XML 58 R47.htm IDEA: XBRL DOCUMENT v3.19.1
Note 12 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended
Aug. 31, 2016
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance   $ 2.80   $ 2.80  
Share-based Payment Arrangement, Expense   $ 690,000 $ 615,000    
OPKO [Member] | Consulting Services [Member]          
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 418,977        
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 4 years        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance $ 1.80        
Share-based Payment Arrangement, Expense   $ 22,000 $ 37,000    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Grant Date Fair Value         $ 5,300,000
Consulting Agreement, Term 4 years        
Consulting Agreement, Term, Length of Automatic Renewal Periods 1 year        
Chairman and Chief Executive Officer of OPKO [Member]          
Related Party, Ownership Percentage 5.00%