Consolidated Statements of Operations - USD ($) shares in Millions, $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues:
Product sales	$ 14,448.9	$ 10,885.8	$ 6,099.9
Royalties and other revenues	711.7	510.8	316.8
Total revenues	15,160.6	11,396.6	6,416.7
Costs and expenses:
Cost of sales	4,700.8	3,816.5	969.0
Research and development	1,763.3	1,439.8	1,564.0
Selling, general and administrative	3,530.9	3,015.2	1,842.5
Amortization of acquired intangible assets	1,768.4	1,173.4	498.7
Integration and acquisition costs	894.5	883.9	39.8
Reorganization costs	47.9	121.4	97.9
Gain on sale of product rights	(0.4)	(16.5)	(14.7)
Total operating expenses	12,705.4	10,433.7	4,997.2
Operating income from continuing operations	2,455.2	962.9	1,419.5
Interest income	9.7	18.4	4.2
Interest expense	(578.9)	(469.6)	(41.6)
Other income/(expense), net	7.4	(25.6)	3.7
Total other expense, net	(561.8)	(476.8)	(33.7)
Income from continuing operations before income taxes and equity in earnings/(losses) of equity method investees	1,893.4	486.1	1,385.8
Income taxes	2,357.6	126.1	(46.1)
Equity in earnings/(losses) of equity method investees, net of taxes	2.5	(8.7)	(2.2)
Income from continuing operations, net of taxes	4,253.5	603.5	1,337.5
Gain/(loss) from discontinued operations, net of taxes	18.0	(276.1)	(34.1)
Net income	$ 4,271.5	$ 327.4	$ 1,303.4
Earnings per Ordinary Share – basic
Earnings from continuing operations (in usd per share)	$ 4.69	$ 0.78	$ 2.27
Earnings/(loss) from discontinued operations (in usd per share)	0.02	(0.35)	(0.06)
Earnings per Ordinary Share - basic (in usd per share)	4.71	0.43	2.21
Earnings per Ordinary Share – diluted
Earnings from continuing operations (in usd per share)	4.66	0.77	2.26
Earnings/(loss) from discontinued operations (in usd per share)	0.02	(0.35)	(0.06)
Earnings per Ordinary Share - diluted (in usd per share)	$ 4.68	$ 0.42	$ 2.20
Weighted average number of shares:
Basic (in shares)	906.5	770.1	590.4
Diluted (in shares)	912.0	776.2	593.1
New Shire Income Access Share Trust
Costs and expenses:
Dividend income	$ 245.6	$ 150.6	$ 127.7
Net income	$ 245.6	$ 150.6	$ 127.7