8-K

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the

Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): November 25, 2008

Shire plc

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(Exact name of registrant as specified in its charter)

Jersey

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(State or other jurisdiction of incorporation)

0-29630                                                  98-0484822

(Commission File Number)                (IRS Employer Identification No.)

Hampshire International Business Park, Chineham, Basingstoke,

Hampshire RG24 8EP England

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(Address of principal executive offices)                              (Zip code)

Registrant's telephone number, including area code               44 1256 894 000

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(Former name or former address, if changed since last report)

Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2.):

[  ]  Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)

[  ]  Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)

[  ]  Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))

[  ]  Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.f13e-4(c))

Item 8.01.  Other Events

     Shire plc has issued the press releases attached hereto as Exhibit 99.01 and 99.02 which are incorporated by reference herein.

Item 9.01.  Financial Statements and Exhibits

                  (d)  Exhibits.  The following exhibits are filed herewith:

99.01             Press Release dated November 25, 2008

99.02             Press Release dated November 25, 2008

SIGNATURE

Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant  has duly caused  this report to be signed on its behalf by the undersigned hereunto duly authorized.

SHIRE PLC
By:	/s/ A C Russell
	Name:	Angus Russell
	Title:	Chief Executive Officer

Dated: November 25, 2008

EXHIBIT INDEX
Number	Description
99.01	Press Release dated November 25, 2008
99.02	Press Release dated November 25, 2008

EX-99.1

Exhibit 99.01

Press Release
www.shire.com

Director/PDMR Shareholding

November 25, 2008 - Shire plc (LSE: SHP, NASDAQ: SHPGY), the global specialty biopharmaceutical company, announces that on November 1, 2008 the following Persons Discharging Managerial Responsibility were granted options over American Depository Shares (“ADS”) in the Company pursuant to the Shire Employee Stock Purchase Plan (the “Plan”).  The options are exercisable over the number of ADS’ that may be purchased at the end of a 12 month saving period with the fortnightly savings made.  The option price is the lower of 85% of the fair market value of the Company’s ADS’ on November 1, 2008, being $33.53, and 85% of the fair market value of the Company’s ADS’ on October 31, 2009.   The options are normally exercisable on October 31, 2009.

Name	Fortnightly Savings
Barbara Deptula	$480.76
Anita Graham	$480.76
Sylvie Gregoire	$480.76

Tony Guthrie

Deputy Company Secretary

For further information please contact:

Investor Relations	Cléa Rosenfeld (Rest of the World)	+44 1256 894 160
	Eric Rojas (North America)	+1 617 551 9715

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician.  Shire focuses its business on attention deficit hyperactivity disorder (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other therapeutic areas to the extent they arise through acquisitions.  Shire’s in-licensing, merger and acquisition efforts are focused on products in specialist markets with strong intellectual property protection and global rights.  Shire believes that a carefully selected and balanced portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company’s website: www.shire.com.

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

EX-99.2

Exhibit 99.02

Press Release
www.shire.com

BLOCK LISTING SIX MONTHLY RETURN

November 25, 2008 - Shire plc (LSE: SHP, NASDAQ: SHPGY)

Name of applicant:		Shire plc
Name of scheme:		1996 Executive Share Option Scheme
Period of return:	From:	23 May 2008	To:	22 November 2008
Balance of unallotted securities under scheme(s) from previous return:		N/A
Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		82,000 (newly listed on 23 May 2008)
Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		Nil
Equals:  Balance under scheme(s) not yet issued/allotted at end of period:		82,000

Name of applicant:		Shire plc
Name of scheme:		2000 Executive Share Option Scheme
Period of return:	From:	23 May 2008	To:	22 November 2008
Balance of unallotted securities under scheme(s) from previous return:		N/A
Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		6,200,000 (newly listed on 23 May 2008)
Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		299,385
Equals:  Balance under scheme(s) not yet issued/allotted at end of period:		5,900,615

Registered in Jersey, No. 99854, 22 Grenville Street, St Helier, Jersey JE4 8PX

Name of applicant:		Shire plc
Name of scheme:		Shire Sharesave Scheme
Period of return:	From:	23 May 2008	To:	22 November 2008
Balance of unallotted securities under scheme(s) from previous return:		N/A
Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		82,000 (newly listed on 23 May 2008)
Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		5,315
Equals:  Balance under scheme(s) not yet issued/allotted at end of period:		76,685

Name of applicant:		Shire plc
Name of scheme:		Biochem Pharma Stock Option Plan
Period of return:	From:	23 May 2008	To:	22 November 2008
Balance of unallotted securities under scheme(s) from previous return:		N/A
Plus:  The amount by which the block scheme(s) has been increased since the date of the last return (if any increase has been applied for):		14,000 (newly listed on 23 May 2008)
Less:  Number of securities issued/allotted under scheme(s) during period (see LR3.5.7G):		Nil
Equals:  Balance under scheme(s) not yet issued/allotted at end of period:		14,000

Name of contact:	Tony Guthrie, Deputy Company Secretary
Address of contact:	Hampshire International Business Park Basingstoke, Hampshire, RG24 8EP
Telephone number of contact:	01256 894754