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Note 10 - Share-based Compensation - Stock Option Activity (Details) - USD ($)
12 Months Ended
Nov. 26, 2019
Dec. 31, 2019
Dec. 31, 2018
Stock options outstanding, beginning of period (in shares)   608,547  
Balance, weighted average exercise price, beginning of period (in dollars per share)   $ 25.20  
Stock options outstanding, weighted average remaining contractual term (Year)   7 years 219 days 7 years 292 days
Stock options outstanding, aggregate intrinsic value  
Stock options granted (in shares) 515,036 254,785  
Stock options granted, weighted average exercise price (in dollars per share)   $ 5.28  
Stock options exercised (in shares)    
Stock options exercised, weighted average exercise price (in dollars per share)    
Stock options canceled (in shares)   (41,868)  
Stock options canceled, weighted average exercise price (in dollars per share)   $ 26.86  
Stock options outstanding, end of period (in shares)   821,464 608,547
Balance, weighted average exercise price, end of period (in dollars per share)   $ 18.99 $ 25.20
Exercisable and vested (in shares)   428,793  
Exercisable and vested, weighted average exercise price (in dollars per share)   $ 23.62  
Exercisable and vested, weighted average remaining contractual term (Year)   6 years 219 days  
Exercisable and vested, aggregate intrinsic value