EXHIBIT 99.01
Hampshire International Business Park Chineham Basingstoke Hampshire RG24 8EP United Kingdom Tel +44 (0)1256 894000 Fax +44 (0)1256 894708 www.shire.com
Press Release

SHIRE PHARMACEUTICALS GROUP PLC

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	ROBERTS PHARMACEUTICALS OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	25,038,293
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	0
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	25,038,293
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	134,788,867
	AND THE DATE OF ADMISSION:	22 DECEMBER 1999
.	PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS
		492,654,408

Registered in England 2883758 Registered Office as above

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	STOCK PURCHASE PLAN
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	806,323
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	13,635
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	792,688
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	1,011,958
	AND THE DATE OF ADMISSION:	2 APRIL 1996
	(A FURTHER LISTING OF 513,488 SHARES WAS GRANTED ON 19 APRIL 2002)
	(A FURTHER LISTING OF 100,000 SHARES WAS GRANTED ON 12 JUNE 2002)
	(A FURTHER LISTING OF 1,000,000 SHARES WAS GRANTED ON 8 JULY 2004)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	"B" EXECUTIVE SHARE OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	258,430
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	2,219,359
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	539,321
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	1,750,000
	AND THE DATE OF ADMISSION:	12 MARCH 1999
	(A FURTHER LISTING OF 3,250,000 SHARES WAS GRANTED IN AUGUST 2001)
	(A FURTHER LISTING OF 250,000 SHARES WAS GRANTED IN SEPTEMBER 2003)
	(A FURTHER LISTING OF 2,500,00 SHARES WAS GRANTED IN JANUARY 2005)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	"A" EXECUTIVE SHARE OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	135,427
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	26,418
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	109,009
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	250,000
	AND THE DATE OF ADMISSION:	12 MARCH 1999
	(A FURTHER LISTING OF 200,000 SHARES WAS GRANTED ON 19 APRIL 2002)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	SHIRE PHARMACEUTICALS SHARESAVE SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	47,444
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	1,173
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	45,624
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	247,500
	AND THE DATE OF ADMISSION:	21 AUGUST 1999
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	SHIRE RICHWOOD INC SHARE OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	388,852
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	NIL
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	388,852
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	1,597,816
	AND THE DATE OF ADMISSION:	31 MARCH 1999
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	SHIRELABORATORIES INC SHARE OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	7,843
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	5,503
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	3,609
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	1,741,654
	AND THE DATE OF ADMISSION:	18 MARCH 1998
	(A FURTHER LISTING OF 390,226 SHARES WAS GRANTED ON 31 MARCH 1999)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	SHIRE HOLDINGS LTD SHARE OPTION SCHEME
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	3,040
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	NIL
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	3,040
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	1,011,958
	AND THE DATE OF ADMISSION:	31 MARCH 1999
	(A FURTHER LISTING OF 318,912 SHARES WAS GRANTED ON 19 APRIL 2002)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	SHIRE BIOCHEM STOCK OPTION PLAN
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	5,292,951
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	31,859
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	5,261,092
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	14,822,713
	AND THE DATE OF ADMISSION:	AUGUST 2001
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

BLOCK LISTING SIX MONTHLY REVIEW

1.	NAME OF COMPANY:	SHIRE PHARMACEUTICALS GROUP PLC
2.	NAME OF SCHEME:	TPC WARRANTS
3.	PERIOD OF RETURN:	FROM: 01 JANUARY 2005 TO: 30 JUNE 2005
4.	NUMBER AND CLASS OF SHARES(S) (AMOUNT OF STOCK/DEBT SECURITY) NOT ISSUED UNDER SCHEME

	AT END OF THE LAST PERIOD:	1,346,407
5.	NUMBER OF SHARES ISSUED/ALLOTTED
	UNDER SCHEME DURING PERIOD:	NIL
6.	BALANCE UNDER SCHEME NOT YET ISSUED/ALLOTTED
	AT END OF PERIOD:	1,346,407
7.	NUMBER AND CLASS OF SHARE(S) (AMOUNT OF STOCK/DEBT SECURITIES)
	ORIGINALLY LISTED:	741,812
	AND THE DATE OF ADMISSION:	29 APRIL 2002
	(A FURTHER LISTING OF 604,595 SHARES WAS GRANTED ON 27 NOVEMBER 2002)
PLEASE CONFIRM TOTAL NUMBER OF SHARES IN ISSUE AT THE END OF THE PERIOD IN ORDER FOR US TO UPDATE OUR RECORDS.
		492,654,408

For further information please contact:
Vivienne Hemming – Deputy Company Secretary	+44 1256 894 276

Notes to editors

Shire Pharmaceuticals Group plc

Shire Pharmaceuticals Group plc (Shire) is a global specialty pharmaceutical company with a strategic focus on meeting the needs of the specialist physician and currently focuses on developing and marketing products in the areas of central nervous system (CNS), gastrointestinal (GI), renal diseases and human genetics. Shire has operations in the world’s key pharmaceutical markets (US, Canada, UK, France, Italy, Spain and Germany) as well as a specialist drug delivery unit in the US.

For further information on Shire, please visit the Company’s website: www.shire.com.