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Note 5 - Property and Equipment, Net (Tables)
 9 Months Ended
Sep. 30, 2018
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
September
30,
2018
    
December 31,
2017
  
Computer equipment and software
   $
116
     $
106
  
Laboratory and manufacturing equipment
    
474
      
447
  
Furniture and fixtures
    
55
      
48
  
Leasehold improvements
    
331
      
326
  
Construction in progress
    
1
      
—
  
Property and equipment, gross
    
977
      
927
  
Less accumulated depreciation
    
(823
)
    
(758
)
Property and equipment, net
   $
154
     $
169