Exhibit 21.1

LIST OF SUBSIDIARIES
	Principal subsidiary/undertaking	Jurisdiction of incorporation
	Shire Pharmaceuticals Group plc	England and Wales
	Shire Pharmaceuticals Limited	England and Wales
	Shire Pharmaceutical Development Limited	England and Wales
	Shire Pharmaceutical Contracts Limited	England and Wales
	Shire Pharmaceuticals Ireland Limited	Ireland
	Shire International Licensing BV	Netherlands
	Shire Deutschland GmbH & Co. KG	Germany
	Shire France S.A.	France
	Shire Italia SpA	Italy
	Shire Pharmaceuticals Iberica S.L.	Spain
	Shire Finance Limited	Cayman Islands
	Shire US Inc.	State of New Jersey, USA
	Shire Pharmaceuticals Inc.	State of Delaware, USA
	Shire LLC	State of Kentucky, USA
	Shire Pharmaceuticals US Development Inc.	State of Maryland, USA
	Shire Development Inc.	State of Delaware, USA
	Shire Regulatory Inc.	State of Delaware, USA
	Shire US Manufacturing Inc.	State of Maryland, USA
	Shire BioChem Inc.	Canada
	Transkaryotic Therapies, Inc.	State of Delaware, USA
	TKT Europe AB	Sweden
	All subsidiary undertakings of Shire plc are beneficially owned (directly or indirectly) as to 100% and are all consolidated in the consolidated financial statements of Shire plc.