Note 5 - Property and Equipment, Net - Summary of Property and Equipment, Net (Details) - USD ($) $ in Thousands	Sep. 30, 2018	Dec. 31, 2017
Property and equipment, gross	$ 977	$ 927
Less accumulated depreciation	(823)	(758)
Property and equipment, net	154	169
Computer Equipment and Software [Member]
Property and equipment, gross	116	106
Laboratory and Manufacturing Equipment [Member]
Property and equipment, gross	474	447
Furniture and Fixtures [Member]
Property and equipment, gross	55	48
Leasehold Improvements [Member]
Property and equipment, gross	331	326
Construction in Progress [Member]
Property and equipment, gross	$ 1

Amount of accumulated depreciation, depletion and amortization for physical assets used in the normal conduct of business to produce goods and services.

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Amount before accumulated depreciation, depletion and amortization of physical assets used in the normal conduct of business and not intended for resale. Examples include, but are not limited to, land, buildings, machinery and equipment, office equipment, and furniture and fixtures.

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