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Note 8 - Net Loss Per Share (Tables)
9 Months Ended
Sep. 30, 2018
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
September
30,
 
   
2018
   
2017
 
Stock options to purchase common stock
   
5,549,106
     
4,142,692
 
Unvested restricted stock units
   
267,359
     
97,996
 
Total
   
5,816,465
     
4,240,688