Shire Pharmaceuticals Group plc
Hampshire International Business Park,
Chineham, Basingstoke RG24 8EP UK
Tel +44 1256 894000 Fax +44 1256 894708
http://www.shire.com


23 November 2004

Shire Pharmaceuticals Group plc (the “Company”)

The Company announces that on 19 November 2004, Mr David Kappler, a non-executive director of the Company, acquired 5,000 ordinary shares of £0.05 each in the Company at a price of 535p per share.

As a result of this transaction Mr Kappler has a total interest in 5,000 ordinary shares of £0.05p each in the Company.

T May
Company Secretary

For further information please contact:
Investor Relations
Cléa Rosenfeld	+44 1256 894 160

Notes to editors

Shire Pharmaceuticals Group plc

Shire Pharmaceuticals Group plc (Shire) is a global specialty pharmaceutical company with a strategic focus on meeting the needs of the specialist physician and currently focuses on developing projects and marketing products in the areas of central nervous system (CNS), gastrointestinal (GI) and renal diseases. Shire has operations in the world’s key pharmaceutical markets (US, Canada, UK, France, Italy, Spain and Germany) as well as a specialist drug delivery unit in the US.

For further information on Shire, please visit the Company’s website: www.shire.com