UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                    Form 13F

                               Form 13F COVER PAGE

Report for the Calendar Year or Quarter Ended: March 31, 2006

Check here if Amendment [ ];       Amendment Number: __________

This Amendment (Check only one.): [ ] is a restatement.
                                  [ ] adds new holdings entries.

Name:    The Manufacturers Life Insurance Company
Address: 200 Bloor Street, East
         Compliance Dept. NT - 5
         Toronto, Ontario, Canada M4W 1E5

Form 13F File Number: 028 -04428

The institutional investment manager filing this report and the person by whom
it is signed hereby represent that the person signing the report is authorized
to submit it, that all information contained herein is true, correct and
complete, and that it is understood that all required items, statements,
schedules, lists and tables, are considered integral parts of this form.

Person Signing this Report on Behalf of Reporting Manager:

Name:Gordon Pansegrau
Title:Chief Compliance Officer, Investments
Phone:(416) 926-5685


Gordon Pansegrau   Toronto, Ontario, Canada   May 12, 2006

Report Type (check only one.):

[ ]  13F HOLDINGS REPORT. (Check here if all holdings of this reporting manager
     are reported in this report.

[ ]  13F NOTICE. (Check here if no holdings reported are in this report, and all
     holdings are reported by other reporting manager(s).

[X]  13F COMBINATION REPORT. (Check here if a portion of the holdings for this
     report manager are reported in this report and a portion are reported by
     other reporting manager(s).

List of Other Managers Reporting for this Manager:
[If there are no entries in this list, omit this section.]



Form 13F File Number   Name
--------------------   ----
                    
028-10490              MFC Global Investment Management (U.S.A.) Limited




                             FORM 13F SUMMARY PAGE

                                                               
Report Summary:

Number of Other Included Managers:                                             2

Form 13F Information Table Entry Total:                                      754

Form 13F Information Table Value Total:                           $7,082,362,722




List of Other Included Managers:

Provide a numbered list of the name(s) and Form 13F file numbers(s) of all
institutional investment managers with respect to which this report is filed,
other than the manager filing this report.

No.      Form 13F File Number           Name

 1       028-11519                      Manulife Financial Corporation

 2       028-11524                      Elliott & Page Limited



13F REPORTING AS OF MARCH 31, 2006



                                                                                            INVESTMENT    OTHER     VOTING
         ISSUER NAME                CLASS         CUSIP     MARKET VALUE  NUMBER OF SHARES  DISCRETION  MANAGERS  AUTHORITY
----------------------------  ----------------  ---------  -------------  ----------------  ----------  --------  ---------