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Liquidity (Narrative) (Details)
3 Months Ended
Mar. 31, 2022
USD ($)
$ / shares
shares
Feb. 09, 2022
USD ($)
tranche
$ / shares
shares
Oct. 28, 2021
USD ($)
$ / shares
shares
Jan. 26, 2021
$ / shares
shares
Mar. 31, 2022
USD ($)
$ / shares
shares
Mar. 31, 2021
USD ($)
tranche
Dec. 31, 2021
USD ($)
$ / shares
Cash and cash equivalents | $ $ 46,408,000       $ 46,408,000 $ 22,455,000 $ 10,288,000
Liquidity, management evaluation         The Company has prepared its consolidated financial statements on a going concern basis, which assumes that the Company will realize its assets and satisfy its liabilities in the normal course of business. However, the Company has incurred net losses since its inception and has negative operating cash flows. These circumstances raise substantial doubt about the Company’s ability to continue as a going concern. The accompanying financial statements do not include any adjustments to reflect the possible future effects on the recoverability and classification of assets or the amounts and classifications of liabilities that may result from the outcome of the uncertainty concerning the Company’s ability to continue as a going concern.    
Common stock, par value (in dollars per share) | $ / shares $ 0.01   $ 0.01   $ 0.01   $ 0.01
Securities Purchase Agreement [Member]              
Proceeds from equity offerings, gross | $     $ 7,000,000.0     20,000,000.0  
Shares Issued, Price Per Share | $ / shares     $ 3.30 $ 3.25      
Securities Purchase Agreement [Member] | Cystic Fibrosis Foundation [Member]              
Stock Issued During Period, Shares, New Issues     909,091        
Securities Purchase Agreement [Member] | Innoviva Strategic Opportunities LLC [Member]              
Number of tranches | tranche   2          
Shares Issued, Price Per Share | $ / shares   $ 5.00          
Stock Issued During Period, Shares, New Issues   9,000,000 1,212,122        
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   4,500,000          
Exercise price of warrants | $ / shares   $ 5.00          
Securities Purchase Agreement [Member] | Common Stock Subject to Mandatory Redemption [Member]              
Shares Issued, Price Per Share | $ / shares       $ 3.25      
Stock Issued During Period, Shares, New Issues       6,153,847      
Securities Purchase Agreement [Member] | Warrants and Rights Subject to Mandatory Redemption [Member]              
Proceeds from equity offerings, gross | $           $ 20,000,000.0  
Number of tranches | tranche           2  
Securities Purchase Agreement [Member] | Warrants and Rights Subject to Mandatory Redemption [Member] | Maximum [Member]              
Class of Warrant or Right, Number of Securities Called by Warrants or Rights       6,153,847      
Securities Purchase Agreement First Tranche [Member] | Innoviva Strategic Opportunities LLC [Member]              
Stock Issued During Period, Shares, New Issues   3,614,792          
Class of Warrant or Right, Number of Securities Called by Warrants or Rights   1,807,396          
Proceeds from issuance of common stock and warrants | $   $ 18,100,000          
Securities Purchase Agreement Second Tranche [Member] | Innoviva Strategic Opportunities LLC [Member]              
Stock Issued During Period, Shares, New Issues 5,385,208            
Class of Warrant or Right, Number of Securities Called by Warrants or Rights 2,692,604       2,692,604    
Proceeds from issuance of common stock and warrants | $ $ 26,900,000