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Note 5 - Property and Equipment, Net - Summary of Property and Equipment, Net (Details) - USD ($)
$ in Thousands
Mar. 31, 2018
Dec. 31, 2017
Property and equipment, gross $ 931 $ 927
Less accumulated depreciation (779) (758)
Property and equipment, net 152 169
Computer Equipment and Software [Member]    
Property and equipment, gross 110 106
Laboratory and Manufacturing Equipment [Member]    
Property and equipment, gross 447 447
Furniture and Fixtures [Member]    
Property and equipment, gross 48 48
Leasehold Improvements [Member]    
Property and equipment, gross $ 326 $ 326