UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, DC 20549

SCHEDULE 14A

(Rule 14a-101)

SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the

Securities Exchange Act of 1934

(Amendment No.   )

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SURMODICS, INC.

(Name of Registrant as Specified In Its Charter)

(Name of Person(s) Filing Proxy Statement, if Other Than the Registrant)

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Your Vote Counts! SURMODICS, INC. 2022 Annual Meeting Vote by February 9, 2022 11:59 PM ET SURMODICS, INC. C/O BROADRIDGE CORPORATE ISSUER SOLUTIONS P.O. BOX 1342 BRENTWOOD, NY 11717 D64640-P62743 You invested in SURMODICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the shareholder meeting to be held on February 10, 2022. Get informed before you vote View the Notice and Proxy Statement and 10K online OR you can receive a free paper or email copy of the material(s) by requesting prior to January 27, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. For complete information and to vote, visit www.ProxyVote.com Control # Vote Virtually at the Meeting* February 10, 2022 4:00 PM, CST Smartphone users Point your camera here and vote without entering a control number Virtually at: www.virtualshareholdermeeting.com/SRDX22 *Please check the meeting materials for any special requirements for meeting attendance. V1.1  

Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items 1. Election of Directors  Nominees: For 01) Ronald B. Kalich  02) Gary R. Maharaj 2. Set the number of directors at six (6); For 3. Ratify the appointment of Deloitte & Touche LLP as Surmodics’ independent registered public accounting firm for fiscal year 2022; For 4. Approve, in a non-binding advisory vote, the Company’s executive compensation; and For 5. Approve an amendment to the Surmodics, Inc. 2019 Equity Incentive Plan. For NOTE: To consider and act upon such other matters as may properly come before the meeting or any adjournment or postponement of the meeting. Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. D64641-P62743