EXHIBIT 99.2

Shire Pharmaceuticals Group plc
Hampshire International Business Park,
Chineham, Basingstoke RG24 8EP UK
Tel +44 1256 894000 Fax +44 1256 894708
http://www.shire.com

1 March 2004

Shire Pharmaceuticals Group plc (the “Company”)

The Company announces that it was notified on 27 February 2004 under Sections 198 to 202 of the Companies Act that on 26 February 2004 Franklin Resources, Inc. and its affiliates had holdings managed on behalf of investment clients of 66,766,848 ordinary shares of £0.05p each in the capital of the Company. These holdings represent 13,9413 per cent of the issued ordinary share capital of the Company.

T May

Company Secretary

For further information please contact:

Investor Relations

Cléa Rosenfeld           +44 1256 894 160

Notes to editors

Shire Pharmaceuticals Group plc

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Shire Pharmaceuticals Group plc (Shire) is a global specialty pharmaceutical company with a strategic focus on meeting the needs of the specialist physician and currently has a range of projects and products in the areas of central nervous system (CNS), gastrointestinal (GI), and renal diseases. Shire has operations in the world’s key pharmaceutical markets (US, Canada, UK, France, Italy, Spain and Germany) as well as a specialist drug delivery unit in the US.

For further information on Shire, please visit the Company’s website: www.shire.com

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