Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	3 Months Ended		9 Months Ended
	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017
Revenues:
Total revenues	$ 3,871.7	$ 3,697.6	$ 11,556.9	$ 11,015.7
Costs and expenses:
Cost of sales	1,157.6	1,001.4	3,398.3	3,437.3
Research and development	407.2	402.8	1,240.0	1,324.5
Selling, general and administrative	836.8	859.7	2,549.3	2,647.7
Amortization of acquired intangible assets	433.7	482.4	1,375.3	1,280.5
Integration and acquisition costs	93.0	237.0	512.0	696.7
Reorganization costs	254.8	5.4	268.9	24.5
(Gain)/loss on sale of Oncology and product rights	(267.2)	0.3	(267.2)	(0.4)
Total operating expenses	2,915.9	2,989.0	9,076.6	9,410.8
Operating income from continuing operations	955.8	708.6	2,480.3	1,604.9
Interest income	1.3	1.5	4.8	5.7
Interest expense	(125.2)	(141.8)	(378.1)	(425.4)
Other (expense)/income, net	(96.1)	(0.2)	(43.9)	6.8
Total other expense, net	(220.0)	(140.5)	(417.2)	(412.9)
Income from continuing operations before income taxes and equity in earnings of equity method investees	735.8	568.1	2,063.1	1,192.0
Income taxes	(203.3)	(13.5)	(371.0)	(44.6)
Equity in earnings/(losses) of equity method investees, net of taxes	4.7	(3.4)	11.2	0.1
Income from continuing operations, net of taxes	537.2	551.2	1,703.3	1,147.5
(Loss)/gain from discontinued operations, net of taxes	0.0	(0.4)	0.0	18.6
Net income	$ 537.2	$ 550.8	$ 1,703.3	$ 1,166.1
Earnings per Ordinary Share – basic
Earnings from continuing operations (in usd per share)	$ 0.59	$ 0.61	$ 1.87	$ 1.27
Earnings from discontinued operations (in usd per share)	0.00	0.00	0.00	0.02
Earnings per Ordinary Share - basic (in usd per share)	0.59	0.61	1.87	1.29
Earnings per Ordinary Share – diluted
Earnings from continuing operations (in usd per share)	0.58	0.60	1.86	1.26
Earnings from discontinued operations (in usd per share)	0.00	0.00	0.00	0.02
Earnings per Ordinary Share - diluted (in usd per share)	$ 0.58	$ 0.60	$ 1.86	$ 1.28
Weighted average number of shares:
Basic (in shares)	914.0	907.2	912.0	905.9
Diluted (in shares)	921.1	911.6	916.9	912.1
Product sales
Revenues:
Total revenues	$ 3,752.8	$ 3,533.8	$ 11,198.5	$ 10,537.9
Royalties and other revenues
Revenues:
Total revenues	$ 118.9	$ 163.8	$ 358.4	$ 477.8