-----BEGIN PRIVACY-ENHANCED MESSAGE-----
Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
Originator-Key-Asymmetric:
 MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen
 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 BLWRHRkBknL56SmSVMGAowjuiDc5JFeGy06uIY+cirEJsNhJmkQYG9SBTQ1+S/Lu
 sCtiqGBsCludgd1VrwjajA==

<SEC-DOCUMENT>0001209191-06-046114.txt : 20060815
<SEC-HEADER>0001209191-06-046114.hdr.sgml : 20060815
<ACCEPTANCE-DATETIME>20060815205749
ACCESSION NUMBER:		0001209191-06-046114
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20060814
FILED AS OF DATE:		20060815
DATE AS OF CHANGE:		20060815

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Hinds John J
		CENTRAL INDEX KEY:			0001371915

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-24050
		FILM NUMBER:		061036784

	BUSINESS ADDRESS:	
		BUSINESS PHONE:		847-864-3500

	MAIL ADDRESS:	
		STREET 1:		C/O NORTHFIELD LABORATORIES INC.
		STREET 2:		1560 SHERMAN AVENUE, SUITE 1000
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201-4800

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			NORTHFIELD LABORATORIES INC /DE/
		CENTRAL INDEX KEY:			0000920947
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				363378733
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0531

	BUSINESS ADDRESS:	
		STREET 1:		1560 SHERMAN AVE
		STREET 2:		SUITE 1000
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201-4800
		BUSINESS PHONE:		8478643500

	MAIL ADDRESS:	
		STREET 1:		1560 SHERMAN AVE STE 1000
		STREET 2:		37TH FLOOR
		CITY:			EVANSTON
		STATE:			IL
		ZIP:			60201-4800
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>boc07884_02jjh1.xml
<DESCRIPTION>MAIN DOCUMENT DESCRIPTION
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2006-08-14</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0000920947</issuerCik>
        <issuerName>NORTHFIELD LABORATORIES INC /DE/</issuerName>
        <issuerTradingSymbol>NFLD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001371915</rptOwnerCik>
            <rptOwnerName>Hinds John J</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O NORTHFIELD LABORATORIES INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1560 SHERMAN AVENUE, SUITE 1000</rptOwnerStreet2>
            <rptOwnerCity>EVANSTON</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60201-4800</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>Vice President Finance</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <remarks>No securities are beneficially owned.</remarks>

    <ownerSignature>
        <signatureName>/s/ John J. Hinds</signatureName>
        <signatureDate>2006-08-14</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
-----END PRIVACY-ENHANCED MESSAGE-----