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Note 2 - Significant Accounting Policies (Tables)
12 Months Ended
Dec. 31, 2017
Notes Tables  
Property, Plant and Equipment, Useful Life [Table Text Block]
Asset
 
Estimated useful
lives (in years)
 
Computer equipment and software
 
3
 
Laboratory and manufacturing equipment
 
3
 
Furniture and fixtures
 
3
 
Leasehold improvements
 
5 years or lease term, if shorter