Segment Reporting

9 Months Ended

Sep. 30, 2016

Shire operates as one operating and reportable segment engaged in the research, development, licensing, manufacturing, marketing, distribution and sale of innovative specialist medicines to meet significant unmet patient needs.

For a more detailed description of segment disclosures about products, geographic areas and major customers, please read Note 23, Segmental Reporting, of the Shire 2015 Form 10-K.

In the periods set out below, revenues by major product were as follows:



	Nine Months Ended September 30,
(in millions)	2016		2015
Product sales:
HEMOPHILIA	$	978.0	$	—
INHIBITOR THERAPIES	255.7		—
Hematology total	1,233.7		—
CINRYZE	502.6		474.4
ELAPRASE	424.3		405.5
FIRAZYR	411.3		319.8
REPLAGAL	340.5		325.5
VPRIV	259.3		256.2
KALBITOR	39.2		—
Genetic Diseases total	1,977.2		1,781.4
VYVANSE	1,539.5		1,268.9
ADDERALL XR	281.1		259.7
Other Neuroscience	81.2		81.9
Neuroscience total	1,901.8		1,610.5
IMMUNOGLOBULIN THERAPIES	610.7		—
BIO THERAPEUTICS	185.3		—
Immunology total	796.0		—
LIALDA/MEZAVANT	570.3		483.0
PENTASA	222.3		232.7
GATTEX/REVESTIVE	154.3		95.2
NATPARA	58.8		12.8
Other Internal Medicine	260.6		260.6
Internal Medicine total	1,266.3		1,084.3
Oncology total	75.7		—
Opthalmology Total	14.1		—
Total product sales	7,264.8		4,476.2

Royalties and Other Revenues:
SENSIPAR Royalties	112.2		80.0
3TC and ZEFFIX Royalties	43.3		29.9
FOSRENOL Royalties	34.3		32.4
ADDERALL XR Royalties	15.7		22.2
Other Royalties and Revenues	120.2		60.3
Total Royalties and Other Revenues	325.7		224.8
Total Revenues	$	7,590.5	$	4,701.0

- Definition

The entire disclosure for reporting segments including data and tables. Reportable segments include those that meet any of the following quantitative thresholds a) it's reported revenue, including sales to external customers and intersegment sales or transfers is 10 percent or more of the combined revenue, internal and external, of all operating segments b) the absolute amount of its reported profit or loss is 10 percent or more of the greater, in absolute amount of 1) the combined reported profit of all operating segments that did not report a loss or 2) the combined reported loss of all operating segments that did report a loss c) its assets are 10 percent or more of the combined assets of all operating segments.

+ References

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-Name Accounting Standards Codification
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+ Details