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Note 12 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended 9 Months Ended
Aug. 31, 2016
Sep. 30, 2019
Sep. 30, 2018
Sep. 30, 2019
Sep. 30, 2018
Dec. 31, 2018
Aug. 19, 2016
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross       254,785      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance   $ 18.90   $ 18.90   $ 25.16  
Share-based Payment Arrangement, Noncash Expense, Total       $ 2,142,000 $ 2,083,000    
Chairman and Chief Executive Officer of OPKO [Member]              
Related Party, Ownership Percentage             5.00%
Chairman and Chief Executive Officer of OPKO [Member] | OPKO [Member]              
Share-based Payment Arrangement, Noncash Expense, Total   $ 116,000 $ 59,000 $ 160,000 $ 121,000    
OPKO [Member] | Consulting Services [Member]              
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 46,553            
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 4 years            
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance $ 16.20            
Consulting Agreement, Term 4 years            
Consulting Agreement, Term, Length of Automatic Renewal Periods 1 year