Balance Sheet Components (Tables)
|
12 Months Ended |
Dec. 31, 2015 |
Organization Consolidation And Presentation Of Financial Statements [Abstract] |
|
Schedule of Cash and Cash Equivalents |
Cash and cash equivalents consisted of the following (in thousands):
|
|
December 31, |
|
|
|
2015 |
|
|
2014 |
|
Cash |
|
$ |
75,685 |
|
|
$ |
151,653 |
|
Money market funds |
|
|
77,639 |
|
|
|
13,802 |
|
Total cash and cash equivalents |
|
$ |
153,324 |
|
|
$ |
165,455 |
|
|
Schedule of Property and Equipment |
Property and equipment consisted of the following (in thousands):
|
|
December 31, |
|
|
|
2015 |
|
|
2014 |
|
Laboratory equipment |
|
$ |
18,233 |
|
|
$ |
17,114 |
|
Computer equipment |
|
|
5,701 |
|
|
|
5,106 |
|
Furniture and fixtures |
|
|
5,361 |
|
|
|
5,082 |
|
Leasehold improvements |
|
|
93,380 |
|
|
|
92,790 |
|
Building shell (Refer to Note 8) |
|
|
53,879 |
|
|
|
53,879 |
|
Construction in progress |
|
|
193 |
|
|
|
519 |
|
Total property and equipment |
|
$ |
176,747 |
|
|
$ |
174,490 |
|
Less: accumulated depreciation |
|
|
(47,727 |
) |
|
|
(42,319 |
) |
Property and equipment, net |
|
$ |
129,020 |
|
|
$ |
132,171 |
|
|
Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments |
All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):
|
|
December 31, 2015 |
|
|
|
Amortized Cost |
|
|
Gross Unrealized
Holding Gains |
|
|
Gross Unrealized
Holding Losses |
|
|
Fair Value |
|
Corporate bonds |
|
$ |
126,522 |
|
|
$ |
54 |
|
|
$ |
(473 |
) |
|
$ |
126,103 |
|
Certificate of deposits |
|
|
8,217 |
|
|
|
— |
|
|
|
(2 |
) |
|
|
8,215 |
|
Bond and mutual funds |
|
|
25,052 |
|
|
|
— |
|
|
|
— |
|
|
|
25,052 |
|
Equity investments |
|
|
126 |
|
|
|
71 |
|
|
|
— |
|
|
|
197 |
|
Total investments |
|
$ |
159,917 |
|
|
$ |
125 |
|
|
$ |
(475 |
) |
|
$ |
159,567 |
|
|
|
December 31, 2014 |
|
|
|
Amortized Cost |
|
|
Gross Unrealized
Holding Gains |
|
|
Gross Unrealized
Holding Losses |
|
|
Fair Value |
|
Corporate bonds |
|
$ |
158,692 |
|
|
$ |
254 |
|
|
$ |
(514 |
) |
|
$ |
158,432 |
|
Equity investments |
|
|
124 |
|
|
|
77 |
|
|
|
— |
|
|
|
201 |
|
Total investments |
|
$ |
158,816 |
|
|
$ |
331 |
|
|
$ |
(514 |
) |
|
$ |
158,633 |
|
|
Summary of Contractual Maturities Available-for-Sale Investments at Fair Value |
The contractual maturities of available-for-sale investments were as follows (in thousands):
|
|
December 31, |
|
|
|
2015 |
|
Within one year |
|
$ |
12,797 |
|
After one year through four years |
|
|
121,521 |
|
Total debt investments |
|
|
134,318 |
|
Bond and mutual funds |
|
|
25,052 |
|
Equity investments |
|
|
197 |
|
Total investments |
|
|
159,567 |
|
|
Schedule of Accrued Liabilities |
Accrued liabilities consisted of the following (in thousands):
|
|
December 31, |
|
|
|
2015 |
|
|
2014 |
|
Preclinical and clinical trial accruals |
|
$ |
27,973 |
|
|
$ |
25,418 |
|
Payroll and related accruals |
|
|
13,535 |
|
|
|
15,608 |
|
Professional services |
|
|
1,662 |
|
|
|
2,401 |
|
Other |
|
|
4,762 |
|
|
|
5,558 |
|
Total accrued liabilities |
|
$ |
47,932 |
|
|
$ |
48,985 |
|
|