Some of the statements made during this presentation may be considered forward-looking statements within
the meaning of the Private Securities Litigation Reform Act of 1995. Statements that are not historical or current facts, including statements about growth opportunities, expected revenue growth and annual growth rates, our fiscal 2022
strategic objectives, statements about the commercialization potential of the SurVeil™ drug coated balloon (“DCB”), statements about the premarket approval and commercial launch of the SurVeil DCB, the expected timing of market evaluations of
our products, statements about future potential revenue from our Development and Commercialization Agreement with Abbott Vascular, Inc., expectations regarding completion of the 5-year follow-up in the TRANSCEND study, fiscal 2022 financial
guidance, and estimates of future revenues related to the TRANSCEND study, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties, and important factors could cause actual results to differ
materially from those anticipated, including (1) our ability to successfully develop and commercialize our SurVeil™ DCB (including realization of the full potential benefits of our agreement with Abbott), Avess™ DCB, Sundance™ DCB and other
proprietary products; (2) our reliance on third parties (including our customers and licensees) and their failure to successfully develop, obtain regulatory approval for, market and sell products incorporating our technologies; (3) possible
adverse market conditions and possible adverse impacts on our cash flows; (4) the impacts, duration and severity of the global COVID-19 pandemic and the effects of responses to it on healthcare systems, the general economy, our business
partners, and our operations; (5) whether anticipated increases in our operating expenses are effective in generating profitable revenues; and (6) the factors identified under “Risk Factors” in Part I, Item 1A of our Annual Report on Form 10-K
for the fiscal year ended September 30, 2021, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our website at https://surmodics.gcs-web.com and at the SEC website at www.sec.gov.
Forward-looking statements speak only as of the date they are made, and we undertake no obligation to update them in light of new information or future events. 2 Safe Harbor CAUTION: SurVeil™, Sundance™ and Avess™ Drug-Coated Balloons are
investigational devices. Limited by Federal (or United States) law to investigational use. © 2022 Surmodics, Inc. CONFIDENTIAL All rights reserved.