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Note 9 - Share-based Compensation - Share-based Compensation Expense (Details) - USD ($)
$ in Thousands
3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Share-based compensation expense $ 690 $ 615
Cost of Goods Sold [Member]    
Share-based compensation expense 46 30
Research and Development Expense [Member]    
Share-based compensation expense 242 197
Selling, General and Administrative Expenses [Member]    
Share-based compensation expense $ 402 $ 388