Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the incorporation by reference in the following Registration Statements:

(1) Registration Statements (Form S-1 Nos. 333-213421, 333-217169, 333-217680 and 333-226959) of AmpliPhi Biosciences Corporation,

(2) Registration Statement (Form S-3 No. 333-210974) of AmpliPhi Biosciences Corporation,

(3) Registration Statement (Form S-8 No. 333-203455) pertaining to the 2012 Stock Incentive Plan and 2013 Stock Incentive Plan,

(4) Registration Statement (Form S-8 No. 333-221564) pertaining to the AmpliPhi Biosciences Corporation 2016 Equity Incentive Plan, and

(5) Registration Statements (Form S-8 Nos. 333-212183, 333-217563 and 333-223987) pertaining to the AmpliPhi Biosciences Corporation 2016 Employee Stock Purchase Plan and AmpliPhi Biosciences Corporation 2016 Equity Incentive Plan;

of our report dated March 25, 2019, with respect to the consolidated financial statements of AmpliPhi Biosciences Corporation included in this Annual Report (Form 10-K) of AmpliPhi Biosciences Corporation for the year ended December 31, 2018.

	/s/ Ernst & Young LLP
San Diego, California
March 25, 2019