Notification of the Exercise of an Option and Acquisition of Shares by a Person Discharging Managerial Responsibilities.

The Company announces that on 21 December 2007 it was notified by Mrs Anita Graham, Executive Vice President, Corporate Business Services and Chief Administrative Officer of the acquisition in London on that day, of ordinary shares in the Company, following the exercise on the same day of an option over 10,432 ordinary 5p shares in the capital of the Company at an exercise price of £5.26.

10,432 ordinary 5p shares in the Company were acquired by Mrs Graham being 0.002% of the issued shares of that class. As a result of this transaction, Mrs Graham has a total interest of 12,341 ordinary shares in the Company being 0.0022% of the issued shares of that class.

T May

Company Secretary

For further information please contact:

Investor Relations	Cléa Rosenfeld (Rest of the World)	+44 1256 894 160
	Eric Rojas (North America)	+1 484 595 8252
Media	Jessica Mann (Rest of the World)	+44 1256 894 280
	Matthew Cabrey (North America)	+1 484 595 8248

Notes to editors

SHIRE PLC

Shire’s strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire’s in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results.

For further information on Shire, please visit the Company’s website: www.shire.com.

	Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com


	Press Release