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Fair Value of Financial Assets and Liabilities - Derivative Instruments (Valuation Assumptions for June 2016 Offering Warrants) (Details) - $ / shares
3 Months Ended 12 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Fair Value Assumptions and Methodology for Assets and Liabilities [Line Items]    
Common stock closing price $ 4.30  
June 2016 Offering Liability [Member]    
Fair Value Assumptions and Methodology for Assets and Liabilities [Line Items]    
Volatility 115.00% 118.00%
Expected term (years) 4 years 2 months 1 day 4 years 5 months 1 day
Risk-free interest rate 1.81% 1.80%
Dividend yield 0.00% 0.00%
Exercise price $ 22.50 $ 22.50
Common stock closing price $ 4.30 $ 4.40