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Stock-Based Compensation (Tables)
3 Months Ended
Mar. 31, 2014
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
Following is a summary of the amount included as stock-based compensation expense in the accompanying consolidated statements of operations and comprehensive loss:
 
 
 
Three Months Ended March
31, 2014 (Unaudited)
 
Three Months Ended March
31, 2013 (Unaudited)
 
Year Ended December
31, 2013
 
Stock options:
 
 
 
 
 
 
 
 
 
 
Research and development expense
 
$
38,000
 
$
42,000
 
$
191,000
 
General and administrative expense
 
 
224,000
 
 
112,000
 
 
1,246,000
 
Total stock-based compensation expense
 
$
262,000
 
$
154,000
 
$
1,437,000
 
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
The following table summarizes Option activity:
  
 
 
Shares
 
Weighted Average Exercise
Price
 
Average Remaining
Contractual Term
(Years)
 
Intrinsic Value
 
Outstanding at December 31, 2013
 
 
25,721,000
 
$
0.19
 
 
 
 
 
 
 
Granted
 
 
 
 
 
 
 
 
 
 
 
Exercised
 
 
 
 
 
 
 
 
 
 
 
Forfeited
 
 
 
 
 
 
 
 
 
 
 
Expired
 
 
 
 
 
 
 
 
 
 
 
Outstanding at March 31, 2014
 
 
25,721,000
 
$
0.19
 
 
8.88
 
$
8,416,233
 
Exercisable at March 31, 2014
 
 
10,089,662
 
$
0.19
 
 
8.89
 
$
4,049,376
 
Schedule of Common Stock, Capital Shares Reserved for Future Issuance [Table Text Block]
 
As of March 31, 2013, the Company had reserved shares of its common stock for future issuance as follows:
 
 
 
Shares Reserved
 
Stock options outstanding
 
 
25,721,000
 
Available for future grants under the Stock Incentive Plan
 
 
40,000,000
 
Warrants
 
 
38,425,745
 
Total Shares reserved
 
 
104,146,745