Consolidated Statements of Cash Flows - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	$ 4,271.5	$ 327.4	$ 1,303.4
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation and amortization	2,264.2	1,466.3	637.2
Share based compensation	174.9	318.5	100.3
Amortization of deferred financing fees	12.8	125.5	0.0
Expense related to the unwind of inventory fair value adjustments	747.8	1,118.0	31.1
Change in deferred taxes	(2,916.4)	(594.6)	(198.2)
Change in fair value of contingent consideration	120.7	11.1	(149.9)
Impairment of PP&E and intangible assets	289.9	101.3	643.7
Other, net	55.6	31.4	0.0
Changes in operating assets and liabilities:
Increase in accounts receivable	(487.6)	(701.7)	(211.4)
Increase in sales deduction accrual	314.1	288.3	97.6
Increase in inventory	(145.1)	(255.8)	(63.2)
Decrease/(increase) in prepayments and other assets	81.1	(198.4)	37.2
(Decrease)/increase in accounts payable and other liabilities	(526.8)	621.6	109.2
Net cash provided by operating activities	4,256.7	2,658.9	2,337.0
CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of PP&E	(798.8)	(648.7)	(114.7)
Purchases of businesses, net of cash acquired	0.0	(17,476.2)	(5,553.4)
Proceeds from sale of investments	88.6	0.9	85.7
Movements in restricted cash	(13.7)	62.8	(32.0)
Other, net	23.0	(31.0)	(5.5)
Net cash used in investing activities	(700.9)	(18,092.2)	(5,619.9)
CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from revolving line of credit, long term and short term borrowings	4,236.7	32,443.4	3,760.8
Repayment of revolving line of credit, long term and short term borrowings	(7,681.4)	(16,404.3)	(3,110.9)
Payment of dividend	(281.3)	(171.3)	(134.4)
Debt issuance costs	0.0	(172.3)	(24.1)
Proceeds from issuance of stock for share-based compensation arrangements	134.1	169.2	16.6
Other, net	(27.4)	(38.9)	(69.0)
Net cash (used in)/provided by financing activities	(3,619.3)	15,825.8	439.0
Effect of foreign exchange rate changes on cash and cash equivalents	7.1	0.8	(3.0)
Net (decrease)/increase in cash and cash equivalents	(56.4)	393.3	(2,846.9)
Cash and cash equivalents at beginning of period	528.8	135.5	2,982.4
Cash and cash equivalents at end of period	472.4	528.8	135.5
Supplemental information:
Interest paid	554.2	284.0	20.0
Income taxes paid, net	524.7	431.0	69.0
New Shire Income Access Share Trust
CASH FLOWS FROM OPERATING ACTIVITIES:
Net income	245.6	150.6	127.7
Changes in operating assets and liabilities:
Net cash provided by operating activities	245.6	150.6	127.7
CASH FLOWS FROM INVESTING ACTIVITIES:
Net cash used in investing activities	0.0	0.0	0.0
CASH FLOWS FROM FINANCING ACTIVITIES:
Distributions made	245.6	150.6	127.7
Net cash (used in)/provided by financing activities	(245.6)	(150.6)	(127.7)
Net (decrease)/increase in cash and cash equivalents	0.0	0.0	0.0
Cash and cash equivalents at beginning of period	0.0	0.0	0.0
Cash and cash equivalents at end of period	$ 0.0	$ 0.0	$ 0.0