The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Achillion Pharmaceuticals Inc. | COM | 00448Q201 | 9,979 | 1,279,340 | SH | DFND | 3 | 1,279,340 | 0 | 0 | |
| Agios Pharmaceuticals Inc. | COM | 00847X104 | 99,011 | 2,363,321 | SH | DFND | 3 | 2,363,321 | 0 | 0 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 42,078 | 1,685,150 | SH | DFND | 3 | 1,685,150 | 0 | 0 | |
| Alexion Pharmaceuticals Inc. | COM | 015351109 | 137,710 | 1,179,428 | SH | DFND | 2 | 1,179,428 | 0 | 0 | |
| Alnylam Pharmaceuticals Inc. | COM | 02043Q107 | 66,107 | 1,191,338 | SH | DFND | 3 | 1,191,338 | 0 | 0 | |
| Celgene Corp | COM | 151020104 | 355,985 | 3,609,298 | SH | DFND | 2 | 3,609,298 | 0 | 0 | |
| Cempra Inc. | COM | 15130J109 | 33,671 | 2,041,900 | SH | DFND | 3 | 2,041,900 | 0 | 0 | |
| Cidara Therapeutics Inc. | COM | 171757107 | 7,700 | 746,824 | SH | DFND | 3 | 746,824 | 0 | 0 | |
| Esperion Therapeutics Inc. | COM | 29664W105 | 9,964 | 1,008,542 | SH | DFND | 3 | 1,008,542 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 231,457 | 2,774,596 | SH | DFND | 1 | 2,774,596 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 63,688 | 7,379,832 | SH | DFND | 3 | 7,379,832 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 307,156 | 3,840,406 | SH | DFND | 3 | 3,840,406 | 0 | 0 | |
| Intercept Pharmaceuticals Inc. | COM | 45845P108 | 36,486 | 255,719 | SH | DFND | 3 | 255,719 | 0 | 0 | |
| Intra-Cellular Therapies Inc. | COM | 46116X101 | 27,174 | 700,000 | SH | DFND | 3 | 700,000 | 0 | 0 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 165,472 | 7,104,838 | SH | DFND | 3 | 7,104,838 | 0 | 0 | |
| Juno Therapeutics Inc. | COM | 48205A109 | 50,164 | 1,305,000 | SH | DFND | 3 | 1,305,000 | 0 | 0 | |
| Kite Pharma Inc. | COM | 49803L109 | 37,500 | 750,000 | SH | DFND | 3 | 750,000 | 0 | 0 | |
| MacroGenics Inc. | COM | 556099109 | 14,035 | 520,000 | SH | DFND | 3 | 520,000 | 0 | 0 | |
| Medivation Inc. | COM | 58501N101 | 120,064 | 1,991,112 | SH | DFND | 3 | 1,991,112 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 141,875 | 3,121,552 | SH | DFND | 3 | 3,121,552 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 60,559 | 8,330,000 | SH | DFND | 3 | 8,330,000 | 0 | 0 | |
| Prothena Corp. PLC | COM | G72800108 | 12,236 | 350,000 | SH | DFND | 3 | 350,000 | 0 | 0 | |
| PTC Therapeutics Inc. | COM | 69366J200 | 8,304 | 1,182,912 | SH | DFND | 3 | 1,182,912 | 0 | 0 | |
| Puma Biotechnology Inc. | COM | 74587V107 | 12,869 | 431,991 | SH | DFND | 3 | 431,991 | 0 | 0 | |
| Radius Health Inc. | COM | 750469207 | 160,245 | 4,360,399 | SH | DFND | 4 | 4,360,399 | 0 | 0 | |
| Regeneron Pharmaceuticals Inc. | COM | 75886F107 | 71,592 | 205,000 | SH | DFND | 2 | 205,000 | 0 | 0 | |
| Sage Therapeutics Inc. | COM | 78667J108 | 25,630 | 850,639 | SH | DFND | 3 | 850,639 | 0 | 0 | |
| Tesaro Inc. | COM | 881569107 | 97,043 | 1,154,582 | SH | DFND | 3 | 1,154,582 | 0 | 0 | |
| Tobira Therapeutics Inc. | COM | 88883P101 | 5,878 | 468,000 | SH | DFND | 4 | 468,000 | 0 | 0 | |
| Vertex Pharmaceuticals Inc. | COM | 92532F100 | 121,757 | 1,415,445 | SH | DFND | 3 | 1,415,445 | 0 | 0 | |