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Note 12 - Net Loss Per Share (Tables)
12 Months Ended
Dec. 31, 2019
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Years ended December 31,
 
   
2019
   
2018
   
2017
 
Numerator:
                       
Net loss
  $
(14,709
)   $
(13,987
)   $
(12,308
)
Denominator:
                       
Weighted average shares used to compute net loss per share, basic and diluted
   
5,644,328
     
4,264,178
     
4,240,060
 
Net loss per share, basic and diluted
  $
(2.61
)   $
(3.28
)   $
(2.90
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
Years ended December 31,
 
   
2019
   
2018
   
2017
 
                         
Stock options to purchase common stock
   
821,464
     
608,547
     
468,122
 
Unvested restricted stock units
   
36,981
     
29,698
     
10,888
 
Common stock warrants
   
2,435,808
     
296,296
     
-
 
Total
   
3,294,253
     
934,541
     
479,010