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Note 10 - Related Party Transactions (Details Textual) - USD ($)
1 Months Ended 3 Months Ended
Aug. 31, 2016
Mar. 31, 2018
Mar. 31, 2017
Dec. 31, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross   1,429,075    
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance   $ 2.85   $ 2.96
Allocated Share-based Compensation Expense, Total   $ 615,000 $ 622,000  
OPKO [Member]        
Related Party, Ownership Percentage 5.00%      
OPKO [Member] | Consulting Services [Member]        
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 418,977      
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period 4 years      
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance $ 1.80      
Allocated Share-based Compensation Expense, Total   37,000 $ 122,000  
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested Grant Date Fair Value   $ 5,300,000    
Consulting Agreement, Term 4 years      
Consulting Agreement, Term, Length of Automatic Renewal Periods 1 year      
Chairman and Chief Executive Officer of OPKO [Member]        
Related Party, Ownership Percentage 5.00%