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Note 11 - Share-based Compensation - Nonemployee Stock Option Valuation Assumptions (Details) - Non-employee Stock Options [Member]
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Dec. 31, 2016
Dividend yield 0.00% 0.00% 0.00%
Minimum [Member]      
Risk-free interest rate 2.80% 2.25% 1.60%
Volatility 78.00% 81.00% 89.00%
Expected term (Year) 7 years 219 days 8 years 219 days 9 years 219 days
Maximum [Member]      
Risk-free interest rate 2.95% 2.40% 2.42%
Volatility 85.00% 87.00% 91.00%
Expected term (Year) 8 years 292 days 9 years 292 days 9 years 328 days