If the carrying value is deemed not to be recoverable, the amount of the impairment recognized in the consolidated financial statements is determined by estimating the fair value of the relevant assets and recording animpairment loss for the amount by which the carrying value exceeds the estimated fair value. This fair value is usually determined based on estimated discounted cash flows.

Finance cost of debt

Finance costs relating to debt issued are recorded as a deferred charge and amortized to the consolidated statements of income over the period to the earliest redemption date of the debt, using the effective interest rate method. On extinguishment of the related debt, any unamortized deferred financing costs are written off and charged to interest expense in the consolidated statements of income.

Foreign currency

Monetary assets and liabilities in foreign currencies are translated into the functional currency of the relevant subsidiaryin which they arise at the rate of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into the relevant functional currency at the rate of exchange ruling at the date of the transaction. Transaction gains and losses, other than those related to current and deferred tax assets and liabilities, are recognized in arriving at income from operations before income taxes and equity in earnings of equity method investees. Transaction gains and losses arising on foreign currency denominated current and deferred tax assets and liabilities are included within income taxes in the consolidated statements of income.

The results of operations for subsidiaries, whose functional currency is not the US dollar, are translated into the US dollar at the average rates of exchange during the period, with the subsidiaries' balance sheets translated at the rates ruling at the balance sheet date. The cumulative effect of exchange rate movements is included in a separate component of Other comprehensive income.

Foreign currency exchange transaction losses included in consolidated statements of income in the years to December 31, 2013, 2012 and 2011 amounted to $8.7million, $3.5 million and $2.1 million, respectively.

Income taxes

Uncertain tax positions are recognized in the consolidated financial statements for positions which are considered more likely than not of being sustained, based on the technical merits of the position on audit by the tax authorities. The measurement of the tax benefit recognized in the consolidated financial statements is based upon the largest amount of tax benefit that, in management's judgment, is greater than 50% likely of being realized based on a cumulative probability assessment of the possible outcomes. The Company recognizes interest relating to unrecognized tax benefits and penalties within income taxes.

Deferred tax assets and liabilities are recognized for differences between the carrying amounts of assets and liabilities in the consolidated financial statements and the tax bases of assets and liabilities that will result in future taxable or deductible amounts. The deferred tax assets and liabilities are measured using the enacted tax laws and rates applicable to the periods in which the differences are expected to affect taxable income.

Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized.

Earnings per share

Basic earnings per share is based upon net income attributable to Shire plc divided by the weighted average number of ordinary shares outstanding during the period. Diluted earnings per share is based upon net income attributable to Shire plc adjusted for the impact of interest expense on convertible debt on an “if-converted” basis (whenthe effect is dilutive and prior to the actual conversion or redemption of debt) divided by the weighted average number of ordinary share equivalents outstanding during the period, adjusted for the dilutive effect of all potential ordinary shares equivalents that were outstanding during the year. Such potentially dilutive shares are excluded when the effect would be to increase diluted earnings per share or reduce the diluted loss per share.

Share-based compensation

Share-based compensation represents the cost of share-based awards granted to employees. The Company measures share-based compensation cost for awards classified as equity at the grant date, based on the estimated fair value of the award. Predominantly all of the Company's awards have service and/or performance conditions and the fair values of these awards are estimated using a Black-Scholes valuation model.

For share-based compensation awards which cliff vest, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the employee's requisite service period. For those share-based compensation awards with a graded vesting schedule, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the requisite service period for the entire award (that is, over the requisite service period for the last separately vesting portion of the award). The share based compensation expense is recorded in Cost of product sales, R&D, and SG&A in the consolidated statementsof income based on the employees' respective functions.

The Company records deferred tax assets for awards that result in deductions on the Company's income tax returns, based on the amount of compensation cost recognized and the Company's statutory tax rate in the jurisdiction in which it will receive a deduction. Differences between the deferred tax assets recognized for financial reporting purposes and the actual tax deduction reported on the Company's income tax return are recorded in additional paid-in capital (if the tax deduction exceeds the deferred tax asset) or in the consolidated statements of income (if the deferred tax asset exceeds the tax deduction and no additional paid-in capital exists from previous awards).

The Company's share-based compensation plans are described more fully in Note 27.

Cash and cash equivalents

Cash and cash equivalents are defined as short-term highly liquid investments with original maturities of ninety days or less.

Financial instruments - derivatives

The Company uses derivative financial instruments to manage its exposure to foreign exchange risk associated with intercompany financing. These instruments consist of swap and forward foreign exchange contracts. The Company does not apply hedge accounting for these instruments. The fair values of these instruments are included on the balance sheet in current assets / liabilities, with changes in the fair value recognized in the consolidated statements of income. The cash flows relating to these instruments are presented within net cash provided by operating activities in the consolidated statement of cash flows, unless the derivative instruments are economically hedging specific investing or financing activities.

Inventories

Inventories are stated at the lower of cost or market. Cost incurred in bringing each product to its present location and condition is based on purchase costs calculated on a first-in, first-out basis, including transportation costs.

Inventories include costs relating to both marketed products and,for certain products,cost incurred prior to regulatory approval. Inventories are capitalized prior to regulatory approval if the Company considers that it is probable that the US Food and Drug Administration (“FDA”) or another regulatory body will grant commercial and manufacturing approval for the relevant product, and it is probable that the value of capitalized inventories will be recovered through commercial sale.

Inventories are written down for estimated obsolescence or unmarketable inventory equal to the difference between the cost of inventory and estimated market value based upon assumptions about future demand and market conditions. If actual market conditions are less favorable than those anticipated, inventory adjustments may be required.

Assets held-for-Sale

An asset or asset disposal group is classified as held-for-sale when, amongst other things, the Company has committed to a plan of disposition, the asset or asset disposal group is available for immediate sale, and the plan is not expected to change significantly. Assets held-for-sale are carried at the lower of their carrying amount or fair value less cost to sell.

The Company does not record depreciation or amortization on assets classified as held-for-sale.

Investments

The Company has certain investments in pharmaceutical and biotechnology companies.

Investments are accounted for using the equity method of accounting if the investment gives the Company the ability to exercise significant influence, but not control over, the investee. Significant influence is generally deemed to exist if the Company has an ownership interest in the voting stock of the investee between 20% and 50%, although other factors such as representation on the investee's Board of Directors and the nature of commercial arrangements, are considered in determining whether the equity method of accounting is appropriate. Under the equity method of accounting, the Company records its investments in equity-method investees in the consolidated balance sheet under Investments and its share of the investees' earnings or losses together with other-than-temporary impairments in value under equity in earnings of equity method investees in the consolidated statements of income.

All other equity investments, which consist of investments for which the Company does not have the ability to exercise significant influence, are accounted for under the cost method or at fair value. Investments in private companies are carried at cost, less provisions for other-than-temporary impairment in value. For public companies that have readily determinable fair values, the Company classifies its equity investments as available-for-sale and, accordingly, records these investments at their fair values with unrealized holding gains and losses included in the consolidated statement of comprehensive income, net of any related tax effect. Realized gains and losses, and declines in value of available-for-sale securities judged to be other-than-temporary, are included in other income, net. The cost of securities sold is based on the specific identification method. Interest on securities classified as available-for-sale are included as interest income.

Property, plant and equipment

Property, plant and equipment is shown at cost reduced for impairment losses, net of accumulated depreciation. The cost of significant assets includes capitalized interest incurred during the construction period. Depreciation is recorded on a straight-line basis at rates calculated to write off the cost less estimated residual value of each asset over its estimated useful life as follows:

Buildings       15 to 50 years

Office furniture, fittings and equipment       3 to 10 years

Warehouse, laboratory and manufacturing equipment       3 to 15 years

The cost of land is not depreciated. Assets under the course of construction are not depreciated until the relevant assets are available and ready for their intended use.

Expenditures for maintenance and repairs are charged to the consolidated statements of income as incurred. The costs of major renewals and improvements are capitalized. At the time property, plant and equipment is retired or otherwise disposed of, the cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts. The profit or loss on such disposition is reflected in operating income.

Goodwill and other intangible assets

(i)       Goodwill

In business combinations completed subsequent to January 1, 2009, goodwill represents the excess of the fair value of the consideration given and the fair value of any non-controlling interest in the acquiree over the fair value of the identifiable assets and liabilities acquired. For business combinations completed prior to January 1, 2009 goodwill represents the excess of the fair value of the consideration given over the fair value of the identifiable assets and liabilities acquired.

Goodwill is not amortized, but instead is reviewed for impairment, at least annually or whenever events or changes in circumstances indicate that the carrying value may not be recoverable. For the purpose of assessing the carrying value of goodwill for impairment, goodwill is allocated at the Company's reporting unit level. Events or changes in circumstances which could trigger an impairment review include but are not limited to: significant underperformance of a reporting unit relative to expected historical or projected future operating results; significant changes in the manner of the Company's use of acquired assets or the strategy for the overall business; and significant negative industry trends.

Goodwill is reviewed for impairment by comparing the carrying value of the reporting unit's net assets (including allocated goodwill) to the fair value of the reporting unit. If the reporting unit's carrying amount is greater than its fair value, a second step is performed whereby the portion of the reporting unit's fair value relating to goodwill is compared to the carrying value of the reporting unit's goodwill. The Company recognizes a goodwill impairment charge for the amount by which the carrying value of goodwill exceeds its estimated fair value. In the year to December 31, 2013 the Company has recorded an impairment charge of $198.9 million related to the goodwill allocated to the Company's former Regenerative Medicine (“RM”) reporting unit. See Note 11 for further details.

(ii)       Other intangible assets

Other intangible assets principally comprise intellectual property rights for products with a defined revenue stream, acquired product technology and IPR&D. Intellectual property rights for currently marketed products and acquired product technology are recorded at fair value and amortized over the estimated useful life of the related product, which ranges from 1 to 20 years (weighted average 10.1 years). IPR&D acquired through a business combination is capitalized as an indefinite lived intangible asset until the completion or abandonment of the associated R&D efforts. IPR&D is reviewed for impairment using a “one-step” approach which compares the fair value of the IPR&D asset with its carrying amount. An impairment loss is recognized to the extent that the carrying value exceeds the fair value of the IPR&D asset. Once the R&D efforts are completed the useful life of the relevant assets will be determined, and the IPR&D asset amortized over this useful economic life.

The following factors, where applicable, are considered in estimating the useful lives of Other intangible assets:

• expected use of the asset;
• regulatory, legal or contractual provisions, including the regulatory approval and review process, patent issues and actions by government agencies;
• the effects of obsolescence, changes in demand, competing products and other economic factors, including the stability of the market, known technological advances, development of competing drugs that are more effective clinically or economically;
• actions of competitors, suppliers, regulatory agencies or others that may eliminate current competitive advantages; and
• historical experience of renewing or extending similar arrangements.

When a number of factors apply to an intangible asset, these factors are considered in combination when determining the appropriate useful life for the relevant asset.

Non-monetary transactions

The Company enters into certain non-monetary transactions that involve either the granting of a license over the Company's patents or the disposal of an asset or group of assets in exchange for a non–monetary asset, usually equity. The Company accounts for these transactions at fair value if the Company is able to determine the fair value within reasonable limits. To the extent the Company concludes that it is unable to determine the fair value of a transaction that transaction is accounted for at the recorded amounts of the assets exchanged. Management is required to exercise its judgment in determining whether or not the fair value of the asset received or given up can be determined.

New accounting pronouncements

Adopted during the period

Indefinite-Lived Intangible Assets (Other than Goodwill) Impairment Testing

In July 2012 the Financial Accounting Standard Board (“FASB”) issued guidance on the testing of indefinite-lived intangible assets for impairment. The guidance permits an entity to first assess qualitative factors to determine whether the existence of events or circumstances leads to a determination that it is more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount. If, after assessing the totality of events or circumstances, an entity determines it is not more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount, performing the impairment test is unnecessary. The more-likely-than-not threshold is defined as a likelihood of more than 50 percent. An entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the impairment test and may resume performing the qualitative assessment in any subsequent period. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

Disclosure about offsetting assets and liabilities

In December 2011 the FASB issued guidance on disclosures about offsetting assets and liabilities. In January 2013 the FASB amended the previous guidance to clarify the scope of guidance issued in December 2011. The amended guidance requires entities to disclose both gross and net information about derivatives including bifurcated embedded derivatives, repurchase agreements and reverse repurchase agreements, and securities borrowing and securities lending transactions that are either offset in accordance with FASB guidance on topics “Balance Sheet” and “Derivatives and Hedging” or subject to an enforceable master netting arrangement or similar agreement; to enable users of financial statements tounderstand the effects or potential effects of those arrangements on its financial position. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows. Enhanced disclosure of balance sheetoffsetting as required by this guidance is included in Note 20.

Amounts reclassified out of Comprehensive Income

In February 2013 the FASB issued guidance on reporting amounts reclassified out of accumulated other comprehensive income. The guidance requires entities to provide information about the amount reclassified out of comprehensive income by component and present either on the face of the financial statements or in the notes, significant amounts reclassified out of other comprehensive income by the respective line items of net income, but only if the amount reclassified is required under US GAAP to be reclassified to net income in its entirety in the same reporting period. For other amounts that are not required under US GAAP to be reclassified in their entirety to net income, an entity is required to cross-reference to other disclosures required under US GAAP that provide additional detail about those amounts. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

Presentation of an unrecognized tax benefit

In July 2013 the FASB issued guidance on the financial statement presentation of an unrecognized tax benefit when a net operating loss carry forward, a similar tax loss, or a tax credit carry forward exists. The guidance requires entities to present an unrecognized tax benefit or a portion of an unrecognized tax benefit in the financial statements as a reduction to a deferred tax asset for a net operating loss carry forward, a similar tax loss, or a tax credit carry forward, except as follows: to the extent a net operating loss carry forward, a similar tax loss, or a tax credit carry forward is not available at the reporting date under the tax law of the applicable jurisdiction to settle any additional income taxes that would result from the disallowance of a tax position or the tax law of the applicable jurisdiction does not require the entity to use, and the entity does not intend to use, the deferred tax asset for such purpose, the unrecognized tax benefit should be presented in the financial statements as a liability and should not be combined with deferred tax assets. The assessment of whether a deferred tax asset is available is based on the unrecognized tax benefit and deferred tax asset that exist at the reporting date and should be made presuming disallowance of the tax position at the reporting date. The guidance will be effective for fiscal years, and interim periods within those years, beginning after December 15, 2013, with early adoption permitted. The Company has adopted this guidance in the period. The adoption of the guidance did not materially impact the Company's consolidated financial position, results of operations or cash flows.

Statutory accounts

The consolidated financial statements as at December 31, 2013 and 2012, and for each of the three years in the period to December 31, 2013 do not comprise statutory accounts within the meaning of Section 434 of the UK Companies Act 2006 or Article 104 of the Companies (Jersey) Law 1991.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2012 prepared under UK GAAP and in compliance with Jersey law have been delivered to the Registrar of Companies for Jersey. The consolidated accounts of the Company for the year ended December 31, 2012 prepared in accordance with US GAAP, in fulfillment of the Company's United Kingdom Listing Authority (“UKLA”) annual reporting requirements were filed with the UKLA. The auditor's reports on these accounts were unqualified.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2013 prepared under UK GAAP and in compliance with Jersey law will be delivered to the Registrar of Companies in Jersey in 2014. The Company further expects to file the consolidated accounts of the Company for the year to December 31, 2013, prepared in accordance with US GAAP, in fulfillment of the Company's UKLA annual reporting requirements with the UKLA in 2014.

The Trust

Foreign currency

Income and expense items denominated in currencies other than the functional currency are translated into the functional currency at the rate ruling on their transaction date. Monetary assets and liabilities recorded in currencies other than the functional currency have been expressed in the functional currency at the rates of exchange ruling at the respective balance sheet dates. Differences on translation are included in the consolidated statements of income.

Basis of preparation

The financial statements of the Trust have been prepared in accordance with accounting principles generally accepted in the United States of America(“US GAAP”). The financial statements have been prepared under the historical cost convention.

The preparation of financial statements in conformity with US GAAP requires the use of certain accounting estimates. It also requires management to exercise its judgment in the process of applying the Trust's accounting policies. Actual results may differ from these estimates.

The results of operations, and the financial position and cash flows of the Trust are also consolidated in the Company's financial statements, as contained on pages F-1 to F-67.

Functional currency

The functional currency of the Trust is US dollars.

Dividend income

Interim dividends declared on the Income Access Share are recognized on a paid basis unless the dividend has been confirmed by a general meeting of Shire, in which case income is recognized on the record date of the dividend by Shire on its ordinary shares.

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Shareholders' Equity (Details) (USD $) In Millions, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Nov. 11, 2013	Apr. 30, 2014	Apr. 24, 2012
Equity, Class of Treasury Stock [Line Items]
Ordinary shares authorized (in shares)	1,000,000,000	1,000,000,000
Subscriber ordinary shares authorized (in shares)	2
Distributable reserves	$ 10,400
Treasury Stock
Consideration paid for treasury stock purchased (in USD)	243.8	205.8	151.8
Share Buy-back Program
Authorized amount of share buy-back program (in USD)		500
Cost of share repurchases (in USD)				300.0
Authorized number of shares under share buy-back program					55,741,587	56,253,208
Income Access Share Arrangements
Cash dividends paid to Income Access Share Trustee (in USD)	91.1	81.5	67.6
Irish Witholding Tax, Rate	20.00%
Condition for Ordinary Shareholders, Shares	25,000
Shire 2.75% Convertible Bond due 2014
Convertible bond, convertible into number of ordinary shares	33,806,464
Ordinary Shares
Equity, Class of Treasury Stock [Line Items]
Treasury stock acquired (in shares)	6,191,965
Treasury Stock
Treasury stock held (in shares)	4,200,000	4,500,000	2,700,000
Share Buy-back Program
Treasury stock acquired (in shares)	6,191,965
Cost of share repurchases (in USD)	$ 193.0
Percentage of total share issued that were repurchased during the period	1.00%
Ordinary Shares | Shares held by EBT
Treasury Stock
Treasury stock held (in shares)	2,400,000	3,800,000	4,600,000
Ordinary Shares | Shares held under share buy-back program
Treasury Stock
Treasury stock held (in shares)	7,100,000	2,700,000	0
ADS
Treasury Stock
Treasury stock held (in shares)	800,000	900,000	800,000
ADS | Shares held by EBT
Treasury Stock
Treasury stock held (in shares)	400,000	1,100,000	2,400,000
ADS | Shares held under share buy-back program
Treasury Stock
Treasury stock held (in shares)	900,000	300,000	0

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Quarterly Results of Operations (Details) (USD $) In Millions, except Per Share data, unless otherwise specified	12 Months Ended			3 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Dec. 31, 2013 Previously reported	Sep. 30, 2013 Previously reported	Jun. 30, 2013 Previously reported	Mar. 31, 2013 Previously reported	Dec. 31, 2012 Previously reported	Sep. 30, 2012 Previously reported	Jun. 30, 2012 Previously reported	Mar. 31, 2012 Previously reported	Dec. 31, 2013 Adjusted for Dermagraft	Sep. 30, 2013 Adjusted for Dermagraft	Jun. 30, 2013 Adjusted for Dermagraft	Mar. 31, 2013 Adjusted for Dermagraft	Dec. 31, 2012 Adjusted for Dermagraft	Sep. 30, 2012 Adjusted for Dermagraft	Jun. 30, 2012 Adjusted for Dermagraft	Mar. 31, 2012 Adjusted for Dermagraft	Dec. 31, 2013 As reported	Sep. 30, 2013 As reported	Jun. 30, 2013 As reported	Mar. 31, 2013 As reported	Dec. 31, 2012 As reported	Sep. 30, 2012 As reported	Jun. 30, 2012 As reported	Mar. 31, 2012 As reported
Quarterly Financial Information [Line Items]
Total revenues	$ 4,934.3	$ 4,527.4	$ 4,158.1	$ 1,351.1	$ 1,236.6	$ 1,274.5	$ 1,161.9	$ 1,201.2	$ 1,100.4	$ 1,207.8	$ 1,171.8	$ (25.1)	$ (23.9)	$ (22.3)	$ (18.5)	$ (18.9)	$ (33.7)	$ (52.4)	$ (48.8)	$ 1,326.0	$ 1,212.7	$ 1,252.2	$ 1,143.4	$ 1,182.3	$ 1,066.7	$ 1,155.4	$ 1,123.0
Cost of product sales	670.8	585.8	551.7	196.5	197.1	175.7	155.9	166.6	167.9	152.5	158.4	(17.9)	(16.6)	(11.4)	(8.5)	(16.6)	(16.0)	(17.0)	(10.0)	178.6	180.5	164.3	147.4	150.0	151.9	135.5	148.4
Income from continuing operations, net of taxes	1,419.6	805.7	882.7	64.0	278.2	258.1	64.8	42.0	227.2	237.8	238.4	482.6	22.9	32.8	216.2	26.0	16.2	10.7	7.4	546.6	301.1	290.9	281.0	68.0	243.4	248.5	245.8
Loss from discontinued operations, net of taxes	(754.5)	(60.3)	(17.7)	0	0	0	0	0	0	0	0	(482.6)	(22.9)	(32.8)	(216.2)	(26.0)	(16.2)	(10.7)	(7.4)	(482.6)	(22.9)	(32.8)	(216.2)	(26.0)	(16.2)	(10.7)	(7.4)
Net income	$ 665.1	$ 745.4	$ 865.0	$ 64.0	$ 278.2	$ 258.1	$ 64.8	$ 42.0	$ 227.2	$ 237.8	$ 238.4	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 64.0	$ 278.2	$ 258.1	$ 64.8	$ 42.0	$ 227.2	$ 237.8	$ 238.4
Earnings from continuing operations (in USD per share)	$ 2.572	$ 1.451	$ 1.601	$ 0.115	$ 0.507	$ 0.469	$ 0.117	$ 0.075	$ 0.409	$ 0.427	$ 0.431	$ 0.865	$ 0.042	$ 0.060	$ 0.393	$ 0.047	$ 0.029	$ 0.019	$ 0.013	$ 0.980	$ 0.549	$ 0.529	$ 0.510	$ 0.122	$ 0.438	$ 0.446	$ 0.444
Loss from discontinued operations (in USD per share)	$ (1.367)	$ (0.109)	$ (0.032)	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ (0.865)	$ (0.042)	$ (0.060)	$ (0.393)	$ (0.047)	$ (0.029)	$ (0.019)	$ (0.013)	$ (0.865)	$ (0.042)	$ (0.060)	$ (0.393)	$ (0.047)	$ (0.029)	$ (0.019)	$ (0.013)
Earnings per ordinary share - basic	$ 1.205	$ 1.342	$ 1.569	$ 0.115	$ 0.507	$ 0.469	$ 0.117	$ 0.075	$ 0.409	$ 0.427	$ 0.431	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0.115	$ 0.507	$ 0.469	$ 0.117	$ 0.075	$ 0.409	$ 0.427	$ 0.431
Earnings from continuing operations (in USD per share)	$ 2.453	$ 1.410	$ 1.539	$ 0.117	$ 0.488	$ 0.453	$ 0.117	$ 0.074	$ 0.396	$ 0.413	$ 0.414	$ 0.817	$ 0.039	$ (0.056)	$ 0.367	$ 0.047	$ 0.027	$ 0.018	$ 0.013	$ 0.934	$ 0.527	$ 0.509	$ 0.490	$ 0.121	$ 0.423	$ 0.431	$ 0.427
Loss from discontinued operations (in USD per share)	$ (1.278)	$ (0.101)	$ (0.030)	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ (0.817)	$ (0.039)	$ (0.056)	$ (0.367)	$ (0.047)	$ (0.027)	$ (0.018)	$ (0.013)	$ (0.817)	$ (0.039)	$ (0.056)	$ (0.367)	$ (0.047)	$ (0.027)	$ (0.018)	$ (0.013)
Earnings per ordinary share - diluted	$ 1.175	$ 1.309	$ 1.509	$ 0.117	$ 0.488	$ 0.453	$ 0.117	$ 0.074	$ 0.396	$ 0.413	$ 0.414	$ 0	$ 0	$ (0.112)	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0.117	$ 0.488	$ 0.453	$ 0.123	$ 0.074	$ 0.396	$ 0.413	$ 0.414

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Consolidated Statements of Comprehensive Income (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Statement of Income and Comprehensive Income [Abstract]
Net income	$ 665.1	$ 745.4	$ 865.0
Other comprehensive income:
Foreign currency translation adjustments	25.3	23.7	(24.0)
Unrealized holding (loss)/gain on available-for-sale securities (net of taxes of $0.1 million, $2.5 million and $0.2 million)	(2.0)	2.9	16.2
Other than temporary impairment of available-for-sale securities (net of taxes of $nil in all periods)	0	0	2.4
Realized gain on divestment of available-for-sale securities (net of taxes of $nil, $nil million and $3.5 million)	0	0	(20.0)
Comprehensive income	688.4	772.0	839.6
Components of accumulated other comprehensive income
Foreign currency translation adjustments	110.4	85.1
Unrealized holding (loss)/gain on available-for-sale securities, net of taxes	(0.2)	1.8
Accumulated other comprehensive income	$ 110.2	$ 86.9

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Fair Value Measurement (Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Change in the Fair Value of Contigent Consideration Receivable
Balance at beginning of period	$ 38.3	$ 37.8
Gain/(loss) recognized in the income statement (within Gain/(loss) on sale of product rights) due to change in fair value during the period	15.9	18.1
Reclassification of amounts due to Other receivables within Other current assets	(19.5)	(18.7)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	1.4	1.1
Balance at end of period	36.1	38.3	37.8
Change in the Fair Value of Contigent Consideration Payable
Balance at beginning of period	136.4	0
Initial recognition of contingent consideration payable	451.4	127.8
Change in fair value during the period with the corresponding adjustment recognized as a loss in the income statement (within Integration and acquisition costs)	(159.1)	9.2	0
Reclassification of amounts to Other current liabilities	(13.9)	(8.8)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(8.9)	8.2
Balance at end of period	$ 405.9	$ 136.4	$ 0

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Accumulated Other Comprehensive Income (Tables)

12 Months Ended

Dec. 31, 2013

Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]

Changes in Accumulated Other Comprehensive Income, Net of Tax

		Foreign currency translation adjustment	Unrealized holding gain/(loss) on available-for-sale securities	Accumulated other comprehensive income
		$M	$M	$M
As at January 1, 2013		85.1	1.8	86.9
Current period change:
	Other Comprehensive income before reclassification	25.3	1.5	26.8
	Gain transferred to the income statement (within Other (expense)/income, net) on disposal of available-for-sale securities	0	(3.5)	(3.5)
Net current period other comprehensive income		25.3	(2.0)	23.3
As at December 31, 2013		110.4	(0.2)	110.2

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Segmental Reporting (Revenues and Long-lived Assets by Geographic Location) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues	$ 4,934.3	$ 4,527.4	$ 4,158.1
Long-lived assets	892.8	957.2
Ireland
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues	22.5	20.6	21.1
Long-lived assets	5.8	5.2
United Kingdom
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues	206.7	207.0	219.9
Long-lived assets	70.3	72.2
North America
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues	3,386.2	3,006.1	2,761.8
Long-lived assets	802.9	861.0
Rest of World
Revenues from External Customers and Long-Lived Assets [Line Items]
Revenues	1,318.9	1,293.7	1,155.3
Long-lived assets	$ 13.8	$ 18.8

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Fair Value Measurement

12 Months Ended

Dec. 31, 2013

Fair Value Disclosures [Abstract]

Fair Value Disclosures

21.       Fair value measurement

Assets and liabilities that are measured at fair value on a recurring basis

As at December 31, 2013 and December 31, 2012 the following financial assets and liabilities are measured at fair value on a recurring basis using quoted prices in active markets for identical assets (Level 1); significant other observable inputs (Level 2); and significant unobservable inputs (Level 3).

		Carrying	Fair value
		value
			Total	Level 1	Level 2	Level 3
At December 31, 2013		$'M	$'M	$'M	$'M	$'M
		____________	____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		6.7	6.7	6.7	-	-
Contingent consideration receivable (2)		36.1	36.1	-	-	36.1
Foreign exchange contracts		4.0	4.0	-	4.0	-
Financial liabilities:
Foreign exchange contracts		2.8	2.8	-	2.8	-
Contingent consideration payable(3)		405.9	405.9	-	-	405.9
		____________	____________	___________	___________	___________
			Total	Level 1	Level 2	Level 3
At December 31, 2012		$'M	$'M	$'M	$'M	$'M
		____________	____________	___________	___________	___________
Financial assets:
Available-for-sale securities(1)		14.2	14.2	14.2	-	-
Contingent consideration receivable (2)		38.3	38.3	-	-	38.3
Foreign exchange contracts		1.3	1.3	-	1.3	-
Financial liabilities:
Foreign exchange contracts		3.0	3.0	-	3.0	-
Contingent consideration payable(3)	1	136.4	136.4	-	-	136.4
		____________	____________	___________	___________	___________

(1)Available-for-sale securities are included within Investments in the consolidated balance sheet.

(2)Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

(3)Contingent consideration payableis included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company's intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

• Available-for-sale securities – the fair values of available-for-sale securities are estimated based on quoted market prices for those investments.
• Contingent consideration receivable – the fair value of the contingent consideration receivable has been estimated using the income approach (using a probability weighted discounted cash flow method).
• Foreign exchange contracts – the fair values of the swap and forward foreign exchange contracts have been determined using an income approach based on current market expectations about the future cash flows.
• Contingent consideration payable – the fair value of the contingent consideration payable has been estimated using the income approach (using a probability weighted discounted cash flow method).

Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

The change in the fair value of the Company's contingent consideration receivable and payables, which are measured at fair value on a recurring basis using significant unobservable inputs (Level 3),are as follows:

Contingent consideration receivable
	2013	2012
	$'M	$'M
	____________	____________
Balance at January 1,	38.3	37.8
Gain recognized in the income statement (within Gain on sale of product rights) due to change in fair value during the period	15.9	18.1
Reclassification of amounts to Other receivables within Other current assets	(19.5)	(18.7)
Amounts recorded to other comprehensive income (within foreign currency translation adjustments)	1.4	1.1
Balance at December 31,	36.1	38.3
Contingent consideration payable
	2013	2012
	$'M	$'M
	____________	____________
Balance at January 1,	136.4	-
Initial recognition of contingent consideration payable	451.4	127.8
Change in fair value during the period with the corresponding adjustment recognized as a gain in the income statement (within Integration and acquisition costs)	(159.1)	9.2
Reclassification of amounts to Other current liabilities	(13.9)	(8.8)
Change in fair value during the period with corresponding adjustment to the associated intangible asset	(8.9)	8.2
Balance at December 31,	405.9	136.4

Quantitative Information about Assets and Liabilities Measured at Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3)

Quantitative information about the Company's recurring Level 3 fair value measurements is included below:

Financial assets:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration receivable ("CCR")	36.1	Income approach (probability weighted discounted cash flow)	• Probability weightings applied to different sales scenarios • Future forecast royalties receivable at relevant contractual royalty rates • Assumed market participant discount rate	• 10 to 45% • $40 million to $148 million • 6.2%
	____________	____________	____________	____________
Financial liabilities:	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Range
	$'M
	____________	___________	___________	___________
Contingent consideration payable	405.9	Income approach (probability weighted discounted cash flow)	• Cumulative probability of milestones being achieved • Assumed market participant discount rate • Periods in which milestones are expected to be achieved • Forecast quarterly royalties payable on net sales of relevant products	• 18 to 57% (Weighted average) • 2.9 to 15% (Weighted average) • 2014 to 2025 • $2.4 to $7.6 million
	____________	____________	____________	____________

The Company re-measures the CCR (relating to contingent consideration due to the Company following divestment of one of the Company's products) at fair value at each balance sheet date,with the fair value measurement based on forecast cash flows, over a number of scenarios which vary depending on the expected performance outcome of the product following divestment. The forecast cash flows under each of these differing outcomes have been included in probability weighted estimates used by the Company in determining the fair value of the CCR.

Contingent consideration payable represents future milestones the Company may be required to pay in conjunction with various business combinations and future royalties payable as a result of certain business combinations and licenses. The amount ultimately payable by Shire in relation to business combinations is dependent upon the achievement of specified future milestones, such as the achievement of certain future development, regulatory and sales milestones. The Company assesses the probability, and estimated timing, of these milestones being achieved and re-measures the related contingent consideration to fair value each balance sheet date. The amount of contingent consideration which may ultimately be payable by Shire in relation to future royalties is dependent upon future net sales of the relevant products over the life of the royalty term. The Company assesses the present value of forecast future net sales of the relevant products and re-measures the related contingent consideration to fair value each balance sheet date.

The fair value of the Company's contingent consideration receivable and payable could significantly increase or decrease due to changes in certain assumptions which underpin the fair value measurements. Each set of assumptions and milestones are specific to the individual contingent consideration receivable or payable. The assumptions include, among other things, the probability and expected timing of certain milestones being achieved, the forecast future net sales of the relevant products and related future royalties payable, the probability weightings applied to different sales scenarios of one of the Company's divested products and forecast future royalties receivable under scenarios developed by the Company, and the discount rates used to determine the present value of contingent future cash flows. The Company regularly reviews these assumptions, and makes adjustments to the fair value measurements as required by facts and circumstances.

Assets Measured At Fair Value on a Non-Recurring Basis in the period using Significant Unobservable Inputs (Level 3)

In the second quarter of 2013 the Company reviewed certain IPR&D intangible assets acquired through Movetisfor impairment and recognized an impairment charge of $19.9 million, recorded within R&D in the consolidated income statement, to write-down these assets to their fair value. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, risk-adjusted forecast future cash flows to be generated by these assets and the determination of an appropriate discount rate to be applied in calculating the present value of forecast future cash flows. The fair value of these assets, determined at the time of the impairment review, was $20.3 million.

On January 16, 2014, the Company sold and transferred certain of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc (see Note 8 for details). The Transferred Assets include intellectual property relating to DERMAGRAFT, including patents, trademarks and know-how, regulatory filings and registrations relating to DERMAGRAFT, certain manufacturing plant, equipment and materials relating to the Business, and DERMAGRAFT product inventory and accounts receivable. The Transferred Assets have been measured at their fair value less costs to sell as at December 31, 2013. An impairment charge of $636.9million was recorded within discontinued operations in the consolidated income statement upon re-measurement of the divested assets to their fair value less costs to sell. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs. These unobservable inputs included, among other things, risk-adjusted forecast future cash flows to be generated by Shire following the divestment of these assets and the determination of an appropriate discount rate to be applied in calculating the present value of forecast future cash flows. The fair value of these assets at the date the held-for-sale conditions were met amounted to $31.6 million.

Quantitative information about Non-Recurring Level 3 Fair Value Measurements which occurred in the period is included below:

	Fair Value at the Measurement Date
At December 31, 2013	Fair value	Valuation Technique	Significant unobservable Inputs	Rate used
	$'M
	____________	___________	___________	___________
Movetis-related IPR&D intangible assets	20.3	Income approach (discounted cash flow)	• Decline in forecast peak sales since last impairment test • Assumed market participant discount rate	• 50% • 8.9%
DERMAGRAFT assets held-for-sale	31.6	Income approach (discounted cash flow)	• Future forecast milestones to be received • Assumed market participant discount rate	• $15 -$95 million • 11.5%
	____________	____________	____________	____________

Financial assets and liabilities that are not measured at fair value on a recurring basis

The carrying amounts and estimated fair values as at December 31, 2013 and December 31, 2012 of the Company's financial assets and liabilities which are not measured at fair value on a recurring basis are as follows:

	December 31, 2013		December 31, 2012
	Carrying		Carrying
	amount	Fair value	amount	Fair value
	$’M	$’M	$’M	$’M
	____________	____________	____________	___________
Financial liabilities:
Convertible bonds (Level 1)	-	-	1,100.0	1,228.2
Building financing obligation (Level 3)	7.8	10.1	8.0	10.3
	____________	____________	____________	___________

Certain estimates and judgments were required to develop the fair value amounts. The fair value amounts shown above are not necessarily indicative of the amounts that the Company would realize upon disposition, nor do they indicate the Company's intent or ability to dispose of the financial instrument.

The following methods and assumptions were used to estimate the fair value of each material class of financial instrument:

• Building finance obligations - the fair value of building finance obligations are estimated based on the present value of future cash flows, and an estimate of the residual value of the underlying property at the end of the lease term, associated with these obligations.

The carrying amounts of other financial assets and liabilities materially approximate to their fair value because of the short-term maturity of these amounts.

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Share-based Compensation Plans (Tables)

12 Months Ended

Dec. 31, 2013

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Share-based Compensation Expense

	2013	2012	2011
	$’M	$’M	$’M
	____________	____________	____________
Cost of product sales	4.4	6.3	8.8
Research and development	22.8	25.8	21.8
Selling, general and administrative	46.9	55.0	45.1
Reorganization costs	3.3	-	-
	____________	____________	____________
Total	77.4	87.1	75.7
Less tax	(18.1)	(23.8)	(23.6)
	____________	____________	____________
	59.3	63.3	52.1
	____________	____________	____________

Share-based Awards Outstanding

	Compensation type	Number of awards*	Expiration period from date of issue	Vesting period
	____________	____________	____________	____________
Portfolio Share Plan - Part A	SARs	14,083,748	5 - 7 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
Sharesave Scheme	Stock options	243,783	6 months after vesting	3 or 5 years
Stock Purchase Plan	Stock options	568,828	On vesting date	1 to 5 years
Legacy Plans	Stock options	132,823	7 to 10 years	3-10 years, subject to market or performance criteria
		__________________
Stock-settled SARs and stock options		15,029,182
		__________________
Portfolio Share Plan - Part B	Performance share awards	2,701,299	3 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
		__________________
Performance share awards		2,701,299
		__________________

Summary of Status of Stock Appreciation Rights and Stock Options

	Weighted average exercise price
Year to December 31, 2013	£	Number of	Intrinsic Value
		shares*	£’ M
	_______________	_______________	_______________
Outstanding as at beginning of period	16.66	18,536,947
Granted	20.05	6,914,026
Exercised	22.09	(8,302,740)
Forfeited	18.30	(2,119,051)
	_______________	_______________	________________
Outstanding as at end of period	18.88	15,029,182	143.9
	_______________	_______________	________________
Exercisable as at end of period	15.67	3,670,446	46.9
	_______________	_______________	________________

Schedule of Stock Appreciation Rights and Stock Options Outstanding, by Exercise Price Range

Number of awards outstanding*	Exercise prices	Weighted Average remaining contractual term (Years)	Weighted average exercise price of awards outstanding	Number of awards exercisable	Weighted average exercise price of awards exercisable
	£		£		£
________________	______________	__________	_______________	_____________	_____________
104,658	3.38-7.00	1.1	5.56	104,658	5.56
810,822	7.01-14.00	2.8	11.27	804,402	11.25
14,113,702	14.01-28.00	4.9	18.07	2,761,386	17.34
________________				_____________
15,029,182				3,670,446
________________				_____________

Schedule of Performance Share Awards

Performance share awards	Number of shares*	Aggregate intrinsic value £’M	Weighted average remaining life
	_______________	_______________	_______________
Outstanding as at beginning of period	3,518,138
Granted	1,508,631
Exercised	(1,826,648)
Forfeited	(498,822)
	_______________
Outstanding as at end of period	2,701,299	76.9	5.5
	_______________	_______________	________________
Exercisable as at end of period	-	N/A	N/A
	_______________	_______________	_______________

Schedule of Share-based Payment Award, Valuation Assumptions

Period ended December 31,	2013	2012	2011
	______________	______________	______________
Risk-free interest rate1	0.1-0.9%	0.2-1%	0.1-2.5%
Expected dividend yield	0.4-0.6%	0-0.6%	0-0.5%
Expected life	1-4 years	1-4 years	1-5 years
Volatility	23-26%	24-32%	19-33%
Forfeiture rate	5-9%	5-7%	5-7%

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Results of discontinued operations and other assets held for sale

12 Months Ended

Dec. 31, 2013

DiscontinuedOperationsAndDisposalGroupsAbstract

Assets of discontinued operations and other assets held for sale Disclosure

8.Resultsof discontinued operations and assets held for sale

On January 16, 2014 the Company entered into an Asset Purchase Agreement (the “Asset Purchase Agreement”) with Organogenesis Inc. (the “Purchaser” or “Organogenesis”), pursuant to which, on January 16, 2014 the Company sold and transferred to the Purchaser certain of the assets (the “Transferred Assets”) relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT (the “Business”), and the Purchaser assumed certain of the liabilities relating to the Business. The Company will receive no upfront payment from the Purchaser but is entitled to receive total milestone payments of up to $300 million in cash if the Purchaser meets certain annual net sales targets during the five consecutive calendar years ending with the calendar year ending December 31, 2018.

The Transferred Assets include intellectual property relating to DERMAGRAFT, including patents, trademarks and know-how, regulatory filings and registrations relating to DERMAGRAFT ($611.4 million), certain manufacturing plant, equipment and materials relating to the Business ($29.1 million), and DERMAGRAFT product inventory ($16.2 million) and accounts receivable ($11.8million). The Company is generally retaining liabilities incurred prior to the date of the Asset Purchase Agreement relating to the DERMAGRAFT business, including the previously disclosed investigation by the US Department of Justice relating to the sales and marketing practices of Advanced Biohealing, Inc. (“ABH”).

The Transferred Assets have been measured at their fair value less costs to sell, amounting to $31.6 million, and are presented within “Assets held-for-sale” in the consolidated balance sheet as at December 31, 2013. The fair value of these assets was determined using the income approach, which used significant unobservable (Level 3) inputs (see Note 21 for further details).

On October 22, 2013 Shire announced that it had decided to discontinue the construction of its new manufacturing facility in San Diego. Shire is currently assessing disposal options for this facility. In the year to December 31, 2013, the Company recorded charges of $99.6 million, comprising charges to write down the carrying value of the assets related to this manufacturing facility, accruals for non-cancellable contractual costs in relation to the construction, and a provision for the onerous land lease. These costs have been presented within discontinued operations in the consolidated income statement.

The operating results associated with the DERMAGRAFT business, including the costs of discontinuing the second manufacturing facility, have been classified as discontinued operations in the consolidated statements of income for all periods presented.

The components of discontinued operations which relate to the DERMAGRAFT business are as follows

	2013	2012	2011
	$’M	$’M	$’M
Revenues:	_______________	_______________	_______________
Product revenues	89.8	153.8	105.3
	_______________	_______________	_______________
Loss from discontinued operations before income taxes	(1,080.9)	(96.4)	(27.0)
Income taxes	326.4	36.1	9.3
	_______________	_______________	_______________
Loss from discontinued operations, net of taxes	(754.5)	(60.3)	(17.7)
	_______________	_______________	_______________

The loss from discontinued operations before income taxes in 2013 includes: $191.8million, being the proportion of the RM reporting unit goodwill impairment charge (recorded in the first quarter of 2013) that relates to the DERMAGRAFT business, $636.9million being the impairment charge recorded upon re-measurement of the divested assets to their fair value less costs to sell in the fourth quarter of 2013, and $99.6million being amounts previously recorded to Reorganization costs in relation to the DERMAGRAFT business.

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Shareholders' Equity

12 Months Ended

Dec. 31, 2013

Stockholders' Equity Note [Abstract]

Stockholders' Equity Note Disclosure

22.       Shareholders' equity

Authorized common stock

The authorized stock of Shire plc as at December 31, 2013 was 1,000,000,000 ordinary shares and 2subscriberordinary shares.

Dividends

Under Jersey law, Shire plc is entitled to make payments of dividends from its accumulated profits and other distributable reserves. At December 31, 2013 Shire plc's distributable reserves were approximately $10.4billion.

Treasury stock

The Company records the purchase of its own shares by the EBT and under share buy-back program as a reduction of shareholders' equity based on the price paid for the shares. At December 31, 2013, the EBT held 2.4 million ordinary shares (2012: 3.8 million; 2011: 4.6 million) and 0.4 million ADSs (2012: 1.1 million; 2011: 2.4 million) and shares held under share buy-back program were 7.1 million ordinary shares (2012: 2.7 million; 2011: nil) and 0.9 million ADSs (2012: 0.3 million; 2011: nil). During the year to December 31, 2013 a total of 4.2million(2012: 4.5million; 2011: 2.7million) ordinary shares and 0.8million(2012: 0.9million; 2011: 0.8million) ADSs had been purchased for total consideration of $243.8million(2012: $205.8million; 2011: $151.8million), including stamp duty and broker commission.

Share buy-back Program

In 2012 the Company commenceda share buy-back program of up to $500 million through both direct purchases of ordinary shares and through the purchase of ordinary shares underlying ADRs. The purchases have been made through independent third parties who have made trading decisions independently of, and uninfluenced by, the Company.The independence of the third parties enabled the Company to purchase ordinary shares (including ordinary shares underlying ADRs) during close periods and other prohibited periods, should they arise. The amount, timing or prices of purchases, varied based on market conditions and other factors. The shares purchased to date are held as treasury shares.

During the year ending December 31, 2013, the Company made on-market repurchases totaling 6,191,965 ordinary shares at a cost of $193 million (excluding transaction costs). This represents 1.0% of the issued share capital of the Company as at the end of the quarter. Ordinary shares purchased may be cancelled or be held as treasury shares, in accordance with the authority renewed by shareholders at the Company's Annual General Meeting (“AGM”).  At its AGM on April 24, 2012 the Company was authorized to make market purchases of up to 56,253,208 of its own ordinary shares. That authority expired at the AGM held on April 30, 2013 and was renewed. Under the new authority, which expires on the earlier of July 29, 2014 or the conclusion of the 2014 AGM, the Company was authorized to make market purchases of up to 55,741,587 of its own ordinary shares.

On November 11, 2013, contemporaneous with Shire's announcement of its acquisition of ViroPharma, the Company's share buyback program was terminated.Since the inception of the share buyback program the Company had purchased $300 million of ordinary shares and ordinary shares underlying ADRs.

Conversion of Shire's 2.75% Convertible Bonds

On November 26, 2013, Shire issued an optional redemption notice under the Trust Deed dated May 9, 2007 to holders of the Company's Bonds.Consequently, as of December 31, 2013, Bondholders had voluntarily converted the Bonds into 33,806,464 fully paid ordinary shares. See Note 15for further details.

Income Access Share Arrangements (“IAS Trust”)

Shire has put into place income access arrangements which enable ordinary shareholders, other than ADS holders, to choose whether they receive their dividends from Shire, a company tax resident in the Republic of Ireland, or from Shire Biopharmaceutical Holdings (“Old Shire”), a Shire group company tax resident in the UK.

Old Shire has issued one income access share to the Income Access Trust (the “IAS Trust”) which is held by the trustee of the IAS Trust (the “Trustee”). The mechanics of the arrangements are as follows:

• If a dividend is announced or declared by Shire plc on its ordinary shares, an amount is paid by Old Shire by way of a dividend on the income access share to the Trustee, and such amount is paid by the Trustee to ordinary shareholders who have elected (or are deemed to have elected) to receive dividends under these arrangements. The dividend which would otherwise be payable by Shire plc to its ordinary shareholders will be reduced by an amount equal to the amount paid to its ordinary shareholders by the Trustee.
• If the dividend paid on the income access share and on-paid by the Trustee to ordinary shareholders is less than the total amount of the dividend announced or declared by Shire plc on its ordinary shares, Shire plc will be obliged to pay a dividend on the relevant ordinary shares equivalent to the amount of the shortfall. In such a case, any dividend paid on the ordinary shares will generally be subject to Irish withholding tax at the rate of 20% or such lower rate as may be applicable under exemptions from withholding tax contained in Irish law.
• An ordinary shareholder is entitled to make an income access share election such that she/he will receive his/her dividends (which would otherwise be payable by Shire plc) under these arrangements from Old Shire.
• An ordinary shareholder who holds 25,000 or fewer ordinary shares at the first record date after she/he first becomes an ordinary shareholder, and who does not make a contrary election, will be deemed to have made an election (pursuant to the Shire plc articles of association) such that she/he will receive his/her dividends under these arrangements from Old Shire.

The ADS Depositary has made an election on behalf of all holders of ADSs such that they will receive dividends from Old Shire under the income access share arrangements. Dividends paid by Old Shire under the income access share arrangements will not, under current legislation, be subject to any UK or Irish withholding taxes. If a holder of ADSs does not wish to receive dividends from Old Shire under the income access share arrangements, she/he must withdraw his/her ordinary shares from the ADS program prior to the dividend record date set by the Depositary and request delivery of the Shire plc ordinary shares. This will enable him/her to receive dividends from Shire plc (if necessary, by making an election to that effect).

It is the expectation, although there can be no certainty, that Old Shire will distribute dividends on the income access share to the Trustee for the benefit of all ordinary shareholders who make (or are deemed to make) an income access share election in an amount equal to what would have been such ordinary shareholders' entitlement to dividends from Shire plc in the absence of the income access share election. If any dividend paid on the income access share and or paid to the ordinary shareholders is less than such ordinary shareholders' entitlement to dividends from Shire plc in the absence of the income access share election, the dividend on the income access share will be allocated pro rata among the ordinary shareholders and Shire plc will pay the balance to these ordinary shareholders by way of dividend. In such circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

Shire will be able to suspend or terminate these arrangements at any time, in which case the full Shire plc dividend will be paid directly by Shire plc to those ordinary shareholders (including the Depositary) who have made (or are deemed to have made) an income access share election. In such circumstances, there will be no grossing up by Shire plc in respect of, and Old Shire and Shire plc will not compensate those ordinary shareholders for, any adverse consequences including any Irish withholding tax consequences.

In the year ended December 31, 2013Old Shire paid dividends totaling $91.1million (2012: $81.5million; 2011: $67.6million) on the income access share to the Trustee in an amount equal to the dividend Shire ordinary shareholders would have received from Shire.

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Segmental Reporting (by Segment) (Details)	12 Months Ended
	Dec. 31, 2013 number
One Shire
Segment Reporting Information [Line Items]
Reportable segments	1
Commercial units	4
Historical segments
Segment Reporting Information [Line Items]
Reportable segments	3
Business units	3

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Property, Plant and Equipment, Net

12 Months Ended

Dec. 31, 2013

Property, Plant and Equipment [Abstract]

Property, Plant and Equipment Disclosure

10.Property, plant and equipment, net

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Land and buildings	695.0	701.2
Office furniture, fittings and equipment	467.0	383.8
Warehouse, laboratory and manufacturing equipment	276.2	287.2
Assets under construction	45.6	93.8
	____________	____________
	1,483.8	1,466.0
Less: Accumulated depreciation	(592.0)	(510.2)
	____________	____________
	891.8	955.8
	____________	____________

Depreciation expense for the years to December 31, 2013, 2012 and 2011 was $127.6 million, $109.0million, and $119.5million respectively.

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Business Combinations (Viropharma,SARcode, Premacure and Lotus) (Details) (USD $) In Millions, except Per Share data, unless otherwise specified	12 Months Ended			0 Months Ended	12 Months Ended		0 Months Ended	12 Months Ended				0 Months Ended	12 Months Ended		0 Months Ended	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Feb. 12, 2013 Lotus	Dec. 31, 2013 Lotus	Dec. 31, 2012 Lotus	Apr. 17, 2013 SARcode Biosciences Inc	Dec. 31, 2013 SARcode Biosciences Inc	Dec. 31, 2012 SARcode Biosciences Inc	Dec. 31, 2013 SARcode Biosciences Inc Acquisition and Integration Costs, Gross Amount	Dec. 31, 2013 SARcode Biosciences Inc Acquisition and Integration Costs, Net Amount	Mar. 08, 2013 Premacure	Dec. 31, 2013 Premacure	Dec. 31, 2012 Premacure	Jan. 24, 2014 Viropharma	Dec. 31, 2013 Viropharma	Dec. 31, 2012 Viropharma
Business Acquisition [Line Items]
Percentage of voting interests acquired				100.00%			100.00%					100.00%
Cash consideration paid				$ 49.4			$ 151.0					$ 30.6			$ 4,200.0
Maximum amount of contingent cash consideration				275.0			225.0					169.0
Integration and acquisition costs	(134.1)	13.5	0.1		2.3	0.5			0	5.3	(170.7)		9.5	0		12.8	0
Acquisition-date fair value of consideration totaled				174.2			368.0					140.2
Fair value of contingent consideration payable				124.8			217.0					109.6
Net current assets assumed				6.8
Net non-current liabilities assumed (including deferred tax liabilities)				63.4			122.4					29.5
Post acquisition pre-tax losses included in consolidated statement of income								26.0
IPR&D				176.7			412.0					151.8
Goodwill arising on business acquired	170.3	48.1		54.1	54.1		86.6	86.6				29.6
Net current liabilities assumed							8.2					11.7
Purchase price paid per share of acquiree (in USD per share)															$ 50
Change in fair value of contingent consideration											$ (176.0)

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Share-based Compensation Plans (Share-based Compensation Expense) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 77.4	$ 87.1	$ 75.7
Less tax	(18.1)	(23.8)	(23.6)
Share-based compensation expense, net	59.3	63.3	52.1
Unrecognized compensation cost relating to non-vested awards	97.0	102.3
Unrecognized compensation cost relating to non-vested awards, expected period for recognition	3 years
Unrecognized compensation cost relating to non-vested in the money awards	90.3	74.6
Unrecognized compensation cost relating to non-vested in the money awards, expected period for recognition	1 year 8 months	1 year 8 months
Fair value of in the money awards vested	70.5	113.9
Cost of Product Sales
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	4.4	6.3	8.8
Research and Development
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	22.8	25.8	21.8
Selling, General and Administrative
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	46.9	55.0	45.1
Reorganization costs
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Share-based compensation expense	$ 3.3	$ 0	$ 0

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Consolidated Statements of Comprehensive Income (Parenthetical) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Statement of Income and Comprehensive Income [Abstract]
Unrealized holding (loss)/gain on available-for-sale securities, tax	$ 0.1	$ 2.5	$ 0.2
Other than temporary impairment of available-for-sale securities, tax	0	0	0
Realized gain on divestment of available-for-sale securities, tax	$ 0	$ 0	$ 3.5

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Consolidated Balance Sheets (Parenthetical) (GBP £) In Millions, except Per Share data, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Statement of Financial Position [Abstract]
Common Stock, Par Value (in USD per share)	£ 0.05	£ 0.05
Common Stock, Shares Authorized	1,000	1,000
Common Stock, Shares, Issued	597.5	562.5
Common Stock, Shares, Outstanding	597.5	562.5
Treasury Stock, Shares	13.4	10.7

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Business Combinations

12 Months Ended

Dec. 31, 2013

Business Combinations [Abstract]

Business Combination Disclosure

3.       Business combinations

Acquisition of ViroPharmaInc. (“ViroPharma”)

On November 11, 2013, Shire signed a definitive agreement to acquire all of the outstanding share capital of ViroPharma for $50 per share in cash or approximately $4,200 million. The transaction was completed on January 24, 2014 at which time ViroPharma became a wholly-owned subsidiary.

ViroPharma is a high growth, rare disease biopharmaceutical company, whose commercial product CINRYZE (C1 esterase inhibitor [human]), is a leading brand for the prophylactic treatment of Hereditary Angioedema (“HAE”).

The acquisition of ViroPharma will be accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ViroPharma will be recorded at the date of acquisition, at their fair value. Shire's consolidated financial statements will reflect these fair values at, and the results of ViroPharma will be included in Shire's consolidated statement of income from, January 24, 2014. As the initial accounting for the business combination has not yet been completed, further disclosure relating to this acquisition will be included in the Company's Form 10-Q for the three months ended March 31, 2014.

In the year to December 31, 2013 the Company expensed costs of $12.8 million (2012: $nil) relating to the acquisition of ViroPharma, which have been recorded within integration and acquisition costs in the Company's consolidated income statement.

Acquisition of SARcode Bioscience Inc.(“SARcode”)

On April 17, 2013 Shire completed the acquisition of 100% of the outstanding share capital of SARcode. The acquisition date fair value of consideration totaled $368 million, comprising cash consideration paid on closing of $151 million and the acquisition date fair value of contingent consideration payable of $217 million. Following top-line Phase 3 study results in December 2013, the maximum amount of contingent cash consideration which may now be payable by Shire in future periods is $225 million dependent upon achievement of certain net sales milestones.

This acquisition brings the global rights of a new Phase 3 compound, Lifitegrast, currently under development for the treatment of Dry Eye disease, into Shire's portfolio. Top-line results from OPUS-2, a Phase 3 efficacy and safety study of 5.0% Lifitegrast ophthalmic solution, were announced on December 6, 2013. Shire intends to investigate the full data from OPUS-2 and is planning further interactions with the FDA in the first half of 2014 in order to advance this program.

The acquisition of SARcode has been accounted as a business combination using the acquisition method. The assets and liabilities assumed from SARcode have been recorded at their fair values at the date of acquisition, being April 17, 2013. The Company's consolidated financial statements and results of operations include the results of SARcode from April 17, 2013.In the year to December 31, 2013 the Company's consolidatedincome statement includes pre-tax losses of $26.0 million in relation to the post acquisition results of SARcode.

The purchase price has been allocated to acquired in process research and development (“IPR&D”) in respect of Lifitegrast ($412 million), net current liabilities assumed ($8.2 million), net non-current liabilities assumed, including deferred tax liabilities ($122.4 million) and goodwill ($86.6 million). This acquisition resulted in goodwill of $86.6 million, which is not deductible for tax purposes. Goodwill includes the value of the assembled workforce and the related scientific expertise in ophthalmology which allows for potential expansion into a new therapeutic area.

In the year to December 31, 2013 the Company recorded a net credit of $170.7 million (2012: $nil) within Integration and acquisition costs relating to the acquisition of SARcode.This amount principally comprises a credit of $176.0 million on re-measuring the fair value of the contingent consideration payable following OPUS-2 trial results. In addition, acquisition and integration costs related to SARcode amounted to $5.3 million.

Acquisition of Premacure AB (“Premacure”)

On March 8, 2013 Shire completed the acquisition of 100% of the outstanding share capital of Premacure. The acquisition date fair value of the consideration totaled $140.2 million, comprising cash consideration paid on closing of $30.6 million, and the fair value of contingent consideration payable of $109.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods, dependent upon the successful completion of certain development and commercial milestones, is $169 million. Shire will also pay royalties on relevant net sales.

Premacure is developing a protein replacement therapy(“PREMIPLEX”), currently in Phase 2 development, for the prevention of Retinopathy of Prematurity (“ROP”). ROP is a rare and potentially blinding eye disorder that primarily affects premature infants and is one of the most common causes of visual loss in childhood. Together, the acquisitions of SARcode and Premacure build Shire's presence in the ophthalmology therapeutic area.

The acquisition of Premacure has been accounted for as a business combinationusing the acquisition method. The assets and the liabilities assumed from Premacure have been recorded at their fair values at the date of acquisition, being March 8, 2013. The Company's consolidated financial statements and results of operations include the results of Premacure from March 8, 2013.

The purchase price has been allocated to acquired IPR&D in respect of PREMIPLEX ($151.8 million), net current liabilities assumed ($11.7 million), net non-current liabilities assumed, including deferred tax liabilities ($29.5 million) and goodwill ($29.6 million). This acquisition resulted in goodwill of $29.6 million, which is not deductible for tax purposes.

In the year to December 31, 2013 the Company expensed costs of $9.5 million (2012: nil) relating to the acquisition of Premacure(including charges related to the change in fair value of contingent consideration payable), which have been recorded within integration and acquisition costs in the Company's consolidated income statement.

Acquisition of Lotus Tissue Repair, Inc. (“LotusTissue Repair”)

On February12, 2013 Shire completed the acquisition of 100% of the outstanding share capital ofLotus Tissue Repair.The acquisition date fair value of consideration totaled $174.2 million, comprising cash consideration paid on closing of $49.4 million, and the fair value of contingent consideration payable of $124.8 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $275 million.The amount of contingent cash consideration ultimately payable by Shire is dependent upon achievement of certain pre-clinical and clinical development milestones.

Lotus Tissue Repair is developing a proprietary recombinant form of human collagen Type VII (“rC7”) as the first and only intravenous protein replacement therapy currently being investigated for the treatment of Dystrophic EpidermolysisBullosa (“DEB”).  DEB is a devastating orphan disease for which there is no currently approved treatment option other than palliative care. The acquisition adds to Shire's pipeline a late stage pre-clinical product for the treatment of DEB with global rights.

The acquisition of Lotus Tissue Repair has been accounted for as a business combination using the acquisition method. The assets and the liabilities assumed from Lotus Tissue Repair have been recorded at their fair values at the date of acquisition, being February 12, 2013. The Company's consolidated financial statements and results of operations include the results of Lotus Tissue Repair from February 12, 2013.

The purchase price has been allocated to acquired IPR&D in respect of rC7 ($176.7 million), net current assets assumed ($6.8 million), net non-current liabilities assumed, including deferred tax liabilities ($63.4 million) and goodwill ($54.1 million). This acquisition resulted in goodwill of $54.1 million, which is not deductible for tax purposes.

In the year to December 31, 2013 the Company expensed costs of $2.3 million (2012:$0.5 million) relating to the acquisition of Lotus Tissue Repair, which have been recorded within integration and acquisition costs in the Company's consolidated income statement.

Acquisition of FerroKinBioSciences, Inc. (“FerroKin”)

On April 2, 2012 Shire completed the acquisition of 100% of the outstanding share capital of FerroKin. The acquisition-date fair value of consideration totalled $159.3 million, comprising cash consideration paid on closing of $94.5 million and the fair value of contingent consideration payable of $64.8 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is $225.0 million. The amount of contingent cash consideration ultimately payable by Shire is dependent upon the achievement of certain clinical development, regulatory and net sales milestones.

The acquisition of FerroKin adds global rights to a Phase 2 product, SHP 602 (formerly referred to as FBS0701), to Shire's SP pipeline. SHP 602 is intended to serve a chronic patient need for treatment of iron overload following numerous blood transfusions. Together with the Company's collaboration with Sangamo Biosciences Inc. (“Sangamo”), this acquisition is a strategic step in building Shire's hematology business, which already includes XAGRID and a growing development pipeline.

The acquisition of FerroKin has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from FerroKin have been recorded at their fair values at the date of acquisition, being April 2, 2012. The Company's consolidated financial statements and results of operations include the results of FerroKin from April 2, 2012. In the year to December 31, 2012 the Company included pre-tax losses of $19.1 million, for FerroKin within its consolidated statement of income.

The purchase price has been allocated to acquired in-process research and development (“IPR&D”)in respect of SHP602 ($166.0 million), net current liabilities assumed ($6.6 million), net non-current liabilities assumed (including deferred tax liabilities) ($46.2 million) and goodwill ($46.1 million). Goodwill arising of $46.1million is not deductible for tax purposes.

In the year to December 31, 2013 the Company expensed costs of $10.4 million (2012: $12.1 million) relating to the FerroKin acquisition, which have been recorded within Integration and acquisition costs in the Company's consolidated statement of income.

Acquisition of certain assets & liabilities of Pervasis Therapeutics, Inc. (“Pervasis”)

On April 19, 2012 Shire acquired substantially all the assets and certain liabilities of Pervasis. The acquisition date fair value of the consideration totaled $26.1 million, comprising cash consideration paid on closing of $2.5 million and the fair value of contingent consideration payable of $23.6 million. The maximum amount of contingent cash consideration which may be payable by Shire in future periods is up to $169.5 million. The amount of contingent cash consideration ultimately payable by Shire isdependent upon achievement of certain clinical development, regulatory and net sales milestones. The acquisition adds SHP613 (formerly VASCUGEL) to Shire's pipeline. SHP613 is currently in Phase 2 development for acute vascular repair, focused on improving hemodialysis access for patients with end-stage renal disease.

The acquisition has been accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from Pervasishave been recorded at their fair values at the date of acquisition, being April 19, 2012.The Company's consolidated financial statements and results of operations include the results of the assets acquired and the liabilities assumed from Pervasis from April 19, 2012. The purchase price has been allocated to acquired IPR&D (principally for VASCUGEL) ($24.3 million), current liabilities assumed ($0.2 million) and goodwill ($2.0 million). Goodwill arising of $2.0 million is not deductible for tax purposes.

Acquisition of Advanced BioHealing, Inc. (“ABH”)

On June 28, 2011 Shire completed its acquisition of 100% of the outstanding shares and other equity instruments of ABH. The fair value of cash consideration paid by the Company during 2011 was$739.6 million.

On January 16, 2014, the Company sold and transferred certain of the assets relating to the manufacturing, marketing, sale and distribution of DERMAGRAFT to Organogenesis Inc. For further information, see Note 8, “Results of discontinued operations and other assets held for sale” to the consolidated financial statements set forth in this Annual Report on Form 10-K.

The acquisition of ABH was accounted for as a business combination using the acquisition method. The assets acquired and the liabilities assumed from ABH have been recorded at their fair values at the date of acquisition, being June 28, 2011. The determination of final fair values was completed on June 28, 2012. The Company's consolidated financial statements and results of operations include the results of ABH from June 28, 2011. The amount of ABH's revenues and pre-tax losses included in the Company's consolidated statement of income for the year ended December 31, 2011 were $105.3 million and $15.3 million (after intangible asset amortization of $20.0 million) respectively.

The Company's allocation of the purchase price to the assets acquired and liabilities assumed is outlined below:

	Fair value
	$’M
ASSETS
Current assets:
Cash and cash equivalents	14.6
Accounts receivable	30.1
Inventories	30.7
Deferred tax assets	51.1
Other current assets	7.9
	_______________
Total current assets	134.4
Non-current assets:
Property, plant and equipment	16.6
Goodwill	197.0
Other intangible assets
- DERMAGRAFT product technology	710.0
- other intangible assets	1.5
Other non-current assets	0.2
	_______________
Total assets	1,059.7
	_______________
LIABILITIES
Current liabilities:
Accounts payable and other current liabilities	52.4
Non-current liabilities:
Long term debt, less current portion	9.1
Deferred tax liabilities	258.5
Other non-current liabilities	0.1
	_______________
Total liabilities	320.1
	_______________
Fair value of identifiable assets acquired and liabilities assumed	739.6
Consideration	_______________
Cash consideration paid	739.6
	_______________

Supplemental disclosure of proforma information

The unaudited pro forma financial information to present the combined results of the operations of Shire, SARcode, Premacure and Lotus Tissue Repair are not provided as the impacts of these acquisitions were not material to the Company's results of continuing operations for any period presented.

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Taxation (Pretax Income from Continuing Operations and Provision for Income Taxes) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Components of pre tax income from continuing operations
Income from continuing operations before income taxes and equity in earnings of equity method investees	$ 1,693.6	$ 1,007.8	$ 1,117.1
Current income taxes:
Other, current	63.4	29.0	40.0
Total current taxes	355.6	270.3	248.8
Deferred taxes:
Other, deferred	(104.7)	(10.0)	(29.6)
Total deferred taxes	(77.7)	(67.2)	(11.9)
Total income taxes	277.9	203.1	236.9
Republic of Ireland
Current income taxes:
Current domestic tax expense (benefit)	0	0	(1.8)
US federal tax
Current income taxes:
Current foreign tax expense (benefit)	274.3	230.0	201.4
Deferred taxes:
Deferred foreign tax expense (benefit)	23.8	(63.8)	23.3
US state and local taxes
Current income taxes:
Current foreign tax expense (benefit)	17.9	11.3	9.2
Deferred taxes:
Deferred foreign tax expense (benefit)	(8.3)	(6.5)	(4.6)
UK corporation tax
Current income taxes:
Current foreign tax expense (benefit)			0
Deferred taxes:
Deferred foreign tax expense (benefit)	11.5	13.1	(1.0)
US Operations
Deferred taxes:
Total income taxes	9.0
Ireland
Components of pre tax income from continuing operations
Republic of Ireland	(47.8)	(74.7)	(65.9)
United Kingdom
Components of pre tax income from continuing operations
Pre-tax income from continuing operations, foreign	10.9	30.7	45.4
United States
Components of pre tax income from continuing operations
Pre-tax income from continuing operations, foreign	1,153.3	683.8	774.6
Other jurisdictions
Components of pre tax income from continuing operations
Pre-tax income from continuing operations, foreign	$ 577.2	$ 368.0	$ 363.0

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Fair Value Measurement (Assets and Liabilities That are Measured and Not Measured at Fair Value on a Recurring Basis) (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013		Dec. 31, 2012
Financial liabilities:
Convertible bonds	$ 0		$ 1,100.0
Carrying value
Financial liabilities:
Building financing obligation	7.8		8.0
Convertible bonds	0
Convertible bonds			1,100.0
Estimated fair value
Financial liabilities:
Convertible bond	0		1,228.2
Building financing obligation	10.1		10.3
Recurring Basis | Carrying value
Financial assets:
Available-for-sale securities	6.7	[1]	14.2	[1]
Contingent consideration receivable	36.1	[2]	38.3	[2]
Foreign exchange contracts, asset	4.0		1.3
Financial liabilities:
Foreign exchange contracts, liability	2.8		3.0
Contingent consideration payable	405.9	[3]	136.4	[3]
Recurring Basis | Estimated fair value
Financial assets:
Available-for-sale securities	6.7	[1]	14.2	[1]
Contingent consideration receivable	36.1	[2]	38.3	[2]
Foreign exchange contracts, asset	4.0		1.3
Financial liabilities:
Foreign exchange contracts, liability	2.8		3.0
Contingent consideration payable	405.9	[3]	136.4	[3]
Recurring Basis | Level 1
Financial assets:
Available-for-sale securities	6.7	[1]	14.2	[1]
Contingent consideration receivable	0	[2]	0	[2]
Foreign exchange contracts, asset	0		0
Financial liabilities:
Foreign exchange contracts, liability	0		0
Contingent consideration payable	0	[3]	0	[3]
Recurring Basis | Level 2
Financial assets:
Available-for-sale securities	0	[1]	0	[1]
Contingent consideration receivable	0	[2]	0	[2]
Foreign exchange contracts, asset	4.0		1.3
Financial liabilities:
Foreign exchange contracts, liability	2.8		3.0
Contingent consideration payable	0	[3]	0	[3]
Recurring Basis | Level 3
Financial assets:
Available-for-sale securities	0	[1]	0	[1]
Contingent consideration receivable	36.1	[2]	38.3	[2]
Foreign exchange contracts, asset	0		0
Financial liabilities:
Foreign exchange contracts, liability	0		0
Contingent consideration payable	$ 405.9	[3]	$ 136.4	[3]

[1] Available-for-sale securities are included within Investments in the consolidated balance sheet.

[2] Contingent consideration receivable is included within Prepaid expenses and other current assets and Other non-current assets in the consolidated balance sheet.

[3] Contingent consideration payable is included within Other current liabilities and Other non-current liabilities in the consolidated balance sheet.

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Financial Instruments (Foreign Exchange Risk and Its Classification on Balance Sheet) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2013 Foreign Exchange Contract contract	Dec. 31, 2013 Foreign Exchange Contract Prepaid expenses and other current assets	Dec. 31, 2012 Foreign Exchange Contract Prepaid expenses and other current assets	Dec. 31, 2013 Foreign Exchange Contract Other current liabilities	Dec. 31, 2012 Foreign Exchange Contract Other current liabilities
Derivatives, Fair Value
Assets			$ 4.0	$ 1.3
Liabilities					2.8	3.0
Net derivative fair value assets		3.3
Net derivative fair value liabilities		2.1
Potential effect of rights of set off associated with the foreign exchange contracts		$ 0.7
Number of swap and forward foreign exchange contracts outstanding		29
Swaps and forward contracts maturity	90 days

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Document and Entity Information (USD $) In Billions, except Share data in Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Feb. 14, 2014	Jun. 30, 2013
Document and Entity Information [Abstract]
Document Type	10-K
Document Period End Date	Dec. 31, 2013
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity Central Index Key	0000936402
Entity Current Reporting Status	Yes
Entity Filer Category	Large Accelerated Filer
Entity Registrant Name	Shire plc
Entity Voluntary Filers	No
Entity Well-known Seasoned Issuer	Yes
Entity Common Stock, Shares Outstanding		597.7
Document Fiscal Year Focus	2013
Document Fiscal Period Focus	FY
Entity Public Float			$ 17.4

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Divestment of Product Rights

12 Months Ended

Dec. 31, 2013

Gains (Losses) on Sales of Assets [Abstract]

Divestment of product rights

4.Divestment of product rights

On October 1, 2010 the Company completed the divestment of DAYTRANA to Noven(Noven developed and manufactures DAYTRANA, and Shire licensed DAYTRANA from Noven in 2003). No consideration was received at the time of divestment, however consideration is receivable from Noven dependent on DAYTRANA's performance in the period subsequent to divestment. On divestment Shire recorded the fair value of contingent consideration receivable from Noven within current and non-current assets. During the year to December 31, 2013the Company recognized a gain of $15.9million (2012: gain of $18.1million, 2011: loss of $6.0 million) due to changes in the fair value of this contingent consideration. At December 31, 2013the Company has recorded a receivablebased on the fair value of future contingent consideration totaling $36.1million (2012: $39.2million), split between current assets $9.6million(2012: $11.6million) and non-current assets $26.5million (2012: $27.6million).

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Other Intangible Assets, Net (Roll Forward) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Other Intangible Assets Roll Forward
As at January 1,	$ 2,388.1	$ 2,493.0
Acquisitions	731.8	281.6
Impairment charges	(19.9)	(197.9)	(16.0)
Reclassification of Dermagraft product technology to assets held for sale	(611.4)	0
Foreign currency translation	15.4	5.5
As at December 31,	2,312.6	2,388.1	2,493.0
Continung operations
Other Intangible Assets Roll Forward
Amortization charged	(152.0)	(153.6)
Discontinued operations
Other Intangible Assets Roll Forward
Amortization charged	(39.4)	(40.5)
DERMAGRAFT
Other Intangible Assets Roll Forward
Reclassification of Dermagraft product technology to assets held for sale	$ 611.4

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Financial Instruments (Interest Rate and Credit Risks) (Details) (USD $)	12 Months Ended
	Dec. 31, 2013 contract
Interest rate risk
Average interest rate received on cash and liquid investments	less than 1% per annum
Debt Instrument [Line Items]
Principal amount	$ 1,100,000,000
Stated interest rate	2.75%
Accounts Receivable
Number of major external customers	3
Product Sales
Accounts Receivable
Concentration risk percentage	52.00%
Government-owned or Supported Healthcare Providers | Italy
Accounts Receivable
Accounts receivable received	144,700,000
Government-owned or Supported Healthcare Providers | Spain
Accounts Receivable
Accounts receivable received	116,800,000
Term Loan Facility One, to finance the acquisition of Viropharma and for the redemption of Shire's Bonds
Debt Instrument [Line Items]
Term loan facility	550,000,000
Term Loan Facilitly Two, to finance the acquisition of Viropharma only
Debt Instrument [Line Items]
Term loan facility	850,000,000
Revolving Credit Facility
Debt Instrument [Line Items]
Principal amount	1,200,000,000
Shire 2.75% Convertible Bond due 2014
Debt Instrument [Line Items]
Principal amount	$ 1,100,000,000
Stated interest rate	2.75%

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Consolidated Statements of Income (USD $) In Millions, except Per Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Revenues:
Product sales	$ 4,757.5		$ 4,252.9		$ 3,844.9
Royalties	153.7		241.6		283.5
Other revenues	23.1		32.9		29.7
Total revenues	4,934.3		4,527.4		4,158.1
Costs and expenses:
Cost of product sales	670.8		585.8		551.7
Research and development	933.4	[1]	953.0	[1]	764.5	[1]
Selling, general and administrative	1,651.3	[1]	1,948.0	[1]	1,675.7	[1]
Goodwill impairment charge	7.1		0		0
(Gain)/ loss on sale of product rights	(15.9)		(18.1)		6.0
Reorganization costs	88.2		0		24.3
Integration and acquisition costs	(134.1)		13.5		0.1
Total operating expenses	3,200.8		3,482.2		3,022.3
Operating income from continuing operations	1,733.5		1,045.2		1,135.8
Interest income	2.1		3.0		1.9
Interest expense	(38.1)		(38.2)		(39.1)
Other (expense)/income, net	(3.9)		(2.2)		18.5
Total other expense, net	(39.9)		(37.4)		(18.7)
Income from continuing operations before income taxes and equity in earnings of equity method investees	1,693.6		1,007.8		1,117.1
Income taxes	(277.9)		(203.1)		(236.9)
Equity in earnings of equity method investees, net of taxes	3.9		1.0		2.5
Income from continuing operations, net of taxes	1,419.6		805.7		882.7
Loss from discontinued operations, net of taxes	(754.5)		(60.3)		(17.7)
Net income	$ 665.1		$ 745.4		$ 865.0
Earnings from continuing operations (in USD per share)	$ 2.572		$ 1.451		$ 1.601
Loss from discontinued operations (in USD per share)	$ (1.367)		$ (0.109)		$ (0.032)
Earnings per ordinary share - basic (in USD per share)	$ 1.205		$ 1.342		$ 1.569
Earnings from continuing operations (in USD per share)	$ 2.453		$ 1.410		$ 1.539
Loss from discontinued operations (in USD per share)	$ (1.278)		$ (0.101)		$ (0.030)
Earnings per ordinary share - diluted (in USD per share)	$ 1.175		$ 1.309		$ 1.509
Weighted average number of shares:
Basic (in shares)	552.0	[2]	555.4	[2]	551.1	[2]
Diluted (in shares)	590.3		593.5		595.4

[1] Research and development (“R&D”) includes intangible asset impairment charges of $19.9 million (2012: $71.2 million, 2011: $16.0 million) for the year to December 31, 2013. Selling, general and administrative (“SG&A”) costs include amortization and impairment charges of intangible assets relating to intellectual property rights acquired of $152.0 million for the year to December 31, 2013 (2012: $280.3 million, 2011: $145.0 million).

[2] Excludes shares purchased by the EBT and under the share buy-back program and presented by Shire as treasury stock

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Shire Income Access Share Trust Statement of Income (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Net income	$ 665.1	$ 745.4	$ 865.0
Shire Income Access Share Trust [Member]
Dividend income	91.1	81.5	67.6
Net income	$ 91.1	$ 81.5	$ 67.6

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Shire Income Access Share Trust Balance Sheet (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
ASSETS
Total assets	$ 8,323.0	$ 7,317.2
LIABILITIES AND EQUITY
Total liabilities	2,957.0	3,508.0
Equity:
Total equity	5,366.0	3,809.2
Total liabilities and equity	8,323.0	7,317.2
Shire Income Access Share Trust
ASSETS
Total assets	0	0
LIABILITIES AND EQUITY
Total liabilities	0	0
Equity:
Total equity	0	0
Total liabilities and equity	$ 0	$ 0

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Prepaid Expenses and Other Current Assets

12 Months Ended

Dec. 31, 2013

Prepaid Expense and Other Assets, Current [Abstract]

Prepaid Expense and Other Assets, Current

9.       Prepaid expenses and other current assets

	December 31,	December 31,
	2013	2012
	$’M	$’M
	______________	____________
Prepaid expenses	29.4	31.7
Income tax receivable	177.4	130.6
Value added taxes receivable	14.5	20.9
Other current assets	41.7	38.6
	______________	______________
	263.0	221.8
	______________	______________

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Reorganization Costs

12 Months Ended

Dec. 31, 2013

Restructuring and Related Activities [Abstract]

Reorganization Costs Disclosure

5.Reorganization costs

Turnhout, Belgium Site Closure

On January 23, 2013 Shire announced that it had decided to proceed with a collective dismissal and business closure at its site in Turnhout, Belgium. This decision follows the conclusion of an information and consultation process. Shire will continue to sell RESOLOR in Europe and the supply of RESOLOR for patients in Europe who rely on the medicine will not be affected. The closure of the Turnhout site was completed during 2013. In the year to December 31, 2013 the Company incurred reorganization costs totaling $23.6 million, relating to employee involuntary termination benefits and other re-organization costs.

One Shire business reorganization

On May 2, 2013, the Company announced that there would be a reorganization of the business to integrate the three divisions into a simplified One Shire organization in order to drive future growth and innovation.

On November 7, 2013 the Company announced that, as part of the One Shire reorganization, the Company had undertaken a review of all of Shire's pipeline programs to identify those projects that fit with Shire's new strategic direction and have an acceptable likelihood of success. Shire's pre-clinical investments will now be primarily focused on Rare Diseases, meaning that the majority of other pre-clinical projects will not continue. Several clinical programs have also been discontinued. The impact of the prioritization and rationalization of the Company's development portfolio means many of the R&D programs currently run from Basingstoke, UK will cease. Taken together with the overall streamlining of the R&D organization, this has resulted in a significant number of R&D roles in Basingstoke being eliminated and some positions being re-located. A small number of functional roles that support R&D in Basingstoke have also been affected.

In addition the Company also announced plans to relocate its international commercial hub from Nyon, Switzerland to Zug, Switzerland. All Nyon-based employees have been impacted by the One Shire transition and the proposed move to Zug. Shire is planning for the new Zug office to be ready for occupancy in summer 2014, and will phase out the Nyon office over a reasonable period of time to enable employees and their families to manage their re-locations.

In the year to December 31, 2013 the Company incurred reorganization costs totaling $64.6 million, relating to employee involuntary termination benefits and other reorganization costs.The One Shire reorganization is expected to be substantially completed by the end of 2014. Currently, the Company estimates that further costs in respect of the One Shire reorganization of approximately $150 million will be expensed as incurred during 2014.

The liability for reorganization costs arising on the closure of Company's site in Turnhout, Belgium andthe One Shire business reorganization at December 31, 2013 is as follows:.

	Opening liability	Amount		Closing liability at
	at January 1,	charged to re-		December 31,
	2013	organization	Paid/Utilized	2013
	$'M	$'M	$'M	$'M
	___________	____________	___________	___________
Involuntary termination benefits	-	44.7	(29.4)	15.3
Other reorganization costs	-	43.5	(34.0)	9.5
	___________	____________	___________	___________
	-	88.2	(63.4)	24.8
	___________	___________	___________	___________

At December 31, 2013the closing reorganization cost liability was recorded within accounts payable and accrued expenses ($24.8million).

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Other long-term debt (Details) (USD $)	12 Months Ended
	Dec. 31, 2013 contract
Line of Credit Facility [Line Items]
Facility agreement initiation date	Nov. 11, 2013
Interest rate description	Interest on any loans made under the facilities will be payable on the last day of each interest period, which may be one week or one, two, three or six months at the election of Shire, or as otherwise agreed with the lenders. The interest rate applicable to the $0.55 billion term loan facility is LIBOR plus 0.75% per annum and increases by 0.25% per annum on August 11, 2014 and on three-month intervals thereafter. The interest rate applicable to the $0.85 billion term loan facility commenced at LIBOR plus 1.15% per annum until delivery of the compliance certificate for the year ending December 31, 2013 and thereafter is subject to change depending upon the prevailing ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement), in respect of the most recently completed financial year or financial half year. 17.        Other non-current liabilities
Rate of commitment fee	35.00%
Covenant terms	The Facilities Agreement includes customary representations and warranties, covenants and events of default, including requirements that the ratio of Net Debt to EBITDA of the Group (each as defined in the Facilities Agreement) must not, at any time, exceed 3.5:1 for the Relevant Period (as defined in the Facilities Agreement), except that following certain acquisitions, including the ViroPharma acquisition, Shire may elect to increase the ratio to 4.0:1 in the relevant period in which the acquisition was completed and the immediately following relevant period. In addition, for each 12-month period ending December 31 or June 30, the ratio of EBITDA of the Group to Net Interest (each as defined in the Facilities Agreement) must not be less than 4.0:1. The Facilities Agreement restricts (subject to certain covenants) Shire’s ability to incur additional financial indebtedness, grant security over its assets or provide or guarantee loans. Further, any lender may require mandatory prepayment of its participation if there is a change of control of Shire. In addition, in certain circumstances, the net proceeds of certain shares, undertakings or business disposals by Shire must be applied towards the mandatory prepayment of the facilities, subject to certain exceptions. Events of default under the facilities include: (i) non-payment of any amounts due under the facilities, (ii) failure to satisfy any financial covenants, (iii) material misrepresentation in any of the finance documents, (iv) failure to pay, or certain other defaults, under other financial indebtedness, (v) certain insolvency events or proceedings, (vi) material adverse changes in the business, operations, assets or financial condition of Shire and its subsidiaries, (vii) if it becomes unlawful for Shire or any of its subsidiaries that are parties to the Facilities Agreement to perform their obligations or (viii) if Shire or any subsidiary of Shire which is a party to the Facilities Agreement repudiates the Facilities Agreement or any other finance document, among others.The Facilities Agreement is governed by English law
Number of term loan facilities	2
Commitment fee description	Before first utilization, the commitment fee rate will increase in stages from 0% to 35% of the applicable margin over a period of 3 months.
Minimum commitment fee
Line of Credit Facility [Line Items]
Rate of commitment fee	0.00%
Maximum commitment fee
Line of Credit Facility [Line Items]
Rate of commitment fee	35.00%
Term Loan Facility One, to finance the acquisition of Viropharma and for the redemption of Shire's Bonds
Line of Credit Facility [Line Items]
Facility agreement expiration date	Nov. 10, 2014
Term loan facility	$ 550,000,000
Option to extend the maturity of credit facility	364 days
Term Loan Facilitly Two, to finance the acquisition of Viropharma only
Line of Credit Facility [Line Items]
Facility agreement expiration date	Nov. 11, 2015
Term loan facility	850,000,000
Original facility
Line of Credit Facility [Line Items]
Facilitiy agreement total amount	2,600,000,000
Original facility | Term Loan Facility One, to finance the acquisition of Viropharma and for the redemption of Shire's Bonds
Line of Credit Facility [Line Items]
Term loan facility	1,750,000,000
Original facility | Term Loan Facilitly Two, to finance the acquisition of Viropharma only
Line of Credit Facility [Line Items]
Term loan facility	850,000,000
Revised facility
Line of Credit Facility [Line Items]
Facilitiy agreement total amount	1,400,000,000
Revised facility | Term Loan Facility One, to finance the acquisition of Viropharma and for the redemption of Shire's Bonds
Line of Credit Facility [Line Items]
Term loan facility	550,000,000
Revised facility | Term Loan Facilitly Two, to finance the acquisition of Viropharma only
Line of Credit Facility [Line Items]
Term loan facility	$ 850,000,000

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Description of Operations

12 Months Ended

Dec. 31, 2013

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Description of Operations

1.Description of operations

Shire plc and its subsidiaries (collectively referred to as either “Shire”, or the “Company”) is a leading specialty biopharmaceutical company that focuses on developing and marketing innovative specialty medicines that address significant unmet patient needs.

The Company has grown through acquisition, completing a series of major transactions that have brought therapeutic, geographic and pipeline growth and diversification. The Company will continue to evaluate companies, products and pipeline opportunities that offer a good strategic fit and have the potential to deliver demonstrable value to all of the Company's stakeholders: patients, physicians, policy makers, payors, investors and employees.

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Financial Instruments (Tables)

12 Months Ended

Dec. 31, 2013

Derivative Instrument Detail [Abstract]

Schedule of Foreign Exchange Contracts, Statement of Financial Position

		Fair value	Fair value
		December 31,	December 31,
		2013	2012
		$’M	$’M
		_____________	_____________
Assets	Prepaid expenses and other current assets	4.0	1.3
Liabilities	Other current liabilities	2.8	3.0
		_____________	_____________

Schedule of Foreign Exchange Contracts, Gain (Loss) in Other Income (Expense)

	Location of net (loss)/gain recognized in income	Amount of net (loss)/gain recognized in income
	__________________________________	____________		____________
In the year to		December 31,	December 31,	December 31,
		2013	2012	2011
		$’M	$’M	$’M
		_____________	_____________	_____________
Foreign exchange contracts	Other income, net	(1.8)	6.2	21.3
		_____________	_____________	_____________

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Share-based Compensation Plans (Stock Options and SARs) (Details) (GBP £) In Millions, except Share data, unless otherwise specified	12 Months Ended
	Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Weighted average grant date fair value of awards granted (per share)	£ 3.37
SARs and Stock Options
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Outstanding as at beginning of period (in shares)	18,536,947
Granted (in shares)	6,914,026
Exercised (in shares)	(8,302,740)
Forfeited (in shares)	(2,119,051)
Outstanding as at end of period (in shares)	15,029,182
Exercisable as at end of period (in shares)	3,670,446
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding as at beginning of period (per share)	£ 16.66
Granted (per share)	£ 20.05
Exercised (per share)	£ 22.09
Forfeited (per share)	£ 18.30
Outstanding as at end of period (per share)	£ 18.88
Exercisable as at end of period (per share)	£ 15.67
Outstanding as at end of period Intrinsic Value (in GBP)	£ 143.9
Exercisable as at end of period Intrinsic Value (in GBP)	£ 46.9
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Abstract]
Number of awards outstanding (in shares)	15,029,182
Number of awards exercisable	3,670,446
SARs and Stock Options | 3.38-7.00 GBP
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Abstract]
Number of awards outstanding (in shares)	104,658
Weighted average remaining contractual term	1 year 1 month
Weighted average exercise price of awards outstanding (per share)	£ 5.56
Number of awards exercisable	104,658
Weighted average exercise price of awards exercisable (per share)	£ 5.56
SARs and Stock Options | 7.01-14.00 GBP
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Abstract]
Number of awards outstanding (in shares)	810,822
Weighted average remaining contractual term	2 years 10 months
Weighted average exercise price of awards outstanding (per share)	£ 11.27
Number of awards exercisable	804,402
Weighted average exercise price of awards exercisable (per share)	£ 11.25
SARs and Stock Options | 14.01-28.00 GBP
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Abstract]
Number of awards outstanding (in shares)	14,113,702
Weighted average remaining contractual term	4 years 11 months
Weighted average exercise price of awards outstanding (per share)	£ 18.07
Number of awards exercisable	2,761,386
Weighted average exercise price of awards exercisable (per share)	£ 17.34

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Shire Income Access Share Trust Statements of Changes in Equity (USD $) In Millions	Total		Shire Income Access Share Trust	Shire Income Access Share Trust Capital account	Shire Income Access Share Trust Revenue account
As at Dec. 31, 2010	$ 2,451.4		$ 0	$ 0	$ 0
Net income	865.0		67.6	0	67.6
Distributions made	(73.8)	[1]	(67.6)	0	(67.6)
As at Dec. 31, 2011	3,185.0		0	0	0
Net income	745.4		81.5	0	81.5
Distributions made	(86.3)	[2]	(81.5)	0	(81.5)
As at Dec. 31, 2012	3,809.2		0	0	0
Net income	665.1		91.1	0	91.1
Distributions made	(96.4)	[3]	(91.1)	0	(91.1)
As at Dec. 31, 2013	$ 5,366.0		$ 0	$ 0	$ 0

[1] Dividends per share During the year to December 31, 2011 Shire plc declared and paid dividends of 13.33 US cents per ordinary share (equivalent to 39.99 US cents per ADS) totaling $73.8 million.

[2] Dividends per share During the year to December 31, 2012 Shire plc declared and paid dividends of 15.32 US cents per ordinary share (equivalent to 45.96 US cents per ADS) totaling $86.3 million

[3] Dividends per share During the year to December 31, 2013 Shire plc declared and paid dividends of 17.60 US cents per ordinary share (equivalent to 52.80 US cents per ADS) totalling $96.4 million

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Shire Income Access Share Trust Statements of Cashflows (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 665.1	$ 745.4	$ 865.0
Net cash provided by operating activities	1,463.0	1,382.9	1,073.6
CASH FLOWS FROM INVESTING ACTIVITIES:
Net cash provided by investing activities	(360.9)	(271.0)	(809.2)
CASH FLOWS FROM FINANCING ACTIVITIES:
Net cash used in financing activities	(344.6)	(244.3)	(195.4)
Net increase in cash and cash equivalents	757.2	862.2	69.4
Cash and cash equivalents at beginning of period	1,482.2	620.0	550.6
Cash and cash equivalents at end of period	2,239.4	1,482.2	620.0
Shire Income Access Share Trust
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	91.1	81.5	67.6
Net cash provided by operating activities	91.1	81.5	67.6
CASH FLOWS FROM INVESTING ACTIVITIES:
Net cash provided by investing activities	0	0	0
CASH FLOWS FROM FINANCING ACTIVITIES:
Distributions made	(91.1)	(81.5)	(67.6)
Net cash used in financing activities	(91.1)	(81.5)	(67.6)
Net increase in cash and cash equivalents	0	0	0
Cash and cash equivalents at beginning of period	0	0	0
Cash and cash equivalents at end of period	$ 0	$ 0	$ 0

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Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2013

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2.       Summary of significant accounting policies

(a)       Basis of preparation

The accompanying consolidated financial statements include the accounts of Shire plc, all of its subsidiary undertakings and the Income Access Share trust, after elimination of inter-company accounts and transactions. They have been prepared in accordance with generally accepted accounting principles in the United States of America (“US GAAP”) and US Securities and Exchange Commission (“SEC”) regulations for annual reporting.

(b)       Use of estimates in consolidated financial statements

The preparation of consolidated financial statements, in conformity with US GAAP and SEC regulations, requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent assets and liabilities at the date of the consolidated financial statements and reported amounts of revenues and expenses during the reporting period. Estimates and assumptions are primarily made in relation to the valuation of intangible assets, sales deductions, income taxes (including provisions for uncertain tax positions and the realization of deferred tax assets), provisions for litigation and legal proceedings, contingent consideration receivable from product divestments,contingent consideration payable in respect of business combinations and asset purchasesand assets held for sale. If actual results differ from the Company's estimates, or to the extent these estimates are adjusted in future periods, the Company's results of operations could either benefit from, or be adversely affected by, any such change in estimate.

(c)       Revenue recognition

The Company recognizes revenue when all of the following conditions are met:

•       there is persuasive evidence of an agreement or arrangement;

•       delivery of products has occurred or services have been rendered;

•       the seller's price to the buyer is fixed or determinable; and

•       collectability is reasonably assured.

Where applicable, all revenues are stated net of value added and similar taxes, and trade discounts. No revenue is recognized for consideration, the value or receipt of which is dependent on future events or future performance.

The Company's principal revenue streams and their respective accounting treatments are discussed below:

Product sales

Revenue for the sale of products is recognized when delivery has occurred and substantially all the risks and rewards of ownership have been transferred to the customer. Provisions for rebates, product returns and discounts to customers are provided for as reductions to revenue in the same period as the related sales are recorded. The provisions made at the time of revenue recognition are based on historical experience and updated for changes in facts and circumstances including the impact of new legislation. The provisions are recognized as a reduction to revenues.

Royalty income

Royalty income relating to licensed technology is recognized when the licensee sells the underlying product, with the amount of royalty income recorded based on sales information received from the relevant licensee. The Company estimates sales amounts and related royalty income based on the historical product information for any period that the sales information is not available from the relevant licensee.

Licensing revenues

Other revenue includes revenues derived from product out-licensing arrangements, which typically consist of an initial upfront payment on inception of the license and subsequent milestone payments contingent on the achievement of certain clinical and sales milestones. Product out-licensing arrangements often require the Company to provide multiple deliverables to the licensee.

Initial license fees received in connection with product out-licensing agreements entered into prior to January 1, 2011 are deferred and recognized over the period in which the Company has continuing substantive performance obligations, typically the period over which the Company participates in the development of the out-licensed product, even where such fees are non-refundable and not creditable against future royalty payments.

For product out-licensing arrangements entered into, or subject to material modification, after January 1, 2011, consideration received is allocated between each of the separable elements in the arrangement using the relative selling price method. An element is considered separable if it has value to the customer on a stand-alone basis. The selling price used for each separable element will be based on vendor specific objective evidence (“VSOE”) if available, third party evidence if VSOE is not available, or estimated selling price if neither VSOE nor third party evidence is available. Revenue is then recognized as each of the separable elements to which the revenue has been allocated is delivered.

Milestone payments which are non-refundable, non creditable and contingent on achieving certain clinical milestones are recognized as revenues either on achievement of such milestones if the milestones are considered substantive or over the period the Company has continuing substantive performance obligations, if the milestones are not considered substantive. If milestone payments are creditable against future royalty payments, the milestones are deferred and released over the period in which the royalties are anticipated to be paid.

(d)       Sales deductions

(i)       Rebates

Rebates primarily consist of statutory rebates to state Medicaid agencies and contractual rebates with health-maintenance organizations. These rebates are based on price differentials between a base price and the selling price. As a result, rebates generally increase as a percentage of the selling price over the life of the product (as prices increase). Provisions for rebates are recorded as reductions to revenue in the same period as the related sales are recorded, with the amount of the rebate based on the Company's best estimate if any uncertainty exists over the unit rebate amount, and with estimates of future utilization derived from historical trends.

(ii)       Returns

The Company estimates the proportion of recorded revenue that will result in a return, based on historical trends and when applicable, specific factors affecting certain products at the balance sheet date. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded.

(iii)       Coupons

The Company uses coupons as a form of sales incentive. An accrual is established based on the Company's expectation of the level of coupon redemption, estimated using historical trends. The accrual is recorded as a reduction to revenue in the same period as the related sales are recorded or the date the coupon is offered, if later than the date the related sales are recorded.

(iv)       Discounts

The Company offers cash discounts to customers for the early payment of receivables which are recorded as reductions to revenue and accounts receivable in the same period as the related sale is recorded.

(v)       Wholesaler chargebacks

The Company has contractual agreements whereby it supplies certain products to third parties at predetermined prices. Wholesalers acting as intermediaries in these transactions are reimbursed by the Company if the predetermined prices are less than the prices paid by the wholesaler to the Company. Accruals for wholesaler chargebacks, which are based on historical trends, are recorded as reductions to revenue in the same period as the related sales are recorded.

(e)       Collaborative arrangements

The Company enters into collaborative arrangements to develop and commercialize drug candidates. These collaborative arrangements often require up-front, milestone, royalty or profit share payments, or a combination of these, with payments often contingent upon the success of the related development and commercialization efforts. Collaboration agreements entered into by the Company may also include expense reimbursements or other such payments to the collaborating partner.

The Company reports costs incurred and revenue generated from transactions with third parties as well as payments between parties to collaborative arrangements either on a gross or net basis, depending on the characteristics of the collaborative relationship.

(f)       Cost of product sales

Cost of product sales includes the cost of purchasing finished product for sale, the cost of raw materials and manufacturing for those products that are manufactured by the Company, shipping and handling costs, depreciation and amortization of intangible assets in respect of favorable manufacturing contracts. Royalties payable on products to which the Company does not own the rights are also included in Cost of product sales.

(g)       Leased assets

The costs of operating leases are charged to operations on a straight-line basis over the lease term, even if rental payments are not made on such a basis.

Assets acquired under capital leases are included in the consolidated balance sheet as property, plant and equipment and are depreciated over the shorter of the period of the lease or their useful lives. The capital element of future lease payments is recorded as a liability, while the interest element is charged to operations over the period of the lease to produce a level yield on the balance of the capital lease obligation.

(h)       Advertising expense

The Company expenses the cost of advertising as incurred. Advertising costs amounted to $60.9 million, $85.8 million and $122.5 million for the years to December 31, 2013, 2012 and 2011 respectively and were included within Selling, general and administrative (“SG&A”) expenses.

(i)       Research and development (“R&D”) expense

R&D costs are expensed as incurred. Upfront and milestone payments made to third parties for in-licensed products that have not yet received marketing approval and for which no alternative future use has been identified are also expensed as incurred.

Milestone payments made to third parties on and subsequent to regulatory approval are capitalized as intangible assets, and amortized over the remaining useful life of the related product.

(j)       Valuation and impairment of long-lived assets other than goodwill, indefinite lived intangible assets and investments

The Company evaluates the carrying value of long-lived assets other than goodwill, indefinite lived intangible assets and investments for impairment whenever events or changes in circumstances indicate that the carrying amounts of the relevant assets may not be recoverable. When such a determination is made, management's estimate of undiscounted cash flows to be generated by the use and ultimate disposition of these assets is compared to the carrying value of the assets to determine whether the carrying value is recoverable. If the carrying value is deemed not to be recoverable, the amount of the impairment recognized in the consolidated financial statements is determined by estimating the fair value of the relevant assets and recording animpairment loss for the amount by which the carrying value exceeds the estimated fair value. This fair value is usually determined based on estimated discounted cash flows.

(k)       Finance costs of debt

Finance costs relating to debt issued are recorded as a deferred charge and amortized to the consolidated statements of income over the period to the earliest redemption date of the debt, using the effective interest rate method. On extinguishment of the related debt, any unamortized deferred financing costs are written off and charged to interest expense in the consolidated statements of income.

(l)       Foreign currency

Monetary assets and liabilities in foreign currencies are translated into the functional currency of the relevant subsidiaryin which they arise at the rate of exchange ruling at the balance sheet date. Transactions in foreign currencies are translated into the relevant functional currency at the rate of exchange ruling at the date of the transaction. Transaction gains and losses, other than those related to current and deferred tax assets and liabilities, are recognized in arriving at income from operations before income taxes and equity in earnings of equity method investees. Transaction gains and losses arising on foreign currency denominated current and deferred tax assets and liabilities are included within income taxes in the consolidated statements of income.

The results of operations for subsidiaries, whose functional currency is not the US dollar, are translated into the US dollar at the average rates of exchange during the period, with the subsidiaries' balance sheets translated at the rates ruling at the balance sheet date. The cumulative effect of exchange rate movements is included in a separate component of Other comprehensive income.

Foreign currency exchange transaction losses included in consolidated statements of income in the years to December 31, 2013, 2012 and 2011 amounted to $8.7million, $3.5 million and $2.1 million, respectively.

(m)       Income taxes

Uncertain tax positions are recognized in the consolidated financial statements for positions which are considered more likely than not of being sustained, based on the technical merits of the position on audit by the tax authorities. The measurement of the tax benefit recognized in the consolidated financial statements is based upon the largest amount of tax benefit that, in management's judgment, is greater than 50% likely of being realized based on a cumulative probability assessment of the possible outcomes. The Company recognizes interest relating to unrecognized tax benefits and penalties within income taxes.

Deferred tax assets and liabilities are recognized for differences between the carrying amounts of assets and liabilities in the consolidated financial statements and the tax bases of assets and liabilities that will result in future taxable or deductible amounts. The deferred tax assets and liabilities are measured using the enacted tax laws and rates applicable to the periods in which the differences are expected to affect taxable income.

Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will not be realized.

(n)       Earnings per share

Basic earnings per share is based upon net income attributable to Shire plc divided by the weighted average number of ordinary shares outstanding during the period. Diluted earnings per share is based upon net income attributable to Shire plc adjusted for the impact of interest expense on convertible debt on an “if-converted” basis (whenthe effect is dilutive and prior to the actual conversion or redemption of debt) divided by the weighted average number of ordinary share equivalents outstanding during the period, adjusted for the dilutive effect of all potential ordinary shares equivalents that were outstanding during the year. Such potentially dilutive shares are excluded when the effect would be to increase diluted earnings per share or reduce the diluted loss per share.

(o)       Share-based compensation

Share-based compensation represents the cost of share-based awards granted to employees. The Company measures share-based compensation cost for awards classified as equity at the grant date, based on the estimated fair value of the award. Predominantly all of the Company's awards have service and/or performance conditions and the fair values of these awards are estimated using a Black-Scholes valuation model.

For share-based compensation awards which cliff vest, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the employee's requisite service period. For those share-based compensation awards with a graded vesting schedule, the Company recognizes the cost of the relevant share based payment award as an expense on a straight-line basis (net of estimated forfeitures) over the requisite service period for the entire award (that is, over the requisite service period for the last separately vesting portion of the award). The share based compensation expense is recorded in Cost of product sales, R&D, and SG&A in the consolidated statementsof income based on the employees' respective functions.

The Company records deferred tax assets for awards that result in deductions on the Company's income tax returns, based on the amount of compensation cost recognized and the Company's statutory tax rate in the jurisdiction in which it will receive a deduction. Differences between the deferred tax assets recognized for financial reporting purposes and the actual tax deduction reported on the Company's income tax return are recorded in additional paid-in capital (if the tax deduction exceeds the deferred tax asset) or in the consolidated statements of income (if the deferred tax asset exceeds the tax deduction and no additional paid-in capital exists from previous awards).

The Company's share-based compensation plans are described more fully in Note 27.

(p)       Cash and cash equivalents

Cash and cash equivalents are defined as short-term highly liquid investments with original maturities of ninety days or less.

(q)       Financial instruments - derivatives

The Company uses derivative financial instruments to manage its exposure to foreign exchange risk associated with intercompany financing. These instruments consist of swap and forward foreign exchange contracts. The Company does not apply hedge accounting for these instruments. The fair values of these instruments are included on the balance sheet in current assets / liabilities, with changes in the fair value recognized in the consolidated statements of income. The cash flows relating to these instruments are presented within net cash provided by operating activities in the consolidated statement of cash flows, unless the derivative instruments are economically hedging specific investing or financing activities.

(r)       Inventories

Inventories are stated at the lower of cost or market. Cost incurred in bringing each product to its present location and condition is based on purchase costs calculated on a first-in, first-out basis, including transportation costs.

Inventories include costs relating to both marketed products and,for certain products,cost incurred prior to regulatory approval. Inventories are capitalized prior to regulatory approval if the Company considers that it is probable that the US Food and Drug Administration (“FDA”) or another regulatory body will grant commercial and manufacturing approval for the relevant product, and it is probable that the value of capitalized inventories will be recovered through commercial sale.

Inventories are written down for estimated obsolescence or unmarketable inventory equal to the difference between the cost of inventory and estimated market value based upon assumptions about future demand and market conditions. If actual market conditions are less favorable than those anticipated, inventory adjustments may be required.

(s)       Assets held-for-sale

An asset or asset disposal group is classified as held-for-sale when, amongst other things, the Company has committed to a plan of disposition, the asset or asset disposal group is available for immediate sale, and the plan is not expected to change significantly. Assets held-for-sale are carried at the lower of their carrying amount or fair value less cost to sell.

The Company does not record depreciation or amortization on assets classified as held-for-sale.

(t)       Investments

The Company has certain investments in pharmaceutical and biotechnology companies.

Investments are accounted for using the equity method of accounting if the investment gives the Company the ability to exercise significant influence, but not control over, the investee. Significant influence is generally deemed to exist if the Company has an ownership interest in the voting stock of the investee between 20% and 50%, although other factors such as representation on the investee's Board of Directors and the nature of commercial arrangements, are considered in determining whether the equity method of accounting is appropriate. Under the equity method of accounting, the Company records its investments in equity-method investees in the consolidated balance sheet under Investments and its share of the investees' earnings or losses together with other-than-temporary impairments in value under equity in earnings of equity method investees in the consolidated statements of income.

All other equity investments, which consist of investments for which the Company does not have the ability to exercise significant influence, are accounted for under the cost method or at fair value. Investments in private companies are carried at cost, less provisions for other-than-temporary impairment in value. For public companies that have readily determinable fair values, the Company classifies its equity investments as available-for-sale and, accordingly, records these investments at their fair values with unrealized holding gains and losses included in the consolidated statement of comprehensive income, net of any related tax effect. Realized gains and losses, and declines in value of available-for-sale securities judged to be other-than-temporary, are included in other income, net. The cost of securities sold is based on the specific identification method. Interest on securities classified as available-for-sale are included as interest income.

(u)       Property, plant and equipment

Property, plant and equipment is shown at cost reduced for impairment losses, net of accumulated depreciation. The cost of significant assets includes capitalized interest incurred during the construction period. Depreciation is recorded on a straight-line basis at rates calculated to write off the cost less estimated residual value of each asset over its estimated useful life as follows:

Buildings       15 to 50 years

Office furniture, fittings and equipment       3 to 10 years

Warehouse, laboratory and manufacturing equipment       3 to 15 years

The cost of land is not depreciated. Assets under the course of construction are not depreciated until the relevant assets are available and ready for their intended use.

Expenditures for maintenance and repairs are charged to the consolidated statements of income as incurred. The costs of major renewals and improvements are capitalized. At the time property, plant and equipment is retired or otherwise disposed of, the cost and accumulated depreciation are eliminated from the asset and accumulated depreciation accounts. The profit or loss on such disposition is reflected in operating income.

(v)       Goodwill and other intangible assets

(i)       Goodwill

In business combinations completed subsequent to January 1, 2009, goodwill represents the excess of the fair value of the consideration given and the fair value of any non-controlling interest in the acquiree over the fair value of the identifiable assets and liabilities acquired. For business combinations completed prior to January 1, 2009 goodwill represents the excess of the fair value of the consideration given over the fair value of the identifiable assets and liabilities acquired.

Goodwill is not amortized, but instead is reviewed for impairment, at least annually or whenever events or changes in circumstances indicate that the carrying value may not be recoverable. For the purpose of assessing the carrying value of goodwill for impairment, goodwill is allocated at the Company's reporting unit level. Events or changes in circumstances which could trigger an impairment review include but are not limited to: significant underperformance of a reporting unit relative to expected historical or projected future operating results; significant changes in the manner of the Company's use of acquired assets or the strategy for the overall business; and significant negative industry trends.

Goodwill is reviewed for impairment by comparing the carrying value of the reporting unit's net assets (including allocated goodwill) to the fair value of the reporting unit. If the reporting unit's carrying amount is greater than its fair value, a second step is performed whereby the portion of the reporting unit's fair value relating to goodwill is compared to the carrying value of the reporting unit's goodwill. The Company recognizes a goodwill impairment charge for the amount by which the carrying value of goodwill exceeds its estimated fair value. In the year to December 31, 2013 the Company has recorded an impairment charge of $198.9 million related to the goodwill allocated to the Company's former Regenerative Medicine (“RM”) reporting unit. See Note 11 for further details.

(ii)       Other intangible assets

Other intangible assets principally comprise intellectual property rights for products with a defined revenue stream, acquired product technology and IPR&D. Intellectual property rights for currently marketed products and acquired product technology are recorded at fair value and amortized over the estimated useful life of the related product, which ranges from 1 to 20 years (weighted average 10.1 years). IPR&D acquired through a business combination is capitalized as an indefinite lived intangible asset until the completion or abandonment of the associated R&D efforts. IPR&D is reviewed for impairment using a “one-step” approach which compares the fair value of the IPR&D asset with its carrying amount. An impairment loss is recognized to the extent that the carrying value exceeds the fair value of the IPR&D asset. Once the R&D efforts are completed the useful life of the relevant assets will be determined, and the IPR&D asset amortized over this useful economic life.

The following factors, where applicable, are considered in estimating the useful lives of Other intangible assets:

• expected use of the asset;
• regulatory, legal or contractual provisions, including the regulatory approval and review process, patent issues and actions by government agencies;
• the effects of obsolescence, changes in demand, competing products and other economic factors, including the stability of the market, known technological advances, development of competing drugs that are more effective clinically or economically;
• actions of competitors, suppliers, regulatory agencies or others that may eliminate current competitive advantages; and
• historical experience of renewing or extending similar arrangements.

When a number of factors apply to an intangible asset, these factors are considered in combination when determining the appropriate useful life for the relevant asset.

(w)       Non-monetary transactions

The Company enters into certain non-monetary transactions that involve either the granting of a license over the Company's patents or the disposal of an asset or group of assets in exchange for a non–monetary asset, usually equity. The Company accounts for these transactions at fair value if the Company is able to determine the fair value within reasonable limits. To the extent the Company concludes that it is unable to determine the fair value of a transaction that transaction is accounted for at the recorded amounts of the assets exchanged. Management is required to exercise its judgment in determining whether or not the fair value of the asset received or given up can be determined.

(x)       New accounting pronouncements

Adopted during the period

Indefinite-Lived Intangible Assets (Other than Goodwill) Impairment Testing

In July 2012 the Financial Accounting Standard Board (“FASB”) issued guidance on the testing of indefinite-lived intangible assets for impairment. The guidance permits an entity to first assess qualitative factors to determine whether the existence of events or circumstances leads to a determination that it is more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount. If, after assessing the totality of events or circumstances, an entity determines it is not more likely than not that the fair value of an indefinite-lived intangible asset is less than its carrying amount, performing the impairment test is unnecessary. The more-likely-than-not threshold is defined as a likelihood of more than 50 percent. An entity also has the option to bypass the qualitative assessment for any indefinite-lived intangible asset in any period and proceed directly to performing the impairment test and may resume performing the qualitative assessment in any subsequent period. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

Disclosure about offsetting assets and liabilities

In December 2011 the FASB issued guidance on disclosures about offsetting assets and liabilities. In January 2013 the FASB amended the previous guidance to clarify the scope of guidance issued in December 2011. The amended guidance requires entities to disclose both gross and net information about derivatives including bifurcated embedded derivatives, repurchase agreements and reverse repurchase agreements, and securities borrowing and securities lending transactions that are either offset in accordance with FASB guidance on topics “Balance Sheet” and “Derivatives and Hedging” or subject to an enforceable master netting arrangement or similar agreement; to enable users of financial statements tounderstand the effects or potential effects of those arrangements on its financial position. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows. Enhanced disclosure of balance sheetoffsetting as required by this guidance is included in Note 20.

Amounts reclassified out of Comprehensive Income

In February 2013 the FASB issued guidance on reporting amounts reclassified out of accumulated other comprehensive income. The guidance requires entities to provide information about the amount reclassified out of comprehensive income by component and present either on the face of the financial statements or in the notes, significant amounts reclassified out of other comprehensive income by the respective line items of net income, but only if the amount reclassified is required under US GAAP to be reclassified to net income in its entirety in the same reporting period. For other amounts that are not required under US GAAP to be reclassified in their entirety to net income, an entity is required to cross-reference to other disclosures required under US GAAP that provide additional detail about those amounts. The guidance has been adopted prospectively from January 1, 2013. The adoption of the guidance did not impact the Company's consolidated financial position, results of operations or cash flows.

Presentation of an unrecognized tax benefit

In July 2013 the FASB issued guidance on the financial statement presentation of an unrecognized tax benefit when a net operating loss carry forward, a similar tax loss, or a tax credit carry forward exists. The guidance requires entities to present an unrecognized tax benefit or a portion of an unrecognized tax benefit in the financial statements as a reduction to a deferred tax asset for a net operating loss carry forward, a similar tax loss, or a tax credit carry forward, except as follows: to the extent a net operating loss carry forward, a similar tax loss, or a tax credit carry forward is not available at the reporting date under the tax law of the applicable jurisdiction to settle any additional income taxes that would result from the disallowance of a tax position or the tax law of the applicable jurisdiction does not require the entity to use, and the entity does not intend to use, the deferred tax asset for such purpose, the unrecognized tax benefit should be presented in the financial statements as a liability and should not be combined with deferred tax assets. The assessment of whether a deferred tax asset is available is based on the unrecognized tax benefit and deferred tax asset that exist at the reporting date and should be made presuming disallowance of the tax position at the reporting date. The guidance will be effective for fiscal years, and interim periods within those years, beginning after December 15, 2013, with early adoption permitted. The Company has adopted this guidance in the period. The adoption of the guidance did not materially impact the Company's consolidated financial position, results of operations or cash flows.

(y)       Statutory accounts

The consolidated financial statements as at December 31, 2013 and 2012, and for each of the three years in the period to December 31, 2013 do not comprise statutory accounts within the meaning of Section 434 of the UK Companies Act 2006 or Article 104 of the Companies (Jersey) Law 1991.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2012 prepared under UK GAAP and in compliance with Jersey law have been delivered to the Registrar of Companies for Jersey. The consolidated accounts of the Company for the year ended December 31, 2012 prepared in accordance with US GAAP, in fulfillment of the Company's United Kingdom Listing Authority (“UKLA”) annual reporting requirements were filed with the UKLA. The auditor's reports on these accounts were unqualified.

Statutory accounts of Shire, consisting of the solus accounts of Shire plc for the year to December 31, 2013 prepared under UK GAAP and in compliance with Jersey law will be delivered to the Registrar of Companies in Jersey in 2014. The Company further expects to file the consolidated accounts of the Company for the year to December 31, 2013, prepared in accordance with US GAAP, in fulfillment of the Company's UKLA annual reporting requirements with the UKLA in 2014.

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Taxation (Tables)

12 Months Ended

Dec. 31, 2013

Income Tax Disclosure [Abstract]

Schedule of Income before Income Tax, Domestic and Foreign

	2013	2012	2011
Year to December 31,	$’M	$’M	$’M
	___________	___________	___________
Republic of Ireland	(47.8)	(74.7)	(65.9)
UK	10.9	30.7	45.4
US	1,153.3	683.8	774.6
Other jurisdictions	577.2	368.0	363.0
	___________	___________	___________
	1,693.6	1,007.8	1,117.1
	___________	___________	___________

Schedule of Components of Income Tax Expense (Benefit)

Year to December 31,
	2013	2012	2011
	$’M	$’M	$’M
	__________	__________	__________
Current income taxes:
Republic of Ireland	-	-	(1.8)
US federal tax	274.3	230.0	201.4
US state and local taxes	17.9	11.3	9.2
Other	63.4	29.0	40.0
	__________	__________	__________
Total current taxes	355.6	270.3	248.8
	__________	__________	__________
Deferred taxes:
US federal tax	23.8	(63.8)	23.3
US state and local taxes	(8.3)	(6.5)	(4.6)
UK corporation tax	11.5	13.1	(1.0)
Other	(104.7)	(10.0)	(29.6)
	__________	__________	__________
Total deferred taxes	(77.7)	(67.2)	(11.9)
	__________	__________	__________
Total income taxes	277.9	203.1	236.9
	__________	__________	__________

Schedule of Effective Income Tax Rate Reconciliation

Year to December 31,
		2013	2012	2011
		$’M	$’M	$’M
		___________	___________	___________
Income from continuing operations before income taxes and equity in earnings of equity method investees		1,693.6	1,007.8	1,117.1
		___________	___________	___________
Statutory tax rate(1)		25.0%	25.0%	25.0%
Adjustments to derive effective rate:
Non-deductable items:
	US R&D credit	(4.5%)	(2.6%)	(4.5%)
	Effect of the convertible bond	0.5%	0.8%	0.8%
	Intra-group items(2)	(9.2%)	(16.0%)	(7.5%)
	Recognition of foreign tax credits	-	(6.6%)	-
	Other permanent items	(0.7%)	0.8%	(0.5%)
Other items:
Change in valuation allowance		0.9%	3.4%	3.2%
Impact of RESOLOR impairment		-	4.9%	-
Difference in taxation rates		7.8%	7.6%	4.6%
Change in provisions for uncertain tax positions		3.8%	1.1%	(1.2%)
Prior year adjustment		(3.4%)	0.8%	0.8%
Change in fair value of contingent consideration		(3.6%)	-	-
Change in tax rates		(0.2%)	0.8%	0.2%
Other		0.0%	0.1%	0.3%
		___________	___________	___________
Provision for income taxes on continuing operations		16.4%	20.1%	21.2%
		___________	___________	___________

Reconciliation of Beginning and Ending Amounts of Unrecognized Tax Benefits

	2013	2012	2011
	$’M	$’M	$’M
	___________	___________	___________
Balance at January 1	278.7	265.5	290.8
Increases based on tax positions related to the current year	56.8	20.5	18.2
Decreases based on tax positions taken in the current year	(0.5)	-	(2.5)
Increases for tax positions taken in prior years	34.5	0.4	1.4
Decreases for tax positions taken in prior years	(0.8)	(3.3)	(12.0)
Decreases resulting from settlements with the taxing authorities	-	(10.6)	(25.7)
Decreases as a result of expiration of the statute of limitations	(0.6)	(0.3)	(0.5)
Foreign currency translation adjustments(1)	(12.9)	6.5	(4.2)
	___________	___________	___________
Balance at December 31(2)	355.2	278.7	265.5
	___________	___________	___________

Schedule of Deferred Tax Assets and Liabilities

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Deferred tax assets:
Deferred revenue	5.2	5.5
Inventory & warranty provisions	48.6	52.5
Losses carried forward (including tax credits)1	500.6	425.7
Provisions for sales deductions and doubtful accounts	151.8	144.9
Intangible assets	10.7	36.7
Share-based compensation	25.5	32.7
Excess of tax value over book value of assets	22.1	-
Accruals and provisions	55.1	44.1
Other	2.6	21.6
	____________	____________
Gross deferred tax assets	822.2	763.7
Less: valuation allowance	(282.4)	(268.6)
	____________	____________
	539.8	495.1
Deferred tax liabilities:
Intangible assets	(586.8)	(702.7)
Excess of book value over tax value of assets and investments	(56.9)	(36.8)
	____________	____________
Net deferred tax liabilities	(103.9)	(244.4)
	____________	____________
Balance sheet classifications:
Deferred tax assets - current	315.6	229.9
Deferred tax assets - non-current	141.1	46.5
Deferred tax liabilities - non-current	(560.6)	(520.8)
	____________	____________
	(103.9)	(244.4)
	____________	____________

Summary of Operating Loss and Tax Credit Carryforwards

	2013	2012
	$’M	$’M
	____________	____________
US federal tax NOLs	32.2	26.1
US state tax NOLs	61.5	31.4
UK NOLs	6.7	20.7
Republic of Ireland NOLs	78.8	72.6
Foreign tax jurisdictions	273.1	208.8
R&D and other tax credits	48.3	66.2
	____________	____________

Schedule of Carryforwards Available to Reduce Future Taxes, Expiration Periods

	December 31,
	2013
	$’M
	___________
Within 1 year	0.9
Within 1 to 2 years	1.1
Within 2 to 3 years	0.7
Within 3 to 4 years	2.9
Within 4 to 5 years	3.0
Within 5 to 6 years	35.6
After 6 years	142.7
Indefinitely	313.7

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Other Non-current Liabilities (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Other Liabilities, Noncurrent [Abstract]
Income taxes payable	$ 115.7	$ 58.9
Deferred revenue	9.8	11.4
Deferred rent	11.3	11.9
Insurance provisions	1.0	12.3
Contingent consideration payable	393.0	120.4
Other non-current liabilities	57.7	26.7
Other noncurrent liabilities, total	$ 588.5	$ 241.6

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Quarterly Results of Operations (Tables)

12 Months Ended

Dec. 31, 2013

Quarterly Financial Information Disclosure [Abstract]

Quarterly Results of Operations

	First quarter of 2013				Second quarter of 2013
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,161.9	(18.5)	1,143.4		1,274.5	(22.3)	1,252.2
Cost of product sales	155.9	(8.5)	147.4		175.7	(11.4)	164.3
Income from continuing operations, net of taxes	64.8	216.2	281.0		258.1	32.8	290.9
Loss from discontinued operations, net of taxes	-	(216.2)	(216.2)		-	(32.8)	(32.8)
Net income	64.8	-	64.8		258.1	-	258.1
Earnings per ordinary share - basic
Earnings from continuing operations	11.7c	39.3c	51.0c		46.9c	6.0c	52.9c
Loss from discontinued operations	-	(39.3c)	(39.3c)		-	(6.0c)	(6.0c)
Earnings per share - basic	11.7c	-	11.7c	1.0	46.9c	-	46.9c
Earnings per ordinary share - diluted
Earnings from continuing operations	11.7c	36.7c	49.0c		45.3c	5.6c	50.9c
Loss from discontinued operations	-	(36.7c)	(36.7c)		-	(5.6c)	(5.6c)
Earnings per share - diluted	11.7c	-	12.3c	1.0	45.3c	-	45.3c
	Third quarter of 2013				Fourth quarter of 2013
	Previously	Adjusted for	As		Memo (prior	Adjusted for	As
	reported	DERMAGRAFT	reported		to adjustment)	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,236.6	(23.9)	1,212.7		1,351.1	(25.1)	1,326.0
Cost of product sales	197.1	(16.6)	180.5		196.5	(17.9)	178.6
Income from continuing operations, net of taxes	278.2	22.9	301.1		64.0	482.6	546.6
Loss from discontinued operations, net of taxes	-	(22.9)	(22.9)		-	(482.6)	(482.6)
Net income	278.2	-	278.2		64.0	-	64.0
Earnings per ordinary share - basic
Earnings from continuing operations	50.7c	4.2c	54.9c		11.5c	86.5c	98.0c
Loss from discontinued operations	-	(4.2c)	(4.2c)		-	(86.5c)	(86.5c)
Earnings per share - basic	50.7c	-	50.7c	1.0	11.5c	-	11.5c
Earnings per ordinary share - diluted
Earnings from continuing operations	48.8c	3.9c	52.7c		11.7c	81.7c	93.4c
Loss from discontinued operations	-	(3.9c)	(3.9c)		-	(81.7c)	(81.7c)
Earnings per share - diluted	48.8c	-	48.8c	1.0	11.7c	-	11.7c
	First quarter of 2012				Second quarter of 2012
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,171.8	(48.8)	1,123.0		1,207.8	(52.4)	1,155.4
Cost of product sales	158.4	(10.0)	148.4		152.5	(17.0)	135.5
Income from continuing operations, net of taxes	238.4	7.4	245.8		237.8	10.7	248.5
Loss from discontinued operations, net of taxes	-	(7.4)	(7.4)		-	(10.7)	(10.7)
Net income	238.4	-	238.4		237.8	-	237.8
Earnings per ordinary share - basic
Earnings from continuing operations	43.1c	1.3c	44.4c		42.7c	1.9c	44.6c
Loss from discontinued operations	-	(1.3c)	(1.3c)		-	(1.9c)	(1.9c)
Earnings per share - basic	43.1c	-	43.1c	1.0	42.7c	-	42.7c
Earnings per ordinary share - diluted
Earnings from continuing operations	41.4c	1.3c	42.7c		41.3c	1.8c	43.1c
Loss from discontinued operations	-	(1.3c)	(1.3c)		-	(1.8c)	(1.8c)
Earnings per share - diluted	41.4c	-	41.4c	1.0	41.3c	-	41.3c
	Third quarter of 2012				Fourth quarter of 2012
	Previously	Adjusted for	As		Previously	Adjusted for	As
	reported	DERMAGRAFT	reported		reported	DERMAGRAFT	reported
	$’M	$’M	$’M		$’M	$’M	$’M
	____________	____________	____________		____________	____________	____________
Total revenues	1,100.4	(33.7)	1,066.7		1,201.2	(18.9)	1,182.3
Cost of product sales	167.9	(16.0)	151.9		166.6	(16.6)	150.0
Income from continuing operations, net of taxes	227.2	16.2	243.4		42.0	26.0	68.0
Loss from discontinued operations, net of taxes	-	(16.2)	(16.2)		-	(26.0)	(26.0)
Net income	227.2	-	227.2		42.0	-	42.0
Earnings per ordinary share - basic
Earnings from continuing operations	40.9c	2.9c	43.8c		7.5c	4.7c	12.2c
Loss from discontinued operations	-	(2.9c)	(2.9c)		-	(4.7c)	(4.7c)
Earnings per share - basic	40.9c	-	40.9c	1.0	7.5c	-	7.5c
Earnings per ordinary share - diluted
Earnings from continuing operations	39.6c	2.7c	42.3c		7.4c	4.7c	12.1c
Loss from discontinued operations	-	(2.7c)	(2.7c)		-	(4.7c)	(4.7c)
Earnings per share - diluted	39.6c	-	39.6c	1.0	7.4c	-	7.4c

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Retirement Benefits (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Compensation and Retirement Disclosure [Abstract]
Contributions to personal defined contribution pension plans	$ 45.7	$ 46.4	$ 44.4

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Segmental Reporting (Tables)

12 Months Ended

Dec. 31, 2013

Segment Reporting [Abstract]

Schedule of Revenue from External Customers and Long-Lived Assets, by Geographical Areas

	2013	2012	2011
Year to December 31,	$’M	$’M	$’M
	___________	___________	___________
Ireland	22.5	20.6	21.1
United Kingdom	206.7	207.0	219.9
North America	3,386.2	3,006.1	2,761.8
Rest of World	1,318.9	1,293.7	1,155.3
	____________	____________	____________
Total revenues	4,934.3	4,527.4	4,158.1
	____________	____________	____________

	2013	2012
Year to December 31,	$’M	$’M
	___________	___________
Ireland	5.8	5.2
United Kingdom	70.3	72.2
North America	802.9	861.0
Rest of World	13.8	18.8
	____________	____________
Total	892.8	957.2
	____________	____________

Schedule of Revenue by Major Customers by Reporting Segments

	2013	2013	2012	2012	2011	2011
Year to December 31,	$’M	% product revenue	$’M	% product revenue	$’M	% product revenue
	___________	___________	___________	___________	___________	___________
McKesson Corp.	902.9	19	835.9	20	742.9	19
Cardinal Health Inc.	853.7	18	1,035.7	24	923.9	24
AmerisourceBergen Corp	721.0	15	307.4	7	276.4	7
	____________	___________	____________	___________	____________	___________

Schedule of Trade Receivables by Major Customers by Reporting Segments

Amounts outstanding as at December 31, in respect of these material customers were as follows:
	2013	2012
December 31,	$’M	$’M
	___________	___________
McKesson Corp.	161.3	127.4
Cardinal Health Inc.	149.5	166.1
AmerisourceBergen Corp	164.6	47.4
	____________	___________

Schedule of Segment Revenue from Major Products

	2013	2012	2011
	$’M	$’M	$’M
	___________	___________	___________
VYVANSE	1,227.8	1,029.8	805.0
ELAPRASE	545.6	497.6	464.9
LIALDA/MEZAVANT	528.9	399.9	372.1
REPLAGAL	467.9	497.5	475.2
ADDERALL XR	375.4	429.0	532.8
VPRIV	342.7	306.6	256.2
INTUNIV	334.9	287.8	223.0
PENTASA	280.6	265.8	251.4
FIRAZYR	234.8	116.3	33.0
FOSRENOL	183.4	172.0	166.9
XAGRID	99.4	97.2	90.6
Other product sales	136.1	153.4	173.8
	____________	____________	____________
Total product sales	4,757.5	4,252.9	3,844.9
	____________	____________	____________

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Financial Instruments (Foreign Exchange Risk and Its Effect on Income Statement) (Details) (Foreign Exchange Contract, Other income, net, USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Foreign Exchange Contract | Other income, net
Derivative Instruments, Gain (Loss) [Line Items]
Amount of net income (loss) recognized in income	$ (1.8)	$ 6.2	$ 21.3

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Financial Instruments

12 Months Ended

Dec. 31, 2013

Derivative Instrument Detail [Abstract]

Financial Instruments Disclosure

20.Financial instruments

Treasury policies and organization

The Company's principal treasury operations are coordinated by its corporate treasury function. All treasury operations are conducted within a framework of policies and procedures approved annually by the Board. As a matter of policy, the Company does not undertake speculative transactions that would increase its currency or interest rate exposure.

Interest rate risk

The Company is exposed to interest rate risk on its $1,200 million Revolving Credit Facility,its $0.55billionterm loan facility, its $0.85 billion term loan facility (the “Facilities”), to the extent the Facilities are utilized,restricted cash, cash and cash equivalents and on foreign exchange contracts on which interest is at floating rates. This exposure is primarily to US dollar, Pounds sterling, Euro and Canadian dollar interest rates. The Company has evaluated the interest rate risk on its debt facilities and considers the floating rate as appropriate.As the Company maintains all of its cash, liquid investments and foreign exchange contracts on a short term basis for liquidity purposes, this risk is not actively managed. In the year to to December 31, 2013 the average interest rate received on cash and liquid investments was less than 1% per annum. The largest proportion of these cash and liquid investments was in US dollar money market and liquidity funds. At December 31, 2013 the Facilities were not utilized.

The Company incurred interest at a fixed rate of 2.75% on its $1,100 million in principal amount convertible bonds which were converted and redeemed at December 31, 2013.

No derivative instruments were entered into during the year to December 31, 2013 to manage interest rate exposure. The Company continues to review its interest rate risk and the policies in place to manage the risk.

Credit risk

Financial instruments that potentially expose Shire to concentrations of credit risk consist primarily of short-term cash investments, derivative contracts and trade accounts receivable (from product sales and from third parties from which the Company receives royalties). Cash is invested in short-term money market instruments, including money market and liquidity funds and bank term deposits. The money market and liquidity funds in which Shire invests are all triple A rated by both Standard and Poor's and by Moody's credit rating agencies.

The Company is exposed to the credit risk of the counterparties with which it enters into derivative instruments. The Company limits this exposure through a system of internal credit limits which vary according to ratings assigned to the counterparties by the major rating agencies. The internal credit limits are approved by the Board and exposure against these limits is monitored by the corporate treasury function. The counterparties to these derivatives contracts are major international financial institutions.

The Company's revenues from product sales in the US are mainly governed by agreements with major pharmaceutical wholesalers and relationships with other pharmaceutical distributors and retail pharmacy chains. For the year to December 31, 2013 there were three customers in the US that accounted for 52% of the Company's product sales. However, such customers typically have significant cash resources and as such the risk from concentration of credit is considered acceptable. The Company has taken positive steps to manage any credit risk associated with these transactions and operates clearly defined credit evaluation procedures. However, an inability of one or more of these wholesalers to honor their debts to the Company could have an adverse effect on the Company's financial condition and results of operations.

A substantial portion of the Company's accounts receivable in countries outside of the United States is derived from product sales to government-owned or government-supported healthcare providers. The Company's recovery of these accounts receivable is therefore dependent upon the financial stability and creditworthiness of the relevant governments. In recent years the creditworthiness and general economic condition of a number of Eurozone countries (including Greece, Italy, Portugal and Spain (the “Relevant Countries”)) has deteriorated. As a result, in some of these countries the Company is experiencing delays in the remittance of receivables due from government-owned or government-supported healthcare providers. The Company continued to receive remittances in relation to government-owned or government-supported healthcare providers in all the Relevant Countries in the year to December 31, 2013, including receiptsof $116.8million and $144.7million in respect of Spanish and Italian receivables, respectively.

To date the Company has not incurred significant losses on accounts receivable in the Relevant Countries, and continues to consider that such accounts receivable are recoverable. The Company will continue to evaluate all its accounts receivable for potential collection risks and has made provision for amounts where collection is considered to be doubtful. If the financial condition of the Relevant Countries or other Eurozone countries suffer significant deterioration, such that their ability to make payments becomes uncertain, or if one or more Eurozone member countries withdraws from the Euro, additional allowances for doubtful accounts may be required, and losses may be incurred, in future periods. Any such loss could have an adverse effect on the Company's financial condition and results of operations.

Foreign exchange risk

The Company trades in numerous countries and as a consequence has transactional and translational foreign exchange exposures.

Transactional exposure arises where transactions occur in currencies different to the functional currency of the relevant subsidiary. The main trading currencies of the Company are the US dollar, Pounds Sterling, Swiss Franc and the Euro. It is the Company's policy that these exposures are minimized to the extent practicable by denominating transactions in the subsidiary's functional currency.

Where significant exposures remain, the Company uses foreign exchange contracts (being spot, forward and swap contracts) to manage the exposure for balance sheet assets and liabilities that are denominated in currencies different to the functional currency of the relevant subsidiary. These assets and liabilities relate predominantly to intercompany financing. The foreign exchange contracts have not been designated as hedging instruments. Cash flows from derivative instruments are presented within net cash provided by operating activities in the consolidated cash flow statement, unless the derivative instruments are economically hedging specific investing or financing activities.

Translational foreign exchange exposure arises on the translation into US dollars of the financial statements of non-US dollar functional subsidiaries.

At December 31, 2013the Company had 29 swap and forward foreign exchange contracts outstanding to manage currency risk. The swap and forward contracts mature within 90 days. The Company did not have credit risk related contingent features or collateral linked to the derivatives. The Company has master netting agreements with a number of counterparties to these foreign exchange contracts and on the occurrence of specified events, the Company has the ability to terminate contracts and settle them with a net payment by one party to the other. The Company has elected to present derivative assets and derivative liabilities on a gross basis in the consolidated balance sheet. As at December 31, 2013 the potential effect of rights of set off associated with the foreign exchange contracts would be an offset to both assets and liabilities of $0.7million, resulting in net derivative assets and derivative liabilities of $3.3million and $2.1million, respectively. Further details are included below:

		Fair value	Fair value
		December 31,	December 31,
		2013	2012
		$’M	$’M
		_____________	_____________
Assets	Prepaid expenses and other current assets	4.0	1.3
Liabilities	Other current liabilities	2.8	3.0
		_____________	_____________

Net (losses)/ gains (both realized and unrealized) arising on foreign exchange contracts have been classified in the consolidated statements of income as follows:

	Location of net (loss)/gain recognized in income	Amount of net (loss)/gain recognized in income
	__________________________________	____________		____________
In the year to		December 31,	December 31,	December 31,
		2013	2012	2011
		$’M	$’M	$’M
		_____________	_____________	_____________
Foreign exchange contracts	Other income, net	(1.8)	6.2	21.3
		_____________	_____________	_____________

These net foreign exchange (losses)/gains are offset within Other income, net by net foreign exchange losses arising on the balance sheet items that these contracts were put in place to manage.

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Prepaid Expenses and Other Current Assets (Tables)

12 Months Ended

Dec. 31, 2013

Prepaid Expense and Other Assets, Current [Abstract]

Prepaid Expense and Other Assets, Current

	December 31,	December 31,
	2013	2012
	$’M	$’M
	______________	____________
Prepaid expenses	29.4	31.7
Income tax receivable	177.4	130.6
Value added taxes receivable	14.5	20.9
Other current assets	41.7	38.6
	______________	______________
	263.0	221.8
	______________	______________

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Inventories

12 Months Ended

Dec. 31, 2013

Inventory Disclosure [Abstract]

Inventory Disclosure

7.       Inventories

Inventories are stated at the lower of cost or market and comprise:

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Finished goods	156.6	124.4
Work-in-progress	240.5	220.6
Raw materials	58.2	91.9
	____________	____________
	455.3	436.9
	____________	____________

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Other Intangible Assets, Net

12 Months Ended

Dec. 31, 2013

Intangible Assets, Net (Excluding Goodwill) [Abstract]

Other Intangible Assets Disclosure

12.       Other intangible assets, net

		December 31,	December 31,
		2013	2012
		$’M	$’M
		________________	________________
Amortized intangible assets
	Intellectual property rights acquired for currently marketed products	2,573.3	2,462.0
	Acquired product technology	-	710.0
	Other intangible assets	46.1	44.5
		________________	________________
		2,619.4	3,216.5
Unamortized intangible assets
	Intellectual property rights acquired for IPR&D	951.5	231.0
		________________	________________
		3,570.9	3,447.5
Less: Accumulated amortization		(1,258.3)	(1,059.4)
		________________	________________
		2,312.6	2,388.1
		________________	________________

The change in the net book value of other intangible assets for the year toto December 31, 2013and 2012is shown in the table below:

	Other intangible assets
	2013	2012
	$’M	$’M
	________________	________________
As at January 1,	2,388.1	2,493.0
Acquisitions	731.8	281.6
Amortization charged	(152.0)	(153.6)
Amortization charged on DERMAGRAFT product technology, presented within discontinued operations in the consolidated income statement	(39.4)	(40.5)
Impairment charges	(19.9)	(197.9)
Reclassification of DERMAGRAFT product technology to assets held for sale	(611.4)	-
Foreign currency translation	15.4	5.5
	________________	________________
As at December 31,	2,312.6	2,388.1
	________________	________________

In the year to December 31, 2013 the Company acquired intangible assets totaling $731.8 million, relating to intangible assets acquired with SARcode, Premacure and Lotus Tissue Repair (see Note 3 for further details).

In the second quarter of 2013 the Company reviewed certain IPR&D intangible assets acquired through Movetis N.V. (“Movetis”) for impairment and recognized an impairment charge of $19.9 million (2012: $197.9 million) recorded within R&D in the consolidated income statement, to write-down these IPR&D assets to their fair value. The fair values of these assets were determined using the income approach, which used significant unobservable (Level 3) inputs (see Note 21 for further details).

Following the divestment of DERMAGRAFT (see Note 8) the Company has reclassified $611.4 million of intangible assets related to the DERMAGRAFT product technology to the assets held for sale.

Management estimates that the annual amortization charge in respect of intangible assets held at December 31, 2013will be approximately $127million for each of the five years to December 31, 2018.Estimated amortization expense can be affected by various factors including future acquisitions, disposals of product rights, regulatory approval and subsequent amortization of acquired IPR&D projects, foreign exchange movements and the technological advancement and regulatory approval of competitor products.

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Fair Value Measurement (Quantitative Information About Recurring and Non-recurring Level 3 Fair Value Measurements) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Fair Value Inputs
Impairment of intangible assets	$ 19.9	$ 197.9	$ 16.0
Impairment of assets held for sale	636.9	0	0
Recurring Basis | Contingent Consideration Payable | Minimum
Fair Value Inputs
Assumed market participant discount rate	2.90%
Cumulative probability of milestones being achieved	18.00%
Periods in which milestones are expected to be achieved	2014
Forecast quarterly royalties payable on net sales of relevant products	2.4
Recurring Basis | Contingent Consideration Payable | Maximum
Fair Value Inputs
Assumed market participant discount rate	15.00%
Cumulative probability of milestones being achieved	57.00%
Periods in which milestones are expected to be achieved	2025
Forecast quarterly royalties payable on net sales of relevant products	7.6
Recurring Basis | Contingent Consideration Payable | Income approach (probability weighted discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Liabilities	405.9
Recurring Basis | Contingent Consideration Receivable
Fair Value Inputs
Assumed market participant discount rate	6.20%
Recurring Basis | Contingent Consideration Receivable | Minimum
Fair Value Inputs
Probability weightings applied to different sales scenarios	10.00%
Future forecast royalties receivable at relevant contractual royalty rates	40.0
Recurring Basis | Contingent Consideration Receivable | Maximum
Fair Value Inputs
Probability weightings applied to different sales scenarios	45.00%
Future forecast royalties receivable at relevant contractual royalty rates	148.0
Recurring Basis | Contingent Consideration Receivable | Income approach (probability weighted discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Assets	36.1
Nonrecurring Basis | Movetis-related IPR&D intangible assets
Fair Value Inputs
Assumed market participant discount rate	8.90%
Decline in forecast peak sales	50.00%
Nonrecurring Basis | Movetis-related IPR&D intangible assets | Income approach (discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Assets	20.3
Nonrecurring Basis | DERMAGRAFT assets held for sale
Fair Value Inputs
Assumed market participant discount rate	11.50%
Nonrecurring Basis | DERMAGRAFT assets held for sale | Minimum
Fair Value Inputs
Future forecast milestones to be received	15
Nonrecurring Basis | DERMAGRAFT assets held for sale | Maximum
Fair Value Inputs
Future forecast milestones to be received	95
Nonrecurring Basis | DERMAGRAFT assets held for sale | Income approach (probability weighted discounted cash flow)
Fair Value Measurements, Recurring and Nonrecurring, Valuation Techniques [Line Items]
Assets	$ 31.6

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Inventories (Tables)

12 Months Ended

Dec. 31, 2013

Inventory Disclosure [Abstract]

Schedule of Inventory

	December 31,	December 31,
	2013	2012
	$’M	$’M
	____________	____________
Finished goods	156.6	124.4
Work-in-progress	240.5	220.6
Raw materials	58.2	91.9
	____________	____________
	455.3	436.9
	____________	____________

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Taxation (Unrecognized Tax Benefits) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012		Dec. 31, 2011
Reconciliation of Unrecognized Tax Benefits
Balance at January 1,	$ 278.7	[1]	$ 265.5	[1]	$ 290.8
Increases based on tax positions related to the current year	56.8		20.5		18.2
Decreases based on tax positions taken in the current year	(0.5)		0		(2.5)
Increases for tax positions taken in prior years	34.5		0.4		1.4
Decreases for tax positions taken in prior years	(0.8)		(3.3)		(12.0)
Decreases resulting from settlements with the taxing authorities	0		(10.6)		(25.7)
Decreases as a result of expiration of the statute of limitations	(0.6)		(0.3)		(0.5)
Foreign currency translation adjustments	(12.9)	[2]	6.5	[2]	(4.2)	[2]
Balance at December 31,	355.2	[1]	278.7	[1]	265.5	[1]
Income tax penalties and interest expense	0.4		5.1		4.0
Income tax penalties and interest expense accrued	112.2		119.6		114.5
Future increase or decrease in the unrecognized tax benefit.	$ 210

[1] The full amount of which would affect the effective rate if recognized

[2] Recognized within Other Comprehensive Income

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Share-based Compensation Plans

12 Months Ended

Dec. 31, 2013

Disclosure of Compensation Related Costs, Share-based Payments [Abstract]

Share-based Compensation Plans Disclosure

27.       Share-based compensation plans

The following table shows the total share-based compensation expense (see below for types of share-based awards) included in the consolidated statements of income:

	2013	2012	2011
	$’M	$’M	$’M
	____________	____________	____________
Cost of product sales	4.4	6.3	8.8
Research and development	22.8	25.8	21.8
Selling, general and administrative	46.9	55.0	45.1
Reorganization costs	3.3	-	-
	____________	____________	____________
Total	77.4	87.1	75.7
Less tax	(18.1)	(23.8)	(23.6)
	____________	____________	____________
	59.3	63.3	52.1
	____________	____________	____________

There were no capitalized share-based compensation costs at December 31, 2013 and 2012.

At December 31, 2013$97.0 million(2012: $102.3 million) of total unrecognized compensation cost relating to non-vested awards is expected to be recognized over a period of 3 years.

At December 31, 2013$90.3 million (2012: $74.6 million) of total unrecognized compensation cost relating to non-vested in the money awards (based on the average share price during the year) is expected to be recognized over a weighted average period of 1.7 years (2012: 1.7 years). The total fair value of in the money awards vested during the yearto December 31, 2013 was $70.5 million (2012: $113.9 million).

Share-based compensation plans

The Company grants stock-settled share appreciation rights (“SARs”) and performance share awards over ordinary shares and ADSs to Executive Directors and employees under the Shire Portfolio Share Plan (Parts A and B). The SARs and PSAs granted under the Shire Portfolio Share Plan (Part A & B) to Executive Directors are exercisable subject to performance and service criteria.

The principal terms and conditions of SARs and PSAs are as follows: (i) the contractual life of SARs is seven years, (ii) the vesting period of SARs and PSAs granted to employees below the level of Executive Vice President allows for graded vesting, and (iii) awards granted to Executive Directors contain performance conditions based on growth in adjusted return on invested capital (“Adjusted ROIC”) and earnings before interest, taxation, depreciation and amortization (“Non-GAAP EBITDA”).

The Company also operates an Employee Share Purchase Plan and a Sharesave Scheme.

The following awards were outstanding as at December 31, 2013:

	Compensation type	Number of awards*	Expiration period from date of issue	Vesting period
	____________	____________	____________	____________
Portfolio Share Plan - Part A	SARs	14,083,748	5 - 7 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
Sharesave Scheme	Stock options	243,783	6 months after vesting	3 or 5 years
Stock Purchase Plan	Stock options	568,828	On vesting date	1 to 5 years
Legacy Plans	Stock options	132,823	7 to 10 years	3-10 years, subject to market or performance criteria
		__________________
Stock-settled SARs and stock options		15,029,182
		__________________
Portfolio Share Plan - Part B	Performance share awards	2,701,299	3 years	3 years cliff or graded vesting, subject to market or performance criteria for Executive Directors only
		__________________
Performance share awards		2,701,299
		__________________

* Number of awards are stated in terms of ordinary share equivalents.

Stock settled SARs and stock options

(a)       Portfolio Share Plan – Part A

Stock-settled share appreciation rights granted under the Portfolio Share Plan – Part A are exercisable subject to performance and service criteria.

In respect of any award made to Executive Directors performance criteria are based on Non-GAAP EBITDA and Adjusted ROIC targets. These performance measures provide increased alignment to the core activities and strategy of the Company.

Awards granted to employees below Executive Director level are not subject to performance conditions and are only subject to service conditions.

Once awards have vested, participants will have until the seventh anniversaryof the date of grant to exercise their awards.

(b)       Shire Sharesave Scheme (Sharesave Scheme)

Options granted under the Sharesave Scheme are granted with an exercise price equal to 80% and 75% of the mid-market price on the day before invitations are issued to UK and Ireland employees, respectively. Employees may enter into three or fiveyear savings contracts. No performance conditions apply.

(c)       Shire Employee Stock Purchase Plan (Stock Purchase Plan)

Under the Stock Purchase Plan, options are granted with an exercise price equal to 85% of the fair market value of a share on the enrolment date (the first day of the offering period) or the exercise date (the last day of the offering period), whichever is the lower. Employees agree to save for a period up to 12 months. No performance conditions apply.

(d)       Legacy plans –principally the Shire 2000 Executive Share Option Scheme

Options granted under this scheme were subject to certain performance criteria, which were based on the Company's share price or diluted EPS growth compared to a fixed growth rate. At December 31, 2013 all stock options outstanding under this scheme had met the required conditions and were exercisable.

A summary of the status of the Company's SARs and stock options as at December 31, 2013 and of the related transactions during the period then ended is presented below:

	Weighted average exercise price
Year to December 31, 2013	£	Number of	Intrinsic Value
		shares*	£’ M
	_______________	_______________	_______________
Outstanding as at beginning of period	16.66	18,536,947
Granted	20.05	6,914,026
Exercised	22.09	(8,302,740)
Forfeited	18.30	(2,119,051)
	_______________	_______________	________________
Outstanding as at end of period	18.88	15,029,182	143.9
	_______________	_______________	________________
Exercisable as at end of period	15.67	3,670,446	46.9
	_______________	_______________	________________

* Number of awards are stated in terms of ordinary share equivalents

The weighted average grant date fair value of SARs and stock options granted in the year ended December 31, 2013was£3.37.

SARs and stock options outstanding as at December 31, 2013 have the following characteristics:

Number of awards outstanding*	Exercise prices	Weighted Average remaining contractual term (Years)	Weighted average exercise price of awards outstanding	Number of awards exercisable	Weighted average exercise price of awards exercisable
	£		£		£
________________	______________	__________	_______________	_____________	_____________
104,658	3.38-7.00	1.1	5.56	104,658	5.56
810,822	7.01-14.00	2.8	11.27	804,402	11.25
14,113,702	14.01-28.00	4.9	18.07	2,761,386	17.34
________________				_____________
15,029,182				3,670,446
________________				_____________

* Number of awards are stated in terms of ordinary share equivalents

Performance shares

Portfolio Share Plan – Part B

Performance share awards granted to Executive Directors under the Portfolio Share Plan – Part B are exercisable subject to certain market, performance and service criteria.

In respect of any award granted to Executive Directors, the performance criteriaare based on Non-GAAP EBITDA and Adjusted ROIC targets.

Awards granted to employees below Executive Director level are not subject to performance conditions and are only subject to service conditions.

A summary of the status of the Company's performance share awards as at December 31, 2013 and of the related transactions during the period then ended is presented below:

Performance share awards	Number of shares*	Aggregate intrinsic value £’M	Weighted average remaining life
	_______________	_______________	_______________
Outstanding as at beginning of period	3,518,138
Granted	1,508,631
Exercised	(1,826,648)
Forfeited	(498,822)
	_______________
Outstanding as at end of period	2,701,299	76.9	5.5
	_______________	_______________	________________
Exercisable as at end of period	-	N/A	N/A
	_______________	_______________	_______________

* Number of awards are stated in terms of ordinary share equivalents

The weighted-average grant date fair value of performance share awards granted in the year to December 31, 2013 is £19.71.

Exercises of employee share-based awards

The total intrinsic values of share-based awards exercised for the years to December 31, 2013, 2012 and 2011 were $298.3 million, $224.1 million and $189.3 million, respectively. The total cash received from employees as a result of employee share option exercises for the period to December 31, 2013, 2012 and 2011 was approximately $17.2 million, $16.2 million and $13.4 million, respectively. In connection with these exercises, the tax benefitcredited to additional paid-in capital for the years to December 31, 2013, 2012 and 2011 was $11.9million,$40.1million and $29.4million respectively.

The Company will settle future employee share award exercises with either newly listed common shares or withshares held in theEBT. The number of shares to be purchased by the EBT during 2013 will be dependent on thenumber of employee share awards granted and exercised during the year and Shire plc's share price. At December 31, 2013 the EBT held 2.4 million ordinary shares and 0.4million ADSs.

Valuation methodologies

The Company estimates the fair value of its share-based awards using a Black-Scholes valuation model. Key input assumptions used to estimate the fair value of share–based awards include the grant price of the award, the expected stock-based award term, volatility of the Company's share price, the risk-free rate and the Company's dividend yield. The Company believes that the valuation technique and the approach utilized to develop the underlying assumptions are appropriate in estimating the fair values of Shire's stock-based awards. Estimates of fair value are not intended to predict actual future events or the value ultimately realized by employees who receive equity awards, and subsequent events are not indicative of the reasonableness of the original estimates of fair value made by the Company under guidance issued by the FASB on share based payment transactions.

The fair value of share awards granted was estimated using the following assumptions:

Period ended December 31,	2013	2012	2011
	______________	______________	______________
Risk-free interest rate1	0.1-0.9%	0.2-1%	0.1-2.5%
Expected dividend yield	0.4-0.6%	0-0.6%	0-0.5%
Expected life	1-4 years	1-4 years	1-5 years
Volatility	23-26%	24-32%	19-33%
Forfeiture rate	5-9%	5-7%	5-7%

(1)       Risk free interest rate is for UK and US grants

The following assumptions were used to value share-based awards:

• risk-free interest rate – for awards granted over ADSs, the US Federal Reserve treasury constant maturities rate with a term consistent with the expected life of the award is used. For awards granted over ordinary shares, the yield on UK government bonds with a term consistent with the expected life of the award is used;
• expected dividend yield – measured as the average annualized dividend estimated to be paid by the Company over the expected life of the award as a percentage of the share price at the grant date;
• expected life – estimated based on the contractual term of the awards and the effects of employees' expected exercise and post-vesting employment termination behaviour;
• expected volatility – measured using historical daily price changes of the Company's share price over the respective expected life of the share-based awards at the date of the award; and
• the forfeiture rate is estimated using historical trends of the number of awards forfeited prior to vesting.

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Taxation (Operating Loss and Tax Credit Carryforwards, and Their Expiration Dates) (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Operating Loss and Tax Credit Carryforwards [Line Items]
Gross value of NOLs and capital losses	$ 2,583.7	$ 1,783.5
Expirations of Tax Benefit Carryforwards
Within 1 year	0.9
Winthin 1 to 2 years	1.1
Winthin 2 to 3 years	0.7
Winthin 3 to 4 years	2.9
Winthin 4 to 5 years	3.0
Winthin 5 to 6 years	35.6
After 6 years	142.7
Indefinitely	313.7
Unremitted earnings of the Company's foreign subsidiaries	8,500
R&D and Other Tax Credits
Operating Loss and Tax Credit Carryforwards [Line Items]
Tax credit carryforwards	48.3	66.2
US Federal
Operating Loss and Tax Credit Carryforwards [Line Items]
NOLs	32.2	26.1
US State
Operating Loss and Tax Credit Carryforwards [Line Items]
NOLs	61.5	31.4
UK
Operating Loss and Tax Credit Carryforwards [Line Items]
NOLs	6.7	20.7
Republic of Ireland
Operating Loss and Tax Credit Carryforwards [Line Items]
NOLs	78.8	72.6
Foreign Tax Jurisdictions
Operating Loss and Tax Credit Carryforwards [Line Items]
NOLs	$ 273.1	$ 208.8

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Consolidated Statements of Income (Parenthetical) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Intangible Assets (Excluding Goodwill) [Line Items]
Impairment of unamortized intangible assets	$ 19.9	$ 71.2	$ 16.0
Impairment charges	19.9	197.9	16.0
Acquired Intellectual Property Rights
Intangible Assets (Excluding Goodwill) [Line Items]
Amortization and impairment charges of intangible assets	$ 152.0	$ 280.3	$ 145.0

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Commitments and Contingencies (Commitments and Loss Contingency) (Details) (USD $) In Millions, unless otherwise specified			12 Months Ended		12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2013 INTUNIV	Dec. 31, 2012 Settlement costs related to agreement in principle to resolve a civil subpoena	Dec. 31, 2013 Settlement costs related to ADDERALL XR supply agreement dispute	Dec. 31, 2013 Clinical Testing	Dec. 31, 2012 Clinical Testing	Dec. 31, 2013 Contract Manufacturing	Dec. 31, 2012 Contract Manufacturing	Dec. 31, 2013 Other Purchasing Commitment	Dec. 31, 2012 Other Purchasing Commitment	Dec. 31, 2013 Investment Commitment	Dec. 31, 2012 Investment Commitment	Dec. 31, 2013 Capital Commitment	Dec. 31, 2012 Capital Commitment
Commitment [Line Items]
Commitment amount						$ 346.0	$ 425.0	$ 109.0	$ 125.0	$ 128.0	$ 145.0	$ 14.0	$ 15.0	$ 12.0	$ 97.0
Commitments expected to be paid in next year								109.0		121.0
Legal Matters [Line Items]
Provisions for litigation loss, insurance claims and other disputes	72.7	130.5		57.5
Cash payment to Impax					$ 48.0
Settlement of litigation			Payment of a royalty of 25% of gross profits

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Consolidated Statements of Cash Flows (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 665.1	$ 745.4	$ 865.0
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	324.4	308.6	294.8
Share based compensation	77.4	87.1	75.7
Change in fair value of contingent consideration	(159.1)	9.2	0
Impairment of intangible assets	19.9	197.9	16.0
Goodwill impairment charge	7.1	0	0
Impairment of assets held for sale	636.9	0	0
Write down of assets	58.2	0.9	0
Gain on sale of non-current investments	0	0	(23.5)
(Gain)/ loss on sale of product rights	(15.9)	(18.1)	6.0
Other, net	8.3	7.4	16.1
Movement in deferred taxes	(349.9)	(58.3)	(14.5)
Equity in earnings of equity method investees	(3.9)	(1.0)	(2.5)
Changes in operating assets and liabilities:
(Increase)/decrease in accounts receivable	(148.3)	22.2	(134.0)
Increase in sales deduction accruals	177.5	42.7	80.5
Increase in inventory	(36.6)	(88.2)	(64.4)
Increase in prepayments and other assets	(60.9)	(14.5)	(36.8)
Increase/(decrease) in accounts payable and other liabilities	67.9	136.7	(10.0)
Returns on investment from joint venture	3.1	4.9	5.2
Net cash provided by operating activities	1,463.0	1,382.9	1,073.6
CASH FLOWS FROM INVESTING ACTIVITIES:
Movements in restricted cash	(5.3)	3.5	6.2
Purchases of subsidiary undertakings and businesses, net of cash acquired	(227.8)	(97.0)	(725.0)
Purchases of non-current investments	(10.6)	(18.0)	(10.7)
Purchases of property, plant and equipment ("PP&E")	(157.0)	(149.6)	(194.3)
Purchases of intangible assets	0	(43.5)	(5.2)
Proceeds from disposal of non-current investments and PP&E	12.1	7.2	106.0
Proceeds received on sale of product rights	19.2	17.8	12.0
Returns from equity investments	5.4	0	0
Other, net	3.1	8.6	1.8
Net cash used in investing activities	(360.9)	(271.0)	(809.2)
CASH FLOWS FROM FINANCING ACTIVITIES:
Payments to acquire shares (in USD)	(243.8)	(205.8)	(151.8)
Payment of dividend	(96.4)	(86.3)	(73.8)
Proceeds from exercise of options	17.2	16.2	13.4
Proceeds from drawing of revolving credit facility ("RCF")	0	0	30.0
Repayment of RCF	0	0	(30.0)
Repayment of debt acquired through business combinations	(6.0)	0	(13.1)
Facility arrangement fee	(13.9)	0	0
Excess tax benefit associated with exercise of stock options	13.4	40.7	31.4
Contingent consideration payments	(14.1)	(5.8)	0
Other, net	(1.0)	(3.3)	(1.5)
Net cash used in financing activities	(344.6)	(244.3)	(195.4)
Effect of foreign exchange rate changes on cash and cash equivalents	(0.3)	(5.4)	0.4
Net increase in cash and cash equivalents	757.2	862.2	69.4
Cash and cash equivalents at beginning of period	1,482.2	620.0	550.6
Cash and cash equivalents at end of period	2,239.4	1,482.2	620.0
Supplemental information associated with continuing operations:
Interest paid	(29.9)	(34.6)	(33.3)
Income taxes paid	(290.2)	(199.2)	(286.1)
Continung operations
Adjustments to reconcile net income to net cash provided by operating activities:
Goodwill impairment charge	7.1
Discontinued operations
Adjustments to reconcile net income to net cash provided by operating activities:
Goodwill impairment charge	191.8
Goowill impairment charge total
Adjustments to reconcile net income to net cash provided by operating activities:
Goodwill impairment charge	198.9
EBT
CASH FLOWS FROM FINANCING ACTIVITIES:
Payments to acquire shares (in USD)	(50.0)	(99.3)	(151.8)
Share Buy-back Program
CASH FLOWS FROM FINANCING ACTIVITIES:
Payments to acquire shares (in USD)	$ (193.8)	$ (106.5)	$ 0

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Commitments and Contingencies (Tables)

12 Months Ended

Dec. 31, 2013

Commitments and Contingencies Disclosure [Abstract]

Future Minimum Lease Payments under Operating Leases

	Operating
	leases
	$’M
	_____________
2014	44.9
2015	33.6
2016	23.9
2017	17.9
2018	12.2
Thereafter	83.4
	_____________
	215.9
	_____________

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Other Current Liabilities (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Other Liabilities, Current [Abstract]
Income taxes payable	$ 69.0	$ 78.4
Value added taxes	15.8	23.6
Contingent consideration payable	12.9	16.0
Other current liabilities	21.8	26.1
Other current liabilities, total	$ 119.5	$ 144.1

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Taxation (Deferred Tax Assets and Liabilities, and Valuation Allowances) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013		Dec. 31, 2012
Deferred tax assets:
Deferred revenue	$ 5.2		$ 5.5
Inventory & warranty provisions	48.6		52.5
Losses carried forward (including tax credits)	500.6	[1]	425.7	[1]
Provision for sales deductions and doubtful accounts	151.8		144.9
Intangible assets	10.7		36.7
Share-based compensation	25.5		32.7
Excess of tax value over book value of fixed assets	22.1		0
Accruals and provisions	55.1		44.1
Other	2.6		21.6
Gross deferred tax assets	822.2		763.7
Less: valuation allowance	(282.4)		(268.6)
Deferred tax assets, net	539.8		495.1
Deferred tax liabilities:
Intangible assets	(586.8)		(702.7)
Excess of book value over tax value of assets and investments	(56.9)		(36.8)
Net deferred tax liabilities	(103.9)		(244.4)
Net operating losses that result from excess stock based compensation	15.0		6.8
Balance Sheet Classifications
Deferred tax assets - current	315.6		229.9
Deferred tax assets - non-current	141.1		46.5
Deferred tax liabilities - non-current	(560.6)		(520.8)
Valuation Allowance [Line Items]
Valuation Allowances	282.4		268.6
Net increase in valuation allowances	13.8
ValuationAllowanceDeferredTaxAssetExplanationOfChange	The net increase in valuation allowances of $13.8 million includes (i) increases of $104.5 million primarily in respect of losses and other temporary differences in various jurisdictions where management consider that there is insufficient positive evidence in respect of the factors described above to overcome cumulative losses and therefore it is more likely than not that the relevant deferred tax assets will not be realized in full, and (ii) a decrease of $90.7 million primarily in respect of German tax losses ($67.4m), which based on the assessment of the factors described above now provides sufficient positive evidence to support that the losses are more likely than not to be realized. The release of this valuation allowance has been recorded in the current period due to changes in the financing of the German subsidiary.
Ireland
Deferred tax assets:
Less: valuation allowance	(78.8)		(73.9)
Valuation Allowance [Line Items]
Valuation Allowances	78.8		73.9
United States
Deferred tax assets:
Less: valuation allowance	(60.9)		(37.2)
Valuation Allowance [Line Items]
Valuation Allowances	60.9		37.2
Germany
Deferred tax assets:
Less: valuation allowance	(30.8)		(96.9)
Valuation Allowance [Line Items]
Valuation Allowances	30.8		96.9
Other foreign tax jurisdictions
Deferred tax assets:
Less: valuation allowance	(111.9)		(60.6)
Valuation Allowance [Line Items]
Valuation Allowances	$ 111.9		$ 60.6

[1] Excluding $15.0 million of deferred tax assets at December 31, 2013 (2012: $6.8 million), related to the net operating losses that result from excess stock based compensation and for which any benefit realized will be recorded to stockholders’ equity

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Business Combinations (FerroKin and Pervasis) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended			0 Months Ended	12 Months Ended		1 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011	Apr. 02, 2012 FerroKin	Dec. 31, 2013 FerroKin	Dec. 31, 2012 FerroKin	Apr. 19, 2012 Pervasis
Business Acquisition [Line Items]
Percentage of voting interests acquired				100.00%
Acquisition-date fair value of consideration				$ 159.3			$ 26.1
Cash consideration paid				94.5			2.5
Fair value of contingent consideration payable				64.8			23.6
Maximum amount of contingent cash consideration				225.0			169.5
Integration and acquisition costs	(134.1)	13.5	0.1		10.4	12.1
Post acquisition pre-tax losses included in consolidated statement of income						19.1
Purchase Price Allocation
IPR&D				166.0			24.3
Net current liabilities assumed				6.6			0.2
Net non-current liabilities assumed (including deferred tax liabilities)				46.2
Goodwill arising on business acquired	$ 170.3	$ 48.1		$ 46.1			$ 2.0

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Accounts Payable and Accrued Expenses

12 Months Ended

Dec. 31, 2013

Accounts Payable and Accrued Liabilities, Current [Abstract]

Accounts Payable and Accrued Expenses Disclosure

13.       Accounts payable and accrued expenses

	December 31,	December 31,
	2013	2012
	$’M	$’M
	________________	________________
Trade accounts payable and accrued purchases	202.6	208.1
Accrued rebates – Medicaid	549.1	455.6
Accrued rebates – Managed care	258.1	184.9
Sales return reserve	98.8	90.5
Accrued bonuses	130.9	109.0
Accrued employee compensation and benefits payable	79.4	64.5
R&D accruals	69.6	73.5
Provisions for litigation losses and other claims	71.7	118.2
Other accrued expenses	228.2	197.2
	________________	________________
	1,688.4	1,501.5
	________________	________________

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Inventories (Details) (USD $) In Millions, unless otherwise specified	Dec. 31, 2013	Dec. 31, 2012
Schedule of Inventory
Finished goods	$ 156.6	$ 124.4
Work-in-progress	240.5	220.6
Raw materials	58.2	91.9
Total inventories	$ 455.3	$ 436.9

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Segmental Reporting

12 Months Ended

Dec. 31, 2013

Segment Reporting [Abstract]

Segment Reporting Disclosure

24.       Segmental reporting

Historically the Company had three business units and three reportable segments: Specialty Pharmaceuticals (“SP”), Human Genetic Therapies (“HGT”) and RM.

On May 2, 2013 the Company announced that there would be a reorganization of the Company's business to integrate the operation of these business units into a simplified One Shire organization in order to drive future growth and innovation. Consequently the SP, HGT and RM segmentsno longer exist.

Shire now comprises a single operating and reportable segment, consistent with the One Shire approach that underpins the business simplification. This segment is engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs.

This segment is supported by several key functions: a Pipeline group, consisting of R&D and Business Development, will prioritize its activities towards late stage development programs across a variety of therapeutic areas, while focusing its pre-clinical development activities primarily in rare diseases; a Technical Operations group will be responsible for the Company's global supply chain; and an In-line marketed products group will focus on commercialized products. The In-Line marketed products group currently consists of four commercial units focused exclusively on commercial delivery to drive optimum performance of currently marketed products. The business is also supported by a simplified, centralized corporate function group. None of these functional groups meets all of the criteria to be an operating segment.

The reorganization to a single operating and reportable segment is consistent with the financial information regularly reviewed by the Executive Committee (which is Shire's chief operating decision maker) for the purposes of evaluating performance, allocating resources, and planning and forecasting future periods.

Geographic information

Revenues (based on the geographic location from which the sale originated):

	2013	2012	2011
Year to December 31,	$’M	$’M	$’M
	___________	___________	___________
Ireland	22.5	20.6	21.1
United Kingdom	206.7	207.0	219.9
North America	3,386.2	3,006.1	2,761.8
Rest of World	1,318.9	1,293.7	1,155.3
	____________	____________	____________
Total revenues	4,934.3	4,527.4	4,158.1
	____________	____________	____________

Long-lived assets comprise all non-current assets, (excluding goodwill and other intangible assets, deferred contingent consideration assets, deferred tax assets, investments and financial instruments) based on the geographic location within which the economic benefits arise:

	2013	2012
Year to December 31,	$’M	$’M
	___________	___________
Ireland	5.8	5.2
United Kingdom	70.3	72.2
North America	802.9	861.0
Rest of World	13.8	18.8
	____________	____________
Total	892.8	957.2
	____________	____________

Material customers

In the periods set out below, certain customers, accounted for greater than 10% of the Company's product revenues:

	2013	2013	2012	2012	2011	2011
Year to December 31,	$’M	% product revenue	$’M	% product revenue	$’M	% product revenue
	___________	___________	___________	___________	___________	___________
McKesson Corp.	902.9	19	835.9	20	742.9	19
Cardinal Health Inc.	853.7	18	1,035.7	24	923.9	24
AmerisourceBergen Corp	721.0	15	307.4	7	276.4	7
	____________	___________	____________	___________	____________	___________
Amounts outstanding as at December 31, in respect of these material customers were as follows:
					2013	2012
December 31,					$’M	$’M
					___________	___________
McKesson Corp.					161.3	127.4
Cardinal Health Inc.					149.5	166.1
AmerisourceBergen Corp					164.6	47.4
					____________	___________

In the periods set out below, revenues by major product were as follows:

	2013	2012	2011
	$’M	$’M	$’M
	___________	___________	___________
VYVANSE	1,227.8	1,029.8	805.0
ELAPRASE	545.6	497.6	464.9
LIALDA/MEZAVANT	528.9	399.9	372.1
REPLAGAL	467.9	497.5	475.2
ADDERALL XR	375.4	429.0	532.8
VPRIV	342.7	306.6	256.2
INTUNIV	334.9	287.8	223.0
PENTASA	280.6	265.8	251.4
FIRAZYR	234.8	116.3	33.0
FOSRENOL	183.4	172.0	166.9
XAGRID	99.4	97.2	90.6
Other product sales	136.1	153.4	173.8
	____________	____________	____________
Total product sales	4,757.5	4,252.9	3,844.9
	____________	____________	____________

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Accounts Receivable, Net

12 Months Ended

Dec. 31, 2013

Receivables [Abstract]

Accounts Receivable Disclosure

6.Accounts receivable, net

Accounts receivable at December 31, 2013 of $961.2 million(December 31, 2012: $824.2 million), are stated net of a provision for discounts and doubtful accounts of $47.9 million (December 31, 2012: $41.7million, December 31, 2011: $31.1 million).

Provision for discounts and doubtful accounts:

	2013	2012	2011
	$’M	$’M	$’M
	_____________	_____________	_____________
As at January 1,	41.7	31.1	23.4
Provision charged to operations	306.8	283.3	240.8
Provision utilization	(300.6)	(272.7)	(233.1)
	_____________	_____________	_____________
As at December 31,	47.9	41.7	31.1
	_____________	_____________	_____________

At December 31, 2013 accounts receivable included $37.8 million (December 31, 2012: $38.5 million) related to royalty income.

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Segmental Reporting (Revenue by Product) (Details) (USD $) In Millions, unless otherwise specified	12 Months Ended
	Dec. 31, 2013	Dec. 31, 2012	Dec. 31, 2011
Revenue from External Customer [Line Items]
Product sales	$ 4,757.5	$ 4,252.9	$ 3,844.9
VYVANSE
Revenue from External Customer [Line Items]
Product sales	1,227.8	1,029.8	805.0
ADDERALL XR
Revenue from External Customer [Line Items]
Product sales	375.4	429.0	532.8
INTUNIV
Revenue from External Customer [Line Items]
Product sales	334.9	287.8	223.0
LIALDA and MEZAVANT
Revenue from External Customer [Line Items]
Product sales	528.9	399.9	372.1
PENTASA
Revenue from External Customer [Line Items]
Product sales	280.6	265.8	251.4
FOSRENOL
Revenue from External Customer [Line Items]
Product sales	183.4	172.0	166.9
XAGRID
Revenue from External Customer [Line Items]
Product sales	99.4	97.2	90.6
Other Products
Revenue from External Customer [Line Items]
Product sales	136.1	153.4	173.8
REPLAGAL
Revenue from External Customer [Line Items]
Product sales	467.9	497.5	475.2
ELAPRASE
Revenue from External Customer [Line Items]
Product sales	545.6	497.6	464.9
VPRIV
Revenue from External Customer [Line Items]
Product sales	342.7	306.6	256.2
FIRAZYR
Revenue from External Customer [Line Items]
Product sales	$ 234.8	$ 116.3	$ 33.0