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Note 8 - Share-based Compensation (Tables)
3 Months Ended
Mar. 31, 2023
Notes Tables  
Schedule of Share-based Compensation, Expense [Table Text Block]
   

Three months ended

 
   

March 31,

 
   

2023

   

2022

 

Research and development

  $ 139     $ 127  

Selling, general and administrative

    139       192  

Total share-based compensation

  $ 278     $ 319  
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
   

Options outstanding

                 
   

Number of

shares

   

Weighted

average

exercise

price

   

Weighted

average

remaining

contractual

term (years)

   

Aggregate

intrinsic value
(in thousands)

 
                                 

Balance, December 31, 2022

    2,182,708     $ 4.04       7.5     $ 343  

Stock options exercised

    (199 )     1.49                  

Stock options forfeited

    (14,059 )     2.77                  

Balance, March 31, 2023

    2,168,450     $ 4.05       7.3     $ 256  

Exercisable, March 31, 2023

    1,241,371     $ 5.27       6.3     $ 49  
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
           

Weighted

 
           

average

 
           

grant date

 
   

Number of

   

fair value

 
   

shares

   

per share

 

Balance, December 31, 2022

    21,526     $ 4.33  

RSUs released

    (18,792 )     4.34  

Balance, March 31, 2023

    2,734     $ 4.26