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Note 8 - Share-based Compensation (Tables)
6 Months Ended
Jun. 30, 2021
Notes Tables  
Schedule of Share-based Compensation, Expense [Table Text Block]
   

Three months ended

   

Six months ended

 
   

June 30,

   

June 30,

 
   

2021

   

2020

   

2021

   

2020

 

Research and development

  $ 211     $ 318     $ 417     $ 731  

Selling, general and administrative

    173       337       383       865  

Total share-based compensation

  $ 384     $ 655     $ 800     $ 1,596  
Share-based Payment Arrangement, Option, Activity [Table Text Block]
   

Options outstanding

                 
   

Number of

shares

   

Weighted average exercise price

   

Weighted

average

remaining

contractual

term (years)

   

Aggregate

intrinsic value
(in thousands)

 
                                 

Balance, December 31, 2020

    1,114,306     $ 5.89       7.5     $ 177.1  

Stock options granted

    717,935       3.61                  

Stock options exercised

    (1,580 )     2.49                  

Stock options forfeited

    (145,477 )     4.57                  

Stock options expired

    (125 )     5.32                  

Balance, June 30, 2021

    1,685,059     $ 5.04       8.0     $ 604.3  

Exercisable, June 30, 2021

    668,537     $ 7.13       5.8     $ 89.0  
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
           

Weighted

 
           

average

 
           

grant date

 
   

Number of

   

fair value

 
   

shares

   

per share

 

Balance, December 31, 2020

    224,311     $ 4.12  

RSUs granted

    131,375       3.61  

RSUs released

    (118,472 )     3.73  

RSUs forfeited

    (36,943 )     3.49  

Balance, June 30, 2021

    200,271     $ 4.13