Note 17 - Subsequent Events (Details Textual)							12 Months Ended
	Mar. 07, 2023 $ / shares shares	Feb. 27, 2023 USD ($) shares	Jan. 25, 2023 USD ($) shares	Jan. 12, 2023 USD ($)	Jan. 03, 2023 USD ($) $ / shares shares	Dec. 29, 2022 $ / shares shares	Dec. 31, 2022 ft² $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Mar. 03, 2023 shares	Jun. 24, 2021 shares	Dec. 08, 2020 shares
Stock Issued During Period, Value, Warrants Exercised | $								$ 7,991,101
Common Stock, Shares Authorized (in shares)							20,000,000	20,000,000		20,000,000	10,000,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)							226,746	222,700
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share) | $ / shares							$ 3.18	$ 7.45
Officers and Employees [Member] | Share-Based Payment Arrangement, Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)	4 years
Office Lease [Member]
Area of Real Estate Property (Square Foot) | ft²							1,500
Pre-funded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						1,678,696
Class of Warrant or Right, Purchase Price of Warrants or Rights (in dollars per share) | $ / shares						$ 1.6099
Series A-1 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						2,608,696
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares						$ 1.36
Warrants and Rights Outstanding, Term (Year)						5 years
Series A-2 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						2,608,696
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares						$ 1.36
Warrants and Rights Outstanding, Term (Year)						3 years
Subsequent Event [Member]
Common Stock, Shares Authorized (in shares)									50,000,000
Subsequent Event [Member] | Officers and Employees [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)	329,131
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 1.28
Subsequent Event [Member] | Each of Five Non-employee Directors [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)	3,350
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share) | $ / shares	$ 1.28
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Year)	1 year
Subsequent Event [Member] | Office Lease [Member]
Lessee, Operating Lease, Renewal Term (Year)				3 years
Operating Lease, Monthly Payment | $				$ 1,700
Lessee, Operating Lease, Extension Option, Renewal Term (Year)				3 years
Subsequent Event [Member] | Pre-funded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					1,678,696
Class of Warrant or Right, Purchase Price of Warrants or Rights (in dollars per share) | $ / shares					$ 1.6099
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares					$ 0.0001
Stock Issued During Period, Shares, Warrants Exercised (in shares)		741,000	400,696
Stock Issued During Period, Value, Warrants Exercised | $		$ 74	$ 40
Subsequent Event [Member] | Series A-1 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					2,608,696
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares					$ 1.36
Warrants and Rights Outstanding, Term (Year)					5 years
Subsequent Event [Member] | Series A-2 Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					2,608,696
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares					$ 1.36
Warrants and Rights Outstanding, Term (Year)					3 years
Subsequent Event [Member] | Warrants Issued to Placement Agent [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					156,522
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares					$ 2.0125
Warrants and Rights Outstanding, Term (Year)					5 years
Registered Direct Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)						930,000
Shares Issued, Price Per Share (in dollars per share) | $ / shares						$ 1.61
Registered Direct Offering [Member] | Subsequent Event [Member]
Stock Issued During Period, Shares, New Issues (in shares)					930,000
Shares Issued, Price Per Share (in dollars per share) | $ / shares					$ 1.61
Proceeds from Issuance or Sale of Equity, Total | $					$ 3,700,000
Stock Issued, Offering Fee, Percentage of Proceeds					7.50%
Stock Issued, Management Fee, Percentage of Proceeds					1.00%
Non-accountable Expense | $					$ 35,000
Legal Counsel Expense and Other Out-of-pocket Expense | $					50,000
Clearing Expense | $					$ 15,950