Shire Pharmaceuticals Group plc
Hampshire International Business Park,
Chineham, Basingstoke RG24 8EP UK
Tel +44 1256 894000 Fax +44 1256 894708
http://www.shire.com EXHIBIT 99.4

July 7^th 2004

Shire Pharmaceuticals Group plc (the "Company")

Application has been made to the London Stock Exchange and the UK Listing Authority for the block listing of 1,000,000 ordinary shares of 5 pence each fully paid in the Company. The shares may be issued pursuant to obligations that may arise under the Employee Stock Purchase Plan