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Note 10 - Net Loss Per Share (Tables)
6 Months Ended
Jun. 30, 2019
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
June 30,
 
   
2019
   
2018
 
Stock options to purchase common stock
   
618,366
     
630,911
 
Unvested restricted stock units
   
27,426
     
4,543
 
Common stock warrants
   
296,296
     
-
 
Total
   
942,088
     
635,454