8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): May 3, 2013

Shire plc

(Exact name of registrant as specified in its charter)

Jersey, Channel Islands

(State or other jurisdiction of incorporation)

0-29630	98-0601486
(Commission File Number)	(IRS Employer Identification No.)

5 Riverwalk, Citywest Business Campus, Dublin 24, Republic of Ireland
(Address of principal executive offices)	(Zip code)

Registrant's telephone number, including area code +353 1 429 7700

(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):

o  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

o  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

o  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

o  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 8.01.    Other Events

Shire plc has issued the press releases attached hereto as Exhibit 99.01 and Exhibit 99.02 which are incorporated by reference herein.

Item 9.01.    Financial Statements and Exhibits

(d)  Exhibits.  The following exhibits are filed herewith:

99.01   Press Release dated May 3, 2013

99.02   Press Release dated May 3, 2013

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.

SHIRE PLC
By:	/s/ T May
	Name:	Tatjana May
	Title:	General Counsel

Dated: May 3, 2013

EXHIBIT INDEX
Number	Description
99.01	Press release dated May 3, 2013
99.02	Press release dated May 3, 2013

EX-99.01

Exhibit 99.01

Press Release www.shire.com

Director’s Share Dealings

May 3, 2013 - Shire plc (LSE: SHP, NASDAQ: SHPG) announces that, following the appointment of Flemming Ornskov, MD, to the Board of Shire plc as Chief Executive Officer Designate on January 2, 2013 and in accordance with the terms of his employment agreement, on May 2, 2013 Dr. Ornskov was conditionally granted 15,286 deferred American Depository Shares (“ADSs”) and a replacement equity award under the Shire Portfolio Share Plan over 29,805 ADSs.

The deferred ADSs represent approximately 75% of the replacement payment paid to Dr. Ornskov as compensation for the sign-on bonus and annual bonus he forfeited in connection with the termination of his prior employment. These ADSs will be released on February 28, 2015, the second anniversary of the originally planned date of grant of February 28, 2013, subject to Dr. Ornskov’s continued employment at the date of vesting.

Dr. Ornskov’s replacement equity award comprises Stock Appreciation Rights (“SARs”) over 18,984 ADSs at an exercise price of $91.59 per ADS and Performance Share Awards (“PSAs”) over 10,821 ADSs. The SARs and PSAs will normally vest on the third anniversary of the date of grant, subject to performance targets being satisfied. No consideration was paid for the grant of SARs and PSAs.

Following this transaction, Dr. Ornskov holds awards of SARs, PSAs and deferred shares over 124,893 ADSs. One ADS is equal to three Shire ordinary shares of 5 pence each.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure and Transparency Rules.

Tony Guthrie

Deputy Company Secretary

For further information please contact:

Investor Relations
Eric Rojas	erojas@shire.com	+1 781 482 0999
Sarah Elton-Farr	seltonfarr@shire.com	+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal, Internal Medicine and Regenerative Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas.

www.shire.com

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

EX-99.02

Exhibit 99.02

Press Release www.shire.com

Transaction in Own Shares

May 3, 2013 – Shire plc (LSE: SHP, NASDAQ: SHPG) (the “Company”), announces that in accordance with the authority granted by shareholders at the Company's Annual General Meeting on April 24, 2012 it purchased 570,000 of its ordinary shares of 5 pence each (“Ordinary Shares”) on May 2, 2013 through both direct purchases of Ordinary Shares and through the purchase of Ordinary Shares underlying ADRs. The highest and lowest price paid for the directly acquired Ordinary Shares was 2021.00 pence per share and 1868.00 pence per share respectively and for those Ordinary Shares acquired through the purchase of ADRs was 2941.16cents per share and 2910.66 cents per share respectively.

The purchased shares will be held as treasury shares.  Following the above purchase, the Company holds 7,984,097Ordinary Shares as treasury shares and has 554,842,325 Ordinary Shares in issue (excluding treasury shares).

The purchases were made by an independent third party which makes its trading decisions independently of, and uninfluenced by the Company.  The independence of the third party enables the Company to continue to purchase Ordinary Shares (including Ordinary Shares underlying ADRs) during close periods and other prohibited periods, should they arise. The third party has been appointed by the Company to make purchases to December 31, 2013.

For further information please contact:

Investor Relations
Eric Rojas	erojas@shire.com	+1 781 482 0999
Sarah Elton-Farr	seltonfarr@shire.com	+44 1256 894157

NOTES TO EDITORS

Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty medicines to meet significant unmet patient needs.

We provide treatments in Neuroscience, Rare Diseases, Gastrointestinal, Internal Medicine and Regenerative Medicine and we are developing treatments for symptomatic conditions treated by specialist physicians in other targeted therapeutic areas.

www.shire.com

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX