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Income Taxes (Details) (USD $)
Dec. 31, 2014
Dec. 31, 2013
Deferred tax assets/(liabilities)    
Net operating loss carry-forwards $ 61,332,000us-gaap_DeferredTaxAssetsOperatingLossCarryforwards $ 59,051,000us-gaap_DeferredTaxAssetsOperatingLossCarryforwards
Research and orphan drug credit carry-forwards 3,855,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch 3,700,000us-gaap_DeferredTaxAssetsTaxCreditCarryforwardsResearch
Depreciation and amortization (8,000)aphb_DeferredTaxAssetsDepreciationAndAmortization (4,000)aphb_DeferredTaxAssetsDepreciationAndAmortization
Stock options and other 1,381,000us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost 1,121,000us-gaap_DeferredTaxAssetsTaxDeferredExpenseCompensationAndBenefitsShareBasedCompensationCost
Intangible assets (3,155,000)us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets (3,162,000)us-gaap_DeferredTaxAssetsGoodwillAndIntangibleAssets
Net deferred tax assets/(liabilities) 63,405,000us-gaap_DeferredTaxAssetsGross 60,708,000us-gaap_DeferredTaxAssetsGross
Valuation allowance for deferred tax assets (66,483,000)us-gaap_DeferredTaxAssetsValuationAllowance (63,786,000)us-gaap_DeferredTaxAssetsValuationAllowance
Net deferred tax assets/(liabilities) $ (3,078,000)us-gaap_DeferredTaxAssetsLiabilitiesNet $ (3,078,000)us-gaap_DeferredTaxAssetsLiabilitiesNet