EXHIBIT 31.2

CERTIFICATION OF GRAHAM HETHERINGTON PURSUANT TO

RULE 13A-14 UNDER THE

SECURITIES EXCHANGE ACT OF 1934

FORM 10-Q/A FOR THE QUARTER ENDED

MARCH 31, 2012 OF

SHIRE PLC

I, Graham Hetherington, certify that:

1. I have reviewed this amendment no. 1 to the quarterly report on Form 10-Q of Shire plc; and

2. Based on my knowledge, this amendment no. 1 to the quarterly report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report.

Date: May 23, 2012

/s/ Graham Hetherington

Graham Hetherington

Chief Financial Officer