EXHIBIT 32.2


               CERTIFICATION PURSUANT TO 18 U.S.C. SECTION 1350,
                             AS ADOPTED PURSUANT TO
                 SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

      In connection with the accompanying Quarterly Report of Targeted Genetics
Corporation (the "Company") on Form 10-Q for the period ended March 31, 2005 as
filed with the Securities and Exchange Commission on the date hereof (the
"Report"), I, Todd E. Simpson, Vice President, Finance and Administration, Chief
Financial Officer, Secretary and Treasurer of the Company, certify, pursuant to
18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley
Act of 2002, that:

      (1) The Report fully complies with the requirements of Section 13(a) or
      15(d) of the Securities Exchange Act of 1934, as amended; and

      (2) The information contained in the Report fairly presents, in all
      material respects, the financial condition and results of operations of
      the Company.

Date: April 27, 2005            /s/ Todd E. Simpson
--------------------            ------------------------------------------------
                                Todd E. Simpson
                                Vice President, Finance and Administration,
                                Chief Financial Officer, Secretary and Treasurer