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Note 6 - Property and Equipment, Net (Tables)
12 Months Ended
Dec. 31, 2017
Notes Tables  
Property, Plant and Equipment [Table Text Block]
   
December 31,
 
   
201
7
   
201
6
 
Computer equipment and softwar
e
  $
106
     
143
 
Laboratory and manufacturing equipmen
t
   
447
     
366
 
Furniture and fixture
s
   
48
     
48
 
Leasehold improvement
s
   
326
     
325
 
Property and equipment, gros
s
   
927
     
882
 
Less accumulated depreciatio
n
   
(758
)    
(771
)
Property and equipment, ne
t
  $
169
     
111