NOTICE OF TERMINATION


          WHEREAS, on April 1, 2002, Sanguine Corporation (the "Company" and
the  "Licensor") entered into an Exclusive License Agreement with
Ascendiant-South America, LLC,  a Nevada limited liability corporation (the
"Licensee"), pursuant to which the Licensee agreed to  certain minimum levels
of annual production of the Licensed Products (the "Minimum  Production"); and
in the event the Licensee failed to achieve the Minimum Production, to pay a
royalty to the Licensor; and

          WHEREAS, the Licensee has failed to meet the Minimum Production (as
defined  therein) and has failed to pay the Make-Up Royalty (as defined
therein) payments to the  Licensor as set forth in Section 2.2 of the
Exclusive License Agreement and in the amounts per  commercial Unit Produced
(as defined therein) as provided in Section 5.1 thereof;

          NOW, THEREFORE, pursuant to Section 13.2 of the Exclusive License
Agreement, the Company hereby elects to terminate the above referenced
Exclusive License  Agreement.

          DATED this 24th day of September, 2004.

                              SANGUINE CORPORATION

                              By /s/ Thomas C. Drees
                                   Thomas C. Drees, Ph.D., MBA