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Note 5 - Property and Equipment, Net (Tables)
3 Months Ended
Mar. 31, 2019
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
March 31,
   
December 31,
 
   
2019
   
2018
 
Computer equipment and software
  $
121
     
119
 
Laboratory and manufacturing equipment
   
532
     
481
 
Furniture and fixtures
   
55
     
55
 
Leasehold improvements
   
332
     
332
 
Construction in progress
   
3
     
3
 
Property and equipment, gross
   
1,043
     
990
 
Less accumulated depreciation
   
(868
)    
(845
)
Property and equipment, net
  $
175
     
145