The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 5,386 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 165,828 | 2,839,528 | SH | DFND | 3 | 2,839,528 | 0 | 0 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 35,051 | 1,685,150 | SH | DFND | 3 | 1,685,150 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 149,056 | 1,229,428 | SH | DFND | 2 | 1,229,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 63,619 | 1,241,338 | SH | DFND | 3 | 1,241,338 | 0 | 0 | |
| AveXis, Inc. | COM | 05366U100 | 25,303 | 332,800 | SH | DFND | 3 | 332,800 | 0 | 0 | |
| Celgene Corp | COM | 151020104 | 415,509 | 3,339,298 | SH | DFND | 2 | 3,339,298 | 0 | 0 | |
| Cidara Therapeutics Inc. | COM | 171757107 | 8,142 | 1,043,824 | SH | DFND | 3 | 1,043,824 | 0 | 0 | |
| Esperion Therapeutics Inc. | COM | 29664W105 | 49,736 | 1,408,542 | SH | DFND | 3 | 1,408,542 | 0 | 0 | |
| Five Prime Therapeutics Inc. | COM | 33830X104 | 26,299 | 727,500 | SH | DFND | 3 | 727,500 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 188,451 | 2,774,596 | SH | DFND | 1 | 2,774,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 100,438 | 7,749,832 | SH | DFND | 3 | 7,749,832 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 466,485 | 3,489,822 | SH | DFND | 3 | 3,489,822 | 0 | 0 | |
| Intercept Pharmaceuticals Inc. | COM | 45845P108 | 28,922 | 255,719 | SH | DFND | 3 | 255,719 | 0 | 0 | |
| Intra-Cellular Therapies Inc. | COM | 46116X101 | 31,281 | 1,925,000 | SH | DFND | 3 | 1,925,000 | 0 | 0 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 299,944 | 7,461,295 | SH | DFND | 3 | 7,461,295 | 0 | 0 | |
| Juno Therapeutics Inc. | COM | 48205A109 | 48,485 | 2,185,000 | SH | DFND | 3 | 2,185,000 | 0 | 0 | |
| Kite Pharma Inc. | COM | 49803L109 | 58,083 | 740,000 | SH | DFND | 3 | 740,000 | 0 | 0 | |
| MacroGenics Inc. | COM | 556099109 | 42,036 | 2,260,000 | SH | DFND | 3 | 2,260,000 | 0 | 0 | |
| Myovant Sciences Ltd. | COM | G637AM102 | 38,775 | 3,302,835 | SH | DFND | 3 | 3,302,835 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 138,627 | 3,201,552 | SH | DFND | 3 | 3,201,552 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 10,662 | 8,330,000 | SH | DFND | 3 | 8,330,000 | 0 | 0 | |
| Prothena Corp. PLC | COM | G72800108 | 19,527 | 350,000 | SH | DFND | 3 | 350,000 | 0 | 0 | |
| PTC Therapeutics Inc. | COM | 69366J200 | 6,720 | 682,912 | SH | DFND | 3 | 682,912 | 0 | 0 | |
| Puma Biotechnology Inc. | COM | 74587V107 | 9,137 | 245,616 | SH | DFND | 3 | 245,616 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 175,486 | 4,540,399 | SH | DFND | 4 | 4,540,399 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 94,940 | 245,000 | SH | DFND | 2 | 245,000 | 0 | 0 | |
| Sage Therapeutics Inc. | COM | 78667J108 | 69,111 | 972,439 | SH | DFND | 3 | 972,439 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 126,878 | 824,582 | SH | DFND | 3 | 824,582 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 159,153 | 1,455,445 | SH | DFND | 3 | 1,455,445 | 0 | 0 | |