8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): August 17, 2010

Shire plc

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(Exact name of registrant as specified in its charter)

Jersey, Channel Islands

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(State or other jurisdiction of incorporation)

0-29630                                                  98-0601486

(Commission File Number)                (IRS Employer Identification No.)

5 Riverwalk, Citywest Business Campus, Dublin

24, Republic of Ireland

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(Address of principal executive offices)                              (Zip code)

Registrant's telephone number, including area code               +353 1 429 7700

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(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):

[  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

[  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

[  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

[  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 8.01.  Other Events

     Shire plc has issued the press release attached hereto as Exhibit 99.01 which is incorporated by reference herein.

Item 9.01.  Financial Statements and Exhibits

                 (d)  Exhibits.  The following exhibit is filed herewith:

99.01         Press Release dated August 17, 2010

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant  has duly caused  this report to be signed on its behalf by the undersigned hereunto duly authorized.

SHIRE PLC
By:	/s/ A C Russell
	Name:  Angus Russell
	Title:    Chief Executive Officer

 Dated: August 17, 2010

EXHIBIT INDEX
Number	Description
99.01	Press Release dated August 17, 2010

EX-99.1

Exhibit 99.01

Press Release
www.shire.com

Director/PDMR Shareholding

August 17, 2010 - Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company (the “Company”), announces that on August 17, 2010, it was notified by Ms Barbara Deptula, a Person Discharging Managerial Responsibility, of the exercise, on August 16, 2010, ofStock Appreciation Rights over 13,334 Shire American Depositary Shares (“ADSs”) at an exercise price of $49.36, resulting in 3,795 ADSs being released.

The Company was also notified by Ms Deptula on August 17, 2010 of the following sale of ADSs and Shire plc ordinary shares of 5p each (“Shares”).

Date of Sale	Number of ADSs sold	Number of Shares sold	Sale Price
August 16, 2010	3,795	-	$69.00
August 13, 2010	13,317	-	$68.816
August 13, 2010	1,300	-	$68.910
August 13, 2010	2,437	-	$68.76
August 13, 2010	-	21,617	£14.767573

Following the above transactions, Ms Deptula holds awards of Stock Appreciation Rights, Performance Shares and Restricted Shares over 81,797 ADSs. One ADS equals 3 Shares.

This notification relates to disclosures made in accordance with 3.1.4(R)(1)(a) of the Disclosure

Tony Guthrie

Deputy Company Secretary

For further information please contact:

Investor Relations
Eric Rojas	erojas@shire.com	+1 781 482 0999

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician.  Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions. Shire’s in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights.  Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company’s website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX