-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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MIC-Info: RSA-MD5,RSA,
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<SEC-DOCUMENT>0000921895-10-001754.txt : 20101124
<SEC-HEADER>0000921895-10-001754.hdr.sgml : 20101124
<ACCEPTANCE-DATETIME>20101124173247
ACCESSION NUMBER:		0000921895-10-001754
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20101116
FILED AS OF DATE:		20101124
DATE AS OF CHANGE:		20101124

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SURMODICS INC
		CENTRAL INDEX KEY:			0000924717
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				411356149
		STATE OF INCORPORATION:			MN
		FISCAL YEAR END:			0930

	BUSINESS ADDRESS:	
		STREET 1:		9924 W 74TH ST
		CITY:			EDEN PRAIRIE
		STATE:			MN
		ZIP:			55344
		BUSINESS PHONE:		6128292700

	MAIL ADDRESS:	
		STREET 1:		9924 WEST 74TH ST
		CITY:			EDEN PRAIRIE
		STATE:			MN
		ZIP:			55344

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BSI CORP
		DATE OF NAME CHANGE:	19970506

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			RAMIUS ADVISORS LLC
		CENTRAL INDEX KEY:			0001275893
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23837
		FILM NUMBER:		101215771

	BUSINESS ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE
		STREET 2:		20TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		2122014823

	MAIL ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE 20TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ramius Value & Opportunity Advisors LLC
		CENTRAL INDEX KEY:			0001329989
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23837
		FILM NUMBER:		101215769

	BUSINESS ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE
		STREET 2:		20TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212-201-4841

	MAIL ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE
		STREET 2:		20TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER NAME:	
		FORMER CONFORMED NAME:	RCG STARBOARD ADVISORS, LLC
		DATE OF NAME CHANGE:	20070719

	FORMER NAME:	
		FORMER CONFORMED NAME:	Admiral Advisors, LLC
		DATE OF NAME CHANGE:	20050613

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			RAMIUS VALUE & OPPORTUNITY MASTER FUND LTD
		CENTRAL INDEX KEY:			0001373638

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23837
		FILM NUMBER:		101215770

	BUSINESS ADDRESS:	
		STREET 1:		C/O RAMIUS LLC
		STREET 2:		599 LEXINGTON AVENUE 2OTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 201-4823

	MAIL ADDRESS:	
		STREET 1:		C/O RAMIUS LLC
		STREET 2:		599 LEXINGTON AVENUE 2OTH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER NAME:	
		FORMER CONFORMED NAME:	Starboard Value & Opportunity Master Fund Ltd
		DATE OF NAME CHANGE:	20060823

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Ramius LLC
		CENTRAL INDEX KEY:			0001475770
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23837
		FILM NUMBER:		101215772

	BUSINESS ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		212 845 7900

	MAIL ADDRESS:	
		STREET 1:		599 LEXINGTON AVENUE
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

	FORMER NAME:	
		FORMER CONFORMED NAME:	Park Exchange LLC
		DATE OF NAME CHANGE:	20091030

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Cowen Overseas Investment LP
		CENTRAL INDEX KEY:			0001506502

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-23837
		FILM NUMBER:		101215773

	BUSINESS ADDRESS:	
		STREET 1:		C/O CITCO FUND SERVICES (CAYMAN ISLANDS)
		STREET 2:		REGATTA OFFICE PARK, WINDWARD 1, 2ND FLO
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1205
		BUSINESS PHONE:		212.845.7900

	MAIL ADDRESS:	
		STREET 1:		C/O CITCO FUND SERVICES (CAYMAN ISLANDS)
		STREET 2:		REGATTA OFFICE PARK, WINDWARD 1, 2ND FLO
		CITY:			GRAND CAYMAN
		STATE:			E9
		ZIP:			KY1-1205
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form306297086_11242010.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0203</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2010-11-16</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000924717</issuerCik>
        <issuerName>SURMODICS INC</issuerName>
        <issuerTradingSymbol>SRDX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001475770</rptOwnerCik>
            <rptOwnerName>Ramius LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>599 LEXINGTON AVE.</rptOwnerStreet1>
            <rptOwnerStreet2>20TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001275893</rptOwnerCik>
            <rptOwnerName>RAMIUS ADVISORS LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O RAMIUS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>599 LEXINGTON AVE., 20TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001373638</rptOwnerCik>
            <rptOwnerName>RAMIUS VALUE &amp; OPPORTUNITY MASTER FUND LTD</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CITCO FUND SERVICES (CAYMAN ISLANDS)</rptOwnerStreet1>
            <rptOwnerStreet2>REGATTA OFFICE PARK, WINDWARD 1</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-1205</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001329989</rptOwnerCik>
            <rptOwnerName>Ramius Value &amp; Opportunity Advisors LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O RAMIUS LLC</rptOwnerStreet1>
            <rptOwnerStreet2>599 LEXINGTON AVE., 20TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001506502</rptOwnerCik>
            <rptOwnerName>Cowen Overseas Investment LP</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CITCO FUND SERVICES (CAYMAN ISLANDS)</rptOwnerStreet1>
            <rptOwnerStreet2>REGATTA OFFICE PARK, WINDWARD 1</rptOwnerStreet2>
            <rptOwnerCity>GRAND CAYMAN</rptOwnerCity>
            <rptOwnerState>E9</rptOwnerState>
            <rptOwnerZipCode>KY1-1205</rptOwnerZipCode>
            <rptOwnerStateDescription>CAYMAN ISLANDS</rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>1</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $0.05 Par Value</value>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>1566567</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By Ramius Value and Opportunity Master Fund Ltd</value>
                    <footnoteId id="F3"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock, $0.05 Par Value</value>
                <footnoteId id="F1"/>
                <footnoteId id="F2"/>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>522193</value>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>Cowen Overseas Investment LP</value>
                    <footnoteId id="F4"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">Each Reporting Person may be deemed to be a member of a Section 13(d) group that owns more than 10% of the Issuer's outstanding shares of Common Stock. To enable all of the Reporting Persons to gain access to the Securities and Exchange Commission's electronic filing system (which only accepts a maximum of 10 joint filers per report), this report is the first of two identical reports relating to the same transaction being filed with the Securities and Exchange Commission.</footnote>
        <footnote id="F2">Each Reporting Person (other than Ramius Value and Opportunity Master Fund Ltd and Cowen Overseas Investment LP) disclaims beneficial ownership of the shares of Common Stock reported herein except to the extent of its pecuniary interest therein, and this report shall not be deemed to be an admission that any Reporting Person is the beneficial owner of such shares of Common Stock for purposes of Section 16 or for any other purpose.</footnote>
        <footnote id="F3">Shares of Common Stock beneficially owned by Ramius Value and Opportunity Master Fund Ltd (Value and Opportunity Master Fund). Ramius Value and Opportunity Advisors LLC (Value and Opportunity Advisors), as the investment manager of Value and Opportunity Master Fund, may be deemed to beneficially own the shares of Common Stock beneficially owned by Value and Opportunity Master Fund. Ramius LLC (Ramius), as the sole member of Value and Opportunity Advisors, may be deemed to beneficially own the shares of Common Stock beneficially owned by Value and Opportunity Master Fund.</footnote>
        <footnote id="F4">Shares of Common Stock beneficially owned by Cowen Overseas Investment LP (COIL). Ramius Advisors, LLC (Ramius Advisors), as the general partner of COIL, may be deemed to beneficially own the shares of Common Stock beneficially owned by COIL. Ramius, as the sole member of Ramius Advisors, may be deemed to beneficially own the shares of Common Stock beneficially owned by COIL.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>By: Ramius LLC; By: /s/ Owen S. Littman, Authorized Signatory</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: Ramius Advisors, LLC; By: /s/ Owen S. Littman, Authorized Signatory</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: Ramius Value and Opportunity Advisors LLC; By: /s/ Owen S. Littman, Authorized Signatory</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: Cowen Overseas Investment LP; By: /s/ Owen S. Littman, Authorized Signatory</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>By: Ramius Value and Opportunity Master Fund Ltd; By: /s/ Owen S. Littman, Authorized Signatory</signatureName>
        <signatureDate>2010-11-24</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----