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Note 6 - Property and Equipment, Net (Tables)
9 Months Ended 12 Months Ended
Sep. 30, 2019
Dec. 31, 2018
Notes Tables    
Property, Plant and Equipment [Table Text Block]
   
September 30,
   
December 31,
 
   
2019
   
2018
 
Computer equipment and software
  $
127
     
119
 
Laboratory and manufacturing equipment
   
550
     
481
 
Furniture and fixtures
   
55
     
55
 
Leasehold improvements
   
332
     
332
 
Construction in progress
   
69
     
3
 
Property and equipment, gross
   
1,133
     
990
 
Less accumulated depreciation
   
(923
)
   
(845
)
Property and equipment, net
  $
210
     
145
 
   
December 31,
 
   
2018
   
2017
 
Computer equipment and software
  $
119
     
106
 
Laboratory and manufacturing equipment
   
481
     
447
 
Furniture and fixtures
   
55
     
48
 
Leasehold improvements
   
332
     
326
 
Construction in progress
   
3
     
 
Property and equipment, gross
   
990
     
927
 
Less accumulated depreciation
   
(845
)    
(758
)
Property and equipment, net
  $
145
     
169