Exhibit 99.1

FOR IMMEDIATE RELEASE

SurModics Reports Third Quarter 2009 Results

EDEN PRAIRIE, Minnesota — July 29, 2009 — SurModics, Inc. (Nasdaq: SRDX), a leading provider of drug delivery and surface modification technologies to the healthcare industry, today reported financial results for the third quarter ended June 30, 2009.

Third Quarter Summary:

• Financial highlights:

• Revenue of $18.2 million

• Operating income of $4.7 million

• Net income of $3.5 million

• Diluted EPS of $0.20

• Revenue by market:

• Therapeutic:

• Cardiovascular — $10.1 million

• Ophthalmology — $1.8 million

• Other Markets — $3.5 million

• Diagnostic — $2.8 million

• Cash and investments of $51.5 million; no debt

• Four new licenses with SurModics customers; achieved full year fiscal 2009 goal of 18 new license agreements

• New drug delivery license agreement for a drug-eluting balloon product

• Three new product classes introduced by our customers; achieved full year fiscal 2009 goal of 10 new product class introductions

“SurModics continues to make important progress both with our customer programs and extending our technology leadership in the healthcare industry,” said Bruce Barclay, president and CEO. “We are pleased to deliver another profitable quarter, particularly in light of the current economic environment and transitions in some of our revenue streams. Most significant of these transitions were the absence of royalty revenue from Abbott following the expiration of our lateral flow immunoassay technology patents and the termination of our agreement with Merck, which together contributed approximately $2.8 million of revenue in the second quarter and were not recurring in the third quarter. Excluding these non-recurring items from second quarter results, our total revenue in the third quarter increased slightly on a sequential basis. I am also encouraged that product

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sales increased 7% on a sequential basis, and 33% compared with the first quarter. In addition, our continued focus on operating efficiency, including the restructuring actions we implemented earlier this year, has enabled us to reduce operating expenses, excluding product costs, by 25% year-over-year.”

“Importantly, we are continuing to make good progress against our published fiscal 2009 goals. After only three quarters, we have already achieved our full year fiscal 2009 objective of signing 18 license agreements, as well as our goal of 10 product class launches by our customers,” continued Barclay. “We are particularly excited about a new license agreement covering the use of SurModics’ drug delivery technology with a drug-eluting balloon product for the treatment of vascular disease. We are pleased to be partnering early in the creation of this potentially revolutionary technology.”

Revenue for the third quarter of fiscal 2009 was $18.2 million, compared with $24.3 million in the year-earlier period. Operating income was $4.7 million, compared with $7.2 million in the prior-year period. Net income was $3.5 million, compared with $4.8 million in the same period last year. Diluted earnings per share was $0.20, compared with $0.26 in the third quarter of fiscal 2008.

For the first nine months of fiscal 2009, revenue was $102.3 million, compared with $73.8 million in the year earlier period. Operating income was $53.5 million, compared with $21.9 million in the prior year period; net income was $34.8 million, compared with $15.6 million in the year earlier period; and diluted net income per share was $1.99, compared with $0.85 in the first nine months of fiscal 2008. Results for the first nine months of fiscal 2009 include the recognition of previously deferred revenue, as well as a milestone payment, totaling approximately $45 million, in connection with Merck’s termination of its agreement with SurModics.

“SurModics’ pipeline continues to represent significant potential,” added Barclay. As of June 30, 2009, SurModics’ customers had 105 licensed product classes generating royalty revenue, compared with 102 a year ago; the total number of licensed product classes not yet launched was 105, comparable with the prior-year period; and major non-licensed opportunities totaled 87, compared with 98 a year ago. In total, SurModics now has a portfolio of 192 potential commercial products in development diversified across multiple clinical indications and technology platforms.

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SurModics’ cash and investment balance totaled $51.5 million as of June 30, 2009, with no debt. Operating cash flow for the third quarter was $7.9 million, compared with $13.7 million in the third quarter of fiscal 2008. For the first nine months of fiscal 2009, operating cash flow was $24.8 million, compared with $22.6 million in the first nine months of fiscal 2008.

“SurModics is in excellent financial condition,” said Phil Ankeny, senior vice president and chief financial officer. “The Company’s strong operating cash flow and healthy balance sheet with zero debt represent a significant competitive advantage in the current environment. In addition, we continue to demonstrate disciplined deployment of capital with a goal of enhancing shareholder value, principally in the areas of facilities-related and business development investments. The build-out of our development and cGMP manufacturing facility in Alabama is progressing smoothly, with encouraging customer interest, and continues to track to our timeline and budget. Additionally, SurModics is continuing to review business development opportunities that leverage our strong balance sheet to support our strategic objectives.”

Barclay concluded, “Given the significant decline in the global economy and the unexpected impact on our customers, SurModics believes that issues mainly related to timing will prevent the Company from achieving its high-level outlook for roughly flat revenue and diluted EPS on a non-GAAP basis in fiscal 2009 compared with fiscal 2008. On a near-term basis, we see a fairly wide range of potential outcomes for our financial results in the fourth quarter; however, at a minimum, we believe fourth quarter revenue will be approximately in line with third quarter revenue.”

Live Webcast

SurModics will host a webcast at 5:00 p.m. ET (4:00 p.m. CT) today to discuss the quarterly results. To access the webcast, go to the investor relations portion of the Company’s website at www.surmodics.com, and click on the third quarter webcast icon. If you do not have access to the Internet and want to listen to the audio by phone, dial 877-941-8605. A replay of the third quarter conference call will be available by dialing 800-406-7325 and entering conference call ID 4107594. The audio replay will be available beginning at 7:00 p.m. CT on Wednesday, July 29, until 7:00 p.m. CT on Wednesday, August 5.

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About SurModics, Inc.

SurModics’ vision is to extend and improve the lives of patients through technology innovation. The Company partners with the world’s foremost medical device, pharmaceutical and life science companies to develop and commercialize innovative products that result in improved diagnosis and treatment for patients. Core offerings include: drug delivery technologies (coatings, microparticles, nanoparticles, and implants); surface modification coating technologies that impart lubricity, prohealing, and biocompatibility capabilities; and components for in vitro diagnostic test kits and specialized surfaces for cell culture and microarrays. SurModics is headquartered in Eden Prairie, Minnesota and its SurModics Pharmaceuticals subsidiary is located in Birmingham, Alabama. For more information about the Company, visit www.surmodics.com. The content of SurModics’ website is not part of this release or part of any filings the Company makes with the SEC.

Safe Harbor for Forward-Looking Statements

This press release contains forward-looking statements. Statements that are not historical or current facts, including statements about beliefs and expectations, such as our expectations about our pipeline, the potential of a drug-eluting balloon for the treatment of vascular disease, our ability to achieve our fiscal 2009 company goals, our continued growth, the build-out of our Alabama facility, and our performance in the near- and long-term, are forward-looking statements. Forward-looking statements involve inherent risks and uncertainties, and important factors could cause actual results to differ materially from those anticipated, including the following: (1) our reliance on third parties (including our customers and licensees) and their failure to successfully develop, obtain regulatory approval for, market and sell products incorporating our technologies may adversely affect our business operations, our ability to realize the full potential of our pipeline, and our ability to achieve our fiscal 2009 company goals; (2) costs or difficulties relating to the integration of the businesses of SurModics Pharmaceuticals and BioFX Laboratories, and the drug delivery assets and collaborative programs acquired from PR Pharmaceuticals, Inc., with SurModics’ business may be greater than expected and may adversely affect the Company’s results of operations and financial condition; (3) developments in the regulatory environment, as well as market and economic conditions, may adversely affect our business operations and profitability; and (4) other factors identified under “Risk Factors” in Part I, Item 1A of our Annual Report on Form 10-K for the fiscal year ended September 30, 2008, and updated in our subsequent reports filed with the SEC. These reports are available in the Investors section of our website at www.surmodics.com and at the SEC website at www.sec.gov. Forward-

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looking statements speak only as of the date they are made, and we undertake no obligation to update them in light of new information or future events.

Contact

Phil Ankeny, Senior Vice President and Chief Financial Officer
(952) 829-2700

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SurModics, Inc. and Subsidiaries
Condensed Consolidated Statements of Income
(In thousands, except per share data)

	Three Months Ended						Nine Months Ended
	June 30,						June 30,
	2009			2008			2009			2008
	(Unaudited)						(Unaudited)
Revenue
Royalties and license fees	$	8,200		$	13,587		$	65,999		$	40,574
Product sales		5,130			4,447			13,762			14,354
Research and development		4,856			6,242			22,566			18,884
Total revenue		18,186			24,276			102,327			73,812
Operating costs and expenses
Product costs		1,988			1,773			5,341			5,902
Research and development		7,627			10,511			25,464			30,415
Selling, general and administrative		3,910			4,808			12,996			15,559
Restructuring charges		—			—			1,798			—
Purchased in-process research and development		—			—			3,200			—
Total operating expenses		13,525			17,092			48,799			51,876
Income from operations		4,661			7,184			53,528			21,936
Investment income		794			626			1,796			3,530
Income before income taxes		5,455			7,810			55,324			25,466
Income tax provision		(1,916	)		(3,010	)		(20,484	)		(9,913	)
Net income	$	3,539		$	4,800		$	34,840		$	15,553
Basic net income per share	$	0.20		$	0.27		$	2.00		$	0.86
Diluted net income per share	$	0.20		$	0.26		$	1.99		$	0.85
Weighted average shares outstanding
Basic		17,356			18,073			17,458			18,058
Diluted		17,379			18,322			17,492			18,373

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SurModics, Inc. and Subsidiaries
Condensed Consolidated Balance Sheets
(In thousands)

	June 30,		September 30,
	2009		2008
	(Unaudited)
Assets
Current assets
Cash and short-term investments	$	21,905	$	24,627
Accounts receivable		11,914		14,589
Inventories		3,109		2,651
Other current assets		1,632		4,642
Total current assets		38,560		46,509
Property and equipment, net		61,583		41,897
Long-term investments		29,598		47,351
Intangibles, net		18,233		16,870
Goodwill		21,070		18,001
Other assets		12,644		20,400
Total assets	$	181,688	$	191,028
Liabilities and Stockholders’ Equity
Current liabilities *	$	7,706	$	8,191
Deferred revenue (current and long-term)		1,762		37,578
Other liabilities		4,717		3,453
Total stockholders’ equity		167,503		141,806
Total liabilities and stockholders’ equity	$	181,688	$	191,028

* Current liabilities exclude current portion of deferred revenue.

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SurModics, Inc. and Subsidiaries
Condensed Consolidated Statements of Cash Flows
(In thousands)

	Nine Months Ended
	June 30,
	2009			2008
	(Unaudited)
Operating Activities:
Net income	$	34,840		$	15,553
Depreciation and amortization		4,352			4,501
Stock-based compensation		4,988			7,181
Purchased in-process research and development		3,200			—
Restructuring charges		1,798			—
Deferred taxes		8,616			(4,339	)
Net other operating activities		(104	)		(1,642	)
Change in operating assets and liabilities:
Accounts receivable		2,675			(8,598	)
Accounts payable and accrued liabilities		(3,261	)		(369	)
Income taxes		3,302			(3,945	)
Deferred revenue		(35,816	)		13,151
Net change in other operating assets and liabilities		179			1,107
Net cash provided by operating activities		24,769			22,600
Investing Activities:
Net purchases of property and equipment		(21,660	)		(16,849	)
Business acquisition		(8,585	)		(2,996	)
Cash restricted for land purchase		—			(1,640	)
Collection of notes receivable		—			5,870
Net other investing activities		11,122			(2,594	)
Net cash used in investing activities		(19,123	)		(18,209	)
Financing Activities:
Issuance of common stock		655			2,955
Purchase of common stock to fund employee taxes		(457	)		(1,495	)
Repurchase of common stock		(14,998	)		(6,717	)
Net other financing activities		(478	)		712
Net cash used in financing activities		(15,278	)		(4,545	)
Net change in cash and cash equivalents		(9,632	)		(154	)
Cash and cash equivalents
Beginning of period		15,376			13,812
End of period	$	5,744		$	13,658