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Balance Sheet Components (Tables)
12 Months Ended
Dec. 31, 2015
Organization Consolidation And Presentation Of Financial Statements [Abstract]  
Schedule of Cash and Cash Equivalents

Cash and cash equivalents consisted of the following (in thousands):

 

 

 

December 31,

 

 

 

2015

 

 

2014

 

Cash

 

$

75,685

 

 

$

151,653

 

Money market funds

 

 

77,639

 

 

 

13,802

 

Total cash and cash equivalents

 

$

153,324

 

 

$

165,455

 

 

Schedule of Property and Equipment

Property and equipment consisted of the following (in thousands):

 

 

 

December 31,

 

 

 

2015

 

 

2014

 

Laboratory equipment

 

$

18,233

 

 

$

17,114

 

Computer equipment

 

 

5,701

 

 

 

5,106

 

Furniture and fixtures

 

 

5,361

 

 

 

5,082

 

Leasehold improvements

 

 

93,380

 

 

 

92,790

 

Building shell (Refer to Note 8)

 

 

53,879

 

 

 

53,879

 

Construction in progress

 

 

193

 

 

 

519

 

Total property and equipment

 

$

176,747

 

 

$

174,490

 

Less: accumulated depreciation

 

 

(47,727

)

 

 

(42,319

)

Property and equipment, net

 

$

129,020

 

 

$

132,171

 

 

Summary of Amortized Cost, Gross Unrealized Holding Gains or Losses, and Fair Value of Available-for-Sale Investments

All investments are classified as available-for-sale. The amortized cost, gross unrealized holding gains or losses, and fair value of the Company’s available-for-sale investments by major investments type are summarized in the tables below (in thousands):

 

 

 

December 31, 2015

 

 

 

Amortized Cost

 

 

Gross Unrealized

Holding Gains

 

 

Gross Unrealized

Holding Losses

 

 

Fair Value

 

Corporate bonds

 

$

126,522

 

 

$

54

 

 

$

(473

)

 

$

126,103

 

Certificate of deposits

 

 

8,217

 

 

 

 

 

 

(2

)

 

 

8,215

 

Bond and mutual funds

 

 

25,052

 

 

 

 

 

 

 

 

 

25,052

 

Equity investments

 

 

126

 

 

 

71

 

 

 

 

 

 

197

 

Total investments

 

$

159,917

 

 

$

125

 

 

$

(475

)

 

$

159,567

 

 

 

 

December 31, 2014

 

 

 

Amortized Cost

 

 

Gross Unrealized

Holding Gains

 

 

Gross Unrealized

Holding Losses

 

 

Fair Value

 

Corporate bonds

 

$

158,692

 

 

$

254

 

 

$

(514

)

 

$

158,432

 

Equity investments

 

 

124

 

 

 

77

 

 

 

 

 

 

201

 

Total investments

 

$

158,816

 

 

$

331

 

 

$

(514

)

 

$

158,633

 

 

Summary of Contractual Maturities Available-for-Sale Investments at Fair Value

The contractual maturities of available-for-sale investments were as follows (in thousands):

 

 

 

December 31,

 

 

 

2015

 

Within one year

 

$

12,797

 

After one year through four years

 

 

121,521

 

Total debt investments

 

 

134,318

 

Bond and mutual funds

 

 

25,052

 

Equity investments

 

 

197

 

Total investments

 

 

159,567

 

 

Schedule of Accrued Liabilities

Accrued liabilities consisted of the following (in thousands):

 

 

 

December 31,

 

 

 

2015

 

 

2014

 

Preclinical and clinical trial accruals

 

$

27,973

 

 

$

25,418

 

Payroll and related accruals

 

 

13,535

 

 

 

15,608

 

Professional services

 

 

1,662

 

 

 

2,401

 

Other

 

 

4,762

 

 

 

5,558

 

Total accrued liabilities

 

$

47,932

 

 

$

48,985